Multidisciplinary Collaborative Therapy for 30 Children with Orbital Rhabdomyosarcoma

Ge, Xin,Huang, Dong-Sheng,Shi, Ji-Tong,Ma, Jian-Min Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Objective: To explore clinical experience and propose new ideas for treating children diagnosed with orbital rhabdomyosarcoma (RMS). Methods: We retrospectively analyzed the clinical data for30 patients (16 males and 14 females, with a median age of 6.2 years) with primary orbital RMS who were enrolled in the Department of Eye Oncology and Pediatrics of our hospital from November 2004 to December 2012. International Rhabdomyosarcoma Organization Staging Standards indicated that among the 30 patients, 4 cases were in phase II, 20 were in phase III, and 6 were in phase IV. All patients underwent a multidisciplinary collaborative model of comprehensive treatment (surgery, chemotherapy, external radiotherapy, $^{125}I$ radioactive particle implantation, and autologous peripheral blood stem-cell transplantation). Results: Follow-up was conducted until March 2013, with a median follow-up time of 47.2 months (5 to 95 months), and 7 deaths occurred. The 2-year estimated survival rate reached 86.1%, the ${\geq}3$-year estimated survival rate was 77%, and the 5-year estimated survival rate was 70.6%. Conclusions: The multidisciplinary collaborative model can be a safe and effective approach to the comprehensive treatment of children with orbital RMS. It has clinical significance in improving the tumor remission rate.

Effects of inflow turbulence and slope on turbulent boundary layers over two-dimensional hills

Tong Wang,Shuyang Cao,Yaojun Ge 한국풍공학회 2014 Wind and Structures, An International Journal (WAS Vol.19 No.2

The characteristics of turbulent boundary layers over hilly terrain depend strongly on the hill slope and upstream condition, especially inflow turbulence. Numerical simulations are carried out to investigate the neutrally stratified turbulent boundary layer over two-dimensional hills. Two kinds of hill shape, a steep one with stable separation and a low one without stable separation, and two kinds of inflow condition, laminar and turbulent, are considered. An auxiliary simulation, based on the local differential quadrature method and the recycling technique, is performed to simulate the inflow turbulence to be imposed at the inlet boundary of the simulation with turbulent inflow, which preserves very well in the computational domain. A large separation bubble is established on the leeside of the steep hill with laminar inflow, while the reattachment point moves upstream under turbulent inflow condition. There is stable separation on the lee side of the low hill with laminar inflow, while not with turbulent inflow. Besides increase of turbulence intensity, inflow turbulence can efficiently enhance the speedup around hills.So in practice, it is unreasonable to study wind flow over hilly terrain without considering inflow turbulence.

Microcalorimetric Study of Changes in the Microbial Activity in Three Selected Vegetable Soil

Ge, Tida,Nie, Sanan,Wang, G.,Yang, D.,Xiao, H.,Tong, C.,Wu, J. 한국토양비료학회 2009 한국토양비료학회 학술발표회 초록집 Vol.2009 No.10

Effects of inflow turbulence and slope on turbulent boundary layer over two-dimensional hills

Wang, Tong,Cao, Shuyang,Ge, Yaojun Techno-Press 2014 Wind and Structures, An International Journal (WAS Vol.19 No.2

The characteristics of turbulent boundary layers over hilly terrain depend strongly on the hill slope and upstream condition, especially inflow turbulence. Numerical simulations are carried out to investigate the neutrally stratified turbulent boundary layer over two-dimensional hills. Two kinds of hill shape, a steep one with stable separation and a low one without stable separation, two kinds of inflow condition, laminar turbulent, are considered. An auxiliary simulation, based on the local differential quadrature method and recycling technique, is performed to simulate the inflow turbulence be imposed at inlet boundary of the turbulent inflow, which preserves very well in the computational domain. A large separation bubble is established on the leeside of the steep hill with laminar inflow, while reattachment point moves upstream under turbulent inflow condition. There is stable separation on the side of low hill with laminar inflow, whilw not turbulent inflow. Besides increase of turbulence intensity, inflow can efficiently enhance the speedup around hills. So in practice, it is unreasonable to study wind flow over hilly terrain without considering inflow turbulence.

