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Usefulness of Colored 3D Imaging of Respiratory Impedance in Asthma
Toshihiro Shirai,Kazutaka Mori,Masashi Mikamo,Yuichiro Shishido,Takefumi Akita,Satoru Morita,Kazuhiro Asada,Masato Fujii,Takafumi Suda,Kingo Chida 대한천식알레르기학회 2013 Allergy, Asthma & Immunology Research Vol.5 No.5
Purpose: Recently, the clinical application of the forced oscillation technique (FOT) has progressed with the spread of commercially available FOT devices, including the impulse oscillation system and MostGraph. We investigated the usefulness of color 3D imaging of respiratory impedance in asthma using MostGraph. Methods: Whole-breath and within-breath respiratory system resistance (Rrs) and reactance (Xrs) were measured in 78 patients with asthma. Color 3D images were classified into three patterns: the chronic obstructive pulmonary disease (COPD)-like pattern (high values of Rrs and Xrs with a marked respiratory cycle and frequency dependence), the asthma pattern (moderately high Rrs over the entire frequency and a respiratory cycle with slight Xrs changes), and a normal-like pattern (low Rrs and Xrs with few within-breath changes). The classification was performed by three researchers, who were unaware of the clinical information, and the clinical characteristics were compared among the three groups. Results: Color 3D imaging provided a COPD-like pattern in 25 patients, an asthma pattern in 39 patients, and a normal-like pattern in 14 patients. Patients with the COPD-like pattern were predominantly female with a higher body mass index, lower forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC), and higher Rrs and Xrs values (whole-breath and within-breath variation). Those with the normal pattern had higher FEV1 and FVC, and a lower single-breath nitrogen washout slope. There were no differences in asthma control or exhaled nitric oxide levels among the three groups. Conclusions: These results suggest that color 3D imaging of respiratory impedance may show asthma phenotypes.
Hino, Aya,Maeda, Takeaki,Morita, Shinya,Kugimiya, Toshihiro The Korean Infomation Display Society 2012 Journal of information display Vol.13 No.2
The double-layered Ti/Si barrier metal is demonstrated for the source/drain Cu interconnections in oxide semiconductor thin-film transistors (TFTs). The transmission electromicroscopy and ion mass spectroscopy analyses revealed that the double-layered barrier structure suppresses the interfacial reaction and the interdiffusion at the interface after thermal annealing at $350^{\circ}C$. The underlying Si layer was found to be very useful for the etch stopper during wet etching for the Cu/Ti layers. The oxide TFTs with a double-layered Ti/Si barrier metal possess excellent TFT characteristics. It is concluded that the present barrier structure facilitates the back-channel-etch-type TFT process in the mass production line, where the four- or five-mask process is used.
Aya Hino,Takeaki Maeda,Shinya Morita,Toshihiro Kugimiya 한국정보디스플레이학회 2012 Journal of information display Vol.13 No.2
The double-layered Ti/Si barrier metal is demonstrated for the source/drain Cu interconnections in oxide semiconductor thin-film transistors (TFTs). The transmission electromicroscopy and ion mass spectroscopy analyses revealed that the doublelayered barrier structure suppresses the interfacial reaction and the interdiffusion at the interface after thermal annealing at 350◦C. The underlying Si layer was found to be very useful for the etch stopper during wet etching for the Cu/Ti layers. The oxide TFTs with a double-layered Ti/Si barrier metal possess excellent TFT characteristics. It is concluded that the present barrier structure facilitates the back-channel-etch-type TFT process in the mass production line, where the four- or five-mask process is used.
Cardiac Rehabilitation Increases Exercise Capacity with a Reduction of Oxidative Stress
Taira Fukuda,Miwa Kurano,Kazuya Fukumura,Tomohiro Yasuda,Haruko Iida,Toshihiro Morita,Yumiko Yamamoto,Nami Takano,Issei Komuro,Toshiaki Nakajima 대한심장학회 2013 Korean Circulation Journal Vol.43 No.7
Background and Objectives: Reactive oxygen species (ROS) mediate various signaling pathways that underlie vascular inflammation in atherogenesis and cardiovascular diseases. Cardiac rehabilitation (CR) has a variety of multiple beneficial effects, including anti-inflam -matory effects. The purpose of the present study was to investigate the effects of CR on ROS in patients with cardiovascular diseases. Subjects and Methods: The serum level of derivatives of reactive oxidative metabolites, an index of oxidative stress, was measured in 100 patients with cardiovascular diseases before, and, subsequently, 3 and 6 months after, CR. A biological antioxidant potential (BAP) test was applied to assess the antioxidant power of the serum. Results: The resting reactive oxidative metabolite levels decreased 3-6 months after CR {pre: 351±97 Carratelli unit (CARR U), 3 months:329±77 CARR U, 6 months: 325±63 CARR U, all p<0.01} with the increase of the percentage of the predicted values of V˙O 2 peak and the percentage of the predicted values of V˙O 2 at the anaerobic threshold (V˙O 2 AT ) and the decrease of the B-type natriuretic peptide (BNP). The BAP test and antioxidative/oxidative stress ratio increased 6 months after CR. The % changes of the antioxidative/oxidative stress ratio was positively correlated with the % changes of V˙O 2 AT , and negatively correlated with the % changes of the BNP. Conclusion: These results suggest that intensive supervised CR significantly improved exercise capacity, which may be attributable to an adaptive response involving more efficient oxidative metabolites or the increased capacity of endogenous anti-oxidative systems in pa -tients with cardiovascular diseases.