Association of urinary phthalate metabolites and phenolics with adipokines and insulin resistance related markers among women of reproductive age

Lee, Inae,Kim, Sunmi,Park, Suhyeon,Mok, Sori,Jeong, Yunsun,Moon, Hyo-Bang,Lee, Jangwoo,Kim, Sungkyoon,Kim, Hai-Joong,Choi, Gyuyeon,Choi, Sooran,Kim, Su Young,Lee, Aram,Park, Jeongim,Choi, Kyungho Elsevier BV 2019 Science of the Total Environment Vol.688 No.-

<P><B>Abstract</B></P> <P>Chemicals such as phthalates and phenolics have been associated with metabolic markers in humans. However, most studies have only looked at a limited number of chemicals, and little is known about their potential effects on adipokines in humans. In the present study, the associations between dozens of urinary chemicals, including phthalate metabolites and phenolics, and markers related to insulin resistance as well as major adipokines, were assessed among the women of reproductive age (<I>n</I> = 459, between 20 and 48 years of age) recruited from major cities in Korea between 2015 and 2016. Adipokines such as adiponectin and leptin, and insulin resistance related markers such as glucose and insulin, were analyzed in serum. Associations between urinary chemicals and the adipokines or insulin resistance related markers were assessed in two steps. First, ordinary least squares (OLS) regression was used to assess the association of each urinary chemical with the adipokines or insulin resistance related markers (single-pollutant model). Second, several chemicals were selected using elastic net regression and were subsequently analyzed with OLS regression model (multi-pollutant model), considering simultaneous exposure to multiple chemicals. In both single- and multi-pollutant models, several urinary chemicals consistently showed significant associations with adipokines or the insulin resistance related markers. The sum of di-(2-ethylhexyl) phthalate metabolites (ΣDEHPm) and ethyl paraben (EtP) were associated with increased serum adiponectin levels. Urinary ΣDEHPm levels also showed positive associations with fasting glucose. Moreover, urinary mono-methyl phthalate (MMP), mono-isobutyl phthalate (MiBP), and bisphenol S (BPS) levels showed positive associations with the homeostasis model assessment for insulin resistance (HOMA-IR). Interestingly, urinary propyl paraben (PrP) levels showed a negative association with HOMA-IR, in both models. Our observations show that among many consumer chemicals, phthalates may affect serum adipokines, and thus glucose, and insulin resistance in adult females. Further confirmation is warranted in other populations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Urinary chemicals and metabolism related markers were measured in women of reproductive age. </LI> <LI> Multiple chemicals were considered in statistical models for adipokines and insulin resistance. </LI> <LI> Sum of DEHP metabolites and EtP were positively associated with serum adiponectin levels. </LI> <LI> Sum of DEHP metabolites was significantly associated with increased fasting glucose. </LI> <LI> MiBP was significantly associated with for increased HOMA-IR. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

The impact of muscle loss on outcomes of cirrhotic patients in medical intensive care unit

( Sunmi Ju ),( Sun Mi Choi ),( Young Sik Park ),( Chang Hoon Lee ),( Sang Min Lee ),( Jae Joon Yim ),( Chul Gyu Yoo ),( Sung Koo Han ),( Jinwoo Lee ) 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-

Objective: To assess the impact of muscle loss on clinical outcomes of cirrhotic patients admitted to the medical ICU. Methods: Cirrhotic patients with at least two or more recent CT scans before admission to the MICU from 2006 to 2015 at Seoul National University Hospital were included for analysis. Muscle cross-sectional area at the level of the third lumbar vertebrae was quantified using the Osirix software. The rate of muscle mass change and skeletal muscle index were also calculated. We used multivariable Cox proportional hazard regression to evaluate the association between muscle loss and ICU/in-hospital mortality. Results: Among 125 patients, 113 patients (90.4%) were classified as sarcopenia. The mean BMI was 22.6 ± 3.9 kg/m2. Thirty-nine patients (31.2%) were within the normal range of muscle mass change while 86 patients (68.8%) had accelerated decline of muscle mass before admission to the MICU. Patients with accelerated muscle loss showed high ICU mortality (59.3%) and in-hospital mortality (77.9%). By multivariate Cox analysis, ICU mortality was associated independently with chronic kidney disease, Acute Physiology and Chronic Health Evaluation (APACHE) II score, Model for End-Stage Liver Disease (MELD) score, whole body muscle index, and accelerated muscle loss. And in-hospital mortality was associated malignancy, APACHE II score, MELD score and accelerated muscle loss. Conclusion: Accelerated muscle loss is correlated with increased ICU mortality and in-hospital mortality in critically ill cirrhotic patients.

