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Jia-He Wang,Yi-Jun Zhou,Xue Bai,Ping He 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.5
Jolkinolide B, a bioactive diterpene isolated from the roots of Euphorbia fischeriana Steud, is known to induce apoptosis in cancer cells. However, the molecular mecha-nism of its anti-cancer activity has not been fully eluci-dated. In the present study, we found that Jolkinolide B reduced cell viability and induced apoptosis in a dose- and time-dependent manner in human leukemic U937. The induction of apoptosis was also accompanied by the downregulation of PI3K/Akt and the inhibitor of apoptosis protein (IAP) family proteins. Moreover, we observed that Jolkinolide B treatment resulted in activation of caspase-3 and -9, which may partly explain the anti-cancer activity of Jolkinolide B. Taken together, our study for the first time suggest that Jolkinolide B is able to enhance apoptosis of U937 cells, at least in part, through downregulation of PI3K/Akt and IAP family proteins. Moreover, triggering of caspase-3 and -9 activation mediated apoptotic induction.
Yu Peng,He Xue-jun,Ren Ai-di 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.12
The alongside replenishment scheduling problem with time constraint determining the partition of the ships, the order of replenishment and the allocation of time to the ships at the same time is analyzed. It is equivalent to a multi-stage flow shop scheduling problem with the object of maximizing the effectiveness value of ship fleet. The problem solving process is divided into three steps, and based on the analysis of the three steps, a heuristic algorithm is proposed. The algorithm firstly considers the time allocated to each ship, and then sequences the ships by heuristic rule combining greed with insertion, finally determines the ships partitioning to the port and standard side. Emulating example with different problems’ scale and time constraints shows that the proposed heuristic algorithm is superior to some other algorithms.
Dongmei, Huang,Xue, Zhu,Shiqing, He,Xuhui, He,Hua, He Techno-Press 2017 Wind and Structures, An International Journal (WAS Vol.24 No.5
In this work, wind tunnel tests of pressure measurements are carried out to assess the global aerodynamic interference factors, the local wind pressure interference factors, and the local lift spectra of an square high-rise building interfered by an identical cross-sections but lower height building arranged in various relative positions. The results show that, when the interfering building is located in an area of oblique upstream, the RMS of the along-wind, across-wind, and torsional aerodynamic forces on the test building increase significantly, and when it is located to a side, the mean across-wind and torsional aerodynamic forces increase; In addition, when the interfering building is located upstream or staggered upstream, the mean wind pressures on the sheltered windward side turn form positive to negative and with a maximum absolute value of up to 1.75 times, and the fluctuating wind pressures on the sheltered windward side and leading edge of the side increase significantly with decreasing spacing ratio (up to a maximum of 3.5 times). When it is located to a side, the mean and fluctuating wind pressures on the leading edge of inner side are significantly increased. The three-dimensional flow around a slightly-shorter disturbing building has a great effect on the average and fluctuating wind pressures on the windward or cross-wind faces. When the disturbing building is near to the test building, the vortex shedding peak in the lift spectra decreases and there are no obvious signs of periodicity, however, the energies of the high frequency components undergo an obvious increase.
Huang Dongmei,Zhu Xue,He Shiqing,He Xuhui,He Hua 한국풍공학회 2017 Wind and Structures, An International Journal (WAS Vol.24 No.5
In this work, wind tunnel tests of pressure measurements are carried out to assess the global aerodynamic interference factors, the local wind pressure interference factors, and the local lift spectra of an square high-rise building interfered by an identical cross-sections but lower height building arranged in various relative positions. The results show that, when the interfering building is located in an area of oblique upstream, the RMS of the along-wind, across-wind, and torsional aerodynamic forces on the test building increase significantly, and when it is located to a side, the mean across-wind and torsional aerodynamic forces increase; In addition, when the interfering building is located upstream or staggered upstream, the mean wind pressures on the sheltered windward side turn form positive to negative and with a maximum absolute value of up to 1.75 times, and the fluctuating wind pressures on the sheltered windward side and leading edge of the side increase significantly with decreasing spacing ratio (up to a maximum of 3.5 times). When it is located to a side, the mean and fluctuating wind pressures on the leading edge of inner side are significantly increased. The three-dimensional flow around a slightly-shorter disturbing building has a great effect on the average and fluctuating wind pressures on the windward or cross-wind faces. When the disturbing building is near to the test building, the vortex shedding peak in the lift spectra decreases and there are no obvious signs of periodicity, however, the energies of the high frequency components undergo an obvious increase.
