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The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts
Tange, Yoshie,Kurabayashi, Atsushi,Goto, Bunshiro,Hoe, Kwang-Lae,Kim, Dong-Uk,Park, Han-Oh,Hayles, Jacqueline,Chikashige, Yuji,Tsutumi, Chihiro,Hiraoka, Yasushi,Yamao, Fumiaki,Nurse, Paul,Niwa, Osami Public Library of Science 2012 PLoS genetics Vol.8 No.6
<P>To identify the genes required to sustain aneuploid viability, we screened a deletion library of non-essential genes in the fission yeast <I>Schizosaccharomyces pombe</I>, in which most types of aneuploidy are eventually lethal to the cell. Aneuploids remain viable for a period of time and can form colonies by reducing the extent of the aneuploidy. We hypothesized that a reduction in colony formation efficiency could be used to screen for gene deletions that compromise aneuploid viability. Deletion mutants were used to measure the effects on the viability of spores derived from triploid meiosis and from a chromosome instability mutant. We found that the CCR4-NOT complex, an evolutionarily conserved general regulator of mRNA turnover, and other related factors, including poly(A)-specific nuclease for mRNA decay, are involved in aneuploid viability. Defective mutations in CCR4-NOT complex components in the distantly related yeast <I>Saccharomyces cerevisiae</I> also affected the viability of spores produced from triploid cells, suggesting that this complex has a conserved role in aneuploids. In addition, our findings suggest that the genes required for homologous recombination repair are important for aneuploid viability.</P><P><B>Author Summary</B></P> <P>Aneuploidy is a major cause of abortive development and is implicated in tumorigenesis in humans. Recent studies revealed that the increased need for protein degradation might account for the detrimental effects of aneuploidy on a cell. Here, we investigated the genetic systems responsible for aneuploid viability. Using a collection of gene deletions in fission yeast, we isolated mutants that affect aneuploid viability. We found that an evolutionarily conserved transcription regulator, the CCR4-NOT complex, and its related factors are required for aneuploid viability, suggesting that regulation of mRNA turnover is required to tolerate aneuploidy. In addition, homologous recombination repair is important for aneuploid viability.</P>
Mikako Yasuoka,Chikako Tange,Yukiko Nishita,Makiko Tomida,Ryota Watanabe,Hiroshi Shimokata,Rei Otsuka,Masayo Kojima 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.1
Background: This study evaluated the chronological changes in physical and cognitive functions in middle-aged and older adults with and without rheumatoid arthritis (RA). Methods: This population-based case-control longitudinal study included individuals aged 40–79 years at baseline who agreed to participate. We identified 42 participants with RA and randomly selected 84 ageand sex-matched controls. Physical function was assessed according to gait speed, grip strength, and skeletal muscle mass. Cognitive function was assessed based on the information, similarities, picture completion, and digit symbol substitution test scores of the Wechsler Adult Intelligence Scale-Revised Short Form. The general linear mixed models comprised the fixed effects of the intercept, case, age, time in years since baseline, and case×time interaction, which were used to examine longitudinal changes in physical and cognitive functions. Results: Regardless of RA status, grip strength decreased and the picture completion score increased in the group aged <65 years, while skeletal muscle mass index and gait speed decreased in the group aged ≥65 years. The interaction of case×follow-up years for grip strength in the group aged ≥65 years was significant (p=0.03). The decline in grip strength in the control group (slope=-0.45) was greater than that in the RA group (slope=-0.19). Conclusion: Chronological changes in physical and cognitive functions were comparable between participants with and without RA; however, the decline in grip strength in the control group was greater among older adults with RA.
이해준,안창원,원성식,Achiri Tange,박봉찬,석해진,김일원 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.66 No.9
Na0.5K0.5NbO3 (NKN) thin films were grown on Pt(111)/Ti/SiO2/Si substrates by using RFmagnetron sputtering. We investigated the behavior of the ferroelectric polarization. Well-saturated P-V hysteresis loops were observed, but the P-V hysteresis loops were sometimes distorted and consisted of three roughly parallel components, such as ferroelectric, dielectric and conductive components. Correction methods were proposed to identify the undesirable components and the pure ferroelectric polarization components from the observed P-V hysteresis loops. A new polarization hysteresis loop measurement technique, the double wave method (DWM), was applied to NKN thin films to obtain pure ferroelectric polarization and elucidate the behaviors of the polarization components.
Chanun Suwanpreecha,Sukrit Songkuea,Pranpreeya Wangjina,Makiko Tange,Wanida Pongsaksawad,Anchalee Manonukul 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11
Ti-Mo alloys have received increasing attention for use in biomedical applications due to their non-toxic alloying elements,reasonable cost and suitable properties. In the present study, the effects of elemental Mo powder additions (5, 7.5, 10 and 15wt%) on the physical, mechanical and corrosion properties in commercially pure Ti fabricated by metal injection moulding(MIM) and sintered at 1250 and 1350 °C were investigated. It was found that tensile strength increases with increasing Mocontent mainly due to solid solution strengthening. However, the strain to failure of the alloys is variable and is influenced bythe formation of TiCx,the relative sintered density and by impurities depending on the Mo content and sintering temperature. From the present study the optimum alloy is Ti-7.5Mo, sintered at 1250 °C for 2 h, which offers a satisfactory balance betweensuitable tensile properties, high relative density (> 96.5%), and excellent corrosion resistance in an artificial saliva environment. Ti-Mo alloys can also tolerate impurities up to 0.5 wt% (Oxygen equivalent, Oeq)without any significant reduction inductility, which is a practical advantage for manufacturing and is attractive for biomedical applications.
