红色资源融入高校党史学习教育的路径研究

张雯雯(Wenwen Zhang),张泽琪(Zeqi Zhang),张博焱(Boyan Zhang),王怡(Yi Wang) YIXIN 출판사 2024 教育教学研究论丛 Vol.2 No.4

红色资源具有强大的文化内涵和育人价值,是启发高校大学生思想政治教育觉悟的重要内容,作为革命老区的山西省,蕴含着丰富的红色资源。探索红色资源融入高校党史学习教育的实践路径是当前思政课教学改革的必然要求,高校应在课堂中发挥“大思政课”主阵地的作用,用好红色资源,提升党史教育成效;在实践中借助社会实践活动的力量,用活红色资源,开展多样化实践活动;新时代高校还应创新传播途径,依托网络新媒体,用足红色资源,拓宽党史传播渠道。 Red resources have strong cultural connotation and educational value, which is an important content to inspire the ideological and political education consciousness of college students. Shanxi Province, as a revolutionary old base area, contains rich red resources. Exploring the practical path of integrating red resources into the study and education of Party history in colleges and universities is the inevitable requirement of the current ideological and political course teaching reform. Colleges and universities should play the role of “big ideological and political course” in the classroom, make good use of red resources, and improve the effectiveness of Party history education. In practice, with the help of social practice activities, use living red resources to carry out diversified practice activities; In the new era, colleges and universities should also innovate communication channels, rely on network new media, and use sufficient red resources to broaden the channels of Party history communication.

Preliminary design and assessment of a heat pipe residual heat removal system for the reactor driven subcritical facility

Wenwen Zhang,Kaichao Sun,Chenglong Wang,Dalin Zhang,Wenxi Tian,Suizheng Qiu,G.H. Su 한국원자력학회 2021 Nuclear Engineering and Technology Vol.53 No.12

A heat pipe residual heat removal system is proposed to be incorporated into the reactor drivensubcritical (RDS) facility, which has been proposed by MIT Nuclear Reactor Laboratory for testing anddemonstrating the Fluoride-salt-cooled High-temperature Reactor (FHR). It aims to reduce the risk of thesystem operation after the shutdown of the facility. One of the main components of the system is an aircooled heat pipe heat exchanger. The alkali-metal high-temperature heat pipe was designed to meet theoperation temperature and residual heat removal requirement of the facility. The heat pipe modeldeveloped in the previous work was adopted to simulate the designed heat pipe and assess the heattransport capability. 3D numerical simulation of the subcritical facility active zone was performed by thecommercial CFD software STAR CCM þ to investigate the operation characteristics of this proposedsystem. The thermal resistance network of the heat pipe was built and incorporated into the CFD model. The nominal condition, partial loss of air flow accident and partial heat pipe failure accident weresimulated and analyzed. The results show that the residual heat removal system can provide sufficientcooling of the subcritical facility with a remarkable safety margin. The heat pipe can work under therecommended operation temperature range and the heat flux is below all thermal limits. The facilitypeak temperature is also lower than the safety limits

Application of Improved Grid Search Algorithm on SVM for Classification of Tumor Gene

Li Wenwen,Xing Xiaoxue,Liu Fu,Zhang Yu 보안공학연구지원센터 2014 International Journal of Multimedia and Ubiquitous Vol.9 No.11

According to the merits and shortcomings of the traditional gridsearch algorithm in parameters optimization of support vector machine (SVM), an improved grid search algorithm is proposed. Dichotomous search algorithm is used to reduce target searching range. First, searching range is determined roughly, and a set of parameters are obtained. Then fine search is applied in reduction the range for searching, and searching the optimum parameters.Three kinds of famous tumor gene data set are used in the comparison experiments to validate the classification accuracy of principal component analysis (PCA)-SVM and kernel principal component analysis (KPCA)-SVM. Experiment results and data analysis shows that, comparing with traditional gridsearch algorithm, the proposed method has higher classification accuracy and less search time.

miR-458b-5p regulates ovarian granulosa cells proliferation through Wnt/β‐catenin signaling pathway by targeting catenin beta-1

Wang Wenwen,Teng Jun,Han Xu,Zhang Shen,Zhang Qin,Tang Hui 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.6

