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Sang-WookKim,Hyun-MeeOh,김범수,Hun-TaegChung,Weon-CheolHan,Eun-CheolKim,Tae-HyeonKim,Geom-SeogSeo,June-HyungLyou,Yong-HoNah,정재창,Suck-CheiChoi,전창덕 생화학분자생물학회 2003 Experimental and molecular medicine Vol.35 No.1
Tumor target-derived soluble secretary factor has been known to influence macrophage activation to induce nitric oxide (NO) production. Since heme oxigenase-1 (HO-1) is induced by a variety of con-ditions associated with oxidative stress, we ques-tioned whether soluble factor from tumor cels induces HO-1 through NO-dependent mechanism in macrophages. We designated this factor as a because of its ability to activate macrophages to induce iNOS. Although TMAF alone showed mod-est activity, TMAF in combination with IFN-γ signi-ficantly induced iNOS expression and NO syn-thesis. Simultaneously, TMAF induced HO-1 and this induction was slightly augmented by IFN-γ. Surprisingly, however, induction of HO-1 by TMAF was not inhibited by the treatment with the highly selective iNOS inhibitor, 1400 W, indicating that pendent mechanism. While rIFN-γ alone induced iNOS, it had no efect on HO-1 induction by itself. Colectively, the current study reveals that soluble factor from tumor target cells induces HO-1 en-zyme in macrophages. However, overall biological significance of this phenomenon remains to be determined.
Effect of Enterococcus faecalis EF-2001 on experimentally induced atopic eczema in mice
최은주,Masahiro Iwasa,한권일,Wan-Jae Kim,YuJiao Tang,Weon-CheolHan,김은경,박지용 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.4
Here, the effects of heat-killed Enterococcus faecalis EF-2001 (EF-2001) on atopic eczema(AE) were assessed. An AE model was established in vivo by repetitious topical exposure to 1-chloro-2,4-dinitrobenzene (CDNB) and dermatophagoidesfarinae extract (DFE) via application on each ear. Mice were administered EF-2001 orally for 4 weeks, dermal and epidermal ear thickness, mast cellinfiltration of the ear tissue, and serum IgE and IgG2a levels were evaluated. Moreover, pathogeniccytokines levels of the ears, splenocytes, and cervical lymph nodes were determined. EF-2001 reducedAE symptoms grounded in the ear thickness, histopathological analysis, and serum IgE levels. Furthermore, EF-2001 attenuated mast cell infiltration in the ears and CDNB/DFE-induced variouspathogenic cytokines levels of the ears, splenocytes and cervical lymph nodes. Thus, our datasuggested that EF-2001 may have potential medicinal applications in the treatment of AE through itsimmunomodulatory properties.