Traumatic brain injury-induced hypo-O-GlcNAcylation contributes to cognitive dysfunction in adult zebrafish

Ngan An Bui,Dong Yeol Kim,Jiwon Park,Sang-Min Kim,Hyun Jae Sung,Thuy-Duong ThiTran,Quynh T N Nguyen,Inn-Oc Han 한국당과학회 2022 한국당과학회 학술대회 Vol.2022 No.07

Traumatic brain injury (TBI) is known as a functional corruption of the brain caused by a bump or blast to the head when an object hits suddenly or pierces the skull and penetrates brain tissues. There is an urgent need of understanding the pathophysiology following TBI because the morbidity and mortality rates worldwide caused by TBI have remained high throughout decades. In this study, we used a novel model of adult zebrafish to study the molecular and physiological changes following TBI. Using T-maze, on the 3rd-day post-stab-lesion injury (dpi), learning and memory deficits and poor social response were observed. Results from mirror biting and novel tank tests also provided us insight into their defective mobility, explorational, and territorial instincts. Neurogenesis impairment and severe brain inflammation were also altered following TBI, especially at 3 dpi. Upon injury, a notable decrease of O-GlcNAc level was remarked at 3dpi. Deregulation of O-GlcNAcylation which led to impaired glucose metabolism was informed to contribute to the pathologies of neurodegenerative diseases. Glucosamine (GlcN), a natural compound found in cartilage, is known as a derivative of the pathway that can increase O-GlcNAcylation by bypassing the reaction catalyzed by a rate liming enzyme GFAT. To further investigate the correlation, after TBI exposure, zebrafish had been recovered 3 days in 0.1g/L glucosamine (GlcN) diluted in water. Under the treatment of GlcN, the inflammation level reduced significantly, indicated by the decrease of Nuclear factor-kappa B and Glial fibrillary acidic protein expression in the telencephalon. TBI-induced downregulation of the cAMP signaling pathway and its relevant proteins in synaptic plasticity were rescued by GlcN. O-GlcNAc deficiency observed previously, as well as L/M capability were retrieved. GlcN also elevated the number of new cells regenerations and neuronal differentiation. As a result, regulation of brain O-GlcNAcylation may hold a potential role in TBI’s recuperation.

EXPLICIT ITERATIVE METHODS FOR MAXIMAL MONOTONE OPERATORS IN HILBERT SPACES

Nguyen T. T. Thuy,Pham T. T. Hoai,Nguyen T. T. Hoa 경남대학교 수학교육과 2020 Nonlinear Functional Analysis and Applications Vol.25 No.4

In this paper, we introduce new explicit iterative methods for solving a variationalinequality problem over the set of zeros for a maximal monotone operator in Hilbertspaces. By using two resolvents of the monotone operator at each iterate, we prove strongconvergence of the methods under a general condition on resolvent parameter. As specialcases, new contraction and generalized proximal point methods are obtained. An exampleis given for illustration and comparison.

Copper Recovery from Printed Circuit Boards Waste Sludge: Multi-step Current Electrolysis and Modeling

Nguyen, Huyen T.T.,Pham, Huy K.,Nguyen, Vu A.,Mai, Tung T.,Le, Hang T.T.,Hoang, Thuy T.B. The Korean Electrochemical Society 2022 Journal of electrochemical science and technology Vol.13 No.2

Heavy metals recovery from Printed Circuit Boards industrial wastewater is crucial because of its cost effectiveness and environmental friendliness. In this study, a copper recovery route combining the sequential processes of acid leaching and LIX 984N extracting with an electrowinning technique from Printed Circuit Boards production's sludge was performed. The used residual sludge was originated from Hanoi Urban Environment One Member Limited Company (URENCO). The extracted solution from the printed circuit boards waste sludge containing a high copper concentration of 19.2 g/L and a small amount of iron (0.575 ppm) was used as electrolyte for the subsequent electrolysis process. By using a simulation model for multi-step current electrolysis, the reasonable current densities for an electrolysis time interval of 30 minutes were determined, to optimize the specific consumption energy for the copper recovery. The mathematical simulation model was built to calculate the important parameters of this process.

The extraction of lignocelluloses and silica from rice husk using a single biorefinery process and their characteristics

Ngoc Thuy Nguyen,Nhat Thong Tran,Tan Phat Phan,Anh Thu Nguyen,My Xuyen T. Nguyen,Nguyen Ngan Nguyen,Young Ho Ko,Dai Hai Nguyen,Tran T.T. Van,DongQuy Hoang 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-

