사계 김장생의 이기론과 심성론 소고

이학당 ( Li Xue-tang ),왕천천 ( Wang Qian-qian ) 우리한문학회 2017 漢文學報 Vol.37 No.-

사계 김장생은 조선 중기의 저명한 예학가이고 교육가이다. 그는 스승 율곡의 "기발리승설"과 "리통기국설" 리기론 사상을 계승하면서 리와 기를 혼연일체의 존재로 보았다. 또한 리는 무형무위이고 기는 유형유위라고 보았다. 사계는 퇴계의 이기호발설을 부정한다. 그는 정호의 “기가 도이고 도가 기이다’는 주장을 근거로 이기불상리를 해석한다. 또한 주희의 “리는 리이고 기는 기이다”는 주장을 근거로 이기불상잡을 해석한다. 율곡이 제창한 ‘기발 이승’을 따르면서 리와 기는 “하나이면서 둘이고 둘이면서 하나다.”는 주장을 하면서 리와 기의 조화를 강조한다. 사계는 리와 기가 둘이면서 하나인 관계를 해석할 적에 이기가 합쳐지는 것이 시간적 선후로 구분하는 것은 아니라는 점을 밝힘과 동시에 공간적으로는 기가 리를 포함한다는 입장을 견지한다. 사계는 리는 기 안에 있고 원래 떨어지지 않는다고 하는데 이런 말은 기의 능동성을 중시하는 사계의 입장을 잘 보여주며 그의 심성론과 예악사상의 이론적 기초를 구성한다. 구용에 이해 방식은 사계 사상의 독자성을 보여준다. 사계는 송강이 “구용은 리이다”라고 하는 주장을 두고 체용을 원용하여 구용을 리의 작용으로 설명한다. 따라서 사계는 율곡의 입장에 기반하여 송강의 주장을 반대하지 않는다. 그러나 “형이상자는 기이고 형이하자는 도이다”는 구절에 대한 사계의 해석은 다소 문제가 있다. 사계는 도와 형을 다른 개념으로 이해하고 형과 기를 같은 개념으로 이해하는데 이런 이해는 사실에 부합하지 않는다. 사계는 율곡사상에 기초하여 심, 성, 정, 의, 지 등 성리학 심성론의 기초 개념을 심도 있게 해석한다. 본 연구는 이후 그가 주장하는 사단칠정론과 인심도심설의 이론적 토대가 된다. Shagai Kim jang-saeng was a famous scientist and educator in the middle of the Chosun Dynasty, on Confucianism he basicly inherited Zhu xi and Lee er's overall spirits, in the view of qi he claimedLi is of intangible and inaction, while Qi is of visible and action, so he denied Lee huang’s theory of which Li and Qi are inspired with each other. He cited Cheng hao’s theory of that "Qi is Dao and Dao is Qi" to explain the Li and Qi are not separated, and also quoted zhu xi's theory of that "Li is Li, Qi is Qi" to explain that the Li and Qi are not mixed. He agreed the Lee er’s idea of that"the Qi emits and Li follows " , he advocated "one is two, two is one", emphasizing the harmony of the Li and Qi. In the explanation of the relationship between "two is one", he was not only explained the combination of Li and Qi in chronological order, but also considered that the combination of Li and Qi was "Li was surrounded by Li"in space order. Shagai often said that "Li is in the Qi and they are not dissimilar"which reflected that he emphasised motility of the Qi, and also laid a theoretical foundation for his theory of mindand ritual thought. The understanding of the problem of "nine looks" reflected the autonomy of Shaxi’s thought. He believed that Songgang’s theory of which"nine looks are Li" was the use of Li from the perspective of body and function, so he did not denid Songgang's viewpoint in accordance with Lee er's thought. But he had some problems in the understanding of that "the person who is above, what is the Dao; There are some problems with the understanding of the "Meta physics is the Dao while the opposite is Qi". He seed that the Xing and Dao are different concept, but he thought that Xing and Qi are the same concept, which was lack of science. In terms of theory of mind, he based on the Yulgok’s thoughts, he made the detailed explanation for the basic concepts of neo-confucianism, such as the heart, character, feeling, idea, aspiration, whichbecame the necessary theoretical matting of the theory of four sides and seven feelings and the theory of people’s mind and Dao’s mind for the next step.

