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PROCESSING OF INTERSTELLAR MEDIUM AS DIVULGED BY AKARI
TAKASHI ONAKA,TAMAMI I. MORI,RYOU OHSAWA,ITSUKI SAKON,AARON C. BELL,MARK HAMMONDS,TAKASHI SHIMONISHI,DAISUKE ISHIHARA,HIDEHIRO KANEDA,YOKO OKADA,MASAHIRO TANAKA 한국천문학회 2017 天文學論叢 Vol.32 No.1
A wide spectral coverage from near-infrared (NIR) to far-infrared (FIR) of {\it AKARI} both for imaging and spectroscopy enablesus to efficiently study the emission from gas and dust in the interstellar medium (ISM). In particular, the Infrared Camera(IRC) onboard {\it AKARI}offers a unique opportunity to carry out sensitive spectroscopy in the NIR (2--5\,$\mu$m) for the first time from a spaceborn telescope. This spectral range contains a number of important dust bands and gas lines, such as the aromatic and aliphatic emissionbands at 3.3 and 3.4--3.5\,$\mu$m, H$_2$O and CO$_2$ ices at 3.0 and 4.3\,$\mu$m, CO, H$_2$, and \ion{H}{I} gas emission lines. In this paper we concentrate on the aromatic and aliphatic emission and ice absorption features. The balance between dust supply and destruction suggests significant dust processing takingplace as well as dust formation in the ISM. Detailed analysis of the aromatic and aliphatic bands of {\it AKARI} observations for a number of\ion{H}{ii} regions and \ion{H}{ii} region-like objectssuggests processing of carbonaceous dust in the ISM. The ice formation process canalso be studied with IRC NIR spectroscopy efficiently. In this review, dust processing in the ISM divulged by recentanalysis of {\it AKARI} data is discussed.
Mori, Kohsuke,Araki, Takashi,Takasaki, Tomoya,Shironita, Sayoko,Yamashita, Hiromi Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.5
Supported Pd catalysts were synthesized using various semiconductor materials by a photo-assisted deposition method under UV-light irradiation. The Pd precursor was deposited and partially reduced by the direct interaction with the photo-excited state of the semiconductor materials, and subsequently transformed into metal particles by $H_2$ reduction. CO adsorption and Pd K-edge XAFS measurements demonstrated that the mean diameter of the deposited Pd particles can be controlled by the type of employed semiconductor materials. The catalytic activities in the direct synthesis of hydrogen peroxide ($H_2O_2$) using $H_2$ and $O_2$ gases under atmospheric pressure were strongly dependent on the type of supports. Here, the use of $TiO_2$ comprising a mixed phase of anatase and rutile was the most efficient based on the amount of Pd. The photo-assisted deposition also provides a simple and straightforward method to synthesize PdAu alloy nanoparticles. For the structural model of PdAu nanoparticles, we suggest that most of the Au atoms are preferentially located in the core region, whereas the Pd atoms are preferentially located in the shell region. The PdAu/$TiO_2$ catalysts prepared by the photo-assisted deposition method were shown to perform significantly better than the pure Pd/$TiO_2$ catalysts.
Sumire Mori,Toshihiko Tomita,Kazuki Fujimura,Haruki Asano,Tomohiro Ogawa,Takahisa Yamasaki,Takashi Kondo,Tomoaki Kono,Katsuyuki Tozawa,Tadayuki Oshima,Hirokazu Fukui,Takeshi Kimura,Jiro Watari,Hiroto 대한소화기 기능성질환∙운동학회 2019 Journal of Neurogastroenterology and Motility (JNM Vol.25 No.4
Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life. Results One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003). Conclusion Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms. Background/Aims Magnesium oxide (MgO) has been frequently used as a treatment for chronic constipation (CC) since the 1980s in Japan. The aim of this study is to evaluate its therapeutic effects of MgO in Japanese CC patients. Methods We conducted a randomized, double-blind placebo-controlled study. Thirty-four female patients with mild to moderate constipation were randomly assigned to either placebo (n = 17) or MgO group (n = 17) 0.5 g × 3/day for 28 days. Primary endpoint was overall improvement over the 4-week study period. Secondary endpoints were changes from baseline in spontaneous bowel movement (SBM), response rates of complete spontaneous bowel movement (CSBM), stool form, colonic transit time (CTT), abdominal symptom, and quality of life. Results One patient failed to complete the medication regimen and was omitted from analysis: data from 16 placebo and 17 MgO patients were analyzed. The primary endpoint was met by 25.0% of placebo vs 70.6% of MgO group (P = 0.015). MgO significantly improved SBM changes compared to placebo (P = 0.002). However, MgO did not significantly improved response rates of CSBM compared to placebo (P = 0.76). In addition, MgO significantly improved Bristol stool form scale changes (P < 0.001) and significantly improved CTT compared to the placebo group (P < 0.001). MgO significantly improved the Japanese version of the patient assessment of constipation quality of life (P = 0.003). Conclusion Our placebo-controlled study demonstrated that MgO was effective treatment for improving defecation status and shortened CTT in Japanese CC patients with mild to moderate symptoms.
