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Wenlong Xu,Xue Yang,Binjie Xin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.1
Polyacrylonitrile (PAN)/cellulose nanofibril (CNF) nanofiber membranes were successfully prepared by anelectrospinning method, in which the amount of CNF kept 1 wt%. The effects of CNF sizes on the morphology and propertyof spinning solutions and PAN electrospun nanofiber membrane were systematically investigated by rheological propertytest, conductivity test, SEM, TG, DSC, contact angle test and mechanical test. The results showed that the viscosity andconductivity of the spinning solution was improved with the increasing of CNF sizes, as the formation of the strong polarinteractions of nitrile groups and the hydroxyl groups between PAN and CNF. All the morphology of the PAN/CNF nanofibermembrane exhibited a uniform diameter with no visible beads or beads to the string structure, and the average diameter of thePAN/CNF nanofiber was decreased with the increasing of the CNF size. Moreover, the addition of CNF could improve thethermal stability, mechanical property, and hydrophilicity of the PAN membrane. And the PAN/CNF-10 nanofiber membraneexhibited the optimal properties.
Application of Dye-coated Ultrasmall Gadolinium Oxide Nanoparticles for Biomedical Dual Imaging
Xu Miao,Wenlong Xu,차현실,장용민,오인택,채권석,이강호 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.9
Nanoparticles are very important in biomedical imaging because their imaging properties are superior to those of small molecules. They can be further functionalized for multimodal imaging through surface modification. In this study, we synthesized dye-coated ultrasmall gadolinium oxide nanoparticles [dye = fluorescein and fluorescein isothiocyanate (FITC)] in one-pot and investigated their dual imaging properties. The dye-coated gadolinium oxide nanoparticles exhibited excellent relaxometric properties suitable for T1 magnetic resonance imaging (MRI): r1 = 9.8 s−1mM−1 (r2/r1 = 2.6) for fluorescein-coated nanoparticles (davg = 1.6 ± 0.1 nm) and r1 = 12.3 s−1mM−1 (r2/r1 = 2.3) for FITC-coated nanoparticles (davg = 1.4 ± 0.1 nm), and strong photoluminescence (PL) in the green region (around 514 nm) suitable for fluorescent imaging (FI). The dye-coated nanoparticles exhibited strong fluorescence in cellular confocal images and high contrast in T1 MR images in mice, suggesting that they are potential dual T1 MRI-FI agents.
Xu, Wenlong,Park, Ja Young,Kattel, Krishna,Bony, Badrul Alam,Heo, Woo Choul,Jin, Seonguk,Park, Jang Woo,Chang, Yongmin,Do, Ji Yeon,Chae, Kwon Seok,Kim, Tae Jeong,Park, Ji Ae,Kwak, Young Woo,Lee, Gang The Royal Society of Chemistry 2012 NEW JOURNAL OF CHEMISTRY Vol.36 No.11
<P>Multiple molecular imaging is a challenging subject. Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium–europium oxide nanoparticles with an average particle diameter of 1.75 nm and an average hydrodynamic diameter of 4.16 nm were synthesized and applied for <I>T</I><SUB>1</SUB>, <I>T</I><SUB>2</SUB> MRI-FI <I>in vitro</I> and <I>in vivo.</I> They had <I>r</I><SUB>1</SUB> and <I>r</I><SUB>2</SUB> values of 11.9 and 38.7 s<SUP>−1</SUP> mM<SUP>−1</SUP>, respectively, and showed clear dose-dependent contrast changes in both <I>R</I><SUB>1</SUB> and <I>R</I><SUB>2</SUB> map images. In addition, they showed both positive and negative contrast enhancements in 3 tesla <I>T</I><SUB>1</SUB> and <I>T</I><SUB>2</SUB> MR images in a mouse, respectively, and fluorescent confocal images in both DU145 cells and <I>C</I>. <I>elegans</I> (a small nematode). This study demonstrates the <I>T</I><SUB>1</SUB>, <I>T</I><SUB>2</SUB> MRI-FI multi-functionality of lactobionic acid coated mixed gadolinium–europium oxide nanoparticles.</P> <P>Graphic Abstract</P><P>Water-soluble and biocompatible lactobionic acid coated ultrasmall mixed gadolinium–europium oxide nanoparticles (<I>d</I><SUB>avg</SUB> = 1.75 nm and <I>a</I><SUB>avg</SUB> = 4.16 nm) showed <I>T</I><SUB>1</SUB>, <I>T</I><SUB>2</SUB> MRI-FI multi-functionality. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2nj40149e'> </P>
Miao, Xu,Xu, Wenlong,Cha, Hyunsil,Chang, Yongmin,Oh, In Taek,Chae, Kwon Seok,Tegafaw, Tirusew,Ho, Son Long,Kim, Sung June,Lee, Gang Ho Elsevier 2019 APPLIED SURFACE SCIENCE - Vol.477 No.-