LncRNA A2M-AS1 lessens the injury of cardiomyocytes caused by hypoxia and reoxygenation via regulating IL1R2

Xue‑Lian Song,Fei‑Fei Zhang,Wen‑Jing Wang,Xin‑Ning Li,Yi Dang,Ying‑Xiao Li,Qian Yang,Mei‑Jing Shi,Xiao‑Yong Qi 한국유전학회 2020 Genes & Genomics Vol.42 No.12

Background: Myocardial ischemia and reperfusion injury (MI/RI) is a complex pathophysiological process, which can lead to severe myocardial injury. The long noncoding RNA alpha-2-macroglobulin antisense RNA 1 (A2M-AS1) has been revealed to be abnormally expressed in MI, However, its function in MI and the potential mechanism are still unclear. Objective: To evaluate the functional role of A2M-AS1 in hypoxia/reoxygenation (H/R)-induced neonatal cardiomyocytes and its potential molecular mechanism. Methods: Dataset GSE66360 was obtained from GEO database for analyzing the RNA expression of A2M-AS1 and interleukin 1 receptor type 2 (IL1R2). KEGG pathway enrichment analysis of the genes that co-expressed with A2M-AS1 was performed. Human neonatal cardiomyocytes were subjected to H/R to construct in vitro models. QRT-PCR and Western blot were adopted to test the levels of mRNA and protein. The viability and apoptosis of cardiomyocytes were tested by CCK-8 and flow cytometry assays, respectively. Results: The expression of A2M-AS1 was notably downregulated in H/R-treated cardiomyocytes. Overexpression of A2M-AS1 can notably enhance the cell viability of H/R-damaged cardiomyocytes, whereas knockdown of A2M-AS1 showed the opposite outcomes. Besides, a negative correlation was showed between A2M-AS1 and IL1R2 expression. In H/R-treated cardiomyocytes, overexpression of IL1R2 weakened the promoting proliferation and anti-apoptosis effects caused by overexpressing A2M-AS1, however, IL1R2-knockdown abolished the anti-proliferation and pro-apoptosis effects caused by silencing A2M-AS1. Conclusion: This study demonstrates the potential regulatory role of A2M-AS1/ IL1R2 axis in cardiomyocytes suffered from H/R, and provides insight into the protection of MI/RI.

Design and Application of Monitoring System of Li-ion Battery Pack

Haiying Wang,Chao Xue,Yujiao Liu,Gechen Li 보안공학연구지원센터 2014 International Journal of Hybrid Information Techno Vol.7 No.5

The Correlation between Thyrotropin and Dyslipidemia in a Population-based Study

Li Lu,Beibei Wang,Zhongyan Shan,Fengwei Jiang,Xiaochun Teng,Yanyan Chen,Yaxin Lai,Jiani Wang,Haibo Xue,Sen Wang,Chenyan Li,He Liu,Ningna Li,Jiashu Yu,Liangfeng Shi,Xin Hou,Qian Xing,Xue Bai,Weiping Te 대한의학회 2011 Journal of Korean medical science Vol.26 No.2

This study investigated the relationship between serum thyrotrophin levels and dyslipidemia in subclinical hypothyroid and euthyroid subjects. A total of 110 subjects with subclinical hypothyroidism and 1,240 euthyroid subjects enrolled in this study. Patients with subclinical hypothyroidism had significantly lower high density lipoprotein cholesterol (HDL-C) levels than those who were euthyroid. The lipid profiles were each categorized and mean thyrotrophin levels were higher in subjects in the dyslipidemia subclasses than subjects in the normal subclasses. Thyrotrophin was positively associated with serum triglyceride and negatively associated with serum HDL-C in women. Thyrotrophin was also positively associated with total cholesterol (TC) in the overweight population along with TC and LDL-C in overweight women. In the euthyroid population, thyrotrophin was positively associated with TC in the overweight population. In conclusion, serum thyrotrophin was correlated with dyslipidemia in subclinical hypothyroid and euthyroid subjects; the correlation was independent of insulin sensitivity.

Dietary exposure and human risk assessment of phthalate esters based on total diet study in Cambodia

Cheng, Zhang,Li, Han-Han,Wang, Hong-sheng,Zhu, Xue-Mei,Sthiannopkao, Suthipong,Kim, Kyoung-Woong,Yasin, Mohamed Salleh Mohamed,Hashim, Jamal Hisham,Wong, Ming-Hung Elsevier 2016 Environmental research Vol.150 No.-

