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( Kyu Sik Jung ),( Jun Yong Park ),( Mi Na Kim ),( Hana Park ),( Yun Bin Lee ),( Joo Ho Lee ),( Yeonjung Ha ),( Beom Kyung Kim ),( Seung Up Kim ),( Sang Hoon Ahn ),( Do Young Kim ),( Hana Park ),( Kyu 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: The change of hepatic steatosis in non-alcoholic fatty liver disease (NAFLD) patients under regular follow up has not been widely investigated. We investigated the serial changes of hepatic steatosis assessed by controlled attenuation parameter (CAP) and the predictors for improvement of hepatic steatosis in NAFLD patients. Methods: Among 513 NAFLD patients diagnosed upon ultrasound and CAP > 250 dB/m at baseline, 304 patients underwent repeated CAP measurement at baseline and at follow up. The improvement of hepatic steatosis was defined as a >10% decline of CAP value from the baseline. Results: Mean age of 304 patients was 58.8 ± 11.4 years and 80.1% were male. The mean CAP value significantly decreased from baseline to follow up (292.3 dB/m to 277.1 dB/m, P<0.001). During the median follow up of 15.3 (9.5-20.3) months, 34.5% patients showed improvement of hepatic steatosis. In a univariate analysis, low body mass index (BMI), low weight, low liver stiffness value, low triglyceride level, and low ALT at follow up were predictors for improvement of hepatic steatosis. In multivariate analyses, low weight (P=0.004; hazard ratio [HR],0.965; confidence interval [CI], 0.941-0.988) and low ALT (P=0.004; HR,0.971;CI, 0.951-0.990) at follow up, or low BMI (P=0.006; HR,0.881; CI, 0.805-0.964) and low ALT (P=0.004; HR,0.971; CI, 0.951-0.990) at follow up were the independent predictors. In patients with weight reduction more than 10% (n=22), CAP value significantly decreased (from 288.0 dB/m to 228.9dB/m, P<0.001). Conclusions: Weight reduction, and ALT decrease were independent predictors for improvement of hepatic steatosis. Long term effect of weight reduction on improvement of hepatic steatosis and fibrosis should be investigated further.
Dkk-1 Promotes Angiogenesis through Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma
( Sang Hyun Seo ),( Hye Jung Park ),( Kyungjoo Cho ),( Hye Won Lee ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Seung Up Kim ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Dickkopf-1(DKK1), a negative regulator of the Wnt/ ß-catenin pathway, has been recently found to be up-regulated in hepatocellular carcinoma (HCC). However, the biological function of DKK1 in HCC has not yet been well documented. Our previous in vitro data suggest that DKK1 can enhance angiogenesis by endothelial cell, independent of the Wnt signaling pathway. This study aimed to investigate the tumorigenic potential and angiogenic role of DKK1 in mouse model. Methods: We assessed tumorigenic functions of DKK1 in Hep3B cells expressing endogenous DKK-1 and in DKK1-deficient Hep3B cells created using CRISPR/Cas9 technology. These edited cells were injected subcutaneously in immunosuppressed mice and tumor growth was followed for 6 weeks. With the evidence of tumorigenic potential in DKK1, transgenic mouse models expressing DKK-1 or luciferase were developed using hydrodynamic transfection. Transposons encoding an activated form of human H-RAS were mixed with transposons encoding either DKK1 or luciferase. All mice were monitored at least twice per week and sacrificed when moribund. Subcutaneous tumors and tumor-bearing livers were formalin fixed for hematoxylin- eosin and immunofluoroscence staining. Results: DKK1-deficient Hep3B xenografts exhibited significantly less growth compared to control Hep3B cells expressing DKK1. In addition, the forced expression of DKK1 with H-RAS through the hydrodynamic transfection formed many tumors in the liver, compared to luciferase liver. We investigated the expression of angiogenesis markers, including CD31, VEGFR2 and mesenchymal markers, including vimentin, fibronectin in the subcutaneous tumors and tumor-bearing livers. Quantity of angiogenic and mesenchymal cells were found to be reduced in the established DKK1 homozygous knockout mice (all P<0.05). Taken together, it was confirmed that the expression of CD31 (P<0.0001), VEGFR2 (P<0.0001), vimentin, and fibronectin (P<0.0001) were up-regulated with DKK1 in the mouse liver. Conclusions: Our findings indicate that DKK1 appears to facilitate angiogenesis, and the progression of HCC through inducing the EMT.
