Cyclooxygenase-2 Polymorphisms and Susceptibility to Colorectal Cancer: A Meta-Analysis

Jun Wang,Xufeng Guo,Jixiang Zhang,Jia Song,Mengyao Ji,Shijie Yu,Jing Wang,Zhuo Cao,Weiguo Dong 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.6

Purpose: Four polymorphisms, -765G>C, -1195G>A, 8473T>C, and Val511Ala, in the cyclooxygenase-2 (COX-2) gene were identified to be associated with colorectal cancer (CRC) risk. However, the results are inconsistent. The objective of this meta-analysis was to evaluate the association between these four polymorphisms and the risk of CRC. Materials and Methods: All eligible case-control studies published up to December 2012 on the association between the four polymorphisms of COX-2 and CRC risk were identified by searching PubMed and Web of Science. The CRC risk associated with the four polymorphisms of the COX-2 gene was estimated for each study by odds ratio (OR) together with its 95% confidence interval (CI), respectively. Results: A total of 15 case-control studies were included. Overall, no evidence has indicated that the -1195A allele, -765C allele, 8473C allele, and 511Ala allele are associated with susceptibility to CRC (-1195G>A: OR=1.11, 95% CI: 0.82-1.51, p=0.78; -765G>C: OR=1.08, 95% CI: 0.96-1.21, p=0.07; 8473T>C: OR=1.03, 95% CI: 0.89-1.18, p=0.91; Val511Ala:OR=0.71, 95% CI: 0.46-1.09, p=0.94). However, stratified analysis with ethnicity indicated that individuals with -765GC or GC/CC genotypes had an increased risk of CRC among Asian populations (GC vs. GG: OR=1.05, 95% CI: 0.87-1.28, p=0.03; GC+CC vs. GG: OR=1.08, 95% CI: 0.96-1.21, p=0.07). Conclusion: This meta-analysis indicated that -765G>C polymorphism was significantly associated with susceptibility to CRC in Asian populations.

Molecular cloning, characterization and expression analysis of bolting-associated genes in flowering Chinese cabbage

Xufeng Xiao,Caijun Wu,Zhiyun Xu,Yingui Yang,Shuying Fan,Heng Wang 한국유전학회 2015 Genes & Genomics Vol.37 No.4

Bolting and flowering enhance the commercial value of flowering Chinese cabbage. FLOWERING LOCUS C (FLC) and FRIGIDA (FRI) are two key flowering time genes in Arabidopsis thaliana. Here we reported on the cloning and characterization of three ‘classical’ genes from the autonomous pathway from flowering Chinese cabbage, BrcuFCA, BrcuFLD and BrcuFVE. The results of expression analysis showed BrcuFLC was a gradually up-regulated with the developmental stages. However, temporal mRNA expression of BrcuFRI, BrcuFCA, BrcuFVE, and BrcuFLD were found to follow the opposite transcription patterns. The spatial expression patterns of BrcuFCA, BrcuFLD, and BrcuFVE were similar with the highest levels in flowers, whereas the highest transcription levels of BrcuFLC occurred in leaves and stems and that of BrcuFRI in roots. We presumed that the main pathway of bolting– flowering regulation in flowering Chinese cabbage might be the autonomous pathway and different from the vernalization pathway and FRI-dependent pathway.

Reliability Evaluation of a Microgrid Considering Its Operating Condition

Xufeng Xu,Joydeep Mitra,Tingting Wang,Longhua Mu 대한전기학회 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

Microgrids offer several reliability benefits, such as the improvement of load-point reliability and the opportunity for reliability-differentiated services. The primary goal of this work is to investigate the impacts of operating condition on the reliability index for microgrid system. It relies on a component failure rate model which quantifies the relationship between component failure rate and state variables. Some parameters involved are characterized by subjective uncertainty. Thus, fuzzy numbers are introduced to represent such parameters, and an optimization model based on Fuzzy Chance Constrained Programming (FCCP) is established for reliability index calculation. In addition, we present a hybrid algorithm which combines scenario enumeration and fuzzy simulation as a solution tool. The simulations in a microgrid test system show that reliability indices without considering operating condition can often prove to be optimistic. We also investigate two groups of situations, which include the different penetration levels of microsource and different confidence levels. The results support the necessity of considering operating condition for achieving accurate reliability evaluation.