Topology design and analysis of compliant mechanisms with composite laminated plates

Xinxing Tong,Wenjie Ge,Yonghong Zhang,Zhenfei Zhao 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.2

To improve the small deformation and high stress level in hinge zones of compliant mechanisms with isotropic material, a topology optimization method of compliant mechanisms with composite laminated plates was proposed. Based on the anisotropy and designability of composite laminated plates, a topology optimization model of compliant mechanisms with composite laminated plates was built to maximize the deformable capability. Numerical examples of designing compliant inverters and grippers were investigated to demonstrate the effectiveness of the proposed method. The influence mechanism of layer sequences on topologic shapes, deformation and loading capability were also discussed. The results showed that the deformable capability and stress levels of compliant mechanisms with composite laminated plates were further improved by a reasonable configuration of layer sequences.

Poster Session : Symposium: Soil Biology as a Catalyst for Bridging Production and Human Well-being ; Microcalorimetric Study of Changes in the Microbial Activity in Three Selected Vegetable Soil

Tida Ge,San`an Nie,G. Wang,D. Yang,H. Xiao,C. Tong,J. Wu 한국토양비료학회 2009 국제학술대회집 Vol.2009 No.0

MiR-466d Targeting MMP13 Promotes the Differentiation of Osteoblasts Exposed to a Static Magnetic Field

Fei Tong,Hongmeng Cheng,Jun Guo,Jianyong Wu,Hongshan Ge,Zhihua Li 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.1

The static magnetic field (SMF) and miRNAs are involved in the regulation of bone remodeling. Hence, this study was designed to investigate the effects of SMF on the proliferation and differentiation of osteoblasts, as well as identify related miRNAs. SMF promoted osteoblast proliferation and differentiation and inhibited osteoblast apoptosis. High-throughput sequencing identified that 41 miRNAs were upregulated and 25 miRNAs down-regulated when osteoblasts were exposed to SMF. The enrichment analysis and validation results indicated differentially expressed miR-466d and its target gene MMP13. In osteoblasts, miR-466d could directly target MMP13, and miR-466d overexpression combined with the exposure to SMF promoted differentiation, suppressing MMP13 expression. SMF increased miR-466 expression in osteoblasts, thereby inhibiting MMP13 expression and increasing osteoblast differentiation ability.

Wnt/β-Catenin Promotes the Osteoblastic Potential of BMP9 Through Down-Regulating Cyp26b1 in Mesenchymal Stem Cells

Yao Xin-Tong,Li Pei-pei,Liu Jiang,Yang Yuan-Yuan,Luo Zhen-Ling,Jiang Hai-Tao,He Wen-Ge,Luo Hong-Hong,Deng Yi-Xuan,He Bai-Cheng 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.5

BACKGROUND: All-trans retinoic acid (ATRA) promotes the osteogenic differentiation induced by bone morphogenetic protein 9 (BMP9), but the intrinsic relationship between BMP9 and ATRA keeps unknown. Herein, we investigated the effect of Cyp26b1, a critical enzyme of ATRA degradation, on the BMP9-induced osteogenic differentiation in mesenchymal stem cells (MSCs), and unveiled possible mechanism through which BMP9 regulates the expression of Cyp26b1. METHODS: ATRA content was detected with ELISA and HPLC–MS/MS. PCR, Western blot, and histochemical staining were used to assay the osteogenic markers. Fetal limbs culture, cranial defect repair model, and micro–computed tomographic were used to evaluate the quality of bone formation. IP and ChIP assay were used to explore possible mechanism. RESULTS: We found that the protein level of Cyp26b1 was increased with age, whereas the ATRA content decreased. The osteogenic markers induced by BMP9 were increased by inhibiting or silencing Cyp26b1 but reduced by exogenous Cyp26b1. The BMP9-induced bone formation was enhanced by inhibiting Cyp26b1. The cranial defect repair was promoted by BMP9, which was strengthened by silencing Cyp26b1 and reduced by exogenous Cyp26b1. Mechanically, Cyp26b1 was reduced by BMP9, which was enhanced by activating Wnt/b-catenin, and reduced by inhibiting this pathway. b-catenin interacts with Smad1/5/9, and both were recruited at the promoter of Cyp26b1. CONCLUSIONS: Our findings suggested the BMP9-induced osteoblastic differentiation was mediated by activating retinoic acid signalling, viadown-regulating Cyp26b1. Meanwhile, Cyp26b1 may be a novel potential therapeutic target for the treatment of bone-related diseases or accelerating bone-tissue engineering.