Objective: Ovarian follicular development, which dependent on the proliferation and differentiation of granulosa cells (GCs), is a complex biological process in which miRNA plays an important role. Our previous study showed that miR-458b-5p is associated with ovarian follicular development in chicken. The detailed function and molecular mechanism of miR-458b-5p in GCs is unclear. Methods: The luciferase reporter assay was used to verify the targeting relationship between miR-458b-5p and catenin beta-1 (CTNNB1), which is an important transcriptional regulatory factor of the Wnt/β-catenin pathway. The cell counting kit-8 (CCK-8) assay, flow cytometry with propidium iodide (PI) and annexin V-fluorescein isothiocyanate (FITC) labeling were applied to explore the effect of miR-458b-5p on proliferation, cell cycle and apoptosis of chicken GCs. Quantitative real-time polymerase chain reaction and Western blot were used to detect the mRNA and protein expression levels. Results: We demonstrated that the expression of miR-458b-5p and CTNNB1 showed the opposite relationship in GCs and theca cells of hierarchical follicles. The luciferase reporter assay confirmed that CTNNB1 is the direct target of miR-458b-5p. Using CCK-8 assay and flow cytometry with PI and Annexin V-FITC labeling, we observed that transfection with the miR-458b-5p mimics significantly reduced proliferation and has no effects on apoptosis of chicken GCs. In addition, miR-458b-5p decreased the mRNA and protein expression of CD44 molecule and matrix metallopeptidase 7, which are the downstream effectors of CTNNB1 in Wnt/β-Catenin pathway and play functional roles in cell proliferation. Conclusion: Taken together, the data indicate that miR-458b-5p regulates ovarian GCs proliferation through Wnt/β-catenin signaling pathway by targeting CTNNB1, suggesting that miR-458b-5p and its target gene CTNNB1 may potentially play a role in chicken ovarian follicular development. Objective: Ovarian follicular development, which dependent on the proliferation and differentiation of granulosa cells (GCs), is a complex biological process in which miRNA plays an important role. Our previous study showed that miR-458b-5p is associated with ovarian follicular development in chicken. The detailed function and molecular mechanism of miR-458b-5p in GCs is unclear.Methods: The luciferase reporter assay was used to verify the targeting relationship between miR-458b-5p and catenin beta-1 (<i><i>CTNNB1</i></i>), which is an important transcriptional regulatory factor of the Wnt/β-catenin pathway. The cell counting kit-8 (CCK-8) assay, flow cytometry with propidium iodide (PI) and annexin V-fluorescein isothiocyanate (FITC) labeling were applied to explore the effect of miR-458b-5p on proliferation, cell cycle and apoptosis of chicken GCs. Quantitative real-time polymerase chain reaction and Western blot were used to detect the mRNA and protein expression levels.Results: We demonstrated that the expression of miR-458b-5p and <i>CTNNB1</i> showed the opposite relationship in GCs and theca cells of hierarchical follicles. The luciferase reporter assay confirmed that <i>CTNNB1</i> is the direct target of miR-458b-5p. Using CCK-8 assay and flow cytometry with PI and Annexin V-FITC labeling, we observed that transfection with the miR-458b-5p mimics significantly reduced proliferation and has no effects on apoptosis of chicken GCs. In addition, miR-458b-5p decreased the mRNA and protein expression of CD44 molecule and matrix metallopeptidase 7, which are the downstream effectors of <i>CTNNB1</i> in Wnt/β-Catenin pathway and play functional roles in cell proliferation.Conclusion: Taken together, the data indicate that miR-458b-5p regulates ovarian GCs proliferation through Wnt/β-catenin signaling pathway by targeting <i>CTNNB1</i>, suggesting that miR-458b-5p and its target gene <i>CTNNB1</i> may potentially play a role in chicken ovarian follicular development.

新时代高校培养好青年的路径探究

张雯雯(Wenwen Zhang),张泽琪(Zeqi Zhang),行国通(Guotong Xing) YIXIN 출판사 2024 教育教学研究论丛 Vol.2 No.3

