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Protective activities of probiotics in letrozole-induced polycystic ovarian syndrome (PCOS) rats
Xinyu Li,Chenyang Xie,Qiuping Huang,Eun Mi Hwang,Bin Jin,Zhewen Dong,Zhen Zeng,Wen He,Qi Qi Pang,Jia-Le Song 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
To investigate the effect of Bifidobacterium, C. butyricum and L. plantarum on the letrozole induced PCOS rats. All female SD rats were randomly divided into five groups, modeling PCOS rats, and respectively given intragastric administration of Bifidobacterium, C. butyricum, and L. plantarum solution (1×10<SUP>9</SUP> CFU/mL) for 30 days, and observed body weight (BW). The serum levels of testosterone (T), LH, E2, FSH, INS, TG, TC, LDL, HDL were determined by ELISA kits. The levels of TGF-β1, smad4, smad3, p-smad3, p-smad2, smad2 were detected by Western Blotting. Compared with normal group, the BW, T, LH, INS, TG, TC LDL-C in PCOS rats were significantly increased, and the levels of E2, FSH and HDL-C were significantly decreased. Administrated with different probiotics can decrease the BW, T, LH, INS, TG, TC,LDL-C, and the levels of E2, FSH and HDL-C increased in PCOS rats. All probiotics significantly decreased the expression of p-smad2, p-smad3, smad4, TGF-β1. Our results showed that Bifidobacterium, C. butyricum and L. plantarum were all effective in regulating hormone levels, improving IR and dyslipidemia, and improving ovarian fibrosis in PCOS rats.
Xinyu Guan,Yanyan Hu,Zengwang Jin,Kaixiang Peng 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.10
This paper is focused on the finite-time sliding mode fault-tolerant control problem for a class of discrete networked control systems with intermittent fault and time-varying delay under the event-triggered scheme. The intermittent fault is described as a randomly occurring fault obeying a Bernoulli distribution. The event-triggered mechanism is introduced to determine the transmission of signal, which can conserve communication resources and reduce network burdens. By means of the sliding mode observer method, a linear sliding mode function is constructed by employing the estimated state and fault information. Based on Lyapunov stability theory, sufficient criteria are derived, which can ensure the closed-loop system is finite-time bounded with pre-specified H∞ performance requirement satisfied. Then, the event-triggered observer-based sliding mode fault-tolerant controller is established to force the system state trajectories onto a pre-set sliding mode region. Afterward, the solvability of the non-convex problem is studied by testifying the feasibility of a minimization problem. Finally, a practice simulation result is provided to illustrate the effectiveness of the proposed theoretical results.
Long Jin,Nan Shen,Xinyu Wen,Weidong Wang,Sun Woo Lim,양철우 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.3
Background/Aims: Although the conversion from tacrolimus (TAC) to cytotoxic T-lymphocyte-associated antigen 4-immunoglobulin (CTLA4-Ig) is effective in reducing TAC-induced nephrotoxicity, it remains unclear whether CTLA4-Ig has a direct effect on TAC-induced renal injury. In this study, we evaluated the effects of CTLA4-Ig on TAC-induced renal injury in terms of oxidative stress. Methods: In vitro study was performed to assess the effect of CTLA4-Ig on TAC-induced cell death, reactive oxygen species (ROS), apoptosis, and the protein kinase B (AKT)/forkhead transcription factor (FOXO) 3 pathway in human kidney 2 cells. In the in vivo study, the effect of CTLA4-Ig on TAC-induced renal injury was evaluated using renal function, histopathology, markers of oxidative stress (8-hydroxy-2’-deoxyguanosine) and metabolites (4-hydroxy-2-hexenal, catalase, glutathione S-transferase, and glutathione reductase), and activation of the AKT/FOXO3 pathway with insulin-like growth factor 1 (IGF-1). Results: CTLA4-Ig significantly decreased cell death, ROS, and apoptosis caused by TAC. TAC treatment increased apoptotic cell death and apoptosis-related proteins (increased Bcl-2-associated X protein and caspase-3 and decreased Bcl-2), but it was reversed by CTLA4-Ig treatment. The activation of p-AKT and p-FOXO3 by TAC decreased with CTLA4-Ig treatment. TAC-induced renal dysfunction and oxidative marker levels were significantly improved by CTLA4-Ig in vivo. Concomitant IGF- 1 treatment abolished the effects of CTLA4-Ig. Conclusions: CTLA4-Ig has a direct protective effect on TAC-induced renal injury via the inhibition of AKT/FOXO3 pathway.