The Development of the Totalized Hydrogen Energy Utilization System for Commercial Buildings
Maeda, Tetsuhiko,Nakano, Akihiro,Ito, Hiroshi,Tange, Manabu,Kawakami, Yoshiaki,Kato, Atsushi,Masuda, Masao The Korean Institute of Electrical Engineers 2011 The Journal of International Council on Electrical Vol.1 No.2
We have proposed the Totalized Hydrogen Energy Utilization System(THEUS) for applying to commercial buildings. THEUS consists of fuel cells, water electrolyzers, metal hydride tanks and their auxiliaries. We evaluated the energy saving of the basic THEUS in view of an actual operation using thermal demand data of actual buildings. The THEUS have ability for achieving energy saving, in comparison with an ice storage system for cooling demand. We have developed the hydrogen storage system using metal hydride and unitized reversible cell (URC) combine the functionality of a fuel cell and an electrolyzer in a single device, these are important components of THEUS. The metal hydride tank designed and manufactured to evaluate that we assumed actual operation in the experiments. We developed the numerical simulation code, and simulation results are in good agreement with experimental data. The simulation about two tanks system was done by using this code. The heat utilization can be improved greatly. To achieve URC commercial use, improvement of durability was examined. It confirmed that our URC had durability for several thousand hours.
고령자의 기능적 체력과 인지기능 저하와의 관련-10년간의 장기종단연구
이성철(Sungchul Lee),니시타 유키코(Yukiko Nishita),탄게 치카고(Chikako Tange),오츠카 레이(Rei Otsuka),안도 후지코(Fujiko Ando),시모카타 히로시(Hisoshi Shimokata),장명재(Myong-Jae Chang),최현민(Hyun-Min Choi) 한국생활환경학회 2016 한국생활환경학회지 Vol.23 No.5
The purpose of this study was to examine whether functional fitness predicts subsequent cognitive decline in community dwelling older adults. The subjects were 1094 (556 men and 538 women) adults aged 60 years or older who completed the baseline (2000-2002) and ten years later (2010-2012) examinations of the National Institute for Longevity Science-Longitudinal Study of Aging (NILS-LSA) in Japan. We examined associations at baseline and over a 10-year follow-up period between seven functional fitness measures: gait speed, step length, one leg standing, reaction time, leg extension power, grip strength and knee extension strength and mini-mental state examination (MMSE). Multivariate logistic regression was used to examine the relationships between functional fitness and cognitive function decline every two years. There was a significant association between the reaction time and risk of becoming decrease to 23 points of MMSE in both model Ⅰ and model Ⅱ of all waves in men and women for 10 years. Gait speed was related to decrease in the cognitive function from after six years (5th wave) in both men (OR, 0.72; CI, 0.53-0.95) and women (OR, 0.79; CI, 0.54-0.97). Leg extension power and grip strength of the physical function were associated with cognitive function decline from after six years it was found in men only. In the women case, it was showed after 10 years. Functional fitness was identified as factors that can predict the decrease in cognitive function. But it turned out that the functional fitness related to cognitive function decreases depending on the time and gender are different.
지역 거주 고령자를 대상으로 신체기능과 인지기능과의 관련성 연구
이성철(Sung-Chul Lee),니시타 유키코(Yukiko Nishita),탄게 치카고(Chikako Tange),오츠카 레이(Rei Otsuka),안도 후지코(Ando Fujiko),시모카타 히로시(Hisoshi Shimokata),장명재(Myoung-Jei Chang),최현민(Hyun-Min Choi) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.5
Cognitive decline and dementia are associated with disability and premature death in old age. We examined whether physical function predicts subsequent cognitive decline in older Japanese. There were 557 adult subjects (293 men and 264 women) aged 60 years or older who completed the baseline evaluation (2000-2002) and final evaluation 8 years later (2008-2010) of the NILS-LSA in Japan. We examined associations at the baseline and after an 8-year follow-up period between MMSE and six physical performance measures: gait speed, one leg standing with eyes closed, reaction time, leg extension power, grip strength and knee extension strength. We examined the effect of physical function on cognitive decline (at least a 3-point decline on the MMSE) by multiple logistic regression controlled for age, sex, BMI, MMSE score at baseline, smoking, self-rated health, CES-D, education, medical history and moderate to vigorous physical activity time. There was a significant association between the leg extension power (OR, 0.26; CI, 0.10-0.68) and the risk of a decrease of up to 3 points in Model 1 was adjusted for age and education. In Model II, leg extension power (OR, 0.28; CI, 0.10-0.76) was related to a decrease in the cognitive function over time and remained statistically significant after controlling for all covariates. However, the other physical functions were not statistically significant in either the limited or full adjustment models. Older Japanese with reduced leg extension power at baseline demonstrated a statistically significant decline in cognitive function over an 8-year period.