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Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Tran Thi Thu Trang,Yoon Ho Bae,NGUYENVAN THU,Nguyen The Tung,Tran Manh Hung,우미희,최재수,민병선 한국생약학회 2012 Natural Product Sciences Vol.18 No.2
Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7'-(3',4'-dimethoxyphenyl)-8,8'-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7′-(3′,4′-methylenedioxyphenyl)-8,8′-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-Δ8′-7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (5), and (+)-erythro-(7S,8R)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.
Isolation of Compounds from Cimicifugae Rhizoma and their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Sang Won Kim,Ji Eun Park,Tran Manh Hung,민병선 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Five known compounds, cimigenol (1), 25-O-acetylcimigenol (2), cimigenol 3-O-b-D-xylopyranoside (3), ferulic acid methyl ester (4), and visnagin (5), were isolated from Cimicifugae Rhizoma (Ranunculaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 5 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro. Among them, compounds 4 and 5 showed moderate inhibitory activity against HL-60 cancer cell lines with IC50 values of 24.8 and 18.1 ?M, respectively.
Cholinesterase Inhibitors from Cleistocalyx operculatus Buds
민병선,TODAO CUONG,이주상,신범수,우미희,Tran Manh Hung 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10
Five flavonoids, myricetin-3'-methylether 3-O-β-D-galactopyranoside (1), myricetin-3',5'-dimethylether 3-O-β-D-galactopyranoside (2), quercetin (3), kaempferol (4), and tamarixetin (5) were isolated from the buds of Cleistocalyx operculatus (Myrtaceae). The chemical structures of these compounds were determined on the basis of spectroscopic analyses, including 2D NMR. Their anti-Alzheimer effects were evaluated via acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activity assays. All five compounds 1-5 showed potential inhibitory activities against AChE with IC50 values of 19.9, 37.8, 25.9, 30.4 and 22.3 μM, respectively, while compounds 1, 3, 4 and 5 also possessed BChE inhibitory activity with IC50 values of 152.5, 177.8, 62.5, and 160.6 μM, respectively.
신우성,TODAO CUONG,이정형,민병선,전병화,임현교,유승우 대한약리학회 2011 The Korean Journal of Physiology & Pharmacology Vol.15 No.3
Caesalpinia sappan (C. sappan) is a medicinal plant used for promoting blood circulation and removing stasis. During a screening procedure on medicinal plants, the ethylacetate extract of the lignum of C. sappan (CLE) showed inhibitory activity on arginase which has recently been reported as a novel therapeutic target for the treatment of cardiovascular diseases such as atherosclerosis. CLE inhibited arginase II activity prepared from kidney lysate in a dose-dependent manner. In HUVECs, inhibition of arginase activity by CLE reciprocally increased NOx production through enhancement of eNOS dimer stability without any significant changes in the protein levels of eNOS and arginase II expression. Furthermore, CLE-dependent arginase inhibition resulted in increase of NO generation and decrease of superoxide production on endothelium of isolated mice aorta. These results indicate that CLE augments NO production on endothelium through inhibition of arginase activity, and may imply their usefulness for the treatment of cardiovascular diseases associated with endothelial dysfunction.
Cholinesterase inhibitors from the roots of Harpagophytum procumbens
배윤호,TODAO CUONG,Tran Manh Hung,김정아,우미희,변정수,최재수,민병선 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.9
Inhibition of cholinesterase has been proposedto be a therapeutic target for the treatment of Alzheimer’sdiseases. In our preliminary screening study on the acetylcholinesterase(AChE) inhibitory activity, an ethyl acetatesoluble fraction of the roots of Harpagophytumprocumbens (Pedaliaceae) was found to inhibit AChEactivity at the concentration of 100 lg/mL. Ten compounds(1–10) were isolated from the active fraction andevaluated for their inhibitory effect on AChE and butyrylcholinesterase(BChE). Among the isolates, verbascosides(5, 6, and 8) containing a caffeoyl and a 3,4-dihydroxyphenethyl groups in their structures, showedeffective AChE inhibitory activity and also possessedBChE inhibitory activity. The findings suggest that verbascosidederivatives may be partially related to the anti-Alzheimer effect of this medicinal plant.
민병선,TODAO CUONG 한국생약학회 2013 Natural Product Sciences Vol.19 No.3
Thirteen phenolic compounds, 1,4-dimethoxybenzene (1), 3,4-dihydroxybenzaldehyde (2), (2E)-3-(4-hydroxy-3,5-dimethoxyphenyl)acrylaldehyde (3), 3,7-dihydroxy-4H-chromen-4-one (4), 2,3-dihydroxy-1-(3,4-dihydroxyphenyl)propan-1-one (5), 4-hydroxy-3-methoxybenzoic acid (6), 4-hydroxy-3,5-dimethoxybenzoic acid (7), methyl 3,4-dihydroxybenzoate (8), 4-hydroxy-3,5-dimethoxybenzaldehyde (9), 3,4-dihydroxybenzoic acid (10), 3-hydroxy-1-(4-hydroxy-3-methoxyphenyl)propan-1-one (11), 2,4,6-trihydroxybenzaldehyde (12) and benzene-1,2,4-triol (13) were isolated from the heartwood of Caesalpinia sappan. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW264.7 cells. Among them, compounds 3 and 8 showed strong inhibitory activities toward the LPS-induced NO production in macrophage RAW264.7 cells with IC50 values of 14.5 and 21.5 mM, respectively.
Compounds from the aerial parts of Piper bavinum and their anti-cholinesterase activity
Hoang Viet Dung,TODAO CUONG,Nguyen Minh Chinh,Do Quyen,김정아,변정수,우미희,Jae Sui Choi,민병선 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
A new alkenylphenol, bavinol A (1), togetherwith six known compounds (2–7) were isolated from theaerial parts of Piper bavinum (Piperaceae). The chemicalstructures of these compounds were determined by spectroscopicanalyses including 2D NMR spectroscopy. Theanti-Alzheimer effects of compounds 1–7 were evaluatedfrom acetylcholinesterase (AChE) and butyrylcholinesterase(BChE) inhibitory activity assays. Bavinol A (1),ampelopsin (3), and violanthin (4) exhibited AChE inhibitoryactivities with IC50 values of 29.80, 59.47 and79.80 lM. Compound 1 also showed the most potentBChE inhibitory activity with an IC50 value of 19.25 lM.
Yoon Ho Bae,TODAO CUONG,Jae Hyun Lee,우미희,최재수,민병선 한국생약학회 2012 Natural Product Sciences Vol.18 No.2
In order to facilitate the quality control of the fruits of Crataegus pinnatifida, a simple, accurate and reliable HPLC method was developed for the simultaneous determination of the three bioactive compounds:chlorogenic acid (1), rutin (2), and hyperin (3), which were selected as the chemical markers of C. pinnatifida. Separation was achieved on an Agilent Eclipse XDB-C18 column with a gradient solvent system of 0.1%trifluoroacetic acid aqueous-acetonitrile at a flow-rate of 1.0 mL/min and detected at 254nm. All three calibration curves showed good linearity (R2 > 0.998). The recoveries of three marker compounds were in the range of 94.87~111.52 %. The contents of chlorogenic acid (1), rutin (2), and hyperin (3) of the fruits of C. pinnatifida collected from 23 district markets in Korea, Japan, and China were 0.16~0.65 mg/g, 0.07~1.24 mg/g, and 0.03~0.62 mg/g, respectively. The results demonstrated that this method is simple and reliable for the quality control of the fruits of C. pinnatifida.