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( Sayuri Yamamoto ),( Yurika Kawamura ),( Kazuhiro Yamamoto ),( Yoshiharu Yamaguchi ),( Yasuhiro Tamura ),( Shinya Izawa ),( Hiroaki Nakagawa ),( Yoshinori Wakita ),( Yasutaka Hijikata ),( Masahide Eb 대한소화기기능성질환·운동학회 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.4
Background/Aims Chronic constipation and lifestyle factors can affect sleep quality. We evaluated the relationship between chronic constipation and sleep in the Japanese population. Methods This cross-sectional internet-based survey included 3000 subjects with constipation, classified according to sleep status (good/poor). Primary endpoints were Bristol stool form scale (BSFS) score and correlations between sleep disorder criteria of the Pittsburgh Sleep Quality Index (PSQI) and sleep status (good/poor sleep). Secondary endpoints included correlations between quality of life (QOL) and mood, medical, lifestyle, and sleep factors. Results The proportion of participants with BSFS category 4 (normal stool) was significantly higher in the good sleep group (P < 0.001). Sleep disturbance (P < 0.05), sleep quality, and duration, use of hypnotic medication, and daytime dysfunction of PSQI (all P < 0.001) significantly correlated with poor sleep. In the poor sleep group, QOL was significantly worse and anxiety and depression levels were significantly higher (all P < 0.001) compared with the good sleep group. Anemia and smoking (both P < 0.05), recent body weight increases, and poor eating habits (all P < 0.001) were significantly higher in the poor sleep group. Male sex, onset associated with change in frequency of stools, sensation of incomplete evacuation for at least 25% of defecations, and manual maneuvers to facilitate at least 25% of defecations correlated with poor sleep. Conclusions Subjects with constipation and poor sleep experienced severe symptoms and had poor QOL. These data support the need for a multifocal treatment approach, including lifestyle advice and pharmacotherapy. (J Neurogastroenterol Motil 2021;27:602-611)
Isomura, Yoshinori,Yamamoto, Kichiro,Morimoto, Shigeo,Maetani, Tatsuo,Watanabe, Akihiko,Nakano, Keisaku Journal of International Conference on Electrical 2014 Journal of international Conference on Electrical Vol.3 No.3
The voltage source PWM inverter generally used to drive the air conditioning (A/C) fans has been posing a large issue that the bearings in air conditioning fan motors are highly possible to be corroded electrically. Potential difference called shaft voltage is generated between inner and outer rings of the bearings due to inverter switching. The shaft voltage causes bearing lubricant breakdown dielectrically. As a result, bearing current is caused. This current causes the bearing corrosion. In previous work, we demonstrated that the shaft voltage can be reduced by using an insulator inserted between the outer and inner cores of the rotor in an air conditioning fan motor without grounding. This paper proposes the other countermeasure for reducing the shaft voltage in fan motors. The countermeasure which adds a capacitor between the brackets and the stator core is effective even for fan motors with non-insulated rotor. The effectiveness is confirmed by both simulated and experimental results.
Naoyuki Tateiwa,Yoshinori Haga,Tatsuma D. Matsuda,Etsuji Yamamoto,Yoshichika Onuki,Zachary Fisk 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We have studied the high-pressure magnetic property in UGe2 where ferromagnetic superconductivityappears under high pressure. In this study, we focus on the magnetic property at pressuresabove the ferromagnetic critical pressure Pc =1.6 GPa. The temperature and magnetic field dependencesof the dc-magnetization have been measured under high pressures up to 5.1 GPa by using aceramic anvil high pressure cell. At pressures above Pc, the magnetic susceptibility χ shows a broadmaximum around Tχmax and the magnetization at 2.0 K shows an abrupt increase (metamagnetictransition) at Hc. With increasing pressure, the peak structure in χ becomes broader, and thepeak position Tχmax moves to the higher temperature region. The metamagnetic field Hc increasesrapidly with increasing pressure. At pressures above 4.1 GPa, χ shows a simple temperature dependence,and the magnetization increases linearly with increasing field. These phenomena in UGe2resemble to those in the intermetallic compounds of 3d transition metals such as Co(S1−xSex) andYCo2. We discuss the experimental results by using the phenomenological spin-fluctuation theory.
Detection of blood vessels on CTA images of the legs
Keita Kozono,Akiyoshi Yamamoto,Yoshinori Itai,Hyoungseop Kim,Joo Kooi Tan,Seiji Ishikawa 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10
The disease that causes the obstruction of blood flow by arteriosclerosis and thickening of the arteries in the legs is called arteriosclerosis obliterans (ASO). The early detection and treatment of ASO is very important issue in the medical field. Recently, by using computer aided diagnosis (CAD), physicians can easily detect the blood vessel on the image and displaying the results by use of the system. One of the techniques for analyzing the blood vessels widely used in medical imaging is computed tomography angiography (CTA). The CTA uses three dimensional (3-D) imaging technologies. It also produces a clear image of main blood vessels throughout the body by using contrast media. The 3-D blood vessel image is made the volume data obtained by the CTA. By using 3-D image, we can observe the image from multi aspect. And also, it leads to the improvement of the diagnosis accuracy. In order to diagnose a symptom of the ASO, we propose a method for visual screening technique by detecting blood vessel area on the images. In this paper, we have developed a technique for separation of bone region and blood vessel area in order to extract blood vessels from a CTA volume image. The proposed technique was applied to two real CTA cases and satisfactory results for segmentation of the blood vessels were obtained. Some experimental results are shown with discussions.