[PG-0011] A Sesame variety ‘Haniall’ with non-shattering capsule and early maturity
Sung-Up Kim(Sung-Up Kim ),Jeongeun Lee(Jeongeun Lee ),Eunyoung Oh(Eunyoung Oh ),Jung In Kim(Jung In Kim ),Sang Woo Kim(Sang Woo Kim ),Min Young Kim(Min Young Kim ),Eunsoo Lee(Eunsoo Lee ),Kwang-Soo Ch 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-
( Young Dae Kim ),( Dongbeom Song ),( Ji Hoe Heo ),( Beom Kyung Kim ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang-hyub Han ),( Kwang Joon Kim ),( Seung Up Kim ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Transient elastography (TE) assess the degree of liver fibrosis and steatosis. The degree of liver fibrosis was associated with the presence and burden of cerebral microbleeds in healthy, asymptomatic participants. We investigated the correlation between the degree of liver fibrosis, as assessed using TE, and the risk of stroke. Methods: Patients who were admitted due to the management of stroke and received TE examination from April 2013 to August 2014 and subjects who underwent a medical health check-up including TE during the same period were recruited. Significant fibrosis was defined as a liver stiffness (LS) value of ≥8 kPa and hepatic steatosis was defined as a controlled attenuation parameter (CAP) of ≥250 dB/m. Subjects with inappropriate TE results and alcoholic/ chronic viral liver diseases were excluded. Further, we conducted propensity score matching to reduce the potential effects of selection bias and confounding factors. Results: A total of 295 patients with stroke and 2,936 subjects with health check-up were analyzed. The mean age and the proportion of hypertension, diabetes, hypercholesterolemia, chronic kidney disease, and metabolic syndrome were significantly higher in patients with stroke than those of subjects with health check-up (all P<0.05). The mean LS value (5.6 kPa, vs. 4.2 kPa) and the proportion of significant fibrosis (9.2% vs. 2.7%) were significantly higher in patients with stroke than those of subjects with health check-up (all P<0.05), whereas the mean CAP value and the proportion of hepatic steatosis were statistically similar between two groups (all P>0.05). When fibrotic burden was assessed using TE, it was significantly higher in patients with stroke than that of subjects with health check-up, regardless of body mass index (BMI) (mean 5.3 kPa vs. 3.9 kPa in BMI<25 kg/m2 and 6.3 kPa vs. 4.7 kPa in BMI ≥25 kg/m2), CAP value (mean 5.3 kPa vs. 3.9 kPa in CAP<250 dB/m and 6.3 kPa vs. 4.7 kPa in CAP≥250 dB/m), and metabolic syndrome (mean 5.3 kPa vs. 4.1 kPa in the absence of metabolic syndrome and 5.9 kPa vs. 5.0 kPa in the presence of metabolic syndrome) (all P<0.05). As a continuous variable, unadjusted odd ratio (OR) of LS value for stroke was 1.161 and adjusted ORs were calculated as between 1.132 to 1.213 according to varying multivariate models. As a categorical variable, unadjusted OR of significant fibrosis was 4.388 and adjusted ORs were calculated as between 3.474 to 6.397 according to varying multivariate models. In a propensity matched analysis using 1:1 ratio (n=197 for each group), LS value was independently associated with the risk of stroke (OR of 1.080 as a continuous variable and 8.488 as a categorical variable) (all P<0.001). Conclusions: In our case-control study, we found that the degree of liver fibrosis, as assessed using TE, was significantly associated with the risk of stroke. Further studies investigating the dynamic link between these two disease entities are required.
Reference ranges for induced sputum eosinophil counts in Korean adult population
Kim, Mi-Yeong,Jo, Eun-Jung,Lee, Seung-Eun,Lee, Suh-Young,Song, Woo-Jung,Kim, Tae-Wan,Hur, Gyu-Young,Lee, Jae-Hyung,Kim, Tae-Bum,Park, Heung-Woo,Chang, Yoon-Seok,Park, Hae-Sim,Min, Kyung-Up,Cho, Sang-H Asia Pacific Association of Allergy, Asthma and Cl 2014 Asia Pacific allergy Vol.4 No.3
<P><B>Background</B></P><P>Induced sputum analyses are widely utilized to evaluate airway inflammation in asthmatics. However, the values have not been examined in Korean adults.</P><P><B>Objective</B></P><P>The purpose of this study is to determine reference ranges for induced sputum eosinophils and their influencing factors in Korean adults.</P><P><B>Methods</B></P><P>A total of 208 healthy nonasthmatic adults were recruited. Sputum induction and processing followed the international standard protocols.</P><P><B>Results</B></P><P>Adequate sputum samples were successfully collected from 81 subjects (38.9%). The upper 90 percentile for sputum eosinophil was calculated as 3.5%. The median value of eosinophil count percentage was significantly higher in subjects with atopy than those without atopy (median, 1.6%; range, 0-11.0% vs. median, 0%; range 0-3.6%, <I>p</I>=0.030). However, no significant correlations were found with age, gender, body mass index, smoking status, blood eosinophil, or fractional exhaled nitric oxide levels.</P><P><B>Conclusion</B></P><P>Current study was the first attempt to determine the reference ranges of induced sputum eosinophils in Korean adults. The cutoff value for sputum eosinophilia was 3.5%, and was significantly associated with atopy.</P>
