THE EFFECT OF A SYNTHETIC ANALOGUE OF PYROPHOSPHATE ON CALCIUM, MAGNESIUM AND PHOSPHORUS HOMEOSTASIS IN SHEEP

Matsui, T.,Kawabata, T.,Harumoto, T.,Yano, H. Asian Australasian Association of Animal Productio 1992 Animal Bioscience Vol.5 No.2

Three female sheep were daily administered a pyrophosphate analogue, disodium 1-hydroxyethylidene-1, 1-bisphosphonate (HEBP) at the level of 4 mg/kg body weight. HEBP largely suppressed bone resorption, which was indicated by the reduction in plasma free hydroxyproline concentration and in calcium mobilization rate during the intravenous infusion of disodium ethylenediaminetetraacetate (EDTA). Contrary to the suppression of bone resorption, plasma total-calcium, magnesium and phosphorus concentrations were not changed by HEBP administration. These results suggest that bone mineral crystals play a meaningless role on calcium, magnesium and phosphorus homeostasis in ruminants if they are fed adequate amounts of these minerals. Plasma magnesium and phosphorus concentrations were not significantly changed after feeding. However, plasma total-calcium was decreased after feeding in both periods and the reduction seemed to be remarkable in the HEBP-treated period. Infusion of EDTA more remarkably reduced plasma ionized calcium concentration in the HEBP-treated that in the untreated period and the recovery of ionized calcium was retarded by HEBP administration. These results suggest that calcium release from bone is necessary for maintenance of plasma calcium when animals rapidly lose calcium.

USE OF A SOLUBLE GLASS BOLUS FOR SUPPLEMENTATION OF COPPER AND SELENIUM TO COWS

Matsui, T.,Inui, T.,Harumoto, T.,Yano, H.,Yoden, Y.,Igarashi, R. Asian Australasian Association of Animal Productio 1989 Animal Bioscience Vol.2 No.3

A NOTE ON THE REMOVAL OF PHYTATE IN SOYBEAN MEAL USING Aspergillus usami

Ilyas, A.,Hirabayasi, M.,Matsui, T.,Yano, H.,Yano, F.,Kikishima, T.,Takebe, M.,Hayakawa, K. Asian Australasian Association of Animal Productio 1995 Animal Bioscience Vol.8 No.2

Soybean meal was fermented by Aspergillus usami in order to reduce phytate content. Aflatoxin B1 was not detected in the fermented soybean meal. The contents of crude protein, crude fiber, ether extract and crude ash were slightly increased following fermentation with a concomitant reduction in nitrogen free extract. Though the fermentation partly degraded proteins in the soybean meal, there was small difference in amino acid composition between the soybean meal and the fermented soybean meal. The results showed that the fermentation did not affect nutritional value of protein in soybean meal. Approximately 55% of phosphorus extracted by trichloroacetic acid was inositol hexaphosphate (phytate) in the soybean meal. The content of inositol tetra to hexaphosphates was not detected in the fermented soybean meal. These results indicated that the fermentation almost completely eliminated phytate in soybean meal. Phytase activity was not detected in the unfermented soybean meal. However, the enzyme activity in the fermented soybean meal was 167.7 U/g. When the fermented soybean meal in supplemented in formula feeds, phytase in the fermented soybean meal might partly degrade the phytate in other ingredients in the digestive tract. The fermented soybean meal is possibly used as a phytate-free protein source of feed, which contains high available phosphorus.

An alternative spliced mouse presenilin-2 mRNA encodes a novel γ-secretase inhibitor

Suzuki, Y.,Ohta, K.,Itoh, M.,Sakoh-Sumitomo, Y.,Mitsuda, T.,Ueda, M.,Hayakawa-Yano, Y.,Li, S.,Hida, Y.,Inuzuka, T.,Jung, Y.K.,Nakagawa, T. North-Holland Pub ; Elsevier Science Ltd 2009 FEBS letters Vol.583 No.9