New Approach Way Using Substituent Group at Core Chromophore for Solution Process Blue Emitter.

Lee, Sunmi,Kim, Seungho,Lee, Jaehyun,Kim, Beomjin,Park, Jongwook American Scientific Publishers 2015 Journal of Nanoscience and Nanotechnology Vol.15 No.2

<P>Comparing the conventional vapor desposition process for OLEDs, the solution process using small molecules has merits of low production cost because of many reasons. For the solution process blue flourescent material, tertiary butyl (T) and anthracene (A) were first introduced as substituents to TAT core part, 2-tert-butyl-9,10-bis(3',5'-diphenylbiphenyl-4'-yl)anthracene (T-TAT) and 2-(9-anthracenyl)-9,10-bis(3',5'-diphenylbiphenyl-4'-yl)anthracene (A-TAT). All three materials indicated typical absorption band of anthracene in the range of 350 to 400 nm. T-TAT exhibited similar optical properties to TAT, but A-TAT has longer absorption and PL emission compared to other two compounds. In case of spin-coated film, A-TAT exhibited absorption maximum value of 408 nm and photoluminescence maximum value of 469 nm. T-TAT and A-TAT can be applicable to solution process as a blue fluorescence material.</P>

Body Mass Index as a Predictor of Acute Kidney Injury in Critically Ill Patients: A Retrospective Single-Center Study

( Sunmi Ju ),( Tae Won Lee ),( Jung-wan Yoo ),( Seung Jun Lee ),( Yu Ji Cho ),( Yi Yeong Jeong ),( Jong Deog Lee ),( Ju-young Kim ),( Gi Dong Lee ),( Ho Cheol Kim ) 대한결핵 및 호흡기학회 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4

Background: The aim of this study was to examine the influence of body mass index (BMI) on the development of acute kidney injury (AKI) in critically ill patients in intensive care unit (ICU). Methods: Data of patients admitted to medical ICU from December 2011 to May 2014 were retrospectively analyzed. Patients were classified into three groups according to their BMI: underweight (<18.5 kg/m²), normal (18.5-24.9 kg/m²), and overweight (≥25 kg/m²). The incidence of AKI was compared among these groups and factors associated with the development of AKI were analyzed. AKI was defined according to the Risk, Injury, Failure, Loss of kidney function, and End-stage (RIFLE) kidney disease criteria. Results: A total of 468 patients were analyzed. Their mean BMI was 21.5±3.9 kg/m², including 102 (21.8%) underweight, 286 (61.1%) normal-weight, and 80 (17.1%) overweight patients. Overall, AKI occurred in 82 (17.5%) patients. The overweight group had significantly (p<0.001) higher incidence of AKI (36.3%) than the underweight (9.8%) or normal group (15.0%). In addition, BMI was significantly higher in patients with AKI than that in those without AKI (23.4±4.2 vs. 21.1±3.7, p<0.001). Multivariate analysis showed that BMI was significantly associated with the development of AKI (odds ratio, 1.893; 95% confidence interval, 1.224-2.927). Conclusion: BMI may be associated with the development of AKI in critically ill patients.

Filtration-Free Recyclable Catalytic Asymmetric Dihydroxylation Using a Ligand Immobilized on Magnetic Mesocellular Mesoporous Silica

Lee, Daewon,Lee, Jinwoo,Lee, Honggeun,Jin, Sunmi,Hyeon, Taeghwan,Kim, B. ,Moon WILEY-VCH Verlag 2006 Advanced synthesis & catalysis Vol.348 No.1

<P>A new magnetic mesocellular mesoporous silica support featuring a 3D open-pore structure has been developed for highly efficient, filtration-free recycling of chiral ligands for catalytic asymmetric dihydroxylation. Reactions using the ligand immobilized on this magnetic silica system exhibited almost the same reactivity and enantioselectivity as those obtained in the homogeneous reaction. Magnetically recovered ligand could be recycled eight times with good to excellent conservation of reaction rates and enantioselectivities.</P> <B>Graphic Abstract</B> <P> <img src='wiley_img/16154150-2006-348-1-2-ADSC200505354-content.gif' alt='wiley_img/16154150-2006-348-1-2-ADSC200505354-content'> </P>