<P><B>Abstract</B></P> <P>Ultrasmall Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles can potentially be used as a positive magnetic resonance imaging (MRI) contrast agent owing to their high content of Gd(III), which exhibits the highest spin magnetic moment of all elements due to its seven unpaired 4<I>f</I> electrons. Herein, the above nanoparticles (average diameter = 2.0 nm) were coated with hydrophilic biocompatible polyacrylic acids (PAAs) of different molecular weights (<I>M</I> <SUB>w</SUB> = 1200, 5100, 15000 Da), and the PAA-size-dependent relaxometric properties of the thus obtained composites were investigated. In addition, the biocompatibility of these composites was assessed by <I>in-vitro</I> cell viability measurements. Finally, dose-dependent <I>R</I> <SUB>1</SUB> map images were acquired, proving that PAA-coated nanoparticles can be used as a <I>T</I> <SUB>1</SUB> MRI contrast agent.</P> <P><B>Highlights</B></P> <P> <UL> <LI> PAA-coated ultrasmall Gd<SUB>2</SUB>O<SUB>3</SUB> nanoparticles showed PAA-size dependent relaxometric properties. </LI> <LI> Both <I>r</I> <SUB>1</SUB> and <I>r</I> <SUB>2</SUB> values decreased with increasing PAA size (<I>M</I> <SUB>w</SUB> = 1200, 5100, 15000 Da). </LI> <LI> All samples showed good biocompatibility. </LI> <LI> All samples can be potential <I>T</I> <SUB>1</SUB> MRI contrast agents. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Bo Xu,Yingzhe WANG,Shixin ZHU,Haizhu ZHOU,Changlong GOU,Wenlong DONG,Yu Wang,Yunhang GAO,Hongxia MA 한국곤충학회 2019 Entomological Research Vol.49 No.1
Chalkbrood, which results from Ascosphaera apis infection, is one of the bee diseases that causes serious damage to the bee colony. Understanding the molecular bases underlying immune response to chalkbrood disease would facilitate the genetic breeding of bees by selecting races with superior chalkbrood resistance. In this study, transcriptome sequencing was performed to identify genes and pathways involved in the immune response to As. apis infection in A. mellifera larvae. In total, 2,890 differentially expressed genes (DEGs) (FDR < 0.001) were identified between the healthy and As. apis infected bee larvae, including 2,214 up‐regulated and 676 down‐regulated unigenes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway classification of the DEGs revealed association with development, energy metabolism, signal transduction, disease, and immune response. Among the immune‐related genes, p38, toll‐like receptors (TLRs), integrin, and antimicrobial peptides were up‐regulated under As. apis infection. This study provides valuable gene transcriptional information towards the investigation of molecular mechanisms related to chalkbrood immune response and host pathogenesis in A. mellifera.
Harris Scale Invariant Corner Detection Algorithm Based on the Significant Region
Wu Peng,Xu Hongling,Li Wenlin,Song Wenlong 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.3
The traditional Harris corner detection algorithm is sensitive to scale change, corners detected throughout the entire image under complex background, thus extracting more false corners, lead to the follow-up of large amount of calculation and a high rate of error matching. To solve this problem, this paper proposes an optimized Harris corner detection algorithm. First, a significant region detection method is used to extract the target area, and take closing operation for the result figure, can effectively achieve target and background segmentation; second, scale invariant describing methods is applied to Harris algorithm, at the same time, combined with the non-maximum suppression methods to extract corners, get more right corners. Through experiment contrasts, the algorithm used in this paper can be improved more corner detection performance.
Tegafaw, Tirusew,Xu, Wenlong,Ahmad, Md. Wasi,Xu, Miao,Chang, Yongmin,Chae, Kwon Seok,Kim, Tae Jeong,Lee, Gang Ho American Scientific Publishers 2016 Journal of Nanoscience and Nanotechnology Vol.16 No.10
<P>Nearly monodisperse Fe3O4 nanoparticles (d(avg) = 20 +/- 1 nm) were synthesized in an aqueous phase under an argon flow, and then coated with fluorescent brightener (FB) 28. The Fe3O4 nanoparticles were superparamagnetic, with large saturation magnetizations of 54.1 emu/g at 5 K and 48.5 emu/g at 300 K. The FB-28-coated Fe3O4 nanoparticles showed a strong fluorescence maximum (lambda(max)) at 435 nm, and also gave strongly fluorescent confocal images in both the green and blue regions, because of the FB 28 coated on the nanoparticles. These magnetic and optical properties will be useful in various biomedical applications.</P>