Does H3K27M Mutation Impact Survival Outcome of High-Grade Spinal Cord Astrocytoma?

Fan Zhang,Lei Cheng,Ze Ding,Shengxi Wang,Xingang Zhao,Zijun Zhao,Cong Liang,Kun Wu,Dongao Zhang,Yinqian Wang,Tao Fan 대한척추신경외과학회 2023 Neurospine Vol.20 No.4

Objective: To evaluate the impact of H3K27M mutation in the prognosis of histological high-grade intramedullary astrocytoma. Methods: A total of 78 patients who were diagnosed with high-grade spinal cord astrocytoma were included. Clinical data consisting demographic, radiological, molecular features and treatment data were recorded. Univariate and multivariate Cox analysis were performed to investigate variables associated with survival outcome of histological high-grade spinal cord astrocytoma. Results: Median survival time was 21 months. Overall survival (OS) at 1 and 3 years was 65.7% and 40.7%, respectively. Sex, location, and tumor span did not present significant association with OS. Patients with H3K27M mutation showed significant shorter duration of symptom than patients with H3K27 wild-type. As respect to adjuvant treatment, adjuvant radiotherapy and chemotherapy were associated with favorable OS (both p = 0.01). Younger patients (age ≤ 18 years) had shorter OS (p = 0.008) than adult patients (age > 18 years). Of note, H3K27M mutation did not show significant impact on the survival outcome, regardless of histology grade 3 or grade 4 (p = 0.3). Conclusion: Histological high-grade spinal cord astrocytoma has dismal prognosis. Our study demonstrated that H3K27M mutation did not show significant impact on survival outcome of histological high-grade spinal cord astrocytoma.

A study on the Improvement of Shandong Logistics Park

Ruonan Zhang,Xingang Huan,Taewon Kang 전북대학교 산업경제연구소 2016 아태경상저널 Vol.8 No.1

This study is to investigate how to promote value added logistics activities for Shandong Province of China. the logistics industry will play more and more important role as assistance service in national economy development. Logistics Park is the new format of modern logistics industry, which develops very rapidly by integrating logistics functions to meet the logistics demands of the port, industrial parks and urban development. It may become one of the main forms of the integration of the logistics industry in future. Therefore, the planning and construction of modern logistics park is great significant, promoting China"s industry and the rapid development of the logistics park play intensive, transport convergence and the support of the joint expansion, and enhance logistics services and management levels, and promote regional economic development.

Clinical Characteristics and Treatment Outcomes of Long-Level Intramedullary Spinal Cord Tumors: A Consecutive Series of 43 Cases

Dongao Zhang,Tao Fan,Wayne Fan,Xingang Zhao,Cong Liang,Yinqian Wang,Kun Wu 대한척추신경외과학회 2023 Neurospine Vol.20 No.1

Objective: Long-level intramedullary spinal cord tumors (LIMSCTs) cause complex treatment issues. However, LIMSCTs have rarely been analyzed separately. The authors reported a large case series of LIMSCTs and analyzed the clinical characteristics and treatment outcomes. Methods: The medical data of patients with LIMSCTs at our institution between January 2015 and December 2019 were retrospectively reviewed. Demographics, tumor size and location, pathology, extent of resection, and neurological functional status were collected. Results: A total of 43 consecutive cases were included. Twenty-three cases (53.5%) of LIMSCTs were ependymal tumors. All patients with ependymal tumors achieved gross total resection (GTR). In ependymal tumor cases, 3 cases (13%) of ependymal tumors experienced postoperative neurological deterioration, and 66% of them showed an improvement at follow-up; 25.6% were low-grade astrocytic tumors. The rates of GTR, subtotal resection (STR) and partial resection (PR) were 63.6%, 27.3%, and 9.1%, respectively. Twenty-seven percent cases showed postoperative neurological worsening, and 33% of them had an improvement at follow-up; 20.9% were high-grade astrocytic tumors. The excision rates were 44.4% for GTR, 44.4% for STR, and 11% for PR, respectively. Fifty-five percent cases showed postoperative neurological worsening, and none of them had an improvement at follow-up. Conclusion: In this series, all LIMSCTs were gliomas. Aggressive tumor resection did not increase the risk of long-term functional deterioration in ependymal tumors and low-grade astrocytic tumors, but in high-grade astrocytic tumors, patients had a higher risk of neurological deterioration and difficulty in recovery. In ependymal tumors and low-grade astrocytic tumors, patients can achieve long-time survival after performing aggressive tumor resection.