<P><B>Abstract</B></P> <P>Phthalate esters are used in a wide variety of consumer products, and human exposure to this class of compounds is widespread. Nevertheless, studies on dietary exposure of human to phthalates are limited. In this study, to assess the daily intakes of phthalate esters and the possible adverse health impacts, different food samples were collected from three areas of Cambodia, one of the poorest countries in the world. The ∑phthalate ester concentrations in Kampong Cham, Kratie and Kandal provinces ranged from 0.05 to 2.34 (median 0.88) μgg<SUP>−1</SUP>, 0.19–1.65 (median 0.86) μgg<SUP>−1</SUP> and 0.24–3.05 (median 0.59) μgg<SUP>−1</SUP> wet weight (ww), respectively. Di-2-Ethylhexyl phthalate (DEHP) and diisobutyl phthalate (DiBP) were the predominant compounds among all foodstuffs. The estimated daily intake (EDI) of phthalate esters for the general population in Kampong Cham, Kratie and Kandal was 34.3, 35.6 and 35.8μgkg<SUP>−1</SUP> bw d<SUP>−1</SUP>, respectively. The dietary daily intake of DEHP, benzylbutyl phthalate (BBP) and di-n-butyl phthalate (DBP) in Kampong Cham, Kratie and Kandal were below the tolerable daily intakes (TDI) imposed by the European Food Safety Authority (EFSA) and reference doses (RfD) imposed by The United States Environmental Protection Agency (USEPA). Rice contributed the greatest quantity of DEHP to the daily intake in Cambodia so may deserve further exploration. To our knowledge, this is the first study to investigate the occurrence and the daily intakes of phthalate esters in Cambodia.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phthalate esters concentration in daily foodstuffs collected from Cambodia. </LI> <LI> Investigate the bioaccessbility of phthalate esters via the foodstuffs consumption. </LI> <LI> Health risk evaluation of dietary exposure to phthalate esters. </LI> </UL> </P>

SERS study of surface plasmon resonance induced carrier movement in Au@Cu₂O core-shell nanoparticles

Chen, Lei,Zhang, Fan,Deng, Xin-Yu,Xue, Xiangxin,Wang, Li,Sun, Yantao,Feng, Jing-Dong,Zhang, Yongjun,Wang, Yaxin,Jung, Young Mee Elsevier 2018 Spectrochimica acta. Part A, Molecular and biomole Vol.189 No.-

<P><B>Abstract</B></P> <P>A plasmon induced carrier movement enhanced mechanism of surface-enhanced Raman scattering (SERS) was investigated using a charge-transfer (CT) enhancement mechanism. Here, we designed a strategy to study SERS in Au@Cu<SUB>2</SUB>O nanoshell nanoparticles with different shell thicknesses. Among the plasmonically coupled nanostructures, Au spheres with Cu<SUB>2</SUB>O shells have been of special interest due to their ultrastrong electromagnetic fields and controllable carrier transfer properties, which are useful for SERS. Au@Cu<SUB>2</SUB>O nanoshell nanoparticles (NPs) with shell thicknesses of 48–56nm are synthesized that exhibit high SERS activity. This high activity originates from plasmonic-induced carrier transfer from Au@Cu<SUB>2</SUB>O to 4-mercaptobenzoic acid (MBA). The CT transition from the valence band (VB) of Cu<SUB>2</SUB>O to the second excited π-π* transition of MBA, and is of b<SUB>2</SUB> electronic symmetry, which was enhanced significantly. The Herzberg-Teller selection rules were employed to predict the observed enhanced b<SUB>2</SUB> symmetry modes. The system constructed in this study combines the long-range electromagnetic effect of Au NPs, localized surface plasmon resonance (LSPR) of the Au@Cu<SUB>2</SUB>O nanoshell, and the CT contribution to assist in understanding the SERS mechanism based on LSPR-induced carrier movement in metal/semiconductor nanocomposites.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We designed a shell-dependent Au@Cu<SUB>2</SUB>O nanoshell for SERS study. </LI> <LI> SERS contribution enables us to understand the possible enhancement of hybrid nanostructures. </LI> <LI> LSPR-induced carrier movement in Au@Cu<SUB>2</SUB>O nanocomposites. </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>We designed the shell-dependent Au@Cu<SUB>2</SUB>O core-shell nanoparticles (NPs) for SERS study. For the electron-hole pairs in the Cu<SUB>2</SUB>O, the plasmon induced resonant energy transfer from Au to the Cu<SUB>2</SUB>O and the direct electron transfer simultaneously which can be observed from the SERS intensity.</P> <P>[DISPLAY OMISSION]</P>

Factors Predicting the Effi cacy of Adefovir Dipivoxil on Treatment-Naïve Chronic Hepatitis B Patients at 48 Weeks

Li-Chun Wang,En-Qiang Chen,Xiao-Feng Zhu,Zhong-Hua Xiong,Li Liu,Lu Xu,Xue-Zhong Lei,Cong Liu,Hong Tang 거트앤리버 소화기연관학회협의회 2011 Gut and Liver Vol.5 No.4

