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- 저자 : Vinay, D. S. (검색결과 219 건)
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Vinay Sharma,Anita Sengar,Rajat Agrawal,Kumkum Bharti 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
This paper is demonstrative of values and the imbibed strength of values observed along the value chains of organizations studied by the authors in past two years. The paper is projective of an intense relationship of values based business ethics observed along the value chains of the organizations concerned with the context and the soul of the conventional definition of marketing given by American Marketing Association in 2007. The value chain of a prominent consumer product’s marketers studied through reflexive research approach exemplifies that how business ethics based on values helped in evolving activities, institutions and processes for creating, communicating, delivering and exchanging offerings that have value for the customers, clients, partners and society at large which is actually the definition of marketing be American Marketing Association: Marketing is the activity, set of institutions, and processes for creating, communicating, delivering, and exchanging offerings that have value for customers, clients, partners, and society at large. (Approved July 2013) Similar observations in the value chains and the marketing process of other organizations validated the fact that if values driven business ethics is followed along the value chain the context of 2007 definition of Marketing gets enlivened.
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Immune evasion in cancer: Mechanistic basis and therapeutic strategies
Vinay, D.S.,Ryan, E.P.,Pawelec, G.,Talib, W.H.,Stagg, J.,Elkord, E.,Lichtor, T.,Decker, W.K.,Whelan, R.L.,Kumara, H.M.C.S.,Signori, E.,Honoki, K.,Georgakilas, A.G.,Amin, A.,Helferich, W.G.,Boosani, C. Saunders Scientific Publications ; Academic Press 2015 SEMINARS IN CANCER BIOLOGY Vol.35 No.suppl
Cancer immune evasion is a major stumbling block in designing effective anticancer therapeutic strategies. Although considerable progress has been made in understanding how cancers evade destructive immunity, measures to counteract tumor escape have not kept pace. There are a number of factors that contribute to tumor persistence despite having a normal host immune system. Immune editing is one of the key aspects why tumors evade surveillance causing the tumors to lie dormant in patients for years through ''equilibrium'' and ''senescence'' before re-emerging. In addition, tumors exploit several immunological processes such as targeting the regulatory T cell function or their secretions, antigen presentation, modifying the production of immune suppressive mediators, tolerance and immune deviation. Besides these, tumor heterogeneity and metastasis also play a critical role in tumor growth. A number of potential targets like promoting Th1, NK cell, γδ T cell responses, inhibiting Treg functionality, induction of IL-12, use of drugs including phytochemicals have been designed to counter tumor progression with much success. Some natural agents and phytochemicals merit further study. For example, use of certain key polysaccharide components from mushrooms and plants have shown to possess therapeutic impact on tumor-imposed genetic instability, anti-growth signaling, replicative immortality, dysregulated metabolism etc. In this review, we will discuss the advances made toward understanding the basis of cancer immune evasion and summarize the efficacy of various therapeutic measures and targets that have been developed or are being investigated to enhance tumor rejection.
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Vinay Padimi,Venkata Sravan Telu,Devarani Devi Ningombam 한국전자통신연구원 2023 ETRI Journal Vol.45 No.6
Stroke is the leading cause of permanent disability in adults, and it can cause permanent brain damage. According to the World Health Organization, 795,000 Americans experience a new or recurrent stroke each year. Early detection of medical disorders, for example, strokes, can minimize the disabling effects. Thus, in this paper, we consider various risk factors that contribute to the occurrence of stoke and machine learning algorithms, for example, the decision tree, random forest, and naive Bayes algorithms, on patient characteristics survey data to achieve high prediction accuracy. We also consider the semisupervised self-training technique to predict the risk of stroke. We then consider the near-miss undersampling technique, which can select only instances in larger classes with the smaller class instances. Experimental results demonstrate that the proposed method obtains an accuracy of approximately 98.83% at low cost, which is significantly higher and more reliable compared with the compared techniques.
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Dynamics and actuating torque optimization of planar robots
Vinay Gupta,Himanshu Chaudhary,Subir K. Saha 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.7
An optimization methodology is presented for design of serial-chain planar robots for minimizing torque at joints, when its endeffectoris supposed to move on a prescribed path. In particular, the end-effector of the robot is allowed to move on a circular path. Forthe respective joint trajectories, the weighted sum of root mean square (RMS) of the actuating torques is minimized by the mass redistributionof the links. To achieve the goal, the DeNOC (Decoupled natural orthogonal complement) based dynamics was formulated byrepresenting the rigid links as a set of rigidly connected point-masses known as equimomental system. The methodology is illustratedusing a planar two-degree-of-freedom (DOF) robot with two revolute joints.
