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ATAD2 is Highly Expressed in Ovarian Carcinomas and Indicates Poor Prognosis
Wan, Wei-Na,Zhang, Yi-Xia,Wang, Xue-Mei,Liu, Yan-Jun,Zhang, Yu-Qin,Que, Yan-Hong,Zhao, Wen-Jing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
The purpose of this study was to explore the expression of ATAD2 in ovarian tumor tissue as well as its relationship with degree of malignancy. Tumor tissue from 110 cases of ovarian cancer was collected in accordance with the Declaration of Helsinki for evaluation of ATAD2 expression iimmunohistochemistry, quantitative PCR (qPCR) and Western blotting. The correlation between the ATAD2 expression and and the prognosis of ovarian cancer was evaluated by Cox regression model. In addition, HO-8910 and OVCAR-3 cells were transfected with two siRNAs targeting ATAD2. Cell viability was evaluated with MTT assay, and cell migration by transwell migration assay. ATAD2 was shown to be highly expressed in 65.5% (72/110) of ovarian cancer cases, both at transcriptional and protein levels. Moreover, highly expression was positively correlated with degree of malignancy. Knock-down of ATAD2 in HO-8910 and OVCAR-3 cells was found to reduce cell migration. In addition, follow-up visits of the patients demonstrated that the 5-year survival rate was lower in patients with high expression of ATAD2. Our study suggested that ovarian tumor tissue may have highly expressed ATAD2, which is associated with tumor stage, omentum-metastasis, ascites and CA-125. Increased ATAD2 may play important roles in tumor proliferation and migration. ATAD2 could serve in particular as a prognostic marker and a therapeutic target for ovarian cancer.
Identification of a Novel Human Zinc Finger Gene, ZNF438, with Transcription Inhibition Activity
( Zhao Min Zhong ),( Bo Wan ),( Yun Qiu ),( Jun Ni ),( Wen Wen Tang ),( Xin Ya Chen ),( Yun Yang ),( Su Qin Shen ),( Ying Wang ),( Mei Rong Bai ),( Qing Yu Lang ),( Long Yu ) 생화학분자생물학회 2007 BMB Reports Vol.40 No.4
Bao Yi-Ni,Dai Wen-Ling,Fan Ji-Fa,Ma Bin,Li Shan-Shan,Zhao Wan-Li,Yu Bo-Yang,Liu Ji-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Dopamine D1 receptor (D1DR) and D2 receptor (D2DR) are closely associated with pain modulation, but their exact effects on neuropathic pain and the underlying mechanisms remain to be identified. Our research revealed that intrathecal administration of D1DR and D2DR antagonists inhibited D1–D2DR complex formation and ameliorated mechanical and thermal hypersensitivity in chronic constriction injury (CCI) rats. The D1–D2DR complex was formed in the rat spinal cord, and the antinociceptive effects of D1DR and D2DR antagonists could be reversed by D1DR, D2DR, and D1–D2DR agonists. Gαq, PLC, and IP3 inhibitors also alleviated CCI-induced neuropathic pain. D1DR, D2DR, and D1–D2DR complex agonists all increased the intracellular calcium concentration in primary cultured spinal neurons, and this increase could be reversed by D1DR, D2DR antagonists and Gαq, IP3, PLC inhibitors. D1DR and D2DR antagonists significantly reduced the expression of p-PKC γ, p-CaMKII, p-CREB, and p-MAPKs. Levo -corydalmine ( l -CDL), a monomeric compound in Corydalis yanhusuo W.T. Wang, was found to obviously suppress the formation of the spinal D1–D2DR complex to alleviate neuropathic pain in CCI rats and to decrease the intracellular calcium concentration in spinal neurons. l- CDL-induced inhibition of p-PKC γ, p-MAPKs, p-CREB, and p-CaMKII was also reversed by D1DR, D2DR, and D1–D2DR complex agonists. In conclusion, these results indicate that D1DR and D2DR form a complex and in turn couple with the Gαq protein to increase neuronal excitability via PKC γ, CaMKII, MAPK, and CREB signaling in the spinal cords of CCI rats; thus, they may serve as potential drug targets for neuropathic pain therapy.
