論中國傳統企業效率問題

康 埈 荣,张守鑫 韓國外國語大學校 外國學綜合硏究센터 中國硏究所 2005 中國硏究 Vol.35 No.-

Wind-resistant performance of cable-supported bridges using carbon fiber reinforced polymer cables

Zhang, Xin-Jun,Ying, Lei-Dong Techno-Press 2007 Wind and Structures, An International Journal (WAS Vol.10 No.2

To gain understanding of the applicability of carbon fiber reinforced polymer (CFRP) cable in cable-supported bridges, based on the Runyang Bridge and Jinsha Bridge, a suspension bridge using CFRP cables and a cable-stayed bridge using CFRP stay cables are schemed, in which the cable's cross-sectional area is determined by the principle of equivalent axial stiffness. Numerical investigations on the dynamic behavior, aerostatic and aerodynamic stability of the two bridges are conducted by 3D nonlinear analysis, and the effect of different cable materials on the wind resistance is discussed. The results show that as CFRP cables are used in cable-supported bridges, (1) structural natural frequencies are all increased, and particularly great increase of the torsional frequency occurs for suspension bridges; (2) under the static wind action, structural deformation is increased, however its aerostatic stability is basically remained the same as that of the case with steel cables; (3) for suspension bridge, its aerodynamic stability is superior to that of the case with steel cables, but for cable-stayed bridge, it is basically the same as that of the case with steel stay cables. Therefore as far as the wind resistance is considered, the use of CFRP cables in cable-supported bridges is feasible, and the cable's cross-sectional area should be determined by the principle of equivalent axial stiffness.

Seismic performance and its favorable structural system of three-tower suspension bridge

Zhang, Xin-Jun,Fu, Guo-Ning Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.50 No.2

Due to the lack of effective longitudinal constraint for center tower, structural stiffness of three-tower suspension bridge becomes less than that of two-tower suspension bridge, and therefore it becomes more susceptible to the seismic action. By taking a three-tower suspension bridge-the Taizhou Highway Bridge over the Yangtze River with two main spans of 1080 m as example, structural dynamic characteristics and seismic performance of the bridge is investigated, and the effects of cable's sag to span ratio, structural stiffness of the center tower, and longitudinal constraint of the girder on seismic response of the bridge are also investigated, and the favorable structural system is discussed with respect to seismic performance. The results show that structural response under lateral seismic action is more remarkable, especially for the side towers, and therefore more attentions should be paid to the lateral seismic performance and also the side towers. Large cable's sag, flexible center tower and the longitudinal elastic cable between the center tower and the girder are favorable to improve structural seismic performance of long-span three-tower suspension bridges.

Protective effects of phillyrin against influenza A virus in vivo

Xin-yan Qu,Qing-jun Li,Hui-min Zhang,Xiao-juan Zhang,Peng-hui Shi,Xiu-juan Zhang,Jing Yang,Zhe Zhou,Sheng-qi Wang 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.7

Influenza A virus infection represents a great threat to public health. However, owing to side effects and the emergence of resistant virus strains, the use of currently available anti-influenza drugs may be limited. In order to identify novel anti-influenza drugs, we investigated the antiviral effects of phillyrin against influenza A virus infection in vivo. The mean survival time, lung index, viral titers, influenza hemagglutinin (HA) protein and serum cytokines levels, and histopathological changes in lung tissue were examined. Administration of phillyrin at a dose of 20 mg/kg/day for 3 days significantly prolonged the mean survival time, reduced the lung index, decreased the virus titers and interleukin-6 levels, reduced the expression of HA, and attenuated lung tissue damage in mice infected with influenza A virus. Taken together, these data showed that phillyrin had potential protective effects against infection caused by influenza A virus.

Exploration of Molecular Mechanisms of Diffuse Large B-cell Lymphoma Development Using a Microarray

Zhang, Zong-Xin,Shen, Cui-Fen,Zou, Wei-Hua,Shou, Li-Hong,Zhang, Hui-Ying,Jin, Wen-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Objective: We aimed to identify key genes, pathways and function modules in the development of diffuse large B-cell lymphoma (DLBCL) with microarray data and interaction network analysis. Methods: Microarray data sets for 7 DLBCL samples and 7 normal controls was downloaded from the Gene Expression Omnibus (GEO) database and differentially expressed genes (DEGs) were identified with Student's t-test. KEGG functional enrichment analysis was performed to uncover their biological functions. Three global networks were established for immune system, signaling molecules and interactions and cancer genes. The DEGs were compared with the networks to observe their distributions and determine important key genes, pathways and modules. Results: A total of 945 DEGs were obtained, 272 up-regulated and 673 down-regulated. KEGG analysis revealed that two groups of pathways were significantly enriched: immune function and signaling molecules and interactions. Following interaction network analysis further confirmed the association of DEGs in immune system, signaling molecules and interactions and cancer genes. Conclusions: Our study could systemically characterize gene expression changes in DLBCL with microarray technology. A range of key genes, pathways and function modules were revealed. Utility in diagnosis and treatment may be expected with further focused research.

Study of seismic performance and favorable structural system of suspension bridges

Xin-Jun Zhang,Chao Zhang 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.60 No.4

By taking the Runyang Highway Bridge over the Yangtze River with 1490 m main span as example, structural response of the bridge under the horizontal and vertical seismic excitations is investigated by the response spectrum and time-history analysis of MIDAS/Civil software respectively, the seismic behavior and the influence of structural nonlinearity on the seismic response of the bridge are revealed. Considering the aspect of seismic performance, the suitability of employing the suspension bridge in super long-span bridges is investigated as compared to the cable-stayed bridge and cable-stayed-suspension hybrid bridge with the similar main span. Furthermore, the effects of structural parameters including the span arrangement, the cable sag to span ratio, the side to main span ratio, the girder height, the central buckle and the girder support system etc on the seismic performance of the bridge are investigated by the seismic response spectrum analysis, and the favorable earthquake-resistant structural system of suspension bridges is also discussed.