青年是国家的希望,民族的未来。培养新时代好青年具有重大的意义,培养新时代好青年有利于高校青年自身素质提高、有利于青年勇于担当历史使命和推动民族复兴。因此高校应以培养新时代理想者、新时代担当者、新时代吃苦者和新时代奋斗者为目标和主要内容。但高校在培养青年过程中存在着诸多问题。为此,高校应形成协同发展的培育模式、建立结构完备的培育机制和健全网络培养体系。高校对新时代好青年的培育有助于增强中国青年的历史使命感和责任感,对党和国家未来的发展和社会主义建设起着重大而深远的意义。 Youth is the hope of a country and the future of a nation. Training good young people in the new era is of great significance, which is conducive to improving the quality of young people in colleges and universities, helping young people to take up the historical mission and promote national rejuvenation. Therefore, colleges and universities should take the training of the new era ideal, the new era of responsibility, the new era of hardship and the new era of strugglers as the goal and main content. But there are many problems in the process of training young people. Therefore, colleges and universities should form the cultivation mode of cooperative development, set up a well-structured cultivation mechanism and perfect network training system. The cultivation of good young people in colleges and universities in the new era helps to enhance the sense of historical mission and responsibility of Chinese youth, and plays a significant and far-reaching significance for the future development of the Party and the country and the construction of socialism.

PVDF membrane with tea powder adhered for efficient separation of emulsified oil

Zhang Junshuang,Wu Yue,Xia Mengsheng,Yang Qijiang,Xu Qinyao,Feng Wenwen 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.10

Conventional oily wastewater treatment can remove slick oil and dispersed oil well, but it is difficult for it to remove emulsified oil. Nonetheless, the development of super wetting materials provides a key role in treating the emulsified oil, but there are some problems, such as expensive raw materials, complicated processes, as well as secondary pollution. In order to treat these problems, a brand-new oil/water separation membrane (TEA/PVDF membrane) was developed by combining the viscosity of sodium alginate (SA) and the filter tea powder (TEA) onto the surface of the polyvinylidene fluoride (PVDF) membrane by a vacuum pump. Furthermore, the underwater oleophobic angle reached 135o. Moreover, the oil-water separation experiments of oil-in-water emulsion utilizing TEA/PVDF membrane demonstrated excellent separation efficiency (99.6%) and good flux (254 L m−2 h−1 bar−1). Notably, upon ten cycles, the oil removal rate was still as high as 99.2%. Moreover, the TEA/PVDF membrane was able to separate oil-in-water emulsions in environments with strong acids, strong bases, and high salt concentrations, with a separation efficiency of over 95.9%. Such a novel oil/water separation membrane is economic, environmentally protective, and simple production process, which exhibits overwhelming potential in practical life for treating oily wastewater.

Isocryptotanshinone Induced Apoptosis and Activated MAPK Signaling in Human Breast Cancer MCF-7 Cells

Xuenong Zhang,Weiwei Luo,Wenwen Zhao,Jinjian Lu,Xiuping Chen 한국유방암학회 2015 Journal of breast cancer Vol.18 No.2

Purpose: Isocryptotanshinone (ICTS) is a natural bioactive product that is isolated from the roots of the widely used medical herb Salvia miltiorrhiza. However, few reports exist on the mechanisms underlying the therapeutic effects of ICTS. Here, we report that ICTS has anticancer activity and describe the mechanism underlying this effect. Methods: The antiproliferative effect of ICTS was determined using 3-(4,5-dimethyl-2-thiazolyl)-2,5- diphenyl-2-H-tetrazolium bromide (MTT) and clonogenic assays. The effect of ICTS on the cell cycle was measured using flow cytometry. Apoptosis was determined by Hoechst 33342 staining, DNA fragmentation assays, and Western blotting for apoptotic proteins. Finally, the effect of ICTS on mitogen-activated protein kinases (MAPKs) was determined by Western blotting. Results: ICTS significantly inhibited proliferation of MCF-7 and MDA-MB-231 human breast cancer cells, HepG2 human liver cancer cells, and A549 human lung cancer cells in vitro. Among the tested cell lines, MCF-7 cells showed the highest sensitivity to ICTS. ICTS significantly inhibited colony formation by MCF-7 cells. Furthermore, exposure of MCF-7 cells to ICTS induced cell cycle arrest at the G1 phase and decreased mitochondrial membrane potential. Hoechst 33342 staining and Western blot analysis for apoptotic proteins suggested that ICTS induced apoptosis in MCF-7 cells. In addition, ICTS activated MAPK signaling in MCF-7 cells by inducing time- and concentration-dependent phosphorylation of JNK, ERK, and p38 MAPK. Conclusion: Our results suggest that ICTS inhibited MCF-7 cell proliferation by inducing apoptosis and activating MAPK signaling pathways.

