DEVELOPMENT OF MAGNETICALLY RESPONSIVE Fe3O4@C CORE/SHELL MICROSPHERES AS POTENTIAL VECTORS FOR DRUG-DELIVERY APPLICATIONS

WENJING YUAN,LING ZHU,PING CHEN,ANJIAN XIE,HUI ZHANG,CUIPING WANG,YUHUA SHEN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.4

The Fe3O4@C core/shell microspheres were fabricated via a two-step process. Fe3O4 microspheres were firstly prepared, and Fe3O4@C core/shell microspheres were subsequently fabricated using glucose as a carbon source by a hydrothermal route, in which the thickness of the carbon coating was about 20 nm. The resulting products were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD) and Fourier transform infrared spectra (FTIR). The Nitrogen adsorption–desorption isotherms reveal their mesoporous structure and larger BET surface area (62.3 m2g-1). The Fe3O4@C core/shell microspheres possess ferromagnetism and high saturation magnetization (39.2 emu ⋅ g-1). Bovine hemoglobin (BHb) was used as a model protein to test the adsorption and desorption properties of the Fe3O4@C core/shell microspheres. The capacity for BHb adsorption was more than 71.3 mg/g. According to the values obtained in the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay the Fe3O4@C core/shell microspheres show a low toxicity. Therefore, the prepared Fe3O4@C core/shell microspheres are of great significance for guided site-specific drug delivery.

The experimental investigation of bisphenol A degradation by Fenton process with different types of cyclodextrins

Wenjing Chen,Changjun Zou,Yuan Liu,Xiaoke Li 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.56 No.-

In this work, the degradation efficiencies of bisphenol A (BPA) by Fenton reaction were comparedsystematically with varying cyclodextrins. The results showed that the removal rate of BPA displays aconsiderable increase by Fenton reaction in presence of b-cyclodextrin (b-CD) and its derivatives. Specifically, 98 2% and 89 2% of BPA was removed with carboxymethyl-b-cyclodextrin (CMCD) andb-CD, respectively. Additionally, to understand the reaction mechanism, the structure activity ofcyclodextrins with substrate and the kinetic of Fenton reaction with cyclodextrins have beeninvestigated. Results showed that the structure activity was the major role for cyclodextrins in thissystem.

Effects of mating on ovarian development and oviposition of Apolygus lucorum

Wenjing Li,Wei Yuan,Xincheng Zhao,Yunhe Li,Kongming Wu 한국응용곤충학회 2017 Journal of Asia-Pacific Entomology Vol.20 No.4

The polyphagous mirid bug Apolygus lucorum (Hemiptera: Miridae) is an important pest of cotton and other crops in China. It would be useful to examine the reproductive biology of A. lucorum for the development of management strategies. In this study, the effect of mating on ovarian development, egg maturation, and oviposition of A. lucorum was investigated. The results showed that mating could induce ovary development and oviposition. During the preoviposition period (< 7 days after emergence), mated females had more follicles than did virgin females at both the vitellogenic and mature stages. The length of the longest ovariole and extent of ovarian development in mated females were also significantly higher than in virgin females. During oviposition, mated females laid more eggs than virgin females, whereas virgin females had more mature follicles than the mated females did. Twenty days after emergence (an old age for this species), the ovaries of mated females had begun to shrink and enter senescence phases, while the ovaries of virgin females still contained 3–5 follicles in each ovariole and remained plump. The results indicate that mating accelerated ovarian development and reproduction of A. lucorum.

Functional Analysis of Wheat TaPaO1 Gene Conferring Pollen Sterility Under Low Temperature

Changping Zhao,Guoliang Yuan,Yukun Wang,Shaohua Yuan,Peng Wang,Wenjing Duan,Jianfang Bai,Hui Sun,Na Wang,Fengting Zhang,Liping Zhang 한국식물학회 2018 Journal of Plant Biology Vol.61 No.1

