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Tran Thien khanh,Ha Pham Thi Thu,Henry Robert. J.,Nguyen Dang Nguyen Thao,Tuyen Phung Thi,Liem Nguyen Thanh 한국미생물·생명공학회 2024 Journal of microbiology and biotechnology Vol.34 No.1
Plants contain a large number of phytochemical components, many of which are known as bioactive compounds and responsible for the expression of various pharmacological activities. The extract of Sonneratia caseolaris fruit collected in Vietnam was investigated for its total phenolic and total flavonoid contents using methanol solvent and different fractions of S. caseolaris fruits (hexane, ethyl acetate, n-butanol, and aqueous). GC–MS analysis was conducted to identify the bioactive chemical constituents occurring in the active extract. Further, the antibacterial activity was tested in vitro on bacterial isolates, namely Escherichia coli, Staphylococcus aureus, and Bacillus subtilis, using the disc diffusion method on tryptic soya agar (TSA) medium. The methanol extract showed high total flavonoid (82.3 ± 0.41 mg QE/g extract) and phenolic (41.0 ± 0.34 mg GAE/g extract) content. GC–MS of the methanol extract and different fractions of S. caseolaris fruits detected 20 compounds, principally fatty alcohols, fatty acids, phenols, lipids, terpenes derivatives, and carboxylic acids derivatives. A 50 mg/ml concentration of methanol extract had the strongest antibacterial activity on E. coli, S. aureus, and B. subtilis. Furthermore, ethyl acetate, aqueous, and n-butanol fractions inhibited S. aureus and B. subtilis the most. The results of the present study suggested that the fruits of S. caseolaris are rich sources of phenolic compounds that can contribute to safe and cost-effective treatments.
Nga Thanh DOAN,Trang Thu TA,Ha Thi Thanh CHU,Anh Thi Quynh LE,May Thi LE,Tuan Hoang PHAM,Thao Thu VUONG 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.2
The purpose of this study is to look at the precise direction and magnitude of cultural elements such as education, gender, power distance, and risk-taking proclivity on ethical decision-making. Data was collected from 194 interviewees in three groups: general business students, accounting major students, and professional auditors in Vietnam. The path analysis is used to test the impact of cultural factors on ethical awareness, ethical judgment, and ethical intention in different dubious scenarios at the personal level as independent variables, intermediate variables, and moderating variables. The metric is the percentage of respondents who believe a particular behavior is unethical based on a set of ethical principles. The researchers used SPSS AMOS software to conduct a confirmatory factor survey to evaluate the convergent and discriminant validity of latent variables. The results show differences between the two groups of students and professionals on these measures, suggesting that all of the four factors have an effect on ethical decision-making. Based on research results, some recommendations are proposed related to the four factors to improve the ethics of future generations of auditors in Vietnam. This study also contributes to the theory of culture in particular and cultural interference in general in the field of accounting-auditing in Vietnam in the process of international integration.
Lan, Nguyen Thi Thao,Phuong, Nguyen Pham Anh,Trang, Nguyen Thi My,Huong, Pham Thi My,An, Nguyen Thu,Le, Hoanh-Su Korea Multimedia Society 2021 The journal of multimedia information system Vol.8 No.1
The paper is based on data collected from the Amazon website (specific in the Handmade's Category) to understand and analyze Vietnamese artisans' business context. Data analysis is also applied to determine the factors that bring success Handmade products and compare products of the same industry among competitors to find out potential products. By collecting data from Amazon and analyzing the data, we extracted useful information for online business developers. Besides, the list of potential products in Handmade sector can be referred to improve the business and compete with competitors. This paper also proposes solutions to help Vietnamese products become more appealing to international customers on the Amazon website.
Nguyen Ngoc Nha Thao,Pham Duy Toan,Nguyen Duc Tuan,Trinh Thi Thu Loan 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.5
Purpose Diabetes mellitus, especially type II, is one of the most common chronic diseases. Its first-line oral treatment is metformin, commonly in combination with another agent such as sitagliptin, a dipeptidyl peptidase-4 inhibitor. The commercial combination is Janumet XR 50/500 mg, in which the extended-release metformin core tablet is coated with an immediaterelease layer of sitagliptin. However, the coating process with solvents and a high temperature might affect the sitagliptin properties and product quality. Hence, the present study aimed to develop bilayer matrix tablets incorporating both drugs into two separate layers, a sustained-release metformin layer, and an immediate-release sitagliptin layer. Methods Wet granulation and direct compression methods were used for the metformin and sitagliptin layer, respectively. The optimal formulation was selected and characterized based on the design of experiments method. In vitro release and in vivo bioequivalence studies were also conducted to compare with the reference Janumet XR 50/500 mg. Results The optimized formulation immediately released sitagliptin (> 95%) within 30 min at pH 1.2 and sustained the release metformin for 10 h at pH 6.8. The in vivo behaviors of the bilayer tablets were bioequivalent to the commercial product, Janumet XR 50/500 mg. Conclusion The bilayer tablets could provide an alternative approach for combination therapy of type II diabetes.
Duy Nguyen Ngoc,Ho Phuong-Thao,Pham Vinh N. T.,Hoan Nguyen Thi Thu 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.1
In this paper, we estimate the production cross section of the unknown super-heavy nuclei 309, 312126 via 58Ni + 251Cf and 64Zn + 248Cm combinations by using approximation methods. For each reaction, the competition between compound nucleus (CN) formation and quasi-fission process is also analyzed. We found that the synthesis cross section for the 309126 isotope is about 3 fb, which is about 5 orders of magnitude higher than that for the 312126 nucleus. The results also suggest that a valley exists around the isotope with A = 313 in the production yields for the 126th element. Moreover, the synthesis of the 310-317126 isotopes is still a challenge for experimental techniques due to the small cross sections, which are less than 1 fb.