<sup>123</sup>I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice
Nakano, Atushi,Kawashima, Hidekazu,Miyake, Yoshinori,Zeniya, Tsutomu,Yamamoto, Akihide,Koshino, Kazuhiro,Temma, Takashi,Fukuda, Tetsuya,Fujita, Yoshiko,Kakino, Akemi,Kanaya, Shigehiko,Sawamura, Tatsuy 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.2
Purpose Oxidized low-density lipoprotein (oxLDL) plays a key role in endothelial dysfunction, vascular inflammation, and atherogenesis. The aim of this study was to assess blood clearance and in vivo kinetics of radiolabeled oxLDL in mice. Methods We synthesized $^{123}I-oxLDL$ by the iodine monochloride method, and performed an uptake study in CHO cells transfected with lectin-like oxLDL receptor-1 (LOX-1). In addition, we evaluated the consistency between the $^{123}I-oxLDL$ autoradiogram and the fluorescence image of DiI-oxLDL after intravenous injection for both spleen and liver. Whole-body dynamic planar images were acquired 10 min post injection of $^{123}I-oxLDL$ to generate regional time-activity curves (TACs) of the liver, heart, lungs, kidney, head, and abdomen. Regional radioactivity for those excised tissues as well as the bladder, stomach, gut, and thyroid were assessed using a gamma counter, yielding percent injected dose (%ID) and dose uptake ratio (DUR). The presence of $^{123}I-oxLDL$ in serum was assessed by radio-HPLC. Results The cellular uptakes of $^{123}I-oxLDL$ were identical to those of DiI-oxLDL, and autoradiograms and fluorescence images also exhibited consistent distributions. TACs after injection of $^{123}I-oxLDL$ demonstrated extremely fast kinetics. The radioactivity uptake at 10 min post-injection was highest in the liver ($40.8{\pm}2.4%$ ID). Notably, radioactivity uptake was equivalent throughout the rest of the body ($39.4{\pm}2.7%$ ID). HPLC analysis revealed no remaining $^{123}I-oxLDL$ or its metabolites in the blood. Conclusion $^{123}I-oxLDL$ was widely distributed not only in the liver, but also throughout the whole body, providing insight into the pathophysiological effects of oxLDL.
Magnetic Phase Diagram of UCoAl
Tatsuma D. Matsuda,Naoyuki Tateiwa,Etsuji Yamamoto,Yoshinori Haga,Yoshichika Onuki,Dai Aoki,Jacques Flouquet,Zachary Fisk 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We report precision c-axis magnetic measurements on a high-quality single crystal of the heavyfermion metamagnet UCoAl. The metamagnetic transition at HM changes from 1st order at lowtemperature to a crossover at high temperature. HM is nearly linearly increasing with increasingtemperature up to a critical temperature T0. The critical temperature T0 is determined from boththe field and the temperature dependences of magnetization to be 11 K. The field dependence ofthe Sommerfeld coefficientis estimated from M(T) by using a Maxwell relation. (H) shows astep-like decrease at HM. This behavior is consistent with the previous reports of specific heat andresistivity measurements at low temperatures.
Paramagnetic-assisted NMR Analyses of Conformational Dynamics of Gangliosides
Ying Zhang,Takumi Yamaguchi,Sayoko Yamamoto,Yoshinori Uekusa,Koichi Kato 한국당과학회 2012 한국당과학회 학술대회 Vol.2012 No.1
For better understanding the molecular basis of the mechanism underlying oligosaccharides functions, it is quite desirable to gain detail information on their conformational dynamics in solution. However, the conformational analysis of oligosaccharides is still a remaining challenge, because of their branched covalent structures and dynamic conformational multiplicities, which hinder conventional analytical methods. For conformational characterization of flexible oligosaccharides, their structures should not be dealt with as a single well-defined global free energy minimum but as an ensemble of low energy conformers. Hence, we have been developing a methodology for evaluating a dynamic ensemble of oligosaccharide conformations by employing paramagnetic-assisted NMR methods based on paramagnetic effects such as pseudocontact shift (PCS) and paramagnetic relaxation enhancement (PRE) in conjunction with molecular dynamics (MD) simulations [1,2]. We applied this approach to the conformational dynamics analyses of branched GM2 tetrasaccharide, βGalNAc-(1-4)-[αNeu5Ac-(2-3)]-βGal-(1-4)-βGlc, which share the common core structure of gangliosides forming an integral part of cellular membranes. We synthesized the GM2 tetrasaccharide covalently attached to a lanthanide chelating-tag (Fig. 1). Upon complexation with paramagnetic lanthanide ions, the tagged sugar exhibited NMR spectral changes due to PCSs. The observed PCS values were in excellent agreement with those back-calculated from the 3D ensemble models derived from the MD calculations. In addition, we have developed spin-labeling method of gangliosides for their NMR analyses in amphipathic environments. These methodologies open a new prospect for conformational analyses of dynamic structures of gangliosides toward decoding glycocodes from the 3D structural aspects.