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식물 유래 항암제와 생산 개선을 위한 식물 합성생물학 연구 동향
박소영,박상규,Vimalraj Mani,이효,이기종,김범기,이샛별 한국약용작물학회 2022 한국약용작물학회지 Vol.30 No.6
Background: Plants are rich in phytochemicals, and their bioactive compounds have been employed in traditional medicine since ancient times. A variety of medicinal plant species and phytochemicals have been used to treat a wide range of chronic diseases, most notably, cancer. Methods and Results: As the global prevalence of cancer increases, numerous investigations are being carried out to develop phytochemical-based medicines. For example, paclitaxel, camptothecin, vinca alkaloids, and podophyllotoxin are US Food and Drug Administration (FDA)-approved anticancer drugs derived from plants. However, plants contain only trace amounts of phytochemicals, which makes it difficult to supply them continuously. Moreover, their complicated structures hinder their ability to produce large quantities of chemicals for commercial use. Recently, researchers have developed a number of biotechnological platforms to enhance the production of phytochmicals. Conclusions: In this review, we summarize the current status of four FDA-approved anticancer drugs derived from plants and provide plant biotechnology strategies, including synthetic biology, to facilitate their production.
Subramanian, Parthiban,Oh, Byung-Ju,Mani, Vimalraj,Lee, Jae Kook,Lee, Chang-Muk,Sim, Joon-Soo,Koo, Ja Choon,Hahn, Bum-Soo MDPI AG 2017 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.18 No.7
<P><I>Meloidogyne incognita</I> is a common root-knot nematode with a wide range of plant hosts. We aimed to study the metabolites produced at each stage of the nematode life cycle to understand its development. Metabolites of <I>Meloidogyne incognita</I> were extracted at egg, J2, J3, J4, and female stages and 110 metabolites with available standards were quantified using CE-TOF/MS. Analyses indicated abundance of stage-specific metabolites with the exception of J3 and J4 stages which shared similar metabolic profiles. The egg stage showed increased abundance in glycolysis and energy metabolism related metabolites while the J2 metabolites are associated with tissue formation, motility, and neurotransmission. The J3 and J4 stages indicated amino acid metabolism and urea cycle- related metabolites. The female stage was characterized with polyamine synthesis, antioxidant activity, and synthesis of reproduction related metabolites. Such metabolic profiling helps us understand the dynamic physiological changes related to each developmental stage of the root-knot nematode life cycle.</P>
Stage-Wise Identification and Analysis of miRNA from Root-Knot Nematode <i>Meloidogyne incognita</i>
Subramanian, Parthiban,Choi, In-Chan,Mani, Vimalraj,Park, Junhyung,Subramaniyam, Sathiyamoorthy,Choi, Kang-Hyun,Sim, Joon-Soo,Lee, Chang-Muk,Koo, Ja Choon,Hahn, Bum-Soo MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.10
<P>In this study, we investigated global changes in miRNAs of <I>Meloidogyne incognita</I> throughout its life cycle. Small RNA sequencing resulted in approximately 62, 38, 38, 35, and 39 Mb reads in the egg, J2, J3, J4, and female stages, respectively. Overall, we identified 2724 known and 383 novel miRNAs (read count > 10) from all stages, of which 169 known and 13 novel miRNA were common to all the five stages. Among the stage-specific miRNAs, miR-286 was highly expressed in eggs, miR-2401 in J2, miR-8 and miR-187 in J3, miR-6736 in J4, and miR-17 in the female stages. These miRNAs are reported to be involved in embryo and neural development, muscular function, and control of apoptosis. Cluster analysis indicated the presence of 91 miRNA clusters, of which 36 clusters were novel and identified in this study. Comparison of miRNA families with other nematodes showed 17 families to be commonly absent in animal parasitic nematodes and <I>M. incognita</I>. Validation of 43 predicted common and stage-specific miRNA by quantitative PCR (qPCR) indicated their expression in the nematode. Stage-wise exploration of <I>M. incognita</I> miRNAs has not been carried out before and this work presents information on common and stage-specific miRNAs of the root-knot nematode.</P>
Kang-Hyun Choi,Parthiban Subramanian,Vimalraj Mani,Joon-Soo Sim,Chang-Muk Lee,Bum-Soo Hahn 한국당과학회 2016 한국당과학회 학술대회 Vol.2016 No.07
Several novel approaches are underway for control of plant-parasitic nematode Meloidogyne incognita. This study was aimed to compare metabolome profiles of the nematode at all its developmental stages. Metabolome analysis was performed in 5 stages (egg, J2, J3, J4 and female) and peaks detected in CE-TOFMS. Among 209 putative metabolites detected (61 anionic mode and 148 cationic mode), 110 metabolites (56 anioic and 54 cationic modes) with available standards were quantified. Principal component analysis showed that the metabolites from stages female and J2; J3 and J4 stages grouped into clusters and metabolites of egg formed a unique cluster. Quantitative analysis indicated amino acids to be the dominant group of metabolites. Further, highly expressed metabolites included osmolytes proline, betaine, hydroxyproline; antioxidant molecules putrescine and glutathione; sensory regulators gama amino benzoic acid (GABA) and β alanine; organic acids lactic and malic acids, molecules in RNA synthesis GMP, AMP and inosine. In general, concentrations of most of these metabolites were low in J3 and J4 stages compared to egg, J2 and female which may be due to the sedentary nature of the nematode in those two stages. Proline was highly expressed in egg stage, muscle tone regulator GABA abundant in J2, whereas J3 and J4 stages possessed high concentrations of alanine and female was enriched with polyamine putrescine and amino acids.