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AzTEC millimetre survey of the COSMOS field – I. Data reduction and source catalogue
Scott, K. S.,Austermann, J. E.,Perera, T. A.,Wilson, G. W.,Aretxaga, I.,Bock, J. J.,Hughes, D. H.,Kang, Y.,Kim, S.,Mauskopf, P. D.,Sanders, D. B.,Scoville, N.,Yun, M. S. Blackwell Publishing Ltd 2008 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.385 No.4
<P>ABSTRACT</P><P>We present a 1.1 mm wavelength imaging survey covering 0.3 deg<SUP>2</SUP> in the COSMOS field. These data, obtained with the AzTEC continuum camera on the James Clerk Maxwell Telescope, were centred on a prominent large-scale structure overdensity which includes a rich X-ray cluster at <I>z</I>≈ 0.73. A total of 50 mm-galaxy candidates, with a significance ranging from 3.5 to 8.5σ, are extracted from the central 0.15 deg<SUP>2</SUP> area which has a uniform sensitivity of ∼1.3 mJy beam<SUP>−1</SUP>. 16 sources are detected with S/N ≥ 4.5, where the expected false-detection rate is zero, of which a surprisingly large number (9) have intrinsic (deboosted) fluxes ≥5 mJy at 1.1 mm. Assuming the emission is dominated by radiation from dust, heated by a massive population of young, optically obscured stars, then these bright AzTEC sources have far-infrared luminosities >6 × 10<SUP>12</SUP> L<SUB>⊙</SUB> and star formation rates >1100 M<SUB>⊙</SUB> yr<SUP>−1</SUP>. Two of these nine bright AzTEC sources are found towards the extreme peripheral region of the X-ray cluster, whilst the remainder are distributed across the larger scale overdensity. We describe the AzTEC data reduction pipeline, the source-extraction algorithm, and the characterization of the source catalogue, including the completeness, flux deboosting correction, false-detection rate and the source positional uncertainty, through an extensive set of Monte Carlo simulations. We conclude with a preliminary comparison, via a stacked analysis, of the overlapping MIPS 24-μm data and radio data with this AzTEC map of the COSMOS field.</P>
Rosa Mistica C. Ignacio,이은숙,Andrew J. Wilson,Alicia Beeghly-Fadiel,Margaret M. Whalen,손덕수 대한면역학회 2018 Immune Network Vol.18 No.6
One-fifth of cancer deaths are associated with obesity. Because the molecular mechanisms by which obesity affects the progression of ovarian cancer (OC) are poorly understood, we investigated if obesity could promote the progression of OC cells using the postmenopausal ob/ob mouse model and peritoneal dissemination of mouse ID8 OC cells. Compared to lean mice, obese mice had earlier OC occurrence, greater metastasis throughout the peritoneal cavity, a trend toward shorter survival, and higher circulating glucose and proinflammatory chemokine CXCL1 levels. Ascites in obese mice had higher levels of macrophages (Mφ) and chemokines including CCL2, CXCL12, CXCL13, G-CSF and M-CSF. Omental tumor tissues in obese mice had more adipocytes than lean mice. Our data suggest that obesity may accelerate the peritoneal dissemination of OC through higher production of pro-inflammatory chemokines and Mφ recruitment.
