http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A SUB-SATURN MASS PLANET, MOA-2009-BLG-319Lb
Miyake, N.,Sumi, T.,Dong, Subo,Street, R.,Mancini, L.,Gould, A.,Bennett, D. P.,Tsapras, Y.,Yee, J. C.,Albrow, M. D.,Bond, I. A.,Fouqué,, P.,Browne, P.,Han, C.,Snodgrass, C.,Finet, F.,Furusawa, K IOP Publishing 2011 The Astrophysical journal Vol.728 No.2
<P>We report the gravitational microlensing discovery of a sub-Saturn mass planet, MOA-2009-BLG-319Lb, orbiting a K-or M-dwarf star in the inner Galactic disk or Galactic bulge. The high-cadence observations of the MOA-II survey discovered this microlensing event and enabled its identification as a high-magnification event approximately 24 hr prior to peak magnification. As a result, the planetary signal at the peak of this light curve was observed by 20 different telescopes, which is the largest number of telescopes to contribute to a planetary discovery to date. The microlensing model for this event indicates a planet-star mass ratio of q = (3.95 +/- 0.02) x 10(-4) and a separation of d = 0.97537 +/- 0.00007 in units of the Einstein radius. A Bayesian analysis based on the measured Einstein radius crossing time, t(E), and angular Einstein radius,theta(E), along with a standard Galactic model indicates a host star mass of M-L = 0.38(-0.18)(+0.34) M-circle dot and a planet mass of M-p = 50(-24)(+44)M(circle plus), which is half the mass of Saturn. This analysis also yields a planet-star three-dimensional separation of a = 2.4(-0.6)(+1.2) AU and a distance to the planetary system of D-L = 6.1(-1.2)(+1.1) kpc. This separation is similar to 2 times the distance of the snow line, a separation similar to most of the other planets discovered by microlensing.</P>
Miyake, N.,Tsukaguchi, H.,Koshimizu, E.,Shono, A.,Matsunaga, S.,Shiina, M.,Mimura, Y.,Imamura, S.,Hirose, T.,Okudela, K.,Nozu, K.,Akioka, Y.,Hattori, M.,Yoshikawa, N.,Kitamura, A.,Cheong, H.,Kagami, S University of Chicago Press [etc.] 2015 American journal of human genetics Vol.97 No.4
The nuclear pore complex (NPC) is a huge protein complex embedded in the nuclear envelope. It has central functions in nucleocytoplasmic transport, nuclear framework, and gene regulation. Nucleoporin 107 kDa (NUP107) is a component of the NPC central scaffold and is an essential protein in all eukaryotic cells. Here, we report on biallelic NUP107 mutations in nine affected individuals who are from five unrelated families and show early-onset steroid-resistant nephrotic syndrome (SRNS). These individuals have pathologically focal segmental glomerulosclerosis, a condition that leads to end-stage renal disease with high frequency. NUP107 is ubiquitously expressed, including in glomerular podocytes. Three of four NUP107 mutations detected in the affected individuals hamper NUP107 binding to NUP133 (nucleoporin 133 kDa) and NUP107 incorporation into NPCs in vitro. Zebrafish with nup107 knockdown generated by morpholino oligonucleotides displayed hypoplastic glomerulus structures and abnormal podocyte foot processes, thereby mimicking the pathological changes seen in the kidneys of the SRNS individuals with NUP107 mutations. Considering the unique properties of the podocyte (highly differentiated foot-process architecture and slit membrane and the inability to regenerate), we propose a ''podocyte-injury model'' as the pathomechanism for SRNS due to biallelic NUP107 mutations.
BGN Mutations in X-Linked Spondyloepimetaphyseal Dysplasia
Cho, S.Y.,Bae, J.S.,Kim, N.K.D.,Forzano, F.,Girisha, K.M.,Baldo, C.,Faravelli, F.,Cho, T.J.,Kim, D.,Lee, K.Y.,Ikegawa, S.,Shim, J.S.,Ko, A.R.,Miyake, N.,Nishimura, G.,Superti-Furga, A.,Spranger, J.,Ki University of Chicago Press [etc.] 2016 American journal of human genetics Vol.98 No.6
<P>Spondyloepimetaphyseal dysplasias (SEMDs) comprise a heterogeneous group of autosomal-dominant and autosomal-recessive disorders. An apparent X-linked recessive (XLR) form of SEMD in a single Italian family was previously reported. We have been able to restudy this family together with a second family from Korea by segregating a severe SEMD in an X-linked pattern. Exome sequencing showed missense mutations in BGN c.439A>G (p.Lys147Glu) in the Korean family and c.776G>T (p.Gly259Val) in the Italian family; the c.439A>G (p.Lys147Glu) mutation was also identified in a further simplex SEMD case from India. Biglycan is an extracellular matrix proteoglycan that can bind transforming growth factor beta (TGF-beta) and thus regulate its free concentration. In 3-dimensional simulation, both altered residues localized to the concave arc of leucine-rich repeat domains of biglycan that interact with TGF-beta. The observation of recurrent BGN mutations in XLR SEMD individuals from different ethnic backgrounds allows us to define 'XLR SEMD, BGN type'' as a nosologic entity.</P>
C.J. Ku,Y. Tamura,A. Yoshida,K. Miyake,L.S. Chou 한국풍공학회 2013 Wind and Structures, An International Journal (WAS Vol.16 No.2
Output-only modal parameter identification is based on the assumption that external forces on a linear structure are white noise. However, harmonic excitations are also often present in real structural vibrations. In particular, it has been realized that the use of forced acceleration responses without knowledge of external forces can pose a problem in the modal parameter identification, because an external force is imparted to its impulse acceleration response function. This paper provides a three-stage identification procedure as a solution to the problem of harmonic and white noise excitations in the acceleration responses of a linear dynamic system. This procedure combines the uses of the mode indicator function, the complex mode indication function, the enhanced frequency response function, an iterative rational fraction polynomial method and mode shape inspection for the correlation-related functions of the force-embedded acceleration responses. The procedure is verified via numerical simulation of a five-floor shear building and a two-dimensional frame and also applied to ambient vibration data of a large-span roof structure. Results show that the modal parameters of these dynamic systems can be satisfactorily identified under the requirement of wide separation between vibration modes and harmonic excitations.