Effect of Different Cooking Methods on the Composition of Intramuscular Fatty Acids of Hyla Rabbit
Xue, Shan,Xiao, Xia,He, Zhifei,Li, Hongjun Korean Society for Food Science of Animal Resource 2016 한국축산식품학회지 Vol.36 No.2
The influence of three cooking methods (stewing, microwaving and Aluminium (Al) foil-baking) was evaluated on the content of intramuscular lipid and the composition of intramuscular fatty acids of Hyla rabbit. The percentage of intramuscular lipid in cooked-longissimus dorsi (LD) (dry weight %) were in the order mentioned below: microwaving > foil-baking > stewing. All treated samples showed decrease in the proportion of polyunsaturated fatty acids (PUFA) and monounsaturated fatty acids (MUFA), whilst increase in the proportion of saturated (SFA) and n-6/n-3 value during processing. All of the cooked samples had the n-6/n-3 ratio within the recommended range (5-10). By the analysis of partial least squares regression (PLSR), the microwaving treatment was better to keep the stability of unsaturated fatty acids (UFA), whilst the long-time Al foil-baking did the most serious damage to UFA, especially the PUFA. In addition, the heating method showed greater influence on the samples than the processing time. The shorter processing time was better to retain the intramuscular PUFA of Hyla rabbit, especially the LC-PUFAs (C20-22). Considering all the factors, microwaving showed the superiority in reserving the composition of intramuscular fatty acids of Hyla rabbit.
He, Dan,Xue, Zhigang,Khan, Mohd Yusuf,Noh, Seok Kyun,Lyoo, Won Seok Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of polymer science Part A, Polymer chemist Vol.48 No.1
<P>Styrene polymerization via generation of activators by monomer addition (GAMA) for atom transfer radical polymerization (ATRP) has been examined extensively with bulk FeX<SUB>3</SUB> and FeX<SUB>2</SUB> at 110 °C in conjunction with various phosphorus-bearing ligands. It was found that GAMA possesses advantages over normal ATRP. Most importantly, narrower polydispersity index (PDI) values were observed from the styrene polymerizations with Fe(III) over those with Fe(II). Every instance of 2-(diphenylphosphino)-N,N′-dimethyl-[1,1′-biphenyl]-2-amine and 2-(diphenylphosphino) pyridine with the Fe(III) system were controlled excellently without addition of any radical initiator or reducing agent additives. Initiator type was found to exert a significant factor to influence on the controllability of polymerization. The initiation of 1-phenylethyl chloride and methyl-2-chloropropionate gave rise to formation of polymers with narrow PDI (1.05–1.20), whereas those from 1-phenylethyl bromide increased to 1.35. The GAMA of bulk styrene exhibited the best performance in terms of both rate and controllability compared with toluene and anisole. Both formation of block copolymer from the macroinitiator and efficient perturbation of polymerization with 2,2,6,6-tetramethylpiperidine 1-oxyl provided firm evidence to support the living and radical characteristics for the GAMA of styrene. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 48: 144–151, 2010</P> <B>Graphic Abstract</B> <P>Styrene polymerization with iron(III) complexes with various phosphorus-containing ligands via generation of activators by monomer addition (GAMA) for atom transfer radical polymerization (ATRP) in the absence of any additive, is herein reported as a new ATRP method. The polymers formed in the GAMA of styrene have better controlled molecular weights and narrower polydispersities than normal ATRP under same conditions. The use of oxidatively stable catalysts can avoid the air-sensitive properties of lower-oxidation-state metals, and in addition, styrene acts as a in situ reducing agent to generate activators (Iron(II) species) as is showed in this mechanism diagram of GAMA of styrene. All the advantages of GAMA make this novel ATRP method much easier for practical production. <img src='wiley_img/0887624X-2010-48-1-POLA23772-gra001.gif' alt='wiley_img/0887624X-2010-48-1-POLA23772-gra001'> </P>
Xue, Shan,He, Zhifei,Lu, Jingzhi,Tao, Xiaoqi,Zheng, Li,Xie, Yuejie,Xiao, Xia,Peng, Rong,Li, Hongjun Korean Society for Food Science of Animal Resource 2015 한국축산식품학회지 Vol.35 No.1
The changes in fatty acid composition of total intramuscular lipid and phospholipids were investigated in the longissimus dorsi, left-hind leg muscle, and abdominal muscle of male Ira rabbits. Changes were monitored at 35, 45, 60, 75, and 90 d. Analysis using gas chromatography identified 21 types of fatty acids. Results showed that the intramuscular lipid increased and the intramuscular phospholipids (total intramuscular lipid %) decreased in all muscles with increasing age (p<0.05). An abundant amount of unsaturated fatty acids, especially polyunsaturated fatty acids, was distributed in male Ira rabbits at different ages and muscles. Palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), linoleic acid (C18:2), and arachidonic acid (C20:4) were the major fatty acids, which account to the dynamic changes of the n-6/n-3 value in Ira rabbit meat.