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Nishiyama, N.,Nakagishi, Y.,Morimoto, Y.,Lai, P.S.,Miyazaki, K.,Urano, K.,Horie, S.,Kumagai, M.,Fukushima, S.,Cheng, Y.,Jang, W.D.,Kikuchi, M.,Kataoka, K. Elsevier Science Publishers 2009 Journal of controlled release Vol.133 No.3
Photodynamic therapy (PDT) is a promising method for the localized treatment of solid tumors. In order to enhance the efficacy of PDT, we have recently developed a novel class of photosensitizer formulation, i.e., the dendrimer phthalocyanine (DPc)-encapsulated polymeric micelle (DPc/m). The DPc/m induced efficient and unprecedentedly rapid cell death accompanied by characteristic morphological changes such as blebbing of cell membranes, when the cells were photoirradiated using a low power halogen lamp or a high power diode laser. The fluorescent microscopic observation using organelle-specific dyes demonstrated that DPc/m might accumulate in the endo-/lysosomes; however, upon photoirradiation, DPc/m might be promptly released into the cytoplasm and photodamage the mitochondria, which may account for the enhanced photocytotoxicity of DPc/m. This study also demonstrated that DPc/m showed significantly higher in vivo PDT efficacy than clinically used Photofrin<SUP>(</SUP>R) (polyhematoporphyrin esters, PHE) in mice bearing human lung adenocarcinoma A549 cells. Furthermore, the DPc/m-treated mice did not show skin phototoxiciy, which was apparently observed for the PHE-treated mice, under the tested conditions. These results strongly suggest the usefulness of DPc/m in clinical PDT.
Search for D0 decays to invisible final states at Belle
Lai, Y.-T.,Wang, M.-Z.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Aushev, T.,Ayad, R.,Badhrees, I.,Bakich, A. M.,Bansal, V.,Barberio, E.,Berger, M.,Bhardwaj, V.,Bhuyan, B.,Biswal, J.,Bobrov, A.,Bo American Physical Society 2017 Physical Review D Vol.95 No.1
<P>We report the result from the first search for D-0 decays to invisible final states. The analysis is performed on a data sample of 924 fb(-1) collected at and near the gamma(4S) and gamma(5S) resonances with the Belle detector at the KEKB asymmetric-energy e(|) e(-) collider. The absolute branching fraction is determined using an inclusive D-0 sample, obtained by fully reconstructing the rest of the particle system including the other charmed particle. No significant signal yield is observed and an upper limit of 9.4 x 10(-5) is set on the branching fraction of D-0 to invisible final states at 90% confidence level.</P>
Lai, Y.-T.,Wang, M.-Z.,Adachi, I.,Aihara, H.,Asner, D. M.,Aulchenko, V.,Aushev, T.,Bakich, A. M.,Bala, A.,Bhuyan, B.,Bobrov, A.,Bozek, A.,Brač,ko, M.,Browder, T. E.,Chang, P.,Chekelian, V.,Chen, American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.5
<P>We search for the charmless B-o decay with final state particles p (Lambda) over bar pi(-)gamma using the full data sample that contains 772 x 10(6)B (B) over bar pairs collected at the Upsilon(4S) resonance with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider. This decay is predicted to proceed predominantly via the b -> s gamma radiative penguin process with a high energy photon. No significant signal is found. We set an upper limit of 6.5 x 10(-7) for the branching fraction of B-o -> p (Lambda) over bar pi(-)gamma at the 90% confidence level.</P>
Measurement of branching fraction and final-state asymmetry for the B¯0→KS0K∓π± decay
Lai, Y.-T.,Adachi, I.,Aihara, H.,Al Said, S.,Asner, D. M.,Atmacan, H.,Aulchenko, V.,Aushev, T.,Babu, V.,Badhrees, I.,Bakich, A. M.,Bansal, V.,Behera, P.,Beleñ,o, C.,Bhuyan, B.,Bilka, T.,Biswal, American Physical Society 2019 Physical Review D Vol.100 No.1
Comparison of Axi-symmetric Single-Hole Nozzle with Multi-Hole Sac Nozzles
( M. C. Lai ),( Y. Zheng ),( X. Xie ),( K. Im ),( S. Moon ),( Z. Liu ),( J. Gao ),( J. Wang ),( J. M. Shi ),( R. E. Winsor ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-
