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Wui, Seo Ri,Kim, Kwang Sung,Ryu, Ji In,Ko, Ara,Do, Hien Thi Thu,Lee, Yeon Jung,Kim, Hark Jun,Lim, Soo Jeong,Park, Shin Ae,Cho, Yang Je,Kim, Chang-Gyeom,Lee, Na Gyong Elsevier 2019 Vaccine Vol.37 No.15
<P><B>Abstract</B></P> <P>Varicella zoster virus (VZV) is a neurotropic and lymphotropic alpha herpesvirus that causes varicella and herpes zoster (HZ). At a primary infection, VZV causes varicella in young children. Reactivation of latent VZV in sensory ganglia causes painful HZ in elderly people, occasionally leading to a serious complication, postherpetic neuralgia (PHN). A live attenuated VZV vaccine, the first vaccine licensed for the prevention of HZ and PHN is not very effective, while a recombinant subunit vaccine provides higher and longer protection against HZ. In the present study, we developed a new adjuvant system CIA09A, which is composed of cationic liposomes, the Toll-like receptor 4 (TLR4) agonist de-<I>O</I>-acylated lipooligosaccharide, and <I>Quillaja</I> saponin fraction QS-21. We then determined its adjuvant activity for recombinant VZV glycoprotein E (gE) in mice. Co-lyophilization of the liposomal adjuvant formulation with gE did not abolish the immune-stimulating activity. In fact, the CIA09A-adjuvanted gE vaccine was highly effective in eliciting both humoral and cellular immune responses to the recombinant gE protein and VZV in a VZV-primed mouse model. Furthermore, the frequency of gE-specific polyfunctional CD4<SUP>+</SUP> T cells expressing interferon (IFN)-γ, tumor necrosis factor (TNF)-α, and interleukin (IL)-2 was significantly increased in mice immunized with the adjuvanted vaccine. These data indicate that co-lyophilization of protein antigens with CIA09A enables development of a liposome-adjuvanted vaccine in a single vial to induce strong cell-mediated immunity required for vaccine efficacy. Thus, the CIA09A-adjuvanted gE vaccine warrants further development as a new prophylactic vaccine against HZ.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We determined the adjuvanticity of CIA09A (cationic liposomes with a TLR4 ligand and QS-21) for VZV gE. </LI> <LI> Co-lyophilization of CIA09A with gE did not abolish the immune-stimulating activity for VZV gE. </LI> <LI> The CIA09A-adjuvanted gE vaccine effectively elicited humoral and CMI responses to gE and VZV. </LI> <LI> The adjuvanted vaccine induced gE-specific CD4<SUP>+</SUP> T cells expressing IFN-γ, TNF-α, and IL-2. </LI> <LI> Co-lyophilization of VZV gE with CIA09A enables manufacture of a subunit vaccine in a single vial. </LI> </UL> </P>
위수광(Wui, Sookwang) 한국중어중문학회 2015 中語中文學 Vol.60 No.-
This research aims at selecting expression items based on communication function items for Korean learners of Chinese. For this goal, the results of previous study were analyzed and the research was conducted step by step. First, the communication function items and communication-centered grammar articles were examined and analyzed, and then corrected and supplemented. The changes in the educational grammar system for foreign learners in the language education grammar system were analyzed, and based on this, the educational expression grammar system for foreign learners was designed in terms of “expression”. With the standard of ""an integrated category"" that exists in almost all languages in common, it was divided into ""an expression-centered category"" and ""a function-centered category"", and the grammar items which should be learned for smooth expressions were presented. In addition, the expression articles, the grammar items necessary for the performance of communication function and expressions, were selected grounded on the expression grammar system. This research is meaningful in that it has provided the opportunity for Korean learners of Chinese to practice educational Chinese grammar as “expressions” rather than as “understanding”.
신의정 ( Wui Jung Shin ),조영아 ( Young Ah Cho ),강경림 ( Kyung Rim Kang ),윤혜정 ( Hye Jung Yoon ),홍성두 ( Seong Doo Hong ),이재일 ( Jae Li Lee ),홍삼표 ( Sam Pyo Hong ) 한국치위생과학회 2013 치위생과학회지 Vol.13 No.3
Verruca vulgaris is one of the most frequent lesions of the skin. Evidences support that this lesion has strong association with low-risk human papillomavirus. Unlike skin lesion, oral verrucae vulgaris are not easily encountered and often misdiagnosed as squamous papilloma. Herein, we reported eight cases of oral verruca vulgaris and analyzed their clinicopathological features.