Thermosensitive male sterility plays an important role in wheat fertility and production. As a key enzyme for chlorophyll degradation, pheophorbide a oxygenase (PaO) can suppress cell death in plants. We cloned the wheat gene TaPaO1 from the thermosensitive genetic male sterile (TGMS) line BS366; it encodes a typical PaO protein, containing a conserved Rieske [2Fe-2S] iron–sulphur motif, a mononuclear non-heme iron-binding motif, and a C-terminal CxxC motif. TaPaO1 was expressed in all tissues and was upregulated during the meiosis stage of BS366 anthers under low temperature. Subcellular localization of TaPaO1 specifically labelled the surrounding of chloroplasts. TaPaO1 regulated by RD29A promoter which responded to low temperature led to pollen sterility in transgenic tobacco. Expression analysis showed that TaPaO1 exhibited a higher level of expression in the anther than in other tissues in transgenic tobacco plants during low temperature treatment. We propose that the higher senescence-related activity of TaPaO1 may lead to the cell death of anthers, which happens at an early developmental stage under low temperature. These results provide new insights into the function of PaO during the early developmental stage of anthers. PaO is closely related to cell death regardless of whether it exhibits increased activity or inactive.

Research on Hydroforming Tubular Parts with Large Perimeter Difference

Xiaosong Wang,Shijian Yuan,Wenjing Yuan 한국소성가공학회 2005 한국소성가공학회 컨퍼런스 Vol.2005 No.11

Query Algebra for the Very Loosely Structured Data Model

Ying Pan,Changan Yuan,Zhengqi Li,Wenjing Li 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.1

In order to realize the idea of pay-as-you-go (PAYG) data management which dataspace emphasizes, the very loosely structured data model is usually used to describe the massive, heterogeneous and dynamic data in dataspace. However, the present study mainly concentrates on the applications of the data model, and the query theory research is less. The query algebra is a theoretical foundation for query and its optimization in a PAYG fashion, so that how to establish a complete algebra based on the characteristics of loosely structured data model is an important problem need to be solved. In this paper, a formal definition of very loosely structured data model is given, then the query model and query algebra based on the model are proposed, which support to not only the operations such as set operators, selection, projection and join, but also association query in dataspace.

Impact of Hepatoprotective Medications on the Safety and Efficacy of OBV/PTV/r plus DSV ± Ribavirin in HCV GT1b-infected Asian Patients

( Wan-long Chuang ),( Yan Luo ),( Jeong Heo ),( Gui-qing Wang ),( Ming-lung Yu ),( Yoon Jun Kim ),( Qing Xie ),( Cheng-yuan Peng ),( Mingxiang Zhang ),( Yan Huang ),( Wenjing Lu ),( Linda M. Fredrick 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Hepatoprotective medications (HPMs) are commonly used in patients with chronic liver disease, especially across Asia. The phase 3 ONYX-I and ONYX-II studies evaluated the safety and efficacy of the 3-DAA regimen of ombitasvir and paritaprevir/ritonavir (OBV/PTV/r) plus dasabuvir (DSV) ± ribavirin (RBV) in an exclusively HCV GT1b-infected Asian population. This post-hoc analysis evaluated the impact of HPM use in patients treated with OBV/PTV/r + DSV ± RBV in these studies. Methods: ONYX-I and ONYX-II enrolled patients in China, South Korea and Taiwan. SVR12, treatment-emergent adverse events (AEs), and alanine transaminase (ALT) normalization, as well as mean changes in ALT over time were assessed in patients using vs not using HPMs. HPM use defined as all medications administered during any treatment period. Results: Overall, 11% (36/325) of non-cirrhotic and 57% (59/104) of cirrhotic patients were receiving HPMs, with ursodeoxycholic acid being the most commonly used in both non-cirrhotic (5.2% [17/325]) and cirrhotic (14.4% [15/104]) patients. SVR12 rates were high (99.7- 100%) in both non-cirrhotic and cirrhotic patients irrespective of HPM use. The regimen was generally well tolerated, with low rates of SAEs and AEs leading to treatment discontinuation (Table). Of patients with ALT above normal at baseline (BL), 100% vs 95% of non-cirrhotic and 98% vs 89% of cirrhotic patients using or not using HPMs, respectively, had normal ALT values at end of treatment (EOT). Mean ALT levels during treatment declined rapidly and similarly with and without HPM use; mean changes from BL to EOT were -38.8 and -37.0 U/L, respectively, in non-cirrhotic and -54.2 and -66.6 U/L, respectively, in cirrhotic patients. Conclusions: OBV/PTV/r + DSV ± RBV achieved high SVR12 and was generally well tolerated regardless of HPM use. HPM use had no impact on the safety profile of OBV/PTV/r + DSV therapy in Asian HCV infected subjects.