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Minghong Qiu,Xudong Shao,Kay Wille,Banfu Yan,Jiajia Wu 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.2
The flexural behavioral properties of ultra high performance concrete (UHPC) low-profile T-beams reinforced with a combination of steel fibers and steel reinforcing bars were investigated in this paper. Five large scale T-beams were tested and analyzed regarding their deflection, ductility, strain, curvature, load capacity and crack development. The experimental variables include the reinforcement ratio, the slenderness (length to diameter ratio) of the fiber reinforcements, and the fiber type. The experiments showed that all specimens exhibit flexural failure with the yielding of steel bars and excessive expansion of flexural crack, and the compression zone in the reinforced UHPC low-profile T-beam is not crushed because of the ultra high compressive strength and area of UHPC. In addition, it was concluded that using hooked-end fibers can effectively increase the specimen’s durability-based cracking load in comparison to straight fibers of same slenderness, whereas the reinforcement ratio and the slenderness of the fibers have little influence on this. Increasing the reinforcement ratio and using hooked-end instead of straight fibers increase the load capacity and bending stiffness of the specimen, as well as reduces the crack width at comparable applied load. A model was established to compute the ultimate capacity of UHPC low-profile T-beams and the prediction agrees well with the experimental results in the present and published investigations.
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Siyan Zhang,Xudong Wang,Kai Zhou,Xuan Shao,Jinfeng Liu 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.11
To solve the problem where the space vector pulse width modulation (SVPWM) of a three-phase inverter produces large harmonic components near the switching frequency (fs) and its doubling frequency, a frequency-optimized random switching frequency SVPWM (FORSF-SVPWM) control strategy is proposed in this paper. In this strategy, the basic principle of the chaotic ant colony algorithm in path optimization is used to determine the optimized scheme of the switching frequency distribution in the FORSF-SVPWM. Research shows that the frequency sample formed by the sigmoid function curve in the switching frequency range can cause the energy that was originally concentrated on the switching frequency and its doubling frequency to be more evenly distributed in the whole frequency range. Moreover, the amplitude of each harmonic wave is shown to be suppressed. The proposed strategy reduces the high-frequency noise and conducted electromagnetic interference (EMI) existing in power switching circuits. Thus, this strategy is obviously better than the traditional random switching frequency SVPWM (RSF-SVPWM) algorithm with its approximately uniform frequency distribution. Simulation and experimental results show that this strategy can work well in the hardware platform of a three-phase inverter without changing the topology of the main circuit of the system. In addition, this strategy is easy to implement.
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Thermo-Mechanical Behavior of Long-Bored Energy Pile: A Full-Scale Field Investigation
Gang Jiang,Dong Shao,Chenfeng Zong,Gen Chen,Jie Huang,Cheng Lin,Xudong Wang,Yuwei Zhang 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.1
A geothermal energy pile is a revolutionary piling technique that combines a pile foundation with a ground source heat pump system that not only supports the structure but also provides heating and cooling for buildings and bridges. The thermo-mechanical behavior of long energy piles in soft clay has rarely been investigated, despite their increasing utilization. A long floating energy pile with a length-to-diameter ratio of 66.7 was evaluated on its own and monitored in service of the supported structure in the city of Kunshan, China. With vertical mechanical loads, the experiment involved alternate cooling and heating cycles, allowing for careful analysis and assessment of the pile's temperature, stress, and displacement. Temperature-induced stress, axial force, and friction resistance of the pile shaft, as well as the change in displacement of the energy pile throughout building, were all studied. The field observations revealed without any surprise that a longer energy pile outperformed a shorter one in terms of heating exchange capacity with a more homogenous temperature distribution along the pile. Following a quasi-linear relationship with the temperature variation, the thermo-induced additional axial force soared with the larger length-diameter ratio of the pile and may even reach four times that of the pile under pure mechanical loads. Important additional settlements were also observed especially in cooling conditions. The shaft frictions along the long bored energy pile were found to have a complicated distribution, which requires further investigations.