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Vinay, T.N.,Park, C.S.,Kim, H.Y.,Jung, S.J. Elsevier 2014 Veterinary immunology and immunopathology Vol. No.
Adjuvants are substances added to vaccines to enhance the immune response of a given antigen. Most of the adjuvants are toxic at certain doses, and toxicity varies in different species. Moreover, there are no standard dosage limits set for adjuvant use in fish vaccines. We evaluated the acute toxicity, serum enzymes (AST/ALT) indicating hepatic injury and histopathological changes due to intra-peritoneal administration of different concentrations of a panel of adjuvants including quillaja saponin, aluminum hydroxide, squalene emulsion and Freund's incomplete adjuvant (FIA) with a dose ranging study of saponin (500, 160, 50, 16 and 5μgfish<SUP>-1</SUP>), aluminum hydroxide (5000, 1600, 500, 160 and 50μgfish<SUP>-1</SUP>), squalene emulsion (20, 10 and 5%), and FIA to determine the acceptable dosage for vaccination in olive flounder (Paralichthys olivaceus) fingerlings measuring 4.66+/-0.41g, 8.47+/-0.42cm. Saponin was highly toxic with a LD<SUB>50</SUB> of approximately 105μgfish<SUP>-1</SUP> (22.4mgkg<SUP>-1</SUP>) causing severe histological damage and AST level was high at dose above 16μgfish<SUP>-1</SUP> and ALT, specific for liver damage was high only at 160μgfish<SUP>-1</SUP> (11U/L) and was safe at 5μgfish<SUP>-1</SUP>. Aluminum hydroxide was toxic at 5000μgfish<SUP>-1</SUP> and was acceptable at dose below 1600μgfish<SUP>-1</SUP> with moderate histology and AST/ALT levels similar with control. Squalene emulsion showed increased inflammation at 20% and 10% emulsions and the inflammatory response was mild at a concentration of 5% oil emulsion and AST/ALT levels being similar to control in 10% and 5% emulsions and elevated in 20% on both sampling days. FIA was not lethal, but induced severe inflammation at injection site and around blood vessels. In comparison to FIA, saponin found to be safe at dose of 5μgfish<SUP>-1</SUP>, aluminum hydroxide below 1600μgfish<SUP>-1</SUP>, and squalene at 5% emulsion and could be accepted for vaccination studies. These results provide an insight for the selection of safer dose of adjuvants for intra-peritoneal vaccination of olive flounder.
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The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases
Vinay, D. S.,Kwon, B. S. Blackwell Publishing Ltd 2011 Clinical and experimental immunology Vol.164 No.2
<P><B>Summary</B></P><P>Autoimmune diseases are characterized by the body's ability to mount immune attacks on self. This results from recognition of self‐proteins and leads to organ damage due to increased production of pathogenic inflammatory molecules and autoantibodies. Over the years, several new potential therapeutic targets have been identified in autoimmune diseases, notable among which are members of the tumour necrosis factor (TNF) superfamily. Here, we review the evidence that certain key members of this superfamily can augment/suppress autoimmune diseases.</P>
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Acute-on-chronic liver failure: Terminology, mechanisms and management
Vinay Kumar BR,Shiv Kumar Sarin 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Acute-on-chronic liver failure is an acute deterioration of liver function manifesting as jaundice and coagulopathy with the development of ascites, with a high probability of extrahepatic organ involvement and high 28-day mortality. The pathogenesis involves extensive hepatic necrosis, which is associated with severe systemic inflammation and subsequently causes the cytokine storm, leading to portal hypertension, organ dysfunction, and organ failure. These patients have increased gut permeability, releasing lipopolysaccharide (LPS) and damage-associated molecular patterns (DAMPS) in the blood, leading to hyper-immune activation and the secretion of cytokines, followed by immune paralysis, causing the development of infections and organ failure in a proportion of patients. Early detection and the institution of treatment, especially in the "Golden Window" period of 7 days, gives an opportunity for reversal of the syndrome. Scores like the Asian Pacific Association for the Study of the Liver (APASL) ACLF research consortium (AARC) score, a model for end stage liver disease (MELD), and the CLIF Consortium acute-on-chronic liver failure (CLIF-C ACLF) score can help in the prediction of mortality. Treatment strategy includes treatment of acute insult. Patients should be considered for early transplant with MELD score >28, AARC score >10, high-grade hepatic encephalopathy, and in the absence of >2 organ failure or overt sepsis to improve survival of up to 80% at five years. Patients, with no option of transplant, can be treated with emerging therapies like faecal microbial transplant, plasma exchange, etc., which need further evaluation.
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