Microblog Sentiment Analysis Method Based on Spectral Clustering

Shi Dong,Xingang Zhang,Ya Li 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.3

This study evaluates the viewpoints of user focus incidents using microblog sentiment analysis, which hasbeen actively researched in academia. Most existing works have adopted traditional supervised machinelearning methods to analyze emotions in microblogs; however, these approaches may not be suitable inChinese due to linguistic differences. This paper proposes a new microblog sentiment analysis method thatmines associated microblog emotions based on a popular microblog through user-building combined withspectral clustering to analyze microblog content. Experimental results for a public microblog benchmarkcorpus show that the proposed method can improve identification accuracy and save manually labeled timecompared to existing methods.

Microblog Sentiment Analysis Method Based on Spectral Clustering

Dong, Shi,Zhang, Xingang,Li, Ya Korea Information Processing Society 2018 Journal of information processing systems Vol.14 No.3

This study evaluates the viewpoints of user focus incidents using microblog sentiment analysis, which has been actively researched in academia. Most existing works have adopted traditional supervised machine learning methods to analyze emotions in microblogs; however, these approaches may not be suitable in Chinese due to linguistic differences. This paper proposes a new microblog sentiment analysis method that mines associated microblog emotions based on a popular microblog through user-building combined with spectral clustering to analyze microblog content. Experimental results for a public microblog benchmark corpus show that the proposed method can improve identification accuracy and save manually labeled time compared to existing methods.

A Hybrid Link Protection Scheme for Ensuring Network Service Availability in Link-state Routing Networks

Haijun Geng,Han Zhang,Xingang Shi,Zhiliang Wang,Xia Yin,Ju Zhang,Zhiguo Hu,Yong Wu 한국통신학회 2020 Journal of communications and networks Vol.22 No.1

The internet is playing an increasingly crucial role inboth personal and business activities. In addition, with the emergenceof real-time, delay sensitive and mission-critical applications,stringent network availability requirement is put forward for internetservice providers (ISPs). However, commonly deployed intradomainlink-state routing protocols react to link failures by globallyexchanging link state advertisements and recalculating routingtable, inevitably causing significant forwarding discontinuityafter a failure. Therefore, the loop-free criterion (LFC) approachhas been widely deployed by many ISPs for coping with the singlenetwork component failure scenario in large internet backbones. The success of LFC lies in its inherent simplicity, but this comesat the expense of letting certain failure scenarios go unprotected. To achieve full failure coverage with LFC without incurring significantextra overhead, we propose a novel link protection scheme,hybrid link protection (HLP), to achieve failure resilient routing. Compared to previous schemes, HLP ensures high network availabilityin a more efficient way. HLP is implemented in two stages. Stage one provides an efficient LFC based method (MNP-e). Thecomplexity of the algorithm is less than that of Dijkstra’s algorithmand can provide the similar network availability with LFC. Stage two provides backup path protection (BPP) based on MNP-e,where only a minimum number of links need to be protected, usingspecial paths and packet headers, to meet the network availabilityrequirement. We evaluate these algorithms in a wide spread ofrelevant topologies, both real and synthetic, and the results revealthat HLP can achieve high network availability without introducingconspicuous overhead. HLP not only needs around 10% time ofthat of full protection, but also provides full protection capabilitiesthat full protection provide.