( Sung Soo Ahn ),( Young Eun Chon ),( Beom Kyung Kim ),( Seung Up Kim ),( Do Young Kim ),( Sang Hoon Ahn ),( Kwang Hyub Han ),( Jun Yong Park ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.3
Background/Aims: This study assessed the antiviral efficacy and safety of tenofovir disoproxil fumarate (TDF) for up to 12 months in Korean treatment-naive chronic hepatitis B (CHB) patients. Methods: A total of 411 treatment-naive CHB patients who had been treated with TDF for at least 3 months (median 5.6) were consecutively enrolled. Clinical, biochemical, virological parameters and treatment adherence were routinely assessed every 3 months. Results: The median age was 51.3 years, 63.0% of the patients were male, 49.6% were HBeAg (+), and 210 patients had liver cirrhosis. The median baseline HBV DNA was 5.98 (SD 1.68) log10 IU/mL. Among the patients completing week 48, 83.3% had a complete virologic response (CVR, <12 IU/mL by HBV PCR assay), and 88.2% had normalized levels of alanine aminotransferase (ALT). The cumulative probabilities of CVR at 3, 6, 9 and 12 months were 22.8 %, 53.1%, 69.3% and 85.0%. During the follow-up period, 9.8% patients achieved HBeAg loss and 7.8% patients achieved HBeAg seroconversion. There was no virological breakthrough after initiating TDF. The most common TDF-related adverse event was gastrointestinal upset, and three patients discontinued TDF therapy. However, no serious life-threatening side effect was noted. Conclusions: In a clinical practice setting, TDF was safe and highly effective when administered for 12 months to Korean treatment-naive CHB patients. (Clin Mol Hepatol 2014;20:261-266)
Application of Fault Location Method to Improve Protect-ability for Distributed Generations
Sung-Il Jang,Duck-Su Lee,Jung-Hwan Choi,Yong-Cheol Kang,Sang-Hee Kang,Kwang-Ho Kim,Yong-Up Park 대한전기학회 2006 Journal of Electrical Engineering & Technology Vol.1 No.2
This paper proposes novel protection schemes for grid-connected distributed generation (DG) units using the fault location algorithm. The grid-connected DG would be influenced by abnormal distribution line conditions. Identification of the fault location for the distribution lines at the relaying point of DG helps solve the problems of the protection relays for DG. The proposed scheme first identifies fault locations using currents and voltages measured at DG and source impedance of distribution networks. Then the actual faulted feeder is identified, applying time-current characteristic curves (TCC) of overcurrent relay (OCR). The method considering the fault location and TCC of OCR might improve the performance of the conventional relays for DG. Test results show that the method prevents the superfluous operations of protection devices by discriminating the faulted feeder, whether it is a distribution line where DG is integrated or out of the line emanated from the substation to which the DGs are connected.
Kim, Sang Gon,Lee, Jin-Seok,Shin, Seong-Hyu,Koo, Sung Cheol,Kim, Jung Tae,Bae, Hwan Hee,Son, Beom-Young,Kim, Yul-Ho,Kim, Sun Lim,Baek, Seong-Bum,Kwon, Young-Up The Korean Society for Applied Biological Chemistr 2015 Applied Biological Chemistry (Appl Biol Chem) Vol.58 No.3
Maize (Zea mays L.) is the most important crop such as food for humans and feed for animals. Although new varieties of maize have been extensively developed in Korea, little is known about differences in the proteomes of mature kernels among maize varieties. Three Korean waxy corn cultivars (Ilmichal, Eolrukchal 1, and Heukjinjuchal) have previously been developed. The total protein content is higher in Ilmichal than in Eolrukchal 1 or Heukjinjuchal, while the starch and fatty acid contents are similar among these three Korean waxy corns. To uncover the differences in proteomic profiles among these three Korean waxy corns, we performed proteomic analysis and compared their protein compositions. We detected 37 differentially expressed protein spots and identified the proteins using MALDI-TOF mass spectrometry. Of these proteins, 37.8 % were identified as storage proteins, 18.9 % as stress-related proteins, and 18.9 % as metabolism-related proteins. Storage proteins (globulin-2) and stress-related proteins (heat shock proteins and general stress proteins) were highly expressed in Ilmichal or Heukjinjuchal. Semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis of corresponding genes of five randomly selected proteins, including glyoxalase family protein (accession number, B6SGF3), globulin-2 (Q7M1Z8), heat shock protein 1 and 3 (B6TGQ2 and B6TDB5), and vicilin-like embryo storage protein (Q03865), showed that the expression levels of the tested genes were well-correlated with protein abundance, suggesting that these proteins are also differentially regulated at the transcriptional level. Taken together, these results provide a better understanding of proteomic differences among Korean waxy corn cultivars and may support further molecular breeding efforts.