Facile synthesis of hierarchically structured flower-like Fe3O4 microspheres for high-performance magnetorheological fluids

Guangshuo Wang,Dexing Zhao,Nannan Li,Yingzhe Zeng,Shuai Han,Yingying Ma,Xufeng Dong,Ruitao Yu 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.79 No.-

In this study,flower-like Fe3O4 microspheres with hierarchical structure were prepared by a one-stepsolvothermal method, and the obtainedflower-like Fe3O4 microspheres were adopted as a newmagnetorheological (MR) material to prepare a uniform MR suspension with high performances. Thesynthesized samples were systematically examined using FE-SEM, TEM, TGA, XRD, XPS, BET and VSM. The preparedflower-like Fe3O4 microspheres-based MRfluid indicated typical MR properties, asevidenced by the fact that shear stress, yield stress, viscoelastic storage modulus and loss modulus of MRfluid strongly depended on magneticfield strengths. Specifically, the resultant MRfluid showed goodsedimentation stability with sedimentation ratio of 86.5% in the settling period. The excellentsedimentation stability could be attributed to the uniqueflower-like hierarchical structure, high specificsurface area and the reduced particle-fluid density mismatch.

Controlled synthesis of CoFe2O4/MoS2 nanocomposites with excellent sedimentation stability for magnetorheological fluid

Guangshuo Wang,Fei Zhou,Ziwei Lu,Yingying Ma,Xiaoguang Li,Yu Tong,Xufeng Dong 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.70 No.-

In this study, we reported novel nanocomposites containing cobalt ferrite (CoFe2O4) nanoparticles andmolybdenum disulfide (MoS2) nanosheets (CoFe2O4/MoS2). The obtained CoFe2O4/MoS2 as dispersedphase was used to prepare magnetorheological (MR)fluid and the rheological properties wereinvestigated in detail. The results of transmission electron microscopy showed that the CoFe2O4nanoparticles were homogeneoused decorated on the surface of MoS2 nanosheets. The successfulpreparation of CoFe2O4/MoS2 was further confirmed by X-ray diffraction, X-ray photoelectronspectroscopy, Raman spectroscopy and vibrating sample magnetometer. The CoFe2O4/MoS2 based MRfluid exhibited typical MR effect with increasing viscosity, shear stress, yield stress and dynamic shearmoduli depending on external magneticfields. More importantly, the preparedfluid showed excellentsedimentation stability due to unique two-dimensional structure and reducedfluid-particle densitymismatch.

Reliability Evaluation of a Microgrid Considering Its Operating Condition

Xu, Xufeng,Mitra, Joydeep,Wang, Tingting,Mu, Longhua The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1

Microgrids offer several reliability benefits, such as the improvement of load-point reliability and the opportunity for reliability-differentiated services. The primary goal of this work is to investigate the impacts of operating condition on the reliability index for microgrid system. It relies on a component failure rate model which quantifies the relationship between component failure rate and state variables. Some parameters involved are characterized by subjective uncertainty. Thus, fuzzy numbers are introduced to represent such parameters, and an optimization model based on Fuzzy Chance Constrained Programming (FCCP) is established for reliability index calculation. In addition, we present a hybrid algorithm which combines scenario enumeration and fuzzy simulation as a solution tool. The simulations in a microgrid test system show that reliability indices without considering operating condition can often prove to be optimistic. We also investigate two groups of situations, which include the different penetration levels of microsource and different confidence levels. The results support the necessity of considering operating condition for achieving accurate reliability evaluation.