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Xia Wang,Hongqin Zhao,Shaonan Yang,Xiaojun Shao,Shumin Nie,Xudong Pan 대한독성 유전단백체 학회 2019 Molecular & cellular toxicology Vol.15 No.3
Backgrounds: Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) is an lncRNA that has been suggested as a key regulator in the onset of atherosclerosis (AS). This study described the role of MALAT1 in oxidized low density lipoprotein (ox-LDL)-induced endothelial cells death. Methods: Human umbilical vein endothelial cells (HUVECs) were subjected to ox-LDL, before which the expression of MALAT1 was overexpressed by transfection. CCK-8 assay, flow cytometer detection, and western blot were carried out to evaluate cell viability, apoptosis and autophagy. qRT-PCR and western blot analyses were performed to investigate the regulatory relationship between MALAT1, Matrix Gla protein (MGP) and mTOR signaling to decode the underlying mechanism. Results: Up-regulation of MALAT1 attenuated ox-LDLinduced HUVECs lose, as evidenced by the promoted cell viability, and the decreased apoptosis rate. This finding was coupled with the down-regulated p53, Bax, active-caspase-3, Beclin-1 and LC3-II, as well as the up-regulated Bcl-2 and p62. Meanwhile, MALAT1 upregulation promoted the phosphorylation of p70S6K and mTOR, and the expression of MGP. MGP up-regulation exhibited MALAT1-like propoties in preventing ox-LDL-induced cell death and mTOR deactivation. Of contrast, MGP silence affected HUVECs survival and mTOR signaling resulted in contrary impacts. Conclusion: The present work described that MALAT1 up-regulation prevented ox-LDL-mediated apoptosis and autophagy in HUVECs. The protective effects of MALAT1 might be partially via up-regulating MGP, which led to the activation of mTOR signaling.
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Bin Liu,Wei Fan,Xu Huang,Xudong Shao,Lijing Kang 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.4
Detailed finite element (FE) models are often employed to predict the impact responses of reinforced concrete (RC) columns. However, they always require substantial investments of time and effort in modeling and analysis so that they are not widely used in practice, particularly in preliminary designs. Moreover, although some simplified models have been established for beams and slabs under impact loading, few attempts have been made on modeling RC columns. For these reasons, this paper proposes a simplified modeling method to accurately capture the impact-induced response and damage of circular RC columns. In the proposed method, a two-degree-of-freedom (DOF) system was used to describe the interaction between the impactor and the impacted column. The formulas, and procedure to estimate the force-deformation relationship with strain-rate effects were presented according to the section-based analysis. The influence of the unloading stiffness on the residual deformation was addressed, and the method to determine the unloading stiffness of circular columns was proposed. Furthermore, a fiber-based beam-column element modeling method was developed to estimate the force-deformation relationship of the columns with strain-rate effects. The proposed simplified method was demonstrated by the drop-hammer impact tests to be capable of predicting the impact response of RC columns well. Its accuracy in the residual deformation is superior to that of the detailed FE simulation. Parametric studies were performed to investigate the damage characteristics of axially-loaded circular RC columns under various impact scenarios.
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Chen, Qian,Zhang, Zhijian,Liu, Jinbo,He, Qinghua,Zhou, Yuepeng,Shao, Genbao,Sun, Xianglan,Cao, Xudong,Gong, Aihua,Jiang, Ping Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.3
Because Schwann cells perform the triple tasks of myelination, axon guidance and neurotrophin synthesis, they are candidates for cell transplantation that might cure some types of nervous-system degenerative diseases or injuries. However, Schwann cells are difficult to obtain. As another option, ectomesenchymal stem cells (EMSCs) can be easily harvested from the nasal respiratory mucosa. Whether fibrin, an important transplantation vehicle, can improve the differentiation of EMSCs into Schwann-like cells (SLCs) deserves further research. EMSCs were isolated from rat nasal respiratory mucosa and were purified using anti-CD133 magnetic cell sorting. The purified cells strongly expressed HNK-1, nestin, $p75^{NTR}$, S-100, and vimentin. Using nuclear staining, the MTT assay and Western blotting analysis of the expression of cell-cycle markers, the proliferation rate of EMSCs on a fibrin matrix was found to be significantly higher than that of cells grown on a plastic surface but insignificantly lower than that of cells grown on fibronectin. Additionally, the EMSCs grown on the fibrin matrix expressed myelination-related molecules, including myelin basic protein (MBP), 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and galactocerebrosides (GalCer), more strongly than did those grown on fibronectin or a plastic surface. Furthermore, the EMSCs grown on the fibrin matrix synthesized more neurotrophins compared with those grown on fibronectin or a plastic surface. The expression level of integrin in EMSCs grown on fibrin was similar to that of cells grown on fibronectin but was higher than that of cells grown on a plastic surface. These results demonstrated that fibrin not only promoted EMSC proliferation but also the differentiation of EMSCs into the SLCs. Our findings suggested that fibrin has great promise as a cell transplantation vehicle for the treatment of some types of nervous system diseases or injuries.
