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Antioxidant Activity of Peach Blossom Extracts
( Myeong Hyeon Wang ),( Chun Mei Li ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.1
Peach blossom, popularly consumed as tea, is believed to promote healthy, young-looking skin. The literature reporting pharmacological studies related to peach blossom is very limited. Thus, the antioxidant activities of the methanolic extract (ME) and the water extract (WE) from peach blossom were evaluated using various in vitro assays including total phenolic and flavonoid contents, total antioxidant activity, 2,2-Diphenyl-2-picrylhydrazyl (DPPH) free radical-scavenging activity, reducing power, metal chelating activity, lipid peroxidation inhibitory activity, and protective effects against DNA and protein damages. Results showed that ME demonstrated slightly higher antioxidant effects than WE, except for protection against protein damage. These results suggest that peach blossom has the potential for use as a source of natural antioxidants in the food and cosmetic industries.
Wang, Lan,Wang, Li,Li, Xiaojuan,Wang, Linsong,Roh, Kwang-Soo,Wang, Myeong-Hyeon The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.2
Light and temperature variations are important during the vegetative stage of the Chinese red radish. We found that peroxidase (POD) and catalase activities and the content of pelargonidin were decreased by treatments of short of light perioid and low temperatures, while the content of hydrogen peroxide was increased. The POD isoenzymes of the radish organs were detected diversely depending on the developmental stages by polyacrylamide gel electrophoresis analysis; semi-quantitative RT-PCR revealed that expression was significantly induced during the flourishing anthesis stage in the bud. These results suggest that POD expression is both time-dependent and tissue-specific and that light and temperature conditions can influence the growth and antioxidant activity of the radish.
( Myeong Hyeon Wang ),( Mohammad Humayun Kabir ) 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.6
Dehydroascorbate reductase (DHAR) plays an important role in the ascorbate-glutathione cycle in plants by controlling the homeostasis of reactive oxygen species. Expression profiles of two DHAR genes (SlDHAR1 and SlDHAR2) in tomato leaves were analyzed in response to abiotic and oxidative stresses as well as their expression in various organs were investigated under normal growth conditions. Multiple copies of SlDHAR homologues exist in the tomato genome. SlDHAR1 expression was dominant in stems and flowers but moderate in leaves; however, SlDHAR2 induction was strong in stems, leaves, and flowers, and young leaves showed the highest expression of SlDHAR2. Both genes were transcribed after treatment with salt, dehydration, and methyl viologen. Prolonged stress reduced SlDHAR genes expression. The level of hydrogen peroxide increased, and DHAR activity was altered by stress treatment. Results indicate that SlDHAR genes could play a role in multiple stress responses.
Myeong-Hyeon Wang,허성일,Ying-Shan Jin,Mee Jung Jung 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4
We investigated the antidiabetic properties of 2,5-dihydroxy-4,3.-di(.-D-glucopyranosyloxy)-trans-stilbene(DGTS) isolated from Morus bombycisKoidzumi in streptozotocin (STZ)-induced diabetic rats. The DGTS prevented the in-crease in aspartate aminotransferase, alanine aminotransferase, and blood urea nitrogen levels in serum of diabetic rats. Atdoses of 200800 mg/kg, DGTS improved hyperglycemia in the rats, and the hypoglycemic effect of DGTS was comparable.-cells and vascu-lar degenerative changes in the islets. DGTS reversed STZ-induced diabetes and had antioxidant activity in assays ofFeCl2/ascorbic acid-induced lipid peroxidation in the rats. Levels of cytochrome P450 2E1 mRNA, as measured by reversetranscription-polymerasee chain reaction, were lower in the livers of the DGTS-treated rats than those of the control group.These results suggest that DGTS might be beneficial in the treatment of type 1 diabetes.
Lan Wang,Ming Lu Xu,Jie Liu,You Wang,Jian He Hu,Myeong-Hyeon Wang 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.6
BACKGROUND/OBJECTIVES: Sonchus asper is used extensively as an herbal anti-inflammatory for treatment of bronchitis, asthma, wounds, burns, and cough; however, further investigation is needed in order to understand the underlying mechanism. To determine its mechanism of action, we examined the effects of an ethyl acetate fraction (EAF) of S. asper on nitric oxide (NO) production and prostaglandin-E2 levels in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. MATERIALS/METHODS: An in vitro culture of RAW264.7 macrophages was treated with LPS to induce inflammation. RESULTS: Treatment with EAF resulted in significant suppression of oxidative stress in RAW264.7 macrophages as demonstrated by increased endogenous superoxide dismutase (SOD) activity and intracellular glutathione levels, decreased generation of reactive oxygen species and lipid peroxidation, and restoration of the mitochondrial membrane potential. To confirm its anti-inflammatory effects, analysis of expression of inducible NO synthase, cyclooxygenase-2, tumor necrosis factor-α, and the anti-inflammatory cytokines IL-1β and IL-6 was performed using semi-quantitative RT-PCR. EAF treatment resulted in significantly reduced dose-dependent expression of all of these factors, and enhanced expression of the antioxidants MnSOD and heme oxygenase-1. In addition, HPLC fingerprint results suggest that rutin, caffeic acid, and quercetin may be the active ingredients in EAF. CONCLUSIONS: Taken together, findings of this study imply that the anti-inflammatory effect of EAF on LPS-stimulated RAW264.7 cells is mediated by suppression of oxidative stress.
Wang, Lan,Son, Hee-Jeong,Xu, Ming-Lu,Hu, Jian-He,Wang, Myeong-Hyeon The Korean Society for Applied Biological Chemistr 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.3
Broussonetia papyrifera radix, fruits, leaves, and stems exhibit antioxidant, antinociceptive, antityrosinase, anti-inflammatory, and antiplatelet activities. However, studies of the anticancer and anti-inflammatory activities of B. papyrifera stem bark are limited. Yet it is important to evaluate these activities to isolate active compounds for potential medicines and food additive. The dichloromethane fraction of B. papyrifera stem bark was found to induce apoptosis-related DNA fragmentation, increase sub-G1 accumulation, increase morphological changes, and inhibit the proliferation of human colon cancer HT-29 cells. Moreover, it significantly increased p53, caspase-3, and Bax expression in HT-29 cells. In addition, the n-butanol fraction inhibited nitric oxide production in RAW 264.7 macrophages by suppressing iNOS expression. These results suggest that B. papyrifera is a potential natural resource for treating cancer and inflammatory diseases.
Lan Wang,Hee Jeong Son,Ming Lu Xu,Jian He Hu,Myeong Hyeon Wang 한국응용생명화학회 2010 Journal of Applied Biological Chemistry (J. Appl. Vol.53 No.3
Broussonetia papyrifera radix, fruits, leaves, and stems exhibit antioxidant, antinociceptive, antityrosinase, anti-inflammatory, and antiplatelet activities. However, studies of the anticancer and anti-inflammatory activities of B. papyrifera stem bark ar