韓國 自生 범부채(Belamcanda chinensis (L.) DC.)의 種子發芽에 關한 硏究

朴潤点,劉成吾,崔權雄,鄭然玉 한국화훼연구회 1995 화훼연구 Vol.4 No.1

These studies were carried out to investigate the seed germination of Belamcanda chinensis (L.) DC. The results obtained are as follows : 1.Optimum temperature of seed germination was 25℃, and the seed germination rate was raised to 92% by 20/30℃ alternative temperature treatment. 2.Under the condition of moist low temperature storage, the germination rate was 53% at 42 days after sowing, but showed the germination rate of 11% at same period with dry low temperature storage. 3.The germination rate was higher in the light condition than in the dark condition. 4.The germination rate was higher when the seed coat was removed than when the seed coat was not removed or the seed coat was stratificated. 5.The germination rate was 80% with 100ppm GA3 treatment, and 76% wihh soaking treatment of 1% KOH solution for 24 hours.

New Promising Therapeutic Modalities for Thyroid Cancers : Histone Deacetylase Inhibitor, PPAR-γ Agonist, and Retinoic Acid

Woong Youn Chung,Orlo H. Clark 대한외과학회 2005 대한외과학회 학술대회 초록집 Vol.2005 No.10

Role of endoscopic surgery in the management of papillary thyroid microcarcinoma

Woong Youn Chung 대한갑상선-내분비외과학회 2007 대한갑상선-내분비외과학회 학술대회 논문집 Vol.2007 No.-

New Promising Therapies for Thyroid Cancers : Combination Treatment with Histone Deacetylase Inhibitor and Retinoic Acid Targeting Up-regulation of RAR β Expression

Woong Youn Chung,Orlo H. Clark 대한두경부종양학회 2005 대한두경부종양학회 학술대회 논문집 Vol.2005 No.2

Parathyroid preservation : How I do it (Robot)

정웅윤(Woong Youn Chung) 대한갑상선-내분비외과학회 2017 대한갑상선-내분비외과학회 학술대회 논문집 Vol.- No.-

여포상 갑상선암종의 종양맥관형성도

정웅윤(Woong Youn Chung),이미경(Mi Kyung Lee),장항석(Hang Suk Chang),박정수(Cheong Soo Park) 대한두경부종양학회 1998 대한두경부 종양학회지 Vol.14 No.2

Objectives: We performed an immunohistochemical study to examine the place of neovascularization in the tumorigenic process of follicular thyroid carcinoma and to determine whether tumor angiogenic activity in follicular carcinoma plays a role in tumor aggression. Materials & Methods: We studied 63 follicular thyroid carcinomas and compared with 22 follicular adenomas. The areas of capsular invasion, vascular invasion and cellular atypism of the tumor were confimed on H & E stains. The paraffin embedded tissues were stained by the use of monoclonal antibodies against Ag CD34. Microvesseles were counted in the area of highest vascular density at 200 times magnification. The microvessel densities(MVD) were analized in relation to histologic type and location of the tumors. Results: There were 59 minimal invasive types and 4 widely invasive types of carcinoma. In the histologic specimens of carcinomas, capsular invasion was identified in all the cases, vascular invasion in 46 and cellular atypism in 24. Mean values of the MVDs of the minimal invasive carcinomas, the widely invasive carcinomas and the adenomas were 263.8±69.2, 256.l±49.3 and 241.5±159.4, respectively and there was no significant difference between each group. In follicular carcinomas, there was a regional difference of the MVDs. The areas of tumor showing cellular atypism and adjacent to or penetrating the capsule, in which represents the tumorigenic process of carcinoma, had a higher rate of vascularization, than other areas of the tumor(p<0.05). However, these features were not noted in the follicular adenomas. Conclusion: Although there was no significant difference of the MVD between follicular carcinomas and adenomas, there was a regional difference of the MVD within the carcinomas and the values were significantly higher in the more malignant areas, as indicated by cellular atypism and capsular invasion. Therefore, tumor angiogenic activity measured by MVD may play a role in tumor aggression in follicular thyroid carcinoma.

갑상선의 Hürthle씨 세포 종양

정웅윤(Woong Youn Chung),김석주(Suk Ju Kim),박정수(Cheong Soo Park) 대한두경부종양학회 1997 대한두경부 종양학회지 Vol.13 No.2

Hürthle cell neoplasm of the thyroid gland is an uncommon, but potentially malignant lesion. However, in many instances, the malignant potential of the Hürthle cell neoplasm is very difficult to judge histologically. For this reason, the biologic behavior of this tumor and its optimal treatment have come under considerable debate in recent years. In order to review the clinicopathologic features of the Hürthle cell neoplasm and to determine its optimal treatment modalities, we studied 26 patients with path logical proof of Hürthle cell tumor from January 1987 to September 1997. We also performed an immunohistochemical study using the monoclonal antibodies against antigen CD34 for the angiogenic activity of this tumor and evaluated the differences of microvessel density(MVD) between benign and malignant tumors. The age of the patients ranged from 1 to 71 years with a mean of 44.2 years. There were 6 males and 20 females(M : F= 1 : 3.3). The accuracies of fine needle aspiration biopsy and frozen section were very low; 6.3% and 34.8%, respectively. There were 20 benign tumors and 6 malignant tumors(23.1%). All the malignant tumors were microinvasive(intermediate) type which had minimal capsular invasion and most of them(5 cases) were diagnosed postoperatively. Any specific clinicopathologic differences were not seen between benign and intermediate groups. Most of the cases had conservative surgeries(15 ipsilateral lobectomy-isthmusectomy, 7 subtotal thyroidectomy) while total thyroidectomy was performed in 4 cases. Of the cases with malignant tumor, 2 had ipsilateral lobectomy-isthmusectomy, 3 had subtotal thyroidectomy and the remaining 1 had total thyroidectomy. Mean size of the tumors was 3.0 cm(0.1- 8.5 cm) in the greatest diameter and multiple tumors were seen in 6 cases(23.1 %). During the follow-up period, only one recurrence(3.8%) of benign tumor occurred but distant metastasis or cause-specific death was seen in the benign or intermediate groups. Mean MVDs of the benign(n=13) and intermediate(n=6) groups were 121.7±35.3 and 114.3±31.7, respectively and there was no statistical significance between them. In conclusion, because of the low accuracies of fine needle aspiration biopsy and frozen section for the Hürthle cell neoplasm, the extent of surgery could be individualized based on permanent pathologic examination; Conservative surgery would be adequate for patients with benign or intermediate Hürthle cell neoplasm and total or near-total thyroidectomy for those with definite malignancy.