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Kexin Peng,Jiankui Guo,Haifeng Chen,Mali Xie,Xi Zhang,Xudong Huang,Guiying Xing,Linjun Shao,Chenze Qi 한국섬유공학회 2023 Fibers and polymers Vol.24 No.11
In this paper, copper phthalocyanine and polystyrene composite superfine fibers were readily prepared by electrospinning technology. After treating these composite fibers with paraformaldehyde in concentrated H2SO4 solution, the copper phthalocyanine molecules were covalently bonded to the polystyrene molecules. Meanwhile, the polystyrene molecules in the fibers were cross-linked to endow these fibers with excellent solvent resistance. The photocatalytic performance of this novel fibrous catalyst was evaluated by photodegradation of methyl orange in the presence of H2O2. The effects of light source, H2O2 dosage, catalyst loading, and temperature on the fiber catalyzed photodegradation of methyl orange were carefully studied. The photodegradation percentage of methyl orange in aqueous solution was up to ~ 97% under optimized reaction conditions. At last, this fibrous catalyst was readily recovered by simple filtration and reused for three times with satisfied photodegradation activities. In all, we have developed a facile way to prepare copper phthalocyanine functionalized polystyrene superfine fibers with excellent photocatalytic performance.
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Effect of ages and season temperatures on bi-surface shear behavior of HESUHPC-NSC composite
Yang Zhang,Yanping Zhu,Pengfei Ma,Shuilong He,Xudong Shao Techno-Press 2023 Advances in concrete construction Vol.15 No.6
Ultra-high-performance concrete (UHPC) has become an attractive cast-in-place repairing material for existing engineering structures. The present study aims to investigate age-dependent high-early-strength UHPC (HESUHPC) material properties (i.e., compressive strength, elastic modulus, flexural strength, and tensile strength) as well as interfacial shear properties of HESUHPC-normal strength concrete (NSC) composites cured at different season temperatures (i.e., summer, autumn, and winter). The typical temperatures were kept for at least seven days in different seasons from weather forecasting to guarantee an approximately consistent curing and testing condition (i.e., temperature and relative humidity) for specimens at different ages. The HESUHPC material properties are tested through standardized testing methods, and the interfacial bond performance is tested through a bi-surface shear testing method. The test results quantify the positive development of HESUHPC material properties at the early age, and the increasing amplitude decreases from summer to winter. Three-day mechanical properties in winter (with the lowest curing temperature) still gain more than 60% of the 28-day mechanical properties, and the impact of season temperatures becomes small at the later age. The HESUHPC shrinkage mainly occurs at the early age, and the final shrinkage value is not significant. The HESUHPC-NSC interface exhibits sound shear performance, the interface in most specimens does not fail, and most interfacial shear strengths are higher than the NSC-NSC composite. The HESUHPC-NSC composites at the shear failure do not exhibit a large relative slip and present a significant brittleness at the failure. The typical failures are characterized by thin-layer NSC debonding near the interface, and NSC pure shear failure. Two load-slip development patterns, and two types of main crack location are identified for the HESUHPC-NSC composites tested in different ages and seasons. In addition, shear capacity of the HESUHPC-NSC composite develops rapidly at the early age, and the increasing amplitude decreases as the season temperature decreases. This study will promote the HESUHPC application in practical engineering as a cast-in-place repairing material subjected to different natural environments.
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Zhijian Zhang,Qian Chen,Jinbo Liu,Qinghua He,Yuepeng Zhou,Genbao Shao,Xianglan Sun,Xudong Cao,Aihua Gong,Ping Jiang 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.3
Because Schwann cells perform the triple tasks of myelination, axon guidance and neurotrophin synthesis, they are candidates for cell transplantation that might cure some types of nervous-system degenerative diseases or injuries. However, Schwann cells are difficult to obtain. As another option, ectomesenchymal stem cells (EMSCs) can be easily harvested from the nasal respiratory mucosa. Whether fibrin, an important transplantation vehicle, can improve the differentiation of EMSCs into Schwann-like cells (SLCs) deserves further research. EMSCs were isolated from rat nasal respiratory mucosa and were purified using anti-CD133 magnetic cell sorting. The purified cells strongly expressed HNK-1, nestin, p75NTR, S-100, and vimentin. Using nuclear staining, the MTT assay and Western blotting analysis of the expression of cell-cycle markers, the proliferation rate of EMSCs on a fibrin matrix was found to be significantly higher than that of cells grown on a plastic surface but insignificantly lower than that of cells grown on fibronectin. Additionally, the EMSCs grown on the fibrin matrix expressed myelination-related molecules, including myelin basic protein (MBP), 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNPase) and galactocerebrosides (GalCer), more strongly than did those grown on fibronectin or a plastic surface. Furthermore, the EMSCs grown on the fibrin matrix synthesized more neurotrophins compared with those grown on fibronectin or a plastic surface. The expression level of integrin in EMSCs grown on fibrin was similar to that of cells grown on fibronectin but was higher than that of cells grown on a plastic surface. These results demonstrated that fibrin notonly promoted EMSC proliferation but also the differentiation of EMSCs into the SLCs. Our findings suggested that fibrin has great promise as a cell transplantation vehicle for the treatment of some types of nervous system diseases or injuries.
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