Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Bangxing Yu,Guoxing Zhang,Yi An,Wen Wang 대한생리학회-대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.13 No.4

Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.

Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Bangxing Yu,Guoxing Zhang,Yi An,Wen Wang 대한약리학회 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1

Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/ kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, IL-1β and TNF-α in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, IL-1β and TNF-α in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.

Disturbance Rejection Control Method Based on Variable Damping and Port Controlled Hamiltonian with Dissipation Model for Induction Drive Motor

Bo Fan,Guoxing Huang,Lifan Sun,Yi Zhao,Hangyu Zhou,Jianxiang Wang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.11

The conventional nonlinear control methods for induction motors have the problem of difficult observation of rotor current, and load disturbances make the dynamic performance of the system speed control unsatisfactory. A novel disturbance rejection control scheme with variable damping model based on port controlled Hamiltonian with dissipation is proposed. The induction drive is regarded as energy conversion device including mechanical and electrical ports. The Euler Lagrange equation of the closed-loop system is obtained by the output feedback to establish the energy shaping control method. The variable damping injection is introduced to improve the dynamic performance of the conventional control methods. The L2disturbance rejection controller is designed to enhance the load disturbance resistance performance of induction motors. The experimental results show that the proposed method can optimize the dynamic and steady-state performance of the induction drive control system and effectively meet the control requirements of the speed and torque under load disturbances.

Static and Seismic Experimental Study of Novel Prefabricated Beam-Column Joints with Elongated-Hole Brackets

Zhang Zhiwei,Li Dong,Wang Huajie,Li Songling,Qian Hongliang,Bi Yanhua,Wang Guoxing,Jin Xiaofei,Fan Feng 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.1

To enhance the structural connectivity of prefabricated steel frame systems and augment their construction effi ciency, this study introduces an innovative prefabricated joint design tailored for square steel columns and H-beams characterized by varying beam heights. This study includes both static loading tests and seismic tests performed on full-scale joints featuring two diff erent beam heights. This investigation involved a comprehensive analysis of the static and seismic performance of the joints, employing various performance metrics such as ultimate load capacities, ultimate rotation angles, hysteresis curves, skeleton curves, stiff ness degradation curves, and ductility coeffi cients, in alignment with established structural codes and standards. The results indicate that the plasticity of the H-beam is fully developed, exhibiting a relative slip phenomenon. Additionally, the joints demonstrate commendable rotational capacity, with hysteresis curves consistently manifesting an inverse S-shape and exhibiting noteworthy stiff ness degradation. Furthermore, the comparison with the unimproved joint shows that the novel joint, in addition to being easy to construct, has better ductility and energy dissipation capacity. The results of the study will provide a technical reference for further optimization and application of prefabricated beam-column joints.

Research on stiffness control of a redundant cable-driven parallel mechanism

Jinshan Yu,Jianguo Tao,Guoxing Wang,Xiao Li,Haowei Wang 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.11

Controlling the stiffness of cable-driven parallel mechanisms (CDPM) is of great significance for improving performance in different tasks. A method for stiffness control of a redundant CDPM is presented in this paper. The stiffness matrix of the redundant CDPM is established. On this basis, considering the effect of coupling stiffness, a complete analytical formula for stiffness in different directions is established. Then, the influence of the vector λ on the stiffness of the CDPM in different directions is analyzed, and a method to control the stiffness of the CDPM through adjusting the vector λ is proposed. To avoid traversing the value of λ in the polygon formed by the set of λ to obtain the appropriate cable tension and keep the cable tension away from the upper and lower limit values, a change path of the vector λ is designed. When the vector λ changes along the path, the stiffness of the mechanism can be changed from the minimum value to the maximum value. This method has high computational efficiency and safety. Finally, the correctness and effectiveness of the stiffness control method are verified by experiments. The stiffness control method proposed in this paper can be used to control the stiffness in different directions, and can also be used for different types of redundant CDPMs.

