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Teraoka, Hiroki,Ito, Shino,Ikeda, Haruki,Kubota, Akira,Abou Elmagd, M M,Kitazawa, Takio,Kim, Eun-Young,Iwata, Hisato,Endoh, Daiji American Chemical Society 2012 Environmental science & technology Vol.46 No.1
<P>To assess possible impacts of environmental pollutants on gene expression profiles in a variety of organisms, we developed a novel differential display system with primer sets that are common in seven vertebrate species, based on degenerate oligonucleotide-primed PCR (DOP-PCR). An 8-mer inverse repeat motif was found in most transcripts from the seven vertebrates including fish to primates with detailed transcriptome information; more than 10,000 motifs were recognized in common in the transcripts of the seven species. Among them, we selected 275 common motifs that cover about 40-70% of transcripts throughout these species, and designed 275 DOP-PCR primers that were common to seven vertebrate species (common DOP-PCR primers). To detect genes responsive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in developing embryos, differential display with common DOP-PCR primers was applied to embryonic liver of two avian species, the chicken (Gallus gallus) and the common cormorant (Phalacrocorax carbo), which were exposed in ovo to TCDD. The cDNA bands that showed differences between the control and TCDD-treated groups were sequenced and the mRNA expression levels were confirmed by real-time RT-PCR. This approach succeeded in isolating novel dioxin-responsive genes that include 10 coding genes in the chicken, and 1 coding gene and 1 unknown transcript in the cormorant, together with cytochrome P450 1As that have already been well established as dioxin markers. These results highlighted the usefulness of systematically designed novel differential display systems to search genes responsive to chemicals in vertebrates, including wild species, for which transcriptome information is not available.</P>
Masaru Teraoka,Koji Morita,Satoshi Sasaki,Daisuke Katsura 국제구조공학회 2001 Steel and Composite Structures, An International J Vol.1 No.3
The purpose of this paper is to propose a new type of steel reinforced concrete (SRC) beam-column joints and to examine the structural performance of the proposed joints, which simplify the construction procedure of steel fabrication, welding works, concrete casting and joint strengthening. In the proposed beam-column joints, the steel element of columns forms continuously built-in crossing of H-sections ( ), with adjacent flanges of column being connected by horizontal stiffeners in a joint at the level of the beam flanges. In addition, simplified lateral reinforcement ( ) is adopted in a joint to confine the longitudinal reinforcing bars in columns. Experimental and analytical studies have been carried out to estimate the structural performance of the proposed joints. Twelve cruciform specimens and seven SRC beam-column subassemblage specimens were prepared and tested. The following can be concluded from this study: (1) SRC subassemblages with the proposed beam-column joints show adequate seismic performances which are superior to the demand of the current code; (2) The yield and ultimate strength capacities of the beam-to-column connections can be estimated by analysis based on the yield line theory; (3) The skeleton curves and the ultimate shear capacities of the beam-column joint panel are predicted with a fair degree of accuracy by considering a simple stress transfer mechanism.
( Yuko Teraoka ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Objective: Progesterone (P4) plays an important role in maintaining pregnancy via its anti-inflammatory effect in the myometrium: however, this effect is less understood in the fetal membrane. We previously reported that mice with dental Porphyromonas gingivalis (P.g ) infection could be useful as a model of preterm birth. In this model, inflammation in the fetal membrane via toll-like receptor 2 (TLR2) is thought to result in preterm birth. We investigated whether P4 prevented preterm birth and the effects of P4 in the fetal membrane in this preterm birth model. Methods: P.g mice were injected subcutaneously with (P.g +P4 mice) or without (P.g mice) 1 mg of P4 daily at days 15.5 to 17.5 of gestation. We observed the mice in these gestational periods. Western blot analysis was performed for detection of TLR2, NF-κB and MAPK in the fetal membrane at day 18 of gestation. We also evaluated inflammatory cytokines (IL-1β, IL-8, TNF-α) and the expression level of TLR2 at the same tissues using RT-PCR. Results: The average gestational period was 20.4 days in P.g +P4 mice and 18.3 days in P.g mice. The enhancement of NF-κB and MAPK expression levels was significantly decreased in P.g +P4 mice, compared with in P.g mice. Treatment with P4 reduced the enhancement of the expression of IL-1β, IL-8, and TNF-α; by 88%, 76% and 59%, respectively. And the enhancement of TLR2 expression was also decreased in P.g +P4 mice. Conclusion: P4 suppressed the activation of inflammatory signaling pathways via TLR2 in the fetal membrane of a chronic inflammation-induced preterm birth mouse model. The anti-inflammatory effect of P4 in the fetal membrane prevented preterm birth.
Ueno, Toshiya,Teraoka, Naoya,Takasu, Shinji,Nakano, Katsuya,Takahashi, Mami,Yamamoto, Masafumi,Fujii, Gen,Komiya, Masami,Yanaka, Akinori,Wakabayashi, Keiji,Mutoh, Michihiro Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Obesity is an established risk factor for colorectal cancer. Pioglitazone is a peroxisome proliferator activated receptor$receptor{\gamma}$ ($PPAR{\gamma}$) agonist that induces differentiation in adipocytes and induces growth arrest and/or apoptosis in vitro in several cancer cell lines. In the present study, we investigated the effect of pioglitazone on the development of azoxymethane-induced colon aberrant crypt foci (ACF) in KK-$A^{\mathcal{Y}}$ obesity and diabetes model mice, and tried to clarify mechanisms by which the $PPAR{\gamma}$ ligand inhibits ACF development. Administration of 800 ppm pioglitazone reduced the number of colon ACF/mouse to 30% of those in untreated mice and improved hypertrophic changes of adipocytes in KK-$A^{\mathcal{Y}}$ mice with significant reduction of serum triglyceride and insulin levels. Moreover, mRNA levels of adipocytokines, such as leptin, monocyte chemoattractant protein-1 and plasminogen activator inhibitor-1, in the visceral fat were decreased. PCNA immunohistochemistry revealed that pioglitazone treatment suppressed cell proliferation in the colorectal epithelium with elevation of p27 and p53 gene expression. These results suggest that pioglitazone prevented obesity-associated colon carcinogenesis through improvement of dysregulated adipocytokine levels and high serum levels of triglyceride and insulin, and increase of p27 and p53 mRNA levels in the colorectal mucosa. These data indicate that pioglitazone warrants attention as a potential chemopreventive agent against obesity-associated colorectal cancer.