The γ-secretase, composed of presenilin-1 (PS1) or presenilin-2 (PS2), nicastrin (NCT), anterior pharynx-defective phenotype 1 (APH-1), and PEN-2, is critical for the development of Alzheimer's disease (AD). PSs are autoproteolytically cleaved, producing an N-terminal fragment (NTF) and a hydrophilic loop domain-containing C-terminal fragment. However, the role of the loop domain in the γ-secretase complex assembly remains unknown. Here, we report a novel PS2 isoform generated by alternative splicing, named PS2β, which is composed of an NTF with a hydrophilic loop domain. PS2β disturbed the interaction between NCT and APH-1, resulting in the inhibition of amyloid-β production. We concluded that PS2β may inhibit γ-secretase activity by affecting the γ-secretase complex assembly. Structured summary: MINT-7025654: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with PEN2 (uniprotkb:Q9NZ42), PS2 beta (uniprotkb:Q61144-2) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007) MINT-7025631: APH1 (uniprotkb:Q96BI3) physically interacts (MI:0218) with NCT (uniprotkb:Q92542), PEN2 (uniprotkb:Q9NZ42) and PS1 (uniprotkb:P49769) by anti tag coimmunoprecipitation (MI:0007)

Magnetic Properties of Fe-doped NiO Nanoparticles

A. Kurokawa,N. Sakai, L. Zhu,H. Takeuchi,S. Yano,T. Yanoh,K. Onuma,T. Kondo,K. Miike,T. Miyasaka,Y. Ichiyanagi 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3

Ni1−xFexO (x = 0, 0.05, 0.1) nanoparticles with several nanometers encapsulated with amorphousSiO2 were prepared by our novel preparation method. A NiO single phase structure was confirmedusing the X-ray diffraction measurements. It is considered that Ni ions are replaced by Fe ionsbecause it is observed that the lattice constant decreases. The temperature dependence behaviorof the magnetization revealed that the blocking temperature, TB, shifted from 17 to 57 K as theamount of Fe ions increased, and that below TB, ferromagnetic behaviors were exhibited. Thecoercive force, HC, increased from 0.8 to 1.5 kOe as the amount of Fe ions increased.

Phthalate Levels in Beverages in Japan and Korea

Yano, K.,Hirosawa, N.,Sakamoto, Y.,Katayama, H.,Moriguchi, T.,Joung, K. E.,Sheen, Y. Y.,Asaoka, K. 梨花女子大學校 藥學硏究所 2002 藥學硏究論文集 Vol.- No.11

Considerable number of endocrine disruptors (7 compounds) are known today (Japan Environmental Agency, 1998). Among them, phthalates are considered to be in most abundance in our environment. The production of phthalates in Japan was 474 thousand tones in 1998 (Kasozai Kogyo Kai, 1999), around 56% of which was di(2-ethylhexyl)phthalate (DEHP) uesd mainly as plasticizers in polyvinyl chloride (PVC) production, is widely used in PVC, nitrocellulose polyvinyl acetate, painting inks, adhesives and lacquers. PVC contains up to 40% phthalates by weight wuthout covalently binding to other ingredients in the PVC(Needham et al., 2000). Thus, significant amounts of DEHP and DBP are easily released from the plastics into the environment during production, used and disposal, resulting in the pollution of food air, water, soil and homes.

FIELD OBSERVATIONS ON SPRING-NEAP TIDE VARIATION OF TIDAL CURRENT AND DENSITY STRATIFICATION IN THE ARIAKE BAY

YANO S,HASHIMOTO Y,KOMATSU T 한국수자원학회 2005 한국수자원학회 학술대회 Vol.2005 No.1

Cooperative catalysis of a trinuclear ruthenium(II) complex in transfer hydrogenation of ketones by formic acid

Yano, Y.,Kojima, T.,Fukuzumi, S. Elsevier Sequoia [etc.] 2011 Inorganica chimica acta Vol.374 No.1