Optical anisotropy of GaNAs grown on GaAs(0 0 1)substrate
Takahiro Mori,Takashi Hanada,Toshiharu Morimura,Meoung-Whan Cho,Takafumi Yao 한국물리학회 2004 Current Applied Physics Vol.4 No.6
In this paper GaNxAs1. x surfaces during growth are observed using reectance dierence or reectance anisotropy spectroscopy(RDS or RAS). The epi-layer was grown by solid-source molecular beam epitaxy (MBE) system with a RF nitrogen prasma source.RD spectra showed broader structure and reduced amplitude compared to those of GaAs surfaces; GaAs(2×4)-like features werestill observed with weak and blue-shifted peaks. In the low growth temperature region, an extra structure was also observed around 3.02 eV. We proposed that GaNxAs1-x surface can be classied into three types of the surface.
Isolation and Mapping of 62 New RFLP Markers on Human Chromosome Ⅱ
Tokino, Takashi,Takahashi, Ei-ichi,Mori, Masaki,Tanigami, Akira,Glaser, Tom,Park, J.W.,Jones, Carol,Hori, Tada-aki,Nakamura, Yusuke 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-
To obtain new RFLP markers on human chromosome 11 for a high-resolution map, we constructed a cosmid library from a Chinese hamster × human somatic hybrid cell line that retains only human chromosome 11 in a Chinese hamster genomic background. A total of 3,500 cosmids were isolated by colony hybridization with labeled human genomic DNA was prepared from 130 of these cosmid clones and examined for RFLP. In 62 of them, polymorphism was detected with one or more enzymes; four RFLPs were VNTR systems. All polymorphism were assigned to on one of 22 intervals obtained by mapping on a deletion panel of 15 somatic hybrid cell lines containing parts of chromosome 11; 11 clones were finely mapped by in situ hybridization. Although RFLP makers were scattered on the whole chromosome, they were found predominantly in the regions of R-banding. These DNA markers will contribute to fine mapping of genes causing inherited disorders and tumor-suppressor genes that reside on chromosome 11. Furthermore, as one-third of the cosmid clones revealed a band or bands in Chinese hamster DNA, indicating sequence conservation, this subset of clones may be useful for isolating biologically important genes on chromosome 11.
Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile
Nobuaki Mori,Takashi Takahashi 대한진단검사의학회 2018 Annals of Laboratory Medicine Vol.38 No.3
Clostridium difficile is a major causative agent of antibiotic-associated diarrhea and has become the most common pathogen of healthcare-associated infection worldwide. The pathogenesis of C. difficile infection (CDI) is mediated by many factors such as colonization involving attachment to host intestinal epithelial cells, sporulation, germination, and toxin production. Bacterial cell surface components are crucial for the interaction between the bacterium and host cells. C. difficile has two distinct surface layer proteins (SLPs): a conserved high-molecular-weight SLP and a highly variable low-molecular-weight SLP. Recent studies have shown that C. difficile SLPs play roles not only in growth and survival, but also in adhesion to host epithelial cells and induction of cytokine production. Sequence typing of the variable region of the slpA gene, which encodes SLPs, is one of the methods currently used for typing C. difficile. SLPs have received much attention in recent years as vaccine candidates and new therapeutic agents in the treatment of C. difficile-associated diseases. Gaining mechanistic insights into the molecular functions of C. difficile SLPs will help advance our understanding of CDI pathogenesis and the development of vaccines and new therapeutic approaches. In this review, we summarize the characteristics and immunological roles of SLPs in C. difficile.
( Yuki Mori ),( Fumihiko Iwamoto ),( Yasuaki Ishida ),( Toru Kuno ),( Shoji Kobayashi ),( Takashi Yoshida ),( Tatsuya Yamaguchi ),( Tadashi Sato ),( Makoto Sudo ),( Daisuke Ichikawa ),( Nobuyuki Enomo 대한장연구학회 2020 Intestinal Research Vol.18 No.4
Behçet’s disease (BD) is a multisystem inflammatory disease of unknown origin. Rarely, BD occurs together with myelodysplastic syndrome (MDS). Interestingly, it is speculated that these are not simple coexistence but that the etiology of intestinal BD is at least partly derived from MDS itself. Furthermore, there is a relationship between MDS in patients with intestinal BD and trisomy 8. Immunosuppressive agents alone are insufficient to control MDS-associated BD, and many of these patients die of infection or hemorrhage. Surgery is considered for intestinal BD patients who are unresponsive to medical treatment or those with bowel complications such as perforation or persistent bleeding. We report a case of intestinal BD associated with MDS and trisomy 8. The patient was unresponsive to oral steroids and immunosuppressive treatment; the patient improved by surgical repair of a bowel perforation. Five years after the surgery, the patient is free of recurrence and not on medication. Our experience suggests that surgery may provide an effective therapeutic option for the treatment of MDS-related BD. (Intest Res 2020;18:469-475)