이하선 종괴로 발현된 악성 림프종

정웅윤(Woong Youn Chung),이효상(Hyo Sang Lee),서진학(Jin Hak Seo),양우익(Woo Ik Yang),박정수(Cheong Soo Park) 대한두경부종양학회 2001 대한두경부 종양학회지 Vol.17 No.1

Background: Primary malignant lymphoma of the parotid gland is a rare disease and defined as any malignant lymphoma that first manifests in the parotid gland, regardless of the subsequent stage of the diseases, whether it arises in the parenchyma or intraglandular lymph nodes. This study was performed to review the clinicopathological characteristics of primary parotid lymphoma and identify its optimal treatment modality. Materials and Methods: Six cases with parotid mass as first presentation of malignant lymphoma between 1988 and 2000, were studied on the basis of clinical features, diagnostic tools, treatment modality, treatment outcomes, and clinical stage by Ann Arbor Criteria. All were microscopically reevaluated and classified by NCI working formulation. Results: All patients were males and mean age was 36.7 years (2-66 years). Rapid growing non-tender mass was presented in all the cases and cervical lymphnodes were palpated in 4 cases. However, there was not any evidence of concurrent autoimmune disease such as Sjogren's syndrom or Rheumatoid arthritis. One case was confirmed by surgical specimen after superficial parotidectomy, 2 by excisional biopsy, and 3 by incisional biopsy. The stage of disease by NCI working formulation was IE in 1 patient, IIE in 4 and IV in 1. All were classified into non-Hodgkin' lymphoma, of which there were 5 cases of B-cell type and 1 case of T-cell type. There were 3 diffuse large cell lymphomas, 1 Burkitt lymphoma, 1 MALT lymphoma and 1 T-lymphoblastic lymphoma. Three cases were treated by chemotherapy only, 2 by radiotherapy only and 1 by chemo-radiotherapy. One case with Burkitt lymphoma was died from the disease and one case was lost to follow-up. The others are alive with no evidence of recurrence. Conclusions: Although primary parotid lymphoma is rare and difficult to diagnose preoperatively, most were detected in early stage and showed a relatively good response to the chemotherapy or radiotherapy like other types of extranodal malignant lymphoma.

좁은 채널밴드를 갖는 고성능 Phase-locked loops를 위한 새로운 구조의 Charge pump

정윤웅(Youn-woong Chung),범진욱(Jinwook Burm) 대한전자공학회 2007 대한전자공학회 학술대회 Vol.2007 No.11

A new charge pump was designed for narrow band phase-locked loop (PLL). The charge pump is a critical element in narrow channel band spacing PLL. The charge pump controlled by phase frequency detector output provides currents to the load capacitor in loop filter. The conventional charge pump has problems of current mismatch, charge sharing, clock feed through, the leakage current, and AC leakage. This problem is improved by the proposed charge pump. So, high performance narrow band PLL is designed by proposed charge pump.

Metabolism of an Anionic Fluorescent Dye, 1-Anilino-8-naphthalene Sulfonate (ANS) by Rat Liver Microsomes

Chung, Youn-Bok,Bae, Woong-Tak,Han, Kun The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.6

The present study was designed to examine the metabolism of 1-anilino-8-naphthalene sulfonate (ANS), an anionic compound which is transported into liver via "multispecific organ ic anion transporter", with rat hepatic microsomes. TLC analysis indicated that the fluorescent metabolites were not produced to a measurable extent, which made it possible to assess the ANS metabolism by measuring the fluorescence disappearance. The metabolism of ANS was remarkably inhibited by the presence of SKF-525A as well as by the substitution of 02 by CO gas. ANS metabolism by microsomes also required NADPH as a cofactor. These results indicated that the microsomal monooxygenase system might be mainly responsible for the ANS metabolism. The maximum velocity ($V_{max}$) and Michaelis constant ($K_m$) were calculated to be $4.3{\pm}0.2$ nmol/min/mg protein and $42.1{\pm}2.0\;{\mu}M$, respectively. Assuming that 1g of liver contains 32mg of microsomal protein, the $V_{max}$ value was extrapolated to that per g of liver ($V_{max}^I$). The intrinsic metabolic clearance ($CL_{int}$) under linear conditions calculated from this in vitro metabolic study was 3.3ml/min/g liver, being comparable with that (3.0ml/min/g liver) calculated by analyzing the in vivo plasma disappearance curve in a previous study. Furthermore, the effects of other organic anions on the metabolism of ANS were examined. Bromophenolblue (BPB) and rose bengal (RB) competitively inhibited the metabolism of ANS, while BSP inhibited it only slightly. The inhibition constant ($K_i$) of BPB ($6\;{\mu}M$) was much smaller than that of RB ($200\;{\mu}M$). In conclusion, the microsomal monooxygenase system plays a major role in the metabolism of ANS, and other unmetabolizable organic anions (BPB and RB) compete for this metabolism.