A novel TPA derivative (TPA=tris(2-pyridylmethyl)amine) having two 1,10-phenanthroline (phen) moieties via amide linkage was synthesized and this ligand reacted with [Ru(hmb)Cl<SUB>2</SUB>]<SUB>2</SUB> (hmb: hexamethylbenzene) to give a trinuclear Ru(II) complex, [RuCl(TPA-{phenRuCl(hmb)}<SUB>2</SUB>-H<SUP>+</SUP>)](PF<SUB>6</SUB>)<SUB>2</SUB> (1-Cl), in a moderate yield. The complex involves a deprotonated and oxygen-coordinated amide linkage, which exhibits reversible protonation-deprotonation equilibrium. The chlorido complex was converted to be an aqua complex, [Ru(H<SUB>2</SUB>O)(TPA-{phenRu(H<SUB>2</SUB>O)<SUB>2</SUB>(hmb)}<SUB>2</SUB>-H<SUP>+</SUP>)](SO<SUB>4</SUB>)<SUB>5/2</SUB> (1-H<SUB>2</SUB>O), by the reaction of 1-Cl with Ag<SUB>2</SUB>SO<SUB>4</SUB> in H<SUB>2</SUB>O. Transfer hydrogenation of ketones was examined by using 1-Cl as a catalyst and HCOONa as a hydride source in H<SUB>2</SUB>O/CH<SUB>3</SUB>OH (1:1 v/v) at 50<SUP>o</SUP>C under Ar. The time-course of the transfer hydrogenation of cyclohexanone to give cyclohexanol revealed that 1-Cl showed a cooperative effect on the catalytic reactivity as compared with that of mononuclear [RuCl(hmb)(phen)] (3-Cl) and [RuCl((1-Naph)<SUB>2</SUB>-TPA)]PF<SUB>6</SUB> in H<SUB>2</SUB>O/CH<SUB>3</SUB>OH (1:2 v/v) under the same conditions. The detailed kinetic study has revealed that the catalytic transfer hydrogenation proceeds via the formato complex, which interacts with a substrate rather than via the hydrido complex. The two Ru centers placed at close proximity in 1-H<SUB>2</SUB>O enhanced the interaction of the formato complex with a substrate, resulting in an increase in the catalytic reactivity as compared with the mononuclear complex.

Reduction of Nitrogen and Phosphorus from Livestock Waste A Major Priority for Intensive Animal Production - Review -

Yano, F.,Nakajima, T.,Matsuda, M. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.4

In current animal production in Japan, a large surplus of nitrogen and phosphorus is given to animals as their feed which are mostly imported from outside of our own country. Today, an excess of nitrogen and phosphorus from animal manure has been spread out of the area of animal production and the surroundings. These components have become the major reason for eutrophication of ground, surface and inland water. Nutritional studies for the reduction of nitrogen and phosphorus from animal waste has been done by many researchers. The reduction of excess protein in animal feed and the supplementation of deficient essential amino acids to feed have a possibility to increase the biological value of feed and to reduce nitrogen excretion, especially, via urine. The use of phytase activity to degrade phytate and to release utilizable inorganic phosphorus make it possible to cut an excess supply of feed additive inorganic phosphorus and to reduce phosphorus excretion from animal waste.

Changes of Serum Mineral Concentrations in Horses during Exercise

Inoue, Y.,Osawa, T.,Matsui, A.,Asai, Y.,Murakami, Y.,Matsui, T.,Yano, H. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.4

We investigated the exercise-induced changes in the serum concentration of several minerals in horses. Four welltrained Thoroughbred horses performed exercise for 5 d. The blood hemoglobin (Hb) concentration increased during exercise, recovered to the pre-exercise level immediately after cooling down and did not change again up till the end of experiment. The changes in serum zinc (Zn) and copper (Cu) concentrations were similar to those of blood Hb during the experiment. The serum magnesium (Mg), inorganic phosphorus (Pi) and iron (Fe) concentrations also increased during exercise. Though the serum Pi concentration recovered to the pre-exercise level immediately after the cooling down, it decreased further before the end of the experiment. The serum Mg concentration was lower immediately after cooling down than its pre-exercise level but gradually recovered from the temporal reduction. The recovery of the serum Fe concentration was delayed compared to that of other minerals and recovered 2 h after cooling down. The serum calcium (Ca) concentration did not change during exercise but rapidly decreased after cooling down. As a result, it was lower immediately after cooling down than its pre-exercise level. It recovered, however, to the pre-exercise level 2 h after cooling down. The temporal increase in the serum concentrations of all minerals except Ca is considered to result from hemoconcentration induced by exercise and the stable concentration of the serum Ca during exercise is possibly due to its strict regulation of homeostasis. These results indicate that the serum concentration of each mineral responds differently to exercise in horses, which may be due to the difference in metabolism among these minerals.