An AzTEC 1.1-mm survey for ULIRGs in the field of the Galaxy Cluster MS 0451.6−0305
Wardlow, J. L.,Smail, Ian,Wilson, G. W.,Yun, M. S.,Coppin, K. E. K.,Cybulski, R.,Geach, J. E.,Ivison, R. J.,Aretxaga, I.,Austermann, J. E.,Edge, A. C.,Fazio, G. G.,Huang, J.,Hughes, D. H.,Kodama, T.,K Blackwell Publishing Ltd 2010 MONTHLY NOTICES- ROYAL ASTRONOMICAL SOCIETY Vol.401 No.4
<P>ABSTRACT</P><P>We have undertaken a deep (σ∼ 1.1 mJy) 1.1-mm survey of the <I>z</I>= 0.54 cluster MS 0451.6−0305 using the AzTEC camera on the James Clerk Maxwell Telescope. We detect 36 sources with signal-to-noise ratio (S/N) ≥ 3.5 in the central 0.10 deg<SUP>2</SUP> and present the AzTEC map, catalogue and number counts. We identify counterparts to 18 sources (50 per cent) using radio, mid-infrared, <I>Spitzer</I> InfraRed Array Camera (IRAC) and Submillimetre Array data. Optical, near- and mid-infrared spectral energy distributions are compiled for the 14 of these galaxies with detectable counterparts, which are expected to contain all likely cluster members. We then use photometric redshifts and colour selection to separate background galaxies from potential cluster members and test the reliability of this technique using archival observations of submillimetre galaxies. We find two potential MS 0451−03 members, which, if they are both cluster galaxies, have a total star formation rate (SFR) of ∼100 M<SUB>⊙</SUB> yr<SUP>−1</SUP>– a significant fraction of the combined SFR of all the other galaxies in MS 0451−03. We also examine the stacked rest-frame mid-infrared, millimetre and radio emission of cluster members below our AzTEC detection limit, and find that the SFRs of mid-IR-selected galaxies in the cluster and redshift-matched field populations are comparable. In contrast, the average SFR of the morphologically classified late-type cluster population is nearly three times less than the corresponding redshift-matched field galaxies. This suggests that these galaxies may be in the process of being transformed on the red sequence by the cluster environment. Our survey demonstrates that although the environment of MS 0451−03 appears to suppress star formation in late-type galaxies, it can support active, dust-obscured mid-IR galaxies and potentially millimetre-detected LIRGs.</P>
Mula, M.,Cavalheiro, E.,Guekht, A.,Kanner, A. M.,Lee, H. W.,zkara, i.,Thomson, A.,Wilson, S. J. EDITIONS JOHN LIBBY EUROTEXT 2017 EPILEPTIC DISORDERS Vol.19 No.2
<P>Conclusions. Results of this survey identify key areas for improvement in managing the psychiatric comorbidities of epilepsy and suggest specific strategies to develop better training for clinicians involved in epilepsy care.</P>
Human Glycemic Response and Phenolic Content of Unsweetened Cranberry Juice
Ted Wilson,Ajay P. Singh,Nicholi Vorsa,Christopher D. Goettl,Katrina M. Kittleson,Cindy M. Roe,Gary M. Kastello,Frances R. Ragsdale 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
This cross-sectional study determined the phenolic composition of an over-the-counter cranberry juice (CBJ)with high-performance liquid chromatography and examined the effects of low- and normal-calorie CBJ formulations on thepostprandial glycemic response in healthy humans. The CBJ used in this study contained seven phenolic acids, with 3- and5-caffeoylquinic acid being the primary components, and 15 flavonol glycosides, with myricetin-3-galactoside and quercetin-3-galactoside being the most prevalent. CBJ proanthocyanidins consisted of three different tetramers and a heptamer, whichwere confirmed with matrix-assisted laser desorption ionization-time of flight-mass spectrometry analysis. Participants re-ceived one of the following six treatments: nothing (no water/beverage), water (480 mL), unsweetened low-calorie CBJ (38Cal/480 mL), normal-calorie CBJ (280 Cal/480 mL), isocaloric normal calorie (high fructose corn syrup [HFCS]), or isocaloriclow-calorie beverages. No significant differences in postprandial blood glucose or insulin were observed in the groups re-ceiving nothing, water, or low-calorie treatments. In contrast, the ingestion of normal-calorie CBJ and normal-calorie controlbeverage resulted in significantly higher blood glucose concentrations 30 minutes postprandially, although the differenceswere no longer significant after 180 minutes. Plasma insulin of normal-calorie CBJ and control (HFCS) recipients was sig-nificantly higher 60 minutes postprandially, but not significantly different 120 minutes postprandially. CBJ ingestion did notaffect heart rate or blood pressure. This study suggests that the consumption of a low-calorie CBJ rich in previously unchar-acterized trimer and heptamer proanthocyanidins is associated with a favorable glycemic response and may be beneficial forpersons with impaired glucose tolerance.
