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Yang Gao,Wan-Shen Xiao,Haiping Zhu 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.5
We in this paper study nonlinear bending of a functionally graded porous nanobeam subjected to multiple physical load based on the nonlocal strain gradient theory. For more reasonable analysis of nanobeams made of porous functionally graded magneto-thermo-electro-elastic materials (PFGMTEEMs), both constituent materials and the porosity appear gradient distribution in the present expression of effective material properties, which is much more suitable to the actual compared with the conventional expression of effective material properties. Besides the displacement function regarding physical neutral surface is introduced to analyze mechanical behaviors of beams made of FGMs. Then we derive nonlinear governing equations of PFGMTEEMs beams using the principle of Hamilton. To obtain analytical solutions, a two-step perturbation method is developed in nonuniform electric field and magnetic field, and then we use it to solve nonlinear equations. Finally, the analytical solutions are utilized to perform a parametric analysis, where the effect of various physical parameters on static bending deformation of nanobeams are studied in detail, such as the nonlocal parameter, strain gradient parameter, the ratio of nonlocal parameter to strain gradient parameter, porosity volume fraction, material volume fraction index, temperature, initial magnetic potentials and external electric potentials.
Yang Gao,Wan-Shen Xiao,Haiping Zhu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.69 No.2
This paper analyzes nonlinear free vibration of the circular nano-tubes made of functionally graded materials in the framework of nonlocal strain gradient theory in conjunction with a refined higher order shear deformation beam model. The effective material properties of the tube related to the change of temperature are assumed to vary along the radius of tube based on the power law. The refined beam model is introduced which not only contains transverse shear deformation but also satisfies the stress boundary conditions where shear stress cancels each other out on the inner and outer surfaces. Moreover, it can degenerate the Euler beam model, the Timoshenko beam model and the Reddy beam model. By incorporating this model with Hamilton’s principle, the nonlinear vibration equations are established. The equations, including a material length scale parameter as well as a nonlocal parameter, can describe the size-dependent in linear and nonlinear vibration of FGM nanotubes. Analytical solution is obtained by using a two-steps perturbation method. Several comparisons are performed to validate the present analysis. Eventually, the effects of various physical parameters on nonlinear and linear natural frequencies of FGM nanotubes are analyzed, such as inner radius, temperature, nonlocal parameter, strain gradient parameter, scale parameter ratio, slenderness ratio, volume indexes, different beam models.
Nonlinear thermal buckling of bi-directional functionally graded nanobeams
Yang Gao,Wan-Shen Xiao,Haiping Zhu 국제구조공학회 2019 Structural Engineering and Mechanics, An Int'l Jou Vol.71 No.6
We in this article study nonlinear thermal buckling of bi-directional functionally graded beams in the theoretical frameworks of nonlocal strain graded theory. To begin with, it is assumed that the effective material properties of beams vary continuously in both the thickness and width directions. Then, we utilize a higher-order shear deformation theory that includes a physical neutral surface to derive the size-dependent governing equations combining with the Hamilton’s principle and the von Kármán geometric nonlinearity. It should be pointed out that the established model, containing a nonlocal parameter and a strain gradient length scale parameter, can availably account for both the influence of nonlocal elastic stress field and the influence of strain gradient stress field. Subsequently, via using a easier group of initial asymptotic solutions, the corresponding analytical solution of thermal buckling of beams is obtained with the help of perturbation method. Finally, a parametric study is carried out in detail after validating the present analysis, especially for the effects of a nonlocal parameter, a strain gradient length scale parameter and the ratio of the two on the critical thermal buckling temperature of beams.
On axial buckling and post-buckling of geometrically imperfect single-layer graphene sheets
Yang Gao,Wan-Shen Xiao,Haiping Zhu 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.33 No.2
The main objective of this paper is to study the axial buckling and post-buckling of geometrically imperfect single-layer graphene sheets (GSs) under in-plane loading in the theoretical framework of the nonlocal strain gradient theory. To begin with, a graphene sheet is modeled by a two-dimensional plate subjected to simply supported ends, and supposed to have a small initial curvature. Then according to the Hamilton*$39;s principle, the nonlinear governing equations are derived with the aid of the classical plate theory and the von-karman nonlinearity theory. Subsequently, for providing a more accurate physical assessment with respect to the influence of respective parameters on the mechanical performances, the approximate analytical solutions are acquired via using a two-step perturbation method. Finally, the authors perform a detailed parametric study based on the solutions, including geometric imperfection, nonlocal parameters, strain gradient parameters and wave mode numbers, and then reaching a significant conclusion that both the size-dependent effect and a geometrical imperfection can't be ignored in analyzing GSs.
Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer
Zhao Qiuyan,Zhu Zhonglin,Xiao Wenqin,Zong Guanzhao,Wang Chuanyang,Jiang Weiliang,Li Kai,Shen Jie,Guo Xingya,Cui Jianhua,Guo Lihong,Wan Rong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Pancreatic cancer (PC) is one of the most malignant tumors. Rapid progression and distant metastasis are the main causes of patient death. Hypoxia is a hallmark of multiple cancers and is involved in tumor biology. However, little is known about the roles of circRNAs in glycolysis and hypoxia-mediated progression of PC. Here, the expression pattern of hypoxia-related circRNAs was analyzed using RNA sequencing. A unique circRNA termed circRNF13 was found to be upregulated in PC tissues and may be a potential prognostic indicator. HIF-1α and EIF4A3 are involved in regulating the biogenesis of circRNF13. Furthermore, circRNF13 was validated to exert a stimulative effect on cell proliferation, angiogenesis, invasion and glycolysis. Importantly, we found that circRNF13 promoted PDK3 levels by acting as a miR-654-3p sponge, thus promoting the PC malignant process. Collectively, our results reveal that hypoxia-induced circRNF13 mediated by HIF-1α and EIF4A3 promotes tumor progression and glycolysis in PC, indicating the potential of circRNF13 as a prognostic biomarker and therapeutic target for PC.
Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy
Guo Yubo,Li Xiao,Gao Yajuan,Shen Kaini,Lin Lu,Wang Jian,Cao Jian,Zhang Zhuoli,Wan Ke,Zhou Xi Yang,Chen Yucheng,Zhang Long Jiang,Li Jian,Wang Yining 대한영상의학회 2024 Korean Journal of Radiology Vol.25 No.5
Objective: Cardiac magnetic resonance (CMR) is a diagnostic tool that provides precise and reproducible information about cardiac structure, function, and tissue characterization, aiding in the monitoring of chemotherapy response in patients with lightchain cardiac amyloidosis (AL-CA). This study aimed to evaluate the feasibility of CMR in monitoring responses to chemotherapy in patients with AL-CA. Materials and Methods: In this prospective study, we enrolled 111 patients with AL-CA (50.5% male; median age, 54 [interquartile range, 49–63] years). Patients underwent longitudinal monitoring using biomarkers and CMR imaging. At followup after chemotherapy, patients were categorized into superior and inferior response groups based on their hematological and cardiac laboratory responses to chemotherapy. Changes in CMR findings across therapies and differences between response groups were analyzed. Results: Following chemotherapy (before vs. after), there were significant increases in myocardial T2 (43.6 ± 3.5 ms vs. 44.6 ± 4.1 ms; P = 0.008), recovery in right ventricular (RV) longitudinal strain (median of -9.6% vs. -11.7%; P = 0.031), and decrease in RV extracellular volume fraction (ECV) (median of 53.9% vs. 51.6%; P = 0.048). These changes were more pronounced in the superior-response group. Patients with superior cardiac laboratory response showed significantly greater reductions in RV ECV (-2.9% [interquartile range, -8.7%–1.1%] vs. 1.7% [-5.5%–7.1%]; P = 0.017) and left ventricular ECV (-2.0% [-6.0%–1.3%] vs. 2.0% [-3.0%–5.0%]; P = 0.01) compared with those with inferior response. Conclusion: Cardiac amyloid deposition can regress following chemotherapy in patients with AL-CA, particularly showing more prominent regression, possibly earlier, in the RV. CMR emerges as an effective tool for monitoring associated tissue characteristics and ventricular functional recovery in patients with AL-CA undergoing chemotherapy, thereby supporting its utility in treatment response assessment.
Study on thermal buckling and post-buckling behaviors of FGM tubes resting on elastic foundations
She, Gui-Lin,Ren, Yi-Ru,Xiao, Wan-Shen,Liu, Haibo Techno-Press 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.6
This paper studies thermal buckling and post-buckling behaviors of functionally graded materials (FGM) tubes subjected to a uniform temperature rise and resting on elastic foundations via a refined beam model. Compared to the Timoshenko beam theory, the number of unknowns of this model are the same and no correction factors are required. The material properties of the FGM tube vary continuously in the radial direction according to a power function. Two ends of the tube are assumed to be simply supported and in-plane boundary conditions are immovable. Energy variation principle is employed to establish the governing equations. A two-step perturbation method is adopted to determine the critical thermal buckling loads and post-buckling paths of the tubes with arbitrary radial non-homogeneity. Through detailed parametric studies, it can be found that the tube has much higher buckling temperature and post-buckling strength when it is supported by an elastic foundation.
Study on thermal buckling and post-buckling behaviors of FGM tubes resting on elastic foundations
Gui-Lin She,Yi-Ru Ren,Wan-Shen Xiao,Hai-Bo Liu 국제구조공학회 2018 Structural Engineering and Mechanics, An Int'l Jou Vol.66 No.6
This paper studies thermal buckling and post-buckling behaviors of functionally graded materials (FGM) tubes subjected to a uniform temperature rise and resting on elastic foundations via a refined beam model. Compared to the Timoshenko beam theory, the number of unknowns of this model are the same and no correction factors are required. The material properties of the FGM tube vary continuously in the radial direction according to a power function. Two ends of the tube are assumed to be simply supported and in-plane boundary conditions are immovable. Energy variation principle is employed to establish the governing equations. A two-step perturbation method is adopted to determine the critical thermal buckling loads and post-buckling paths of the tubes with arbitrary radial non-homogeneity. Through detailed parametric studies, it can be found that the tube has much higher buckling temperature and post-buckling strength when it is supported by an elastic foundation.