While the efficient usage of biomass waste can significantly help in addressing environmental issues,there are only a few reports that discuss about processing such waste effectively at a low-cost. Such challengearises from the strong association between the components biomass. In this study, an abundantagricultural byproduct, rice husk (RH), was used as the starting resource. A simple biorefining processof alkaline peroxide treatment followed by acid precipitation and ethanol extraction was performed onRH to obtain cellulose, hemicellulose, lignin, and silica. The chemical structures, morphologies, andphysic-chemical properties of the separated components were identified through a wide range of characterizationapproaches. The final products obtained from of this process were (i) bundles of fiber-likecellulose with a fiber width of 6 mm and (ii) small particles of hemicellulose and lignin with nonuniformshapes. The lignocelluloses products had over 90 wt% carbon with 52.28% crystalline ratio. Meanwhile, the other products comprising hemicelluloses, lignin, and silica were amorphous. The outcomeof this study contributes to expanding and developing the simple and efficient conversion processof biomass waste into sustainable value-added materials. It is crucial to reduce the environmental impactby using renewable materials as the new building block resources for synthetic chemicals.

The Role of Social Trust on Property Right Protection: Physical Property Versus Intellectual Property

Nguyen Thuy T.,Duong Tien H.,Dinh My T. T.,Truong Thu T. M.,Pham Tram H. H. 한국국제경제학회 2023 International Economic Journal Vol.37 No.2

While there have been numerous papers analyzing the political, economic and social effects of trust, there is little evidence on how social trust has an impact on property rights protection which is fundamental for promoting economic development. This study aims to investigate how trust value is related to property rights protection, focusing on the comparison of the effect on intellectual property rights versus physical property rights. Analyzing the data on property rights protection in 2015 from the Property Right Alliance organization and trust value from the World Value Survey from 1999 to 2014, we find that social trust has a direct effect only on intellectual property rights protection but less consistent on physical property rights protection. However, trust value has indirect effect on both forms of property rights protection via formal institutions. Our study, thus, adds to the literature by clarifying the context through which trust value affects cheating behaviors.

Microbial Inactivation by Cupric Ion in Combination with H₂O₂: Role of Reactive Oxidants

Nguyen, Thuy T. M.,Park, Hee-Jin,Kim, Jee Yeon,Kim, Hyung-Eun,Lee, Hongshin,Yoon, Jeyong,Lee, Changha American Chemical Society 2013 Environmental science & technology Vol.47 No.23

<P>The cupric ion mediated inactivation of Escherichia coli was enhanced by the presence of hydrogen peroxide (H<SUB>2</SUB>O<SUB>2</SUB>), with increasing inactivation efficacy observed in response to increasing concentrations of H<SUB>2</SUB>O<SUB>2</SUB>. The biocidal activity of the Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB> system is believed to result from the oxidative stress caused by reactive oxidants such as the hydroxyl radical (<SUP>•</SUP>OH), cupryl species (Cu(III)), and the superoxide radical (O<SUB>2</SUB><SUP>•–</SUP>), which are produced via the catalytic decomposition of H<SUB>2</SUB>O<SUB>2</SUB>. In E. coli cells treated with Cu(II) and H<SUB>2</SUB>O<SUB>2</SUB>, the intracellular level of <SUP>•</SUP>OH and Cu(III) increased significantly, leading to complete disruption of cell membranes. On the basis of experimental observations made using an <SUP>•</SUP>OH scavenger, copper-chelating agents, and superoxide dismutase, it is concluded that Cu(III) is the predominant species responsible for the death of E. coli cells. It was also found that the production of Cu(III) was promoted by the reactions of copper with intracellular O<SUB>2</SUB><SUP>•–</SUP>. MS2 coliphage was found to be even more susceptible than E. coli to the oxidative stress induced by the Cu(II)/H<SUB>2</SUB>O<SUB>2</SUB> system.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2013/esthag.2013.47.issue-23/es403155a/production/images/medium/es-2013-03155a_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es403155a'>ACS Electronic Supporting Info</A></P>

Evaluating Internet Pricing Schemes: A Three-Dimensional Visual Model

Thuy T.T Nguyen,Grenville J. Armitage 한국전자통신연구원 2005 ETRI Journal Vol.27 No.1

Traditional Internet pricing schemes are coming under continual pressure to adapt to, and encourage, a changing mix of Internet applications and consumer usage patterns. Much research effort over the last decade has been focused on developing more efficient and attractive charging schemes. However, none of the proposed models has been widely deployed. This raises questions regarding the inhibiting factors and missing pieces that make pricing the Internet such a challenge. In this paper, we discuss the problems with current Internet pricing schemes, review the history of Internet pricing research over the last ten years, and summarize the key features and motivations of the most significant models. We develop a novel visual approach to comparing and evaluating such schemes using a three-dimensional (3D) metric encompassing technical efficiency, economic efficiency, and social impact. We address and discuss the important factors that have inhibited the deployment of the reviewed models and suggest productive areas of focus for future Internet pricing research.