Spatial analysis of tuberculosis treatment outcomes in Shanghai: implications for tuberculosis control

Zhang Jing,Shen Xin,Yang Chongguang,Chen Yue,Guo Juntao,Wang Decheng,Zhang Jun,Lynn Henry,Hu Yi,Pan Qichao,Zhang Zhijie 한국역학회 2022 Epidemiology and Health Vol.44 No.-

OBJECTIVES: Tuberculosis (TB) treatment outcomes are a key indicator in the assessment of TB control programs. We aimed to identify spatial factors associated with TB treatment outcomes, and to provide additional insights into TB control from a geographical perspective.METHODS: We collected data from the electronic TB surveillance system in Shanghai, China and included pulmonary TB patients registered from January 1, 2009 to December 31, 2016. We examined the associations of physical accessibility to hospitals, an autoregression term, and random hospital effects with treatment outcomes in logistic regression models after adjusting for demographic, clinical, and treatment factors.RESULTS: Of the 53,475 pulmonary TB patients, 49,002 (91.6%) had successful treatment outcomes. The success rate increased from 89.3% in 2009 to 94.4% in 2016. The successful treatment outcome rate varied among hospitals from 78.6% to 97.8%, and there were 12 spatial clusters of poor treatment outcomes during the 8-year study period. The best-fit model incorporated spatial factors. Both the random hospital effects and autoregression terms had significant impacts on TB treatment outcomes, ranking 6th and 10th, respectively, in terms of statistical importance among 14 factors. The number of bus stations around the home was the least important variable in the model.CONCLUSIONS: Spatial autocorrelation and hospital effects were associated with TB treatment outcomes in Shanghai. In highly-integrated cities like Shanghai, physical accessibility was not related to treatment outcomes. Governments need to pay more attention to the mobility of patients and different success rates of treatment among hospitals.

Study of design parameters on flutter stability of cable-stayed-suspension hybrid bridges

Xin-jun Zhang 한국풍공학회 2006 Wind and Structures, An International Journal (WAS Vol.9 No.4

The cable-stayed-suspension hybrid bridge is a cooperative system developed from the traditional cable-stayed and suspension bridges, and takes some advantages of the two bridge systems. It is also becoming a competitive design alternative for some long and super long-span bridges. But due to its great flexibility, the flutter stability plays an important role in the design and construction of this bridge system. Considering the geometric nonlinearity of bridge structures and the effects of nonlinear wind-structure interaction, method and its solution procedure of three-dimensional nonlinear flutter stability analysis are firstly presented. Parametric analyses on the flutter stability of a cable-stayed-suspension hybrid bridge with main span of 1400 meters are then conducted by nonlinear flutter stability analysis, some design parameters that significantly influence the flutter stability are pointed out, and the favorable structural system of the bridge is also discussed based on the wind stability.

Numerical investigation on the wind stability of super long-span partially earth-anchored cable-stayed bridges

Zhang, Xin-jun,Yao, Mei Techno-Press 2015 Wind and Structures, An International Journal (WAS Vol.21 No.4

To explore the favorable structural system of cable-stayed bridges with ultra-kilometer main span, based on a fully self-anchored cable-stayed bridge with 1400 m main span, a partially earth-anchored cable-stayed bridge scheme with the same main span is designed. Numerical investigation on the dynamic characteristics, aerostatic and aerodynamic stability of both two bridge schemes is conducted, and the results are compared to those of a suspension bridge with similar main span, and considering from the aspect of wind stability, the feasibility of using partially earth-anchored cable-stayed bridge in super long-span bridges with ultra-kilometer main span is discussed. Moreover, the effects of structural design parameters including the length of earth-anchored girder, the number of auxiliary piers in side span, the height and width of girder, the tower height etc on the dynamic characteristics, aerostatic and aerodynamic stability of a partially earth-anchored cable-stayed bridge are analyzed, and their reasonable values are proposed. The results show that as compared to fully self-anchored cable-stayed bridge and suspension bridge with similar main span, the partially earth-anchored cable-stayed bridge has greater structural stiffness and better aerostatic and aerodynamic stability, and consequently becomes a favorable structural system for super long-span bridges with ultra-kilometer main span. The partially earth-anchored cable-stayed bridge can achieve greater stiffness and better wind stability under the cases of increasing the earth-anchored girder length, increasing the height and width of girder, setting several auxiliary piers in side span and increasing the tower height.

Study of design parameters on flutter stability of cable-stayed bridges

Zhang, Xin-Jun,Sun, Bing-Nan Techno-Press 2003 Wind and Structures, An International Journal (WAS Vol.6 No.4

Flutter stability is one of major concerns on the design of long-span cable-stayed bridges. Considering the geometric nonlinearity of cable-stayed bridges and the effects due to the nonlinear wind-structure interactions, a nonlinear method is proposed to analyze the flutter stability of cable-stayed bridges, and a computer program NFAB is also developed. Taking the Jingsha bridge over the Yangtze River as example, parametric analyses on flutter stability of the bridge are carried out, and some important design parameters that affect the flutter stability of cable-stayed bridges are pointed out.