Huan, Le Cong,Tran, Phuong-Thao,Phuong, Cao Viet,Duc, Phan Huy,Anh, Duong Tien,Hai, Pham The,Huong, Le Thi Thu,Thuan, Nguyen Thi,Lee, Hye Jin,Park, Eun Jae,Kang, Jong Soon,Linh, Nguyen Phuong,Hieu, Tr Elsevier 2019 Bioorganic chemistry Vol.92 No.-
<P><B>Abstract</B></P> <P>In search for novel small molecules with antitumor cytotoxicity via activating procaspase-3, we have designed and synthesized three series of novel (E)-<I>N</I>′-benzylidene-4-oxoquinazolin-3(4<I>H</I>)-yl)acetohydrazides (<B>5a-j, 6a-h,</B> and <B>7a-h)</B>. On the phenyl ring ò the benzylidene part, three different substituents, including 2-OH-4-OCH<SUB>3</SUB>, 4-OCH<SUB>3</SUB>, and 4-N(CH<SUB>3</SUB>)<SUB>2</SUB>, were introduced, respectively. Biological evaluation showed that the acetohydrazides in series <B>5a-j</B>, in which the phenyl ring of the benzylidene part was substituted by 2-OH-4-OCH<SUB>3</SUB> substituent, exhibited potent cytotoxicity against three human cancer cell lines (SW620, colon; PC-3, prostate; NCI-H23, lung). Most of the compounds, in this series, especially compounds <B>5c, 5b</B> and <B>5h,</B> also significantly activated caspase-3 activity. Among these, compound <B>5c</B> displayed 1.61-fold more potent than PAC-1 as caspase-3 activator. Cell cycle analysis showed that compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> significantly arrested the cell cycle in G1 phase. Further apoptotic studies also demonstrated compounds <B>5b</B>, <B>5c</B>, and <B>5h</B> as strong apoptotic cell death inducers. The docking simulation studies showed that these compounds could activate procaspase <I>via</I> chelating Zn<SUP>2+</SUP> ion bound to the allosteric site of the zymogen.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel (<I>E</I>)-<I>N</I>′-benzylidene-2-(4-oxoquinazolin-<I>3(4H)-yl</I>)acetohydrazides were synthesized. </LI> <LI> The acetohydrazides <B>5a-i</B> exhibited potent cytotoxicity against three human cancer cell lines. </LI> <LI> A number of cytotoxic compounds exhibited good caspase activation activity. </LI> <LI> The cytotoxic compounds were shown to arrest cells at G1 phase. </LI> <LI> The cytotoxic compounds were shown as strong apoptotic inducers. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
The Impact of COVID-19 Pandemic on Firm Performance: Empirical Evidence from Vietnam
BUI, Trung Huy,NGUYEN, Huong Thu,PHAM, Yen Nhu,NGUYEN, Trang Thu Thi,LE, Linh Thao,LE, Giang Thu Tran Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.7
The outbreak of Coronavirus disease 2019 (COVID-19) has caused serious impacts not only on human health but also on the economies around the world. Enterprises play an important role in the development of every country but it is also one of the most affected sectors during the pandemic. Drawing on panel data of 131 enterprises listed on the Vietnamese stock exchange from 2016Q1 to 2021Q3, this study aims to investigate the impact of the COVID-19 pandemic on firm performance. Enterprises are classified into seven industries including Agriculture, Material, Industry, Real estate and Construction, Energy, Consumer, and Service. The paper also analyzes the variation of the effects among companies, focusing on differences in revenue and capital structure. The results show that the COVID-19 pandemic negatively affects business performance. In addition, the empirical findings indicate that revenue and debt decreasing can cause deterioration of firm performance during the pandemic period. The decrease in revenue has a direct impact on firm profitability. The reduction of debt levels affects the corporate leverage leading to adverse effects on firm performance. The negative effect is more pronounced for companies in some specific sectors including industry, real estate, construction, consumption, and services.
Trong Luan NGUYEN,Ha Ai My NGUYEN,Pham Thao Nguyen LUU,Minh Anh LE,Thi Anh Thu NGUYEN,Ngoc Tram NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.5
As society evolves, people are making more of an effort to learn more about human aspects, one of which is emotional intelligence, a topic on which education experts have traditionally concentrated. This is due to the fact that emotional intelligence has a significant impact on how people think and manage their emotions. On the other side, it promotes the development of expressive ability and aids people in better adapting to life. This study explores the relationship between communication skills, leadership skills, stress management, adaptability, and emotional intelligence of FPT University students to determine the factors that affect students’ emotional intelligence. To survey 500 FPT University students, this study used a sample size of 500. Previous studies used a 5-point Likert scale to assess the four skill elements. According to the results, students who completed the survey showed adequate communication skills, leadership qualities, stress management, adaptability, and emotional intelligence. Emotional intelligence is influenced by communication skills, leadership abilities, stress management, and flexibility. This suggests that students who master these four skills have higher levels of emotional intelligence. The outcomes of this study reveal that students have been conscious of Emotional Intelligence since a young age. The affirmations in this research paper will benefit students and young people interested in enhancing complimentary soft skills that boost Emotional Intelligence.