Laparoscopic hepatectomy for the treatment of Caroli’s disease: a case report
Chao-bo Chen,Wei-dong Hu,Wan-wen Zhao,Yan-yan Gu,Hong-wei Hou,Zheng Pan 대한외과학회 2018 Annals of Surgical Treatment and Research(ASRT) Vol.94 No.3
Caroli disease is a rare congenital disorder characterized by nonobstructive dilatation of intrahepatic ducts. In cases with symptomatic intrahepatic manifestations, treatment should correspond to the type with hepatic resection for localized disease and transplantation for diffuse forms. If possible, complete resection of the cysts can cure the symptoms and avoid the risk of malignancy. A 66-year-old woman presented to Wuxi Xishan People's Hospital with recurrent intermittent upper quadrant abdominal pain. Further examinations suggested the diagnosis of Caroli disease limited to the left hepatic lobe. She underwent laparoscopic hepatectomy. Pathological examination confirmed the diagnosis of Caroli disease, and no malignancy was found. There were no immediate complications and no long-term complications after one and one-half years of follow-up. Laparoscopic hepatectomy could be a feasible, safe treatment option for localized Caroli disease
Zhu, Shan,Yao, Feng,Li, Wen-Huan,Wan, Jin-Nan,Zhang, Yi-Min,Tang, Zhao,Khan, Shahzad,Wang, Chang-Hua,Sun, Sheng-Rong Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Type 2 diabetes mellitus (T2DM) has contributed to advanced breast cancer development over the past decades. However, the mechanism underlying this contribution is poorly understood. In this study, we determined that high glucose enhanced proteasome activity was accompanied by enhanced proliferation, migration and invasion, as well as suppressed apoptosis, in human breast cancer MCF-7 cells. Proteasome inhibitor bortezomib (BZM) pretreatment mitigated high glucose-induced MCF-7 cell growth and invasion. Furthermore, high glucose increased protein kinase C delta ($PKC{\delta}$)-phosphorylation. Administration of the specific $PKC{\delta}$ inhibitor rottlerin attenuated high glucose-stimulated cancer cell growth and invasion. In addition, $PKC{\delta}$ inhibition by both rottlerin and $PKC{\delta}$ shRNA significantly suppressed high glucose-induced proteasome activity. Our results suggest that $PKC{\delta}$-dependent ubiquitin proteasome system activation plays an important role in high glucose-induced breast cancer cell growth and metastasis.
Peirong Li,Tongbing Su,Shuancang Yu,Huiping Wang,Weihong Wan,Yangjun Yu,Deshuang Zhang,Xiuyun Zhao,Changlong Wen,Fenglan Zhang 한국원예학회 2019 Horticulture, Environment, and Biotechnology Vol.60 No.3
Rapid, economical, and reliable genotyping is an important requirement for germplasm analysis and cultivar identifi cationin crop species. Chinese cabbage ( Brassica rapa L. subsp. pekinensis (Lour.) Hanelt) originated in China and is now aneconomically important vegetable crop worldwide, especially in East Asia. In this study, we evaluated 1167 single nucleotidepolymorphisms (SNPs) among 166 representative Chinese cabbage inbred lines using a KASP genotyping assay. Onthe basis of polymorphisms and principal component analysis, we selected 60 core SNPs distributed on all Brassica rapachromosomes with allele frequencies suffi ciently balanced so as to provide adequate information for genetic identifi cation. The core set of SNPs was used for construction of a neighbor-joining dendrogram, in which the 166 inbred lines wereclustered into spring, summer, and autumn ecotype groups. Clustering of the ecotype groups was better resolved than thatachieved with 1167 and 360 polymorphic SNP datasets. Stability and resolution of the core SNP markers were tested using178 commercial hybrid Chinese cabbage cultivars to confi rm their utility in genetic identifi cation. The set of 60 informativeand stable SNP markers showed high discriminatory power and relatively uniform genomic distribution (4–9 markers perchromosome). The SNPs represent a cost-effi cient and accurate marker set for germplasm analysis and cultivar identifi cationand are suitable for molecular marker-assisted breeding in Chinese cabbage.
Bo-Han Zhang,Yu-Qian Wang,Fen Gao,Hua-Ying Wang,Wan-Xin Wen,Yun-Lei Hou,Jing-Zhou Chen,Dong-Lin Zhao 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Transition metal sulfides (TMS) have emerged as promising anode materials for lithium and sodium ionbatteries due to their high theoretical capacity and low cost. However, the severe volume expansion duringthe conversion reaction causes rapid collapse inevitability when used as anode material. Herein, wepertinently fabricated nanoscale Ni3S4/Co3S4 with uniform particle size homogeneously dispersedbetween pleated graphene (Ni3S4/Co3S4@rGO) through facile hydrothermal assisted by cationic surfactants. The construction of 3D nanocomposites significantly shortens ion migration distances and enricheselectronic pathways, accelerating charge transfer kinetics while maintaining good stability. Uniformlydistributed bimetallic sulfides and rGO limit each other’s aggregation, allowing the excellent structuralproperties of the material to be maintained over time. Thus, the Ni3S4-Co3S4@rGO electrodes deliver ahigh reversible capacity of 972.5 mAh/g upon 200 cycles at 100 mA g1 in Lithium-ion battery and487.5 mAh/g upon 150 cycles at 100 mA g1 in Sodium-ion battery, as well as excellent rate capacityin both. These excellent properties show the potential for expansion of this simple synthetic methodin the field of alkali metal batteries.