It is well know that the internal flow field and nozzle geometry affect the spray behavior, but without high-speed microscopic visualization, it is difficult to characterize the spray structure in details. Single-hole Diesel injectors have been used in fundamental spray research, while most direct-injection engines use multi-hole nozzle to tailor the fuel spray to the combustion chamber geometry. Recent engine trends also use smaller orifice and higher injection pressure. This paper discussed the quasi-steady near-nozzle Diesel spray structures of an axisymmetric single-hole nozzle and a symmetric two-hole nozzle configuration, with a nominal nozzle size of 130 ㎛. Both nozzle holes originate from a sac of identical geometry, but different flow structure inside the nozzle cause significant difference in the observed flow structure near the nozzle exit. The ultrafast fast Phase-contrast X-ray images revealed unique surface and internal morphology of the fuel sprays that can be identified. The two-hole nozzle produces much more unstable jet structure under same injection conditions. The early wavelength developed in the jet is measured to be 30~80 ㎛, depending on the injection conditions. The differences between the nozzle configurations are investigated using CFD simulation. The results show that the three-dimensional fluid flow entering the two-hole nozzle generates stronger streamline curvature and stream-wise vortices which are by default absent in the axisymmetric single-hole nozzle. It also produces thicker shear layer and higher turbulence. The interactions of downwash entrance flow with turbulence potentially enhance the instability and produce wider spray cone angles. The number of holes also has interesting effects on the strength of the vortices and the downwash.
Quantification of Pre-parturition Restlessness in Crated Sows Using Ultrasonic Measurement
Wang, J.S.,Huang, Y.S.,Wu, M.C.,Lai, Y.Y.,Chang, H.L.,Young, M.S. Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.6
This study presents a non-video, non-invasive, automatic, on-site monitoring system the system employs ultrasonic transducers to detect behavior in sows before, during and after parturition. An ultrasonic transmitting/receiving (T/R) circuit of 40 kHz was mounted above a conventional parturition bed. The T/R units use ultrasonic time-of-flight (TOF) ranging technology to measure the height of the confined sows at eight predetermined locations. From this data, three momentary postures of the sow are determined, characterized as standing-posture (SP), lateral-lying-posture (LLP) and sitting posture (STP). By examining the frequencies of position switch Stand-Up-Sequence (SUS) between standing-posture (SP), lateral-lying-posture (LLP) and sitting-posture (STP) rate can be determined for the duration of the sow' confinement. Three experimental pureblooded Landrace sows undergoing normal gestation were monitored for the duration of confinement. In agreement with common observation, the sows exhibited increased restlessness as parturition approached. Analysis of the data collected in our study showed a distinct peak in Stand-Up-Sequence (SUS, i.e. the transition from lying laterally to standing up ) and sitting-posture (STP) rate approximately 12 h prior to parturition, the observed peak being 5 to 10 times higher than observed on any other measurement day. It is concluded that the presented methodology is a robust, low-cost, lowlabor method for the continuous remote monitoring of sows and similar large animals for parturition and other behavior. It is suggested that the system could be applied to automatic prediction of sow parturition, with automatic notification of remote management personnel so human attendance at birth could reduce rates of sow and piglet mortality. The results of this study provide a good basis for enhancing automation and reducing costs in large-scale sow husbandry and have applications in the testing of various large mammals for the effects of medications, diets, genetic modifications and environmental factors.
R&D Status of High-current Accelerators at IFP
J. J. Deng,J. S. Shi,W. P. Xie,L. W. Zhang,K. Z. Zhang,S. P. Feng,J. Li,M. Wang,Y. He,L. S. Xia,Z. Y. Dai,H. T. Li,L. Wen,S. F. Chen,X. Li,Q. G. Lai,M. H. Xia,Y. C. Guan,S. Y. Song,L. Chen 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.61
High-current accelerators have many important applications in Z-pinches, high-power microwaves, and free electron lasers, imploding liners and radiography and so on. Research activities on Zpinches, imploding liners, radiography at the Institute of Fluid Physics (IFP) are introduced. Several main high-current accelerators developed and being developed at IFP are described, such as the Linear Induction Accelerator X-Ray Facility Upgrade (LIAXFU, 12 MeV, 2.5 kA, 90 ns), the Dragon-I linear induction accelerator (20 MeV, 2.5 kA, 60 ns), and the Primary Test Stand for Z-pinch (PTS, 10 MA, 120 ns). The design of Dragon-II linear induction accelerator (20 MeV, 2.5 kA, 3 × 60 ns) to be built will be presented briefly.