Background/Aims: To reveal possible factors predicting the effect of adefovir dipivoxil (ADV) treatment on chronic hepatitis B (CHB) and optimize the utilization of ADV. Methods:In total, 168 treatment-naïve CHB patients were enrolled,including 117 hepatitis B e antigen (HBeAg)-positive patients and 51 HBeAg-negative patients who met the inclusion criteria. All patients were treated with ADV 10 mg per day for 48 weeks. Multiple logistic regression analyses were used to investigate baseline factors, and responses at weeks 12and 24 were analyzed as predictive values. Results: Multiple regression analyses showed that baseline HBeAg status and HBV DNA levels signifi cantly affected the virological response (VR) (p<0.05), baseline ALT levels were an independent predictor of serological response (SR) (p<0.05) and the body mass index (BMI) may affect the biochemical response (BR)(p<0.05). There was a statistically significant difference in the VR and SR between patients with a primary nonresponse (PNR) at week 12 and those with a VR at week 12 (p<0.01). Additionally, the VR was significantly different between patients with HBV DNA lower than 10^3 copies/mL at week 24 and those with greater than 10^3 copies/mL (p<0.01). Conclusions: Patients with negative HBeAg, lower HBV DNA levels and higher ALT values at baseline are more suitable for ADV treatment, whereas patients with lower BMIs may be more amenable to ALT normalization. Adjustments for treatment strategy should be considered if PNR at week 12 or HBV DNA ≥103 copies/mL at week 24 is observed.

Order–disorder structural tailoring and its effects on the chemical stability of (Gd, Nd)2(Zr, Ce)2O7 pyrochlore ceramic for nuclear waste forms

Wang Yan,Wang Jin,Zhang Xue,Li Nan,Wang Junxia,Liang Xiaofeng 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.7

Series of unequal quantity Nd/Ce co-doped ceramic nuclear waste forms, (Gd, Nd)2(Zr, Ce)2O7, were prepared to tailor its ordered pyrochlore or disordered fluorite structure. The phase transition, microtopography, and elemental composition of the ceramic samples were systematically investigated, especially the effect of order-disorder structure on the chemical stability. It was confirmed that unequal quantity of Nd/Ce could synchronously replace the Gd/Zr-sites of Gd2Zr2O7. And the phase transition of order-disorder structure could be successfully tailored by regulating the average cationic radius ratio of (Gd, Nd)2(Zr, Ce)2O7 series. The elements of Gd, Nd, Zr, and Ce are uniformly distributed in the ordered or disordered structures. The MCC-1 leaching results showed that (Gd, Nd)2(Zr, Ce)2O7 pyrochlore ceramic nuclear waste forms had excellent chemical stability, whose elements' normalized leaching rates were as low as 104 -107 g‧m2 ‧d1 after 7 days. In particular, the chemical stability of disordered structure was superior to that of ordered structure. It was proposed that the force constant and the closest packing were changed with the structure transformation resulting the chemical stability difference

Identification of MicroRNAs as potential biomarkers for detecting ischemic stroke

Li Kexin,Shen Li,Zheng Pingping,Wang Yanjun,Wang Lijuan,Meng Xiaoli,Lv Yaogai,Xue Zhiqiang,Guo Xin,Zhang Anning,Pan Pan,Bi Chunli,Chen Yang,Feng Tianyu,Li Bo,Jin Lina,Yao Yan 한국유전학회 2022 Genes & Genomics Vol.44 No.1

Background: Increasing epidemic of ischemic stroke (IS) makes it urgent to understand the pathogenesis and regulatory mechanism, previous studies have described microRNAs (miRNAs) is part of the brain's response to ischemia. Objective: The aim of this study was to screen potential biomarkers for the prediction and novel treatment of IS. Methods: Differentially expressed miRNAs were screened from three newly diagnosed IS patients and three controls by RNA sequencing technology. Furthermore, target prediction databases were then used to analysis the target genes of different expressed miRNAs, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database were used to identify the functions and the main biochemical and signal pathways of differentially expressed target genes. Results: Our results revealed that 27 miRNAs were differentially expressed in IS, among which, hsa-miR-659-5p was the most highly increased and was first found to be associated with IS. In addition, KEGG pathway analyses showed that differentially expressed miRNAs were mainly significantly enriched in lysosome pathway, cytokine-cytokine receptor interaction pathway, spliceosome pathway, base excision repair pathway. Conclusions: miRNAs were involved in IS pathogenesis, and hsa-miR-659-5p, hsa-miR-151a-3p and hsa-miR-29c-5p as the three highest |log2FoldChange| regulation in this study, which may be the biomarkers of IS and need further study.

Polyamide 6에서 Cyclic Diphosphonate Ester와 Melamine의 난연 효과

Xue Li Wang,Jian Ming Jiang,Sheng Lin Yang,Jun Hong Jin,Guang Li 한국고분자학회 2008 폴리머 Vol.32 No.2