High-Frequency Isolated Medium-Voltage AC Grid-connected PV Power Generation System Structure based on DC Bus Collection

Lin. Lin,Qi. Chen,Xingang. Wu,Chuang. Liu,Haoran. Zhang,Dongfeng. Yang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

This paper proposes an isolated mediumvoltage AC grid-connected PV power generation system structure based on DC bus collection with high-frequency link concept. The proposed system structure consists of centralized photovoltaic power plant, inverter unit based on isolated bridge converter (I-BC), and capacitor at the junction of dc bus. PV plant is divided into many arrays, each PV array is connected in parallel with each phase inverter unit. Inverter unit is composed of two I-BC. Compare with conventional two-stage PV inverter, I-BC can totally eliminate the individual DC-link capacitors at the highvoltage side, which leads to extremely reduced system volume and voltage-balancing control between individual capacitors. Second harmonic power oscillations seen in typical system structure can also be eliminated or reduced through use of the proposed system. This paper presents the analysis and operation of the proposed PV system structure with experimental results on a scaled-down laboratory.

Determination of Herbicide Propisochlor in Soil, Water and Rice by Quick, Easy, Cheap, Effective, Rugged and Safe (QuEChERS) Method Using by UPLC-ESI-MS/MS

Xiaohu Wu,Jun Xu,Xingang Liu,Feng Shou Dong,Yanbing Wu,Ying Zhang,Yongquan Zheng 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.3

A simple, quick and reliable analytical method for the confirmation and quantification of propisochlor was developed. The propisochlor was extracted from water, soil and rice (stalks, rice and hull) matrices using acetonitrile, and cleaned up with primary secondary amine and determined by UPLC-MS/MS. The LODs of propisochlor ranged from 0.03 μg/kg to 0.12 μg/kg, while the LOQs ranged from 0.1 μg/kg to 0.4 μg/kg in different matrixes. The mean recoveries of propisochlor at three levels (0.005, 0.01 and 0.05 mg/kg) were in the range of 73.7-94.9% with intra-day relative standard deviations (RSD) of 1.1-13.9% and inter-day RSDR of 3.3-12.7%. This method is suitable for routine analysis of propisochlor under field conditions. The half-lives of propisochlor in rice stalks, water and soil were 1.7, 1.5 and 2.3 days in Hunan, 5.7, 1.0 and 1.9 days in Anhui and 4.8, 1.0 and 3.1 days in Guangxi.

2006년 여름철 중국 광저우 지역 대기 중 입자상 탄소성분의 광학적 특성과 혼합상태

정진상,이한림,김영준,Xingang Liu,Jianwei Gu,Yuanhang Zhang 한국기상학회 2008 한국기상학회 학술대회 논문집 Vol.2008 No.-

Dynamic QTL Analysis of Rice Protein Content and Protein Index Using Recombinant Inbred Lines

Leina Zheng,Wenwei Zhang,Xingang Chen,Jing Ma,Weiwei Chen,Zhigang Zhao,Huqu Zhai,Jianmin Wan 한국식물학회 2011 Journal of Plant Biology Vol.54 No.5

Protein content (PC) and protein index (PI) play important roles in determining nutritional quality in rice (Oryza sativa L.). We used 71 lines derived from “Asominori/IR24” to analyze the developmental behavior of PC and PI through unconditional and conditional QTL mapping methods. In all, 10 unconditional QTLs and 6conditional QTLs for PC, and 11 unconditional QTLs and 9conditional QTLs for PI, were identified at four stages of grain filling. More were identified in the first three stages than at the final stage. Temporal patterns of gene expression for PC and PI differed over time, with several QTLs being expressed across two or three stages but many being expressed at only one stage. Some of these QTLs were closely linked with maturity QTLs reported previously. Many QTLs for PC and PI were co-localized, supporting the significant correlation found between PC and PI. Our results suggest that dynamic QTL mapping might be a valid means for revealing more genetic information about protein accumulations during seed development.