Amorphous ytterbium hexaboride nanoparticles for ethanol vapor sensing

Rui Zhou,Dong Ge Tong 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.86 No.-

Ethanol vapor monitoring technologies have received attention for guarding against dangerous accidents. However, existing ethanol sensors often have comparable sensing selectivity for many other gases, whichinterferes in their sensing ability. Furthermore, current sensors need to enhance their sensitivity overethanol vapor with low concentrations. In this work, we developed amorphous ytterbium hexaboride(YbB6) alloy nanoparticles as novel sensing materials over ethanol vapor at room temperature. It showeda rapid (6 s/8s response/recovery time), stable, and selective response to ethanol vapor at 25 C. Itsdetection limit was 10 ppb. Meanwhile, its response ratio of ethanol/methanol reached 20.8. We attributethe good sensing characteristics of the as-prepared YbB6 nanoparticles to the high specific surface area(167.8 m2 g 1) and catalytic activity of ethanol dehydration to form ethyl ether at 25 C in air. In addition,it has a good anti-humidity ability in the RH range of 10%–90% due to the negligible impact of humidity onits permittivity at 100 kHz.

원형탈모증 병변내 주사 치료에서 완충 리도카인 - 트리암시놀론 용액의 주사통증의 감소와 치료효과

손계영,김홍용,김한욱,임철완 ( Ge Yeong Son,Hong Tong Kim,Han Uk Kim,Chull Wan Ihm ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

Background: Intralesional injection of corticosteroids has widely been used for the t,reatment of alopecia areata. The pair produced during the repeated multiple injection procedures is an actual therapeutic obstacle in both adult and child patients. Buffering of the local anesthetics is known to reduce the pain. Objective : The purpos; of this study was to evaluate the degree of pain reduction and hair regrowing effect by the use of buffered lidocain-triamcinolone acetonide suspension(BLT) compared with nonbuffered lidocairi triamcinolone acetonide suspension(LT) in the intralesional injection of alopecia areata. Methods : We evaluat d the degree of pain reduction by the use of BLT compared with LT in the intralesional injection in 40 cases of alopecia areata. The pain was ineasured by patients verbal pain score from zerc to ten and simultaneously observed if there were be any differences in hair regrowing bet,ween the two groups. Results : 1. Remarkable reduction of the pain du~ring the inject,ion was noted by the buffering agent and the pain was further reduced by the vertical insertion of the needle. The pain score of BLT was 1.5 by vertically inserted injections and 2.4 by ~30 degree angle injections while the pain score of LT was 4.4 by the vertical and 5.6 by t.he 30 degree, Z. The mean time for appearance of regrowing hairs was 3.6 weeks in the BLT area and 4.0 weeks in the LT area. The use of BLT area showed a statistically faster response than the LT area. Conclusion : The use ot BLT is recommended not only by it,s remarkable effect on pain reduction but also by its sigriificantly accelerated hair regrowing effect in the trea~tment of alopecia areata. (Kor J Dermatoi 1997;35(1): 41-48)