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Suppression of β-catenin Signaling Pathway in Human Prostate Cancer PC3 Cells by Delphinidin
Wooje Lee,윤정미 대한암예방학회 2016 Journal of cancer prevention Vol.21 No.2
Delphinidin possesses strong anti-oxidant, anti-inflammatory, and anti-cancer properties. Suppression of the Wnt/β-catenin signaling pathway is a potential strategy for chemoprevention and therapy. As aberrant activation of the β-catenin signaling pathway contributes to prostate cancer progression, we evaluated the effect of delphinidin on this pathway in human PC3 prostate cancer cells. An MTT assay showed that treatment with delphinidin (15-180 μM, 72 hours) resulted in a dose-dependent growth inhibition of cells. Treatment with delphinidin increased the phosphorylation of serine or threonine residues on β-catenin and decreased the levels of cytoplasmic β-catenin. Moreover, treatment with delphinidin inhibited the nuclear translocation of β-catenin and the expression of β-catenin target genes such as cyclin D1, c-myc, Axin-2, and T cell factor-1. Delphinidin also induced the phosphorylation of glycogen synthase kinase 3β and the expression of adenomatous polyposis coli and Axin proteins. Our results indicate that inhibition of cell growth by delphinidin is mediated, at least in part, through modulation of the β-catenin signaling pathway. We suggest that delphinidin is a potent inhibitor of Wnt/β-catenin signaling in prostate cancer cells. (J Cancer Prev 2016;21:110-114)
Lee, Wooje,Lee, Sang Yeol,Son, Young-Jin,Yun, Jung-Mi Mary Ann Liebert 2015 Journal of medicinal food Vol.18 No.7
<P>Hyperglycemia contributes to diabetes and several diabetes-related complications. Gallic acid is a polyhydroxy phenolic compound found in various natural products. In this study, we investigated the effects and mechanism of gallic acid on proinflammatory cytokine secretion in high glucose-induced human monocytes (THP-1 cells). THP-1 cells were cultured under normoglycemic or hyperglycemic conditions, in the absence or presence of gallic acid. Hyperglycemic conditions significantly induced histone acetylation, nuclear factor-κB (NF-κB) activation, and proinflammatory cytokine release from THP-1 cells, whereas gallic acid suppressed NF-κB activity and cytokine release. It also significantly reduced CREB-binding protein/p300 (CBP/p300, a NF-κB coactivator) gene expression, acetylation levels, and CBP/p300 histone acetyltransferase (HAT) activity. In addition, histone deacetylase 2 (HDAC2) expression was significantly induced. These results suggest that gallic acid inhibits hyperglycemic-induced cytokine production in monocytes through epigenetic changes involving NF-κB. Therefore, gallic acid may have potential for the treatment and prevention of diabetes and its complications.</P>
Ferroelectric Tunnel Junction for Dense Cross-Point Arrays
Lee, Hong-Sub,Han, Wooje,Chung, Hee-Yoon,Rozenberg, Marcelo,Kim, Kangsik,Lee, Zonghoon,Yeom, Geun Young,Park, Hyung-Ho American Chemical Society 2015 ACS APPLIED MATERIALS & INTERFACES Vol.7 No.40
<P>Cross-point array (CPA) structure memories using a memristor are attracting a great deal of attention due to their high density integration with a 4<I>F</I><SUP>2</SUP> cell. However, a common significant drawback of the CPA configuration is crosstalk between cells. To date, the CPA structure using a redox-based memristor has restrictions to minimize the operating current level due to their resistive switching mechanism. This study demonstrates suitable characteristics of a ferroelectric tunnel junction (FTJ) for the memristor of the CPA structure using an electrostatic model. From the FTJ of the Au/<I>p</I>-type Pr<SUB>0.98</SUB>Ca<SUB>0.02</SUB>MnO<SUB>3</SUB> (4 nm)/ BaTiO<SUB>3</SUB> (4.3 nm)/<I>n</I>-type Ca<SUB>0.98</SUB>Pr<SUB>0.02</SUB>MnO<SUB>3</SUB> (3 nm)/ Pt(111) structure, which has a higher and thicker potential barrier, a good memristive effect for the CPA structure with a high nonlinear current–voltage curve and low current operation, was obtained by Δ Fowler–Nordheim tunneling with effectively blocked direct tunneling and thermionic emission. The FTJ demonstrated reduced sneak current and the possible for high nonlinearity.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2015/aamick.2015.7.issue-40/acsami.5b06117/production/images/medium/am-2015-06117d_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5b06117'>ACS Electronic Supporting Info</A></P>
2륜 독립조향 steer-by-wire 시스템의 제어기 개발
성우제(Wooje Sung),오승규(Seungkyu Oh),김창준(Changjun Kim),한창수(Changsoo Han),이언구(Unkoo Lee),이상호(Sangho Lee),조희영(Heeyoung Cho) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
In this study, the controller of a SBW (Steer-by-Wire) system was developed. As a SBW system is applied in order to improve steering feel and maneuverability, the controller should have two aims. One is controlling steering wheel for the driver's steering feel and the other is controlling the front wheel steering linkage for vehicle stability. In order to the tie-rod actuating SBW controller analysis, 6-bar linkage kinematics was investigated. The controller of the tie-rod actuating SBW was used the Ackerman Geometry for improving the vehicle stability. Verification simulation and performance simulation are showed that the SBW controller was available in this study.
Lee, Yoon Kwang,Mahadik, D.B.,Kim, Taehee,Han, Wooje,Cho, Hyung Hee,Park, Hyung-Ho Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.732 No.-
<P><B>Abstract</B></P> <P>Tin oxide aerogels with different textural structures were obtained using epoxide-initiated gelation of a tin precursor and two different gel drying methods, i.e., ambient pressure drying (APD) and supercritical extraction (SCE) processes. The pore diameters of the tin oxide aerogels synthesized by the APD and SCE methods were 11.3 and 25.3 nm, respectively. Tin oxide aerogels with smaller pore sizes and larger specific surface areas as well as slightly smaller pore volumes and porosities were obtained by the APD process. Different retention properties were observed for the anode materials prepared by APD and SCE, (71.8% and 10.9% after 80 cycles, respectively). This study revealed a relationship between the pore structure of the metal oxide anode material and its cyclability in Li-ion batteries, with metal oxide aerogels with small pore sizes and large specific surface areas showing greatly improved cycling stability in Li-ion battery applications owing to enhanced stability of the pore structure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Tin oxide aerogels were prepared using two different gel-drying methods. </LI> <LI> Ambient pressure drying (APD) produced smaller pore size and larger surface area. </LI> <LI> Supercritical extraction (SCE) drying produced larger pore size and surface area. </LI> <LI> APD-aerogel exhibited high capacity and low capacity loss even after 80 cycles. </LI> <LI> Mechanical strength of pore structure is important for electrochemical properties. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>