Slide Session : OS-105 ; Critical Care : Body Mass Index as a Predictor of Acute Kidney Injury in Critically 3 Patients

( Sunmi Ju ),( Tae Won Lee ),( Wan Chul Kim ),( Seung Hun Lee ),( Seung Jun Lee ),( Yu Ji Cho ),( Yi Yeong Jeong ),( Jong Deog Lee ),( Young Sil Hwang ),( Ho Cheol Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Background: Some studies suggest the existence of an “obesity paradox” in the intensive care unit (ICU). However, reports relating renal function and body mass index (BMI) are limited and controversial. This study aimed to examine the infiuence of BMI on acute kidney injury (AKI) in critically ill patients. Methods: We retrospectively analyzed the prospectively collected data from patients admitted to the ICU at Gyeongsang National University Hospital in Korea from December 2011 to May 2014. Patients were stratified to three classes according to their BMI (“underweight” <18.5 kg/m2, “normal” 18.5-24.9 kg/m2, and “overweight” =25 kg/m2). The occurrence of AKI was defined by Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease criteria, and the impact of BMI on AKI was analyzed. Results: A total 468 patients in the ICU were analyzed, and AKI occurred in 82 (17.5%) patients. The mean BMI was 21.5 ± 4.0 kg/m2; 102 patients (21.8%) were classified as “underweight,” 286 patients (61.1%) were classified as “normal,” and 80 patients (17.1%) were classified as “overweight.” The adjusted analysis showed significantly higher risk of AKI in the overweight group compared to the underweight group (odds ratio, 3.95; 95% confidence interval, 1.74-9). Additional risk factors for AKI in critically ill patients included comorbid liver cirrhosis, septic shock, and acute respiratory distress syndrome. Conclusions: BMI is a possible predictor of AKI in ICU patients, as this study indicated that AKI occurs more frequently in overweight patients than in underweight patients.

Glutathione peroxidase-1 regulates ASK1-dependent apoptosis via interaction with TRAF2 in RIPK3-negative cancer cells

Lee Sunmi,Lee Eun-Kyung,Kang Dong Hoon,Lee Jiyoung,Hong Soo Hyun,Jeong Woojin,Kang Sang Won 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Glutathione peroxidase (GPx) is a selenocysteine-containing peroxidase enzyme that defends mammalian cells against oxidative stress, but the role of GPx signaling is poorly characterized. Here, we show that GPx type 1 (GPx1) plays a key regulatory role in the apoptosis signaling pathway. The absence of GPx1 augmented TNF-α-induced apoptosis in various RIPK3-negative cancer cells by markedly elevating the level of cytosolic H 2 O 2 , which is derived from mitochondria. At the molecular level, the absence of GPx1 led to the strengthened sequential activation of sustained JNK and caspase-8 expression. Two signaling mechanisms are involved in the GPx1-dependent regulation of the apoptosis pathway: (1) GPx1 regulates the level of cytosolic H 2 O 2 that oxidizes the redox protein thioredoxin 1, blocking ASK1 activation, and (2) GPx1 interacts with TRAF2 and interferes with the formation of the active ASK1 complex. Inducible knockdown of GPx1 expression impaired the tumorigenic growth of MDA-MB-231 cells (>70% reduction, P = 0.0034) implanted in mice by promoting apoptosis in vivo. Overall, this study reveals the apoptosis-related signaling function of a GPx family enzyme highly conserved in aerobic organisms.

Cloning metallothionein gene in Zacco platypus and its potential as an exposure biomarker against cadmium.

Lee, Sangwoo,Kim, Cheolmin,Kim, Jungkon,Kim, Woo-Keun,Shin, Hyun Suk,Lim, Eun-Suk,Lee, Jin Wuk,Kim, Sunmi,Kim, Ki-Tae,Lee, Sung-Kyu,Choi, Cheol Young,Choi, Kyungho D. Reidel Pub. Co ; Springer 2015 Environmental monitoring and assessment Vol.187 No.7