Chemical constituents from Inula wissmanniana and their anti-inflammatory activities

Chunhui Wang,Xufeng Zhang,Panlei Wei,Xiangrong Cheng,Jie Ren,Shi Kai Yan,Wei Dong Zhang,Hui Zi Jin 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.12

Two new inositol derivatives, 4-acetate-1,2,3,5-tetrakis(2-methyl-2-butenoate) inositol (1) and 3-acetate-1,2,4,5-tetrakis(2-methyl-2-butenoate) inositol (2), onenew flavonolignan 23-o-acetylsilychristin A (3), and onenew thymol derivative 3-hydroxy-4-(2-hydroxy-1-methylethyl)benzoic acid (4), along with 13 known compounds,including ten flavonolignans (5–14) and three thymolderivatives (15–17) were isolated from the aerial part ofInula wissmanniana. The structures of new compoundswere elucidated by detailed spectroscopic analysis,including HRESIMS and 2D-NMR spectroscopic data. Allthe compounds were isolated from this plant for the firsttime. The anti-inflammatory activities of the compoundswere tested against LPS-induced NO production in RAW264.7 macrophages.

Development of manganese ferrite/graphene oxide nanocomposites for magnetorheological fluid with enhanced sedimentation stability

Guangshuo Wang,Yingying Ma,Yu Tong,Xufeng Dong 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.48 No.-

Novel nanocomposites consisting of manganese ferrite nanoparticles and graphene oxide nanosheets(MnFe2O4/GO) have been synthesized as a promising candidate for magnetorheological (MR)fluid. Themorphology, microstructure, composition and magnetic properties of the obtained MnFe2O4/GO werestudied in detail. It was found that the MnFe2O4 nanoparticles with diameter of 8–12 nm were denselydecorated on the surface of GO nanosheets. The magnetization investigation revealed that as-preparedMnFe2O4/GO had superparamagnetic behavior with saturation magnetization of 36.2 emu/g. The MRfluid was prepared by the obtained MnFe2O4/GO and the corresponding MR properties were investigatedusing a Physica MCR301 rheometerfitted with a magneto-rheological module. The MnFe2O4/GO-basedMRfluid exhibited typical MR effect with increasing shear stress, yield stress and dynamic shear modulusdepending on magneticfields. More importantly, the sedimentation stability of the prepared MRfluidwas found to be improved due to the unique sheet-like structure and the reduced density mismatchbetween the dispersed particles and the carrier medium. The MnFe2O4/GO-basedfluid with typical MReffect and excellent sedimentation stability would provide a feasible candidate for practical applications

A New Interfacial Model for Transverse Mechanical Properties of Unidirectional Fiber Reinforced Composites

Deng’an Cai,Xiaopei Wang,Yaohui Shi,Xufeng Hao,Yuan Qian,Guangming Zhou 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2

Transverse mechanical properties play an important role in the study of fiber reinforced composite materials. Anexperimental and numerical study on mechanical properties and damage behavior of unidirectional fiber reinforcedcomposites under transverse load is presented. The quasi-static tensile and compressive tests were carried out to obtainmechanical properties of unidirectional fiber reinforced composites under transverse tension and compression. The fracturemorphologies of the specimens were observed by scanning electron microscopy (SEM) to reveal their distinct damagemechanism. Considering the effects of interface, a new interfacial model is proposed. Two representative volume elements(RVEs) of basic and interfacial models are established for comparison analysis. The predicted results agree well with theexperimental data. The introduction of interfacial layer has little effect on the prediction of transverse modulus, but canimprove the accuracy of the predicted transverse strength. The fiber volume fraction has a great influence on the transversemechanical properties of unidirectional fiber reinforced composites. As the fiber volume fraction increases, its transversemodulus increases, but both the transverse strength and the ultimate strain decrease.

Surface Quality Controlling Research on High Speed Milling Nickel-Based Superalloy Inconel 718

Yubo Liu,Xu Yanfeng,Xi Wang,Wang Xufeng 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.7

Nickel based superalloy Inconel 718 is difficult to machine as a material. The prediction model of surface roughness in high speed milling of Nickel-based Superalloy Inconel 718 was developed based on multiple regression analysis. The model is established from the experiments conducted on a XH714D matching center. The predicted results by using this model agree very well with those obtained from experiments, and the Prediction model of surface roughness of nickel based superalloy can provide a foundation to optimize cutting parameters and control surface quality.