High-performance Zinc-Tin-Oxide thin film transistors based on environment friendly solution process

Qian Zhang,Guodong Xia,Lubin Li,Wenwen Xia,Hong-Yu Gong,Sumei Wang 한국물리학회 2019 Current Applied Physics Vol.19 No.2

Zinc-Tin-Oxide (ZTO) thin films were fabricated using a simple and eco-friendly sol-gel method and their application in thin film transistors (TFTs) was investigated. Annealing temperature has a crucial influence on the structure and electrical properties of sol-gel ZTO thin films. The ZTO thin films annealed at 300–600 °C revealed smooth and uniform surfaces with amorphous state, in addition, a high optical transparency over 90% of the ZTO films in the visible range was obtained. The electrical performance of ZTO TFTs showed obvious dependence on annealing temperature. The ZTO TFTs annealed at 500 °C showed a high carrier mobility of 5.9 cm2 /V, high on/off current ratio (Ion/off) of 106 -107 , and threshold voltage (Vth) of 1.03 V. To demonstrate the application of sol-gel ZTO films in low-power display fields, we also fabricated ZTO TFTs with a solution-processed high-permittivity (high-k) ZrTiOx dielectric layer. The ZTO/ZrTiOx TFTs showed high mobility of 17.9 cm2 /V and Ion/off of 105 -106 at a low operation voltage of 3 V, indicating that Indium-free ZTO thin films would be potential candidates for low cost, high performance oxide TFT devices.

Stability of phenolic acids and the effect on weed control activity

Li, Jiayu,Zhang, Qi,Hu, Wenwen,Yang, Xiaoyan,He, Haibin 한국응용생명화학회 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.6

Phenolic acid is a very important class of allelochemicals with allelopathic weed control activity. In this study, three benzoic acid derivatives (syringic, 4-hydroxybenzoic, and vanillic acids), three cinnamic acid derivatives (cinnamic, 4-hydroxycinnamic, and ferulic acids) were tested, and high-performance liquid chromatography was used to conduct a dynamic analysis on the changes in the concentration of phenolic acids in a bioassay based on the initial concentration and test time. The results showed that the concentration of individual phenolic acids and a solution of mixed phenolic acids decreased to a certain extent irrespective of environment, i.e., bioassay (4-7 days) or a ricegrowing environment, and a significant decrease in concentration was measured after 48 h. Based on the above results, the laboratory bioassay was conducted using a fresh solution of phenolic acids every 48 h. The results showed that the instability of phenolic acid could affect its weed control activity, and this effect was more significant for high concentrations of phenolic acids. On the other hand, changing the solution did not have a significant impact on the weed control activity of phenolic acids in the natural environment (pH 6.50), in which allelopathic rice release phenolic acids. These results reveal the instability of phenolic acids could significantly reduce the inhibition rate on the growth index for receptor plants in an indoor bioassay.

Regional Homogeneity Brain Alterations in Schizophrenia: An Activation Likelihood Estimation Meta-Analysis

Xiaolei Qiu,Wenwen Xu,Rongrong Zhang,Wei Yan,Wenying Ma,Shiping Xie,Min Zhou 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.8

Objective Resting state functional magnetic resonance imaging (rsfMRI) provides a lot of evidence for local abnormal brain activity in schizophrenia, but the results are not consistent. Our aim is to find out the consistent abnormal brain regions of the patients with schizophrenia by using regional homogeneity (ReHo), and indirectly understand the degree of brain damage of the patients with drug-naive first episode schizophrenia (Dn-FES) and chronic schizophrenia. Methods We performed the experiment by activation likelihood estimation (ALE) software to analysis the differences between people with schizophrenia group (all schizophrenia group and chronic schizophrenia group) and healthy controls. Results Thirteen functional imaging studies were included in quantitative meta-analysis. All schizophrenia group showed decreased ReHo in bilateral precentral gyrus (PreCG) and left middle occipital gyrus (MOG), and increased ReHo in bilateral superior frontal gyrus (SFG) and right insula. Chronic schizophrenia group showed decreased ReHo in bilateral MOG, right fusiform gyrus, left PreCG, left cerebellum, right precuneus, left medial frontal gyrus and left anterior cingulate cortex (ACC). No significant increased brain areas were found in patients with chronic schizophrenia. Conclusion Our findings suggest that patients with chronic schizophrenia have more extensive brain damage than FES, which may contribute to our understanding of the progressive pathophysiology of schizophrenia.