Hydrothermal synthesis of In₂O₃ nanocubes for highly responsive and selective ethanol gas sensing

Nguyen, Thuy T.D.,Choi, Ha-Nui,Ahemad, M. Jamir,Van Dao, Dung,Lee, In-Hwan,Yu, Yeon-Tae Elsevier 2020 Journal of Alloys and Compounds Vol.820 No.-

<P><B>Abstract</B></P> <P>Indium oxide nanocubes (NCs) were prepared via a simple, template-free hydrothermal method at low temperature; the so-obtained structures exhibited large surface area (47.67 m<SUP>2</SUP>/g) and Barrett−Joyner−Halenda (BJH) adsorption average pore diameter (11.92 nm), both higher than for commercial In<SUB>2</SUB>O<SUB>3</SUB> nanoparticles. At the optimal temperature of 300 °C, the In<SUB>2</SUB>O<SUB>3</SUB> NCs-based sensor showed a superior response of 85–100 ppm ethanol, 3.4 times higher than that of the commercial one based on In<SUB>2</SUB>O<SUB>3</SUB> NPs, and also faster response time (15 s) than the commercial device (60 s). The better sensing performance of the synthesized In<SUB>2</SUB>O<SUB>3</SUB> NCs can be attributed to its unique properties that include large BET surface area and BJH adsorption average pore diameter as well as abundance of sharp edges and tips, which result in high surface to volume ratios for the gas adsorption and diffusion processes, facilitating the charge-transfer and sensing reactions at the gas–solid interfaces. In addition, the In<SUB>2</SUB>O<SUB>3</SUB> NCs exhibited excellent selectivity to ethanol among other target gases (CO, CH<SUB>4</SUB>, CH<SUB>3</SUB>CHO, H<SUB>2</SUB>, and CH<SUB>3</SUB>COCH<SUB>3</SUB>). This work provides an effective design pathway for ethanol sensors based on In<SUB>2</SUB>O<SUB>3</SUB> NCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> In<SUB>2</SUB>O<SUB>3</SUB> nanocubes are prepared via a template-free method at low temperature. </LI> <LI> In<SUB>2</SUB>O<SUB>3</SUB> nanocubes show high surface area and large BJH adsorption pore diameter. </LI> <LI> In<SUB>2</SUB>O<SUB>3</SUB> nanocubes show high sensing response and good selectivity to ethanol gas. </LI> <LI> Our finding opens an effective pathway to develop ethanol sensors. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>The graphical abstract for In<SUB>2</SUB>O<SUB>3</SUB> nanocubes ethanol gas sensing.</P> <P>[DISPLAY OMISSION]</P>

N-Capping Effects of Stapled Heptapeptides on Antimicrobial and Hemolytic Activities

Thuy T. T. Dinh,김도희,Thang Q. Nguyen,이봉진,김영우 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.10

In our previous study, we showcased the potential of an all-hydrocarbon stapled heptapeptide as a privileged scaffold for the design of artificial antimicrobial peptides. We demonstrated that the amphipathic helicity and the subtle balance between hydrophobicity and hydrophilicity are important structural features for the antimicrobial activities of this class of antimicrobial agents. In this study, we show that elimination of the N-acetyl cap can further improve the pharmacological properties of the most potent stapled heptapeptides. The structure–activity relationships newly established in this study would serve as a critical asset for the further development of a new class of antimicrobial agents to combat the rising problem of antibiotic resistance.

Factors Affecting Infrastructure Connectivity: An Indian and Vietnamese Perspective

Thuy T.Dang,Nguyen Le Thy Thuong,Pham Thuy Nguyen 한국외국어대학교 인도연구소 2021 남아시아연구 Vol.27 No.3

Infrastructure connectivity plays an important role in Vietnam and India’s trade promotion, and international economic development and cooperation. Vietnam and India have become comprehensive strategic partners since 2016. In its “Act East” Policy, India considered Vietnam as a crucial destination for infrastructure development, trading and investment projects as well as a bridge to connect India with the Southeast Asia region. The article presents direct factors affecting infrastructure connectivity between India and Vietnam, in different aspects including geography and nature; politics and diplomacy; finance and economics; institutional policies and regulations; society and people; and infrastructure. From analyzing these factors, it can be seen that the harmonious diplomatic relations, stable internal politics and the increase in cooperation between Vietnam and India in various fields contribute to ensuring Vietnam - India infrastructure connectivity cooperation. A young, highly skilled workforce and a strong culture of integration also create favorable conditions for infrastructure connectivity between the two countries. However, the remote geographical distance, the limited economic resources, the relative disparity in the level of development of hard and soft infrastructure as well as the limited institutional capacity of each country create certain barriers. Due to the delay in decision-making and planning between the two countries, no direct projects between the two countries have been implemented so far. Currently, it is only possible to place the Vietnam - India infrastructure connectivity projects in the ASEAN - India infrastructure connectivity network, but most of these projects also stop at drafting and planning phase. Therefore, the infrastructure connectivity between Vietnam and India needs to overcome many barriers to achieve certain results.