Zhao, Xinyu,Song, Sung-Jin,Kim, Hak-Joon,Gang, Tie,Kang, Suk-Chull,Choi, Yong-Hwan,Kim, Kyung-Cho,Kang, Sung-Sik The Korean Society for Nondestructive Testing 2007 한국비파괴검사학회지 Vol.27 No.3
Ultrasonic inspection of austenitic steel weldments is a truly difficult task due to complicated wave propagation phenomena such as beam skewing, splitting and distortion. In order to understand these phenomena and design proper inspection procedures, simulation is increasingly paid more attention to. This article addresses a ray tracing based approach to determine incident angle and position of optimal wave mode ultrasonic beam for flaw detection in anisotropic and inhomogeneous austenitic steel weldments. Specially, the optimal mode of ultrasonic wave wave is selected by ray tracing simulation, and an optimization approach based on ray tracing and bi-section search is proposed in order to find the ray path connecting two given points in weldments. With help of this approach, the optimal incident angle and position of ultrasonic beam can be determined for a given flaw position.
Generation, purification and engineering of extracellular vesicles and their biomedical applications
Gao, Jin,Dong, Xinyue,Wang, Zhenjia Elsevier 2020 Methods Vol.177 No.-
<P><B>Abstract</B></P> <P>Extracellular vesicles (EVs), derived from cell membranes, demonstrate the potential to be excellent therapeutics and drug carriers. Although EVs are promising, the process to develop high-quality and scalable EVs for their translation is demanding. Within this research, we analyzed the production of EVs, their purification and their post-bioengineering, and we also discussed the biomedical applications of EVs. We focus on the developments of methods in producing EVs including biological, physical, and chemical approaches. Furthermore, we discuss the challenges and the opportunities that arose when we translated EVs in clinic. With the advancements in nanotechnology and immunology, genetically engineering EVs is a new frontier in developing new therapeutics in order to tailor to individuals and different disease stages in treatments of cancer and inflammatory diseases.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Scalability and high-quality of production of EVs is critical to their translation. </LI> <LI> The biomedical applications of EVs will be discussed. </LI> <LI> The challenges and opportunities of EVs in translation will be discussed. </LI> <LI> Genetically engineering EVs is a new direction to develop personalized medicine. </LI> </UL> </P>
HUI HUANG,JIN-GANG YU,XINYU JIANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.8
A facile and effective approach based on magnetic separation was developed for the adsorption of Rhodamine B (RhB) from aqueous solution using magnetic oxidized multi-walled carbon nanotubes (magnetic o-MWCNTs) as adsorbent. The magnetic o-MWCNTs were simply synthesized by assembling magnetic nanoparticles onto the oxidized MWCNTs. Adsorption conditions such as pH values, the dosage of adsorbent added and adsorption time were investigated and optimized to achieve the best removal value. In addition, kinetics, adsorption isotherms and adsorption thermodynamics were studied to understand the mechanism by which the magnetic o-MWCNTs adsorbed RhB. The results indicated that the proposed method based on magnetic o-MWCNTs as magnetic absorbent was rapid and e±cient for the removal of RhB. Furthermore, the magnetic o-MWCNTs could be easily removed after adsorption process and regenerated through desorption by ethanol.
金何?伊(Jin Heduyi),?昕雨(Yang Xinyu),徐欣(Xu Xin) 글로벌시니어건강증진개발원 2013 글로벌시니어건강증진개발원 논문집 Vol.3 No.2
With the development of economy and culture in current society, people enjoy the improvement of living standards, and then conditions about health and sport attract strong attention, while the channel of obtaining health knowledge and available sport facilities in rural areas lag behind those in cities. Based on the questionnaire survey, mathematical statistics and literature material method, the study selected 300 villagers in NanningandYulinruralareasofGuangxiProvinceasinvestigationsamples,inordertocollectdataonhealthandsportinvestigation.Thisstudyshowedapictureofphysicalhealthandsportsparticipationindeprivedcommunities,whichistypicalandrepresentative.