<P>Zacco platypus, pale chub, is an indigenous freshwater fish of East Asia including Korea and has many useful characteristics as indicator species for water pollution. While utility of Z. platypus as an experimental species has been recognized, genetic-level information is very limited and warrants extensive research. Metallothionein (MT) is widely used and well-known biomarker for heavy metal exposure in many experimental species. In the present study, we cloned MT in Z. platypus and evaluated its utility as a biomarker for metal exposure. For this purpose, we sequenced complete complementary DNA (cDNA) of MT in Z. platypus and carried out phylogenetic analysis with its sequences. The transcription-level responses of MT gene following the exposure to CdCl2 were also assessed to validate the utility of this gene as an exposure biomarker. Analysis of cDNA sequence of MT gene demonstrated high conformity with those of other fish. MT messenger RNA (mRNA) expression and enzymatic MT content significantly increased following CdCl2 exposure in a concentration-dependent manner. The level of CdCl2 that resulted in significant MT changes in Z. platypus was within the range that was reported from other fish. The MT gene of Z. platypus sequenced in the present study can be used as a useful biomarker for heavy metal exposure in the aquatic environment of Korea and other countries where this freshwater fish species represents the ecosystem.</P>

Unplanned Extubation in Patients with Mechanical Ventilation: Experience in the Medical Intensive Care Unit of a Single Tertiary Hospital

Lee, Tae Won,Hong, Jeong Woo,Yoo, Jung-Wan,Ju, Sunmi,Lee, Seung Hun,Lee, Seung Jun,Cho, Yu Ji,Jeong, Yi Yeong,Lee, Jong Deog,Kim, Ho Cheol The Korean Academy of Tuberculosis and Respiratory 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4

Background: Potentially harmful unplanned extubation (UE) may occur in patients on mechanical ventilation (MV) in an intensive care unit (ICU) setting. This study aimed to evaluate the clinical characteristics of UE and its impact on clinical outcomes in patients with MV in a medical ICU (MICU). Methods: We retrospectively evaluated MICU data prospectively collected between December 2011 and May 2014. Results: A total of 468 patients were admitted to the MICU, of whom 450 were on MV. Of the patients on MV, 30 (6.7%) experienced UE; 13 (43.3%) required reintubation after UE, whereas 17 (56.7%) did not require reintubation. Patients who required reintubation had a significantly longer MV duration and ICU stay than did those not requiring reintubation ($19.4{\pm}15.1days$ vs. $5.9{\pm}5.9days$ days and $18.1{\pm}14.2days$ vs. $7.1{\pm}6.5days$, respectively; p<0.05). In addition, mortality rate was significantly higher among patients requiring reintubation than among those not requiring reintubation (54.5% vs. 5.9%; p=0.007). These two groups of patients exhibited no significant differences, within 2 hours after UE, in the fraction of inspired oxygen, blood pressure, heart rate, respiratory rate, and pH. Conclusion: Although reintubation may not always be required in patients with UE, it is associated with a poor outcome after UE.

Body Mass Index as a Predictor of Acute Kidney Injury in Critically Ill Patients: A Retrospective Single-Center Study

Ju, Sunmi,Lee, Tae Won,Yoo, Jung-Wan,Lee, Seung Jun,Cho, Yu Ji,Jeong, Yi Yeong,Lee, Jong Deog,Kim, Ju-young,Lee, Gi Dong,Kim, Ho Cheol The Korean Academy of Tuberculosis and Respiratory 2018 Tuberculosis and Respiratory Diseases Vol.81 No.4

Background: The aim of this study was to examine the influence of body mass index (BMI) on the development of acute kidney injury (AKI) in critically ill patients in intensive care unit (ICU). Methods: Data of patients admitted to medical ICU from December 2011 to May 2014 were retrospectively analyzed. Patients were classified into three groups according to their BMI: underweight (< $18.5kg/m^2$), normal ($18.5-24.9kg/m^2$), and overweight (${\geq}25kg/m^2$). The incidence of AKI was compared among these groups and factors associated with the development of AKI were analyzed. AKI was defined according to the Risk, Injury, Failure, Loss of kidney function, and End-stage (RIFLE) kidney disease criteria. Results: A total of 468 patients were analyzed. Their mean BMI was $21.5{\pm}3.9kg/m^2$, including 102 (21.8%) underweight, 286 (61.1%) normal-weight, and 80 (17.1%) overweight patients. Overall, AKI occurred in 82 (17.5%) patients. The overweight group had significantly (p<0.001) higher incidence of AKI (36.3%) than the underweight (9.8%) or normal group (15.0%). In addition, BMI was significantly higher in patients with AKI than that in those without AKI ($23.4{\pm}4.2$ vs. $21.1{\pm}3.7$, p<0.001). Multivariate analysis showed that BMI was significantly associated with the development of AKI (odds ratio, 1.893; 95% confidence interval, 1.224-2.927). Conclusion: BMI may be associated with the development of AKI in critically ill patients.