Study on optimal conditions and adsorption kinetics of copper from water by collodion membrane cross-linked poly-γ-glutamic acid

Xiangting Wu,Aiyin Wang,Xiaojie Zheng,Guoxing Li,Xinjiao Dong,Mingjiang Wu 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.6

Poly-γ-glutamic acid (γ-PGA) is a novel polyamino acid formed through microorganism fermentation and biosynthesis. In the present test, membrane (PGA-C) formation by γ-PGA and collodion was performed by using 0.1%glutaraldehyde as a cross-linking agent. A study was conducted on the PGA-C adsorption of Cu2+, specifically the related adsorption equilibrium and kinetics, desorption and regeneration. The results show that with an initial solution pH=5.5and at 318 K, the static adsorption isotherm behavior of PGA-C is in compliance with the Langmuir model and is beneficial to the adsorption of the metal. Meanwhile, with the reaction lasting for 30min, adsorption equilibrium was reached with a maximum adsorption capacity up to 7.431 mg/g. The entire reaction process follows the pseudo-second-order kinetics. By using PGA-C, good regeneration results were obtained after adsorption-generation-adsorption cycling with an HCl solution (0.1 mol/L) as regeneration liquid.

Morroniside on anti-inflammation activities in rats following acute myocardial infarction

Yu, Bangxing,Zhang, Guoxing,An, Yi,Wang, Wen The Korean Society of Pharmacology 2018 The Korean Journal of Physiology & Pharmacology Vol.22 No.1

Our previous studies have confirmed that morroniside has neuroprotective effects. However, the effects of morroniside on cardiac myocardium remain unknown. Rats were anaesthetized with 10% chloral hydrate (0.35~0.4 mL/kg) and an acute myocardial infarction (AMI) was induced by ligating the anterior descending coronary artery (LAD). Following AMI, morroniside was administered intragastrically for 3 consecutive days at doses of 45, 90 and 180 mg/kg, respectively. Lactate dehydrogenase (LDH) and cardiac troponin T (cTnT) activities in AMI rats in the serum were detected with commercial kits. The expression of IL-6, $IL-1{\beta}$ and $TNF-{\alpha}$ in myocardium was detected by Western blotting analysis. We observed a significant decline in the Q(q) wave amplitude in morroniside-treated rats after 72 h. Additionally, treatment of morroniside decreased the levels of LDH and cTnT in AMI rats. We also observed that morroniside reduced the expression of IL-6, $IL-1{\beta}$ and $TNF-{\alpha}$ in myocardium. Taken together, our findings demonstrate that morroniside had effective anti-inflammatory properties in AMI rats.

Dielectric Meta-Holograms Enabled with Dual Magnetic Resonances in Visible Light

Li, Zile,Kim, Inki,Zhang, Lei,Mehmood, Muhammad Q.,Anwar, Muhammad S.,Saleem, Murtaza,Lee, Dasol,Nam, Ki Tae,Zhang, Shuang,Luk’yanchuk, Boris,Wang, Yu,Zheng, Guoxing,Rho, Junsuk,Qiu, Cheng-Wei American Chemical Society 2017 ACS NANO Vol.11 No.9

<P>Efficient transmission-type meta-holograms have been demonstrated using high-index dielectric nanostructures based on Huygens principle. It is crucial that the geometry size of building blocks be judiciously optimized individually for spectral overlap of electric and magnetic dipoles. In contrast, reflection-type meta-holograms using the metal/insulator/metal scheme and geometric phase can be readily achieved with high efficiency and small thickness. Here, we demonstrate a general platform for design of dual magnetic resonance based meta-holograms based on the geometric phase using silicon nanostructures that are quarter wavelength thick for visible light. Significantly, the projected holographic image can be unambiguously observed without a receiving screen even under the illumination of natural light. Within the well-developed semiconductor industry, our ultrathin magnetic resonance-based meta-holograms may have promising applications in anticounterfeiting and information security.</P>