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Park, Yeo-Ul,Jung, Jong-Hyun,Seo, Dong-Ho,Jung, Dong-Hyun,Kim, Jae-Han,Seo, Ean-Jeong,Baek, Nam-In,Park, Cheon-Seok Elsevier 2018 Enzyme and microbial technology Vol.114 No.-
<P><B>Abstract</B></P> <P> <I>Desulfurococcus amylolyticus</I> is an anaerobic and hyperthermophilic crenarchaeon that can use various carbohydrates as energy sources. We found a gene encoding a glycoside hydrolase family 57 amylolytic enzymes (DApu) in a putative carbohydrate utilization gene cluster in the genome of <I>D. amylolyticus</I>. This gene has an open reading frame of 1,878 bp and consists of 626 amino acids with a molecular mass of 71 kDa. Recombinant DApu (rDApu) completely hydrolyzed pullulan to maltotriose by attacking α-1,6-glycosidic linkages, and was able to produce glucose and maltose from soluble starch and amylopectin. Although rDApu showed no activity toward α-cyclodextrin (CD) and β-CD, maltooctaose (G8) was detected from reaction with γ-CD. The highest activity of rDApu was measured at pH 5.0 and 95 °C. The half-life of rDApu was 12.7 h at 95 °C and 27 min at 98 °C. Interestingly, rDApu was able to transfer a maltose unit to 6-<I>O</I>-α-maltosyl-β-CD via transglycosylation. Structure analysis using MALDI-TOF/TOF MS and nuclear magnetic resonance revealed that the new transglycosylated products were 6<SUP>1</SUP>, 6<SUP>4</SUP>-di-<I>O</I>-maltosyl-β-CD and 6<SUP>1</SUP>, 6<SUP>3</SUP>, 6<SUP>5</SUP>-tri-<I>O</I>-maltosyl-β-CD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> GH57 amylopullulanase from <I>Desulfurococcus amylolyticus</I> (DApu) was characterized. </LI> <LI> DApu exhibits not only hydrolysis activity but also transglycosylation activity. </LI> <LI> Branched cyclodextrins were formed by transfer of a maltose unit by DApu. </LI> </UL> </P>
우리나라 만성 C형간염 환자에서 페그인터페론과 리바비린의 병합치료에 대한 효과
강명주 ( Myoung Joo Kang ),정은욱 ( Eun Uk Jung ),박상원 ( Sang Won Park ),최바울 ( Pa Ul Choi ),김지현 ( Ji Hyun Kim ),박성재 ( Sung Jae Park ),박은택 ( Eun Taek Park ),이연재 ( Youn Jae Lee ),이상혁 ( Sang Hyuk Lee ),설상영 ( Sa 대한간학회 2008 Clinical and Molecular Hepatology(대한간학회지) Vol.14 No.3
이재환(Jae-Hwan Lee),아코마링(Kothilngam Maring),김소울(So-Ul Kim),오택찬(Taek-Chan Oh),박병재(Byoung-Jae Park) 한국해양공학회 2016 韓國海洋工學會誌 Vol.30 No.3
In this paper, an aluminum pressure vessel (cylinder) for a 200 m water depth is designed and analyzed. Because of their lack of usage in the deep sea, only a few papers about pressure vessels subjected to external pressures have previously been published. Moreover, the high level of imported external-pressure-vessel products limits the academic pursuit. Yet, research on internal pressure vessels is widely available because of their broad usage at onshore. This paper presents the process of basic designing and modelling of pressure vessels using the design rules of American Standard of Mechanical Engineering (ASME) Section VIII Division 1. To promote understanding, finite element analysis (FEA) result of an existing sample cylinder which was not designed by ASME code is compared with the design obtained in this paper. Several methodologies are used for the finite element analysis, including rectangular, cylindrical, and axisymmetric coordinate, to attain an accurate stress result. Same dimensions except the thickness of the cylinder and loading condition of 0.200 MPa was given for the current study. Finally, a rigorous design procedure is added for the bolt and boundary conditions of the cylindrical body and its ends. The obtained stress level satisfies the allowable design stress value specified in the ASME code.
Pluronics: Intelligent building units for targeted cancer therapy and molecular imaging
Khaliq, Nisar Ul,Park, Dal Yong,Yun, Byeong Min,Yang, Da Hye,Jung, Yong Woo,Seo, Jae Hong,Hwang, Chang Soon,Yuk, Soon Hong Elsevier 2019 International journal of pharmaceutics Vol.556 No.-
<P><B>Abstract</B></P> <P>Pluronics are triblock copolymers, in which two hydrophilic poly (ethylene oxide) (PEO) blocks are connected via a hydrophobic poly propylene oxide (PPO) block. Because of their low molecular weight and high content of PEO, Pluronics have demonstrated the micellization phenomenon, which is dependent on temperature and/or concentration. With an understanding of micellization phenomenon in more detail, information on the morphology, micelle core radius, aggregation behavior with critical micelle concentration (CMC) and critical micelle temperature (CMT) and so on has been revealed. Based on this acquired information, various studies have been performed for biomedical applications such as drug delivery systems, tissue regeneration scaffolders, and biosurfactants. This review discusses the delivery of small molecules and macromolecules using Pluronic-based NPs and their composites.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>