AzTEC 1.1 mm OBSERVATIONS OF THE MBM12 MOLECULAR CLOUD
Kim, M. J.,Kim, S.,Youn, S.,Yun, M. S.,Wilson, G. W.,Aretxaga, I.,Williams, J. P.,Hughes, D. H.,Humphrey, A.,Austermann, J. E.,Perera, T. A.,Mauskopf, P. D.,Magnani, L.,Kang, Y.-W. IOP Publishing 2012 The Astrophysical journal Vol.746 No.1
<P>We present 1.1 mm observations of the dust continuum emission from the MBM12 high-latitude molecular cloud observed with the Astronomical Thermal Emission Camera (AzTEC) mounted on the James Clerk Maxwell Telescope on Mauna Kea, Hawaii. We surveyed 6.34 deg(2) centered on MBM12, making this the largest area that has ever been surveyed in this region with submillimeter and millimeter telescopes. Eight secure individual sources were detected with a signal-to-noise ratio of over 4.4. These eight AzTEC sources can be considered to be real astronomical objects compared to the other candidates based on calculations of the false detection rate. The distribution of the detected 1.1 mm sources or compact 1.1 mm peaks is spatially anti-correlated with that of the 100 mu m emission and the (CO)-C-12 emission. We detected the 1.1 mm dust continuum emitting sources associated with two classical T Tauri stars, LkH alpha 262 and LkH alpha 264. Observations of spectral energy distributions (SEDs) indicate that LkH alpha 262 is likely to be Class II (pre-main-sequence star), but there are also indications that it could be a late Class I (protostar). A flared disk and a bipolar cavity in the models of Class I sources lead to more complicated SEDs. From the present AzTEC observations of the MBM12 region, it appears that other sources detected with AzTEC are likely to be extragalactic and located behind MBM12. Some of these have radio counterparts and their star formation rates are derived from a fit of the SEDs to the photometric evolution of galaxies in which the effects of a dusty interstellar medium have been included.</P>
Choi, M.C.,Raviv, U.,Miller, H.P.,Gaylord, M.R.,Kiris, E.,Ventimiglia, D.,Needleman, D.J.,Kim, M.W.,Wilson, L.,Feinstein, S.C.,Safinya, C.R. Biophysical Society ; Published for the Biophysica 2009 Biophysical journal Vol.97 No.2
Microtubules (MTs), a major component of the eukaryotic cytoskeleton, are 25 nm protein nanotubes with walls comprised of assembled protofilaments built from αβ heterodimeric tubulin. In neural cells, different isoforms of the microtubule-associated-protein (MAP) tau regulate tubulin assembly and MT stability. Using synchrotron small angle x-ray scattering (SAXS), we have examined the effects of all six naturally occurring central nervous system tau isoforms on the assembly structure of taxol-stabilized MTs. Most notably, we found that tau regulates the distribution of protofilament numbers in MTs as reflected in the observed increase in the average radius <R<SUP>MT</SUP>> of MTs with increasing Φ, the tau/tubulin-dimer molar ratio. Within experimental scatter, the change in <R<SUP>MT</SUP>> seems to be isoform independent. Significantly, <R<SUP>MT</SUP>> was observed to rapidly increase for 0 < Φ < 0.2 and saturate for Φ between 0.2-0.5. Thus, a local shape distortion of the tubulin dimer on tau binding, at coverages much less than a monolayer, is spread collectively over many dimers on the scale of protofilaments. This implies that tau regulates the shape of protofilaments and thus the spontaneous curvature C<SUB>o</SUB><SUP>MT</SUP> of MTs leading to changes in the curvature C<SUP>MT</SUP> (=1/R<SUP>MT</SUP>). An important biological implication of these findings is a possible allosteric role for tau where the tau-induced shape changes of the MT surface may effect the MT binding activity of other MAPs present in neurons. Furthermore, the results, which provide insight into the regulation of the elastic properties of MTs by tau, may also impact biomaterials applications requiring radial size-controlled nanotubes.