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Precancerous Conditions of Uterine Cervix and its Relation to Trichomonal Infection
Namkoong, Sung Eun,Kim, Seung Jo,Lee, Yong Seon,Kim, Yoon Ho,Kim, Sun Moo CATHOLIC MEDICAL CENTER 1979 Bulletin of the Clinical Research Institute Vol.7 No.1
Trichomonas Vaginalis, first described by Donne, 1836, for many years has been associated with lesions of the female genital tract.
Polymorphisms of p53, p21 and IRF-1 and Cervical Cancer Susceptibility in Korean Women
Sung Jong Lee,Sung Eun Namkoong,Won Chul Lee,Jae Woong Sul,Sun Ha Jee,Youn Kyoung You,Jong Eun Lee,Jong Sup Park 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: The aim of this study was to identify genegeneand gene-environmental factor on cervical carcinogenesisin Korean women.Materials and Methods: We evaluated 185 womenpatients who had cervical cancer with 345 normal controlhealthy women. The single nucleotide polymorphisms(SNPs) of the p53 codon 72, the p21 codon 31 and theIRF-1 intron 6 were evaluated from extracted DNA ofperipheral blood with an automatic DNA sequencer. Thedifference of each SNP, gene-gene and gene-environmentalinteraction between normal controls and patients,were evaluated in an adjusted environmental background.Results: With regard to environmental factors, thecervical cancer increased in the women with a lower levelof education, a younger age at first sexual intercourseand with the increased number of children borne. Thewomen who had p53 (Arg/Arg), IRF-1 (T/T) and an educationof less than 6 years showed a 14.7 fold increasedrisk of cervical cancer than those women who had p53(~Pro), IRF-1 (~C) and an education of more than 15years. The women who had p53 (Arg/Arg), p21 (Ser/Ser)and more than 3 children showed a 6.4 fold increased riskof cervical cancer than those women who had p53 (~Pro),p21 (~Arg) and had borne no child. The women who hadp53 (Arg/Arg), IRF-1 (T/T) and had experience of firstsexual intercourse before the age of 22-years showed a5.5 fold increased risk of cervical cancer than thosewomen who had p53 (~Pro), IRF-1 (~C) and hadexperience of first sexual intercourse after the age of26-years.Conclusion: We found that the level of education, theage at first intercourse, and the number of children borne,were independent risk factors in cervical carcinogenesis.The specific combination of p53, p21 and IRF-1 gene-geneand gene-environmental interactions were significantlynoted in the cervical carcinogenesis of Korean women.(Cancer Res Treat. 2002;34:357-364)
Effect of anti-muscarinic autoantibodies on leukocyte function in Sjögren’s syndrome
Namkoong, Eun,Lee, Sang-woo,Kim, Nahyun,Choi, Youngnim,Park, Kyungpyo 3M Company 2017 Molecular immunology Vol.90 No.-
<P>Our results suggest that anti-M3R autoantibodies in primary Sjogren's syndrome induce downregulation of plasma membrane-resident M3R and MHC class I molecules in leukocytes followed by NK cell-mediated cell death. This mechanism may explain the frequency of leukopenia occurrence in patients with primary Sjogren's syndrome.</P>
Eun Kyung Park,Young Wook Kim,Joon Mo Lee,Sung Eun NamKoong,Do Gang Kim,Heung Jae Chun,Byoung Don Han,Su Mi Bae,Hyun Sun Jin,Jeong Im Sin,Woong Shick Ahn 대한암학회 2005 Cancer Research and Treatment Vol.37 No.1
Purpose: Human papillomavirus (HPV) infection has a significant role in cervical carcinogenesis, and HPV oncoprotein E7 plays an important part in the formation and maintenance of cervical cancer. Interleukin-12 (IL-12) has been reported to induce a cellular immune response, and to suppress the tumor growth and the E7 production. Here we describe the use of adenoviral delivery of the HPV 16 E7 subunit (AdE7) along with adenoviral delivery of IL-12 (AdIL-12) in mice with HPV-associated tumors. Materials and Methods: Mice were injected with TC-1 cells to establish TC-1 tumor, and then they were immunized with AdIL-12 and/or AdE7 intratumorally. The anti tumor effects induced by AdIL-12 and/or E7 were evaluated by measuring the size of the tumor. E7-specific antibody and INF-gamma production in sera, and the T-helper cell proliferative responses were then measured. Cytotoxic T-lymphocyte (CTL) and T cell subset depletion studies were also performed. Results: Combined AdIL-12 and AdE7 infection at the tumor sites significantly enhanced the antitumor effects more than that of AdIL-12 or AdE7 single infection. This combined infection resulted in regression of the 9 mm sized tumors in 80% of animals as compare to the PBS group. E7-specific antibody and INF-gamma production in the sera, and the T-helper cell proliferative responses were significantly higher with coinfection of AdIL-12 and AdE7 than with AdIL-12 or AdE7 alone. CTL response induced by AdIL-12 and AdE7 in the coinjected group suggested that tumor suppression was mediated by mostly CD8 and only a little by the CD4 T cells. Conclusion: IL-12 and E7 application using adenovirus vector showed antitumor immunity effects against TC-1 tumor, and this system could be use in clinical applications for HPV-associated cancer.
A real-time optoelectronic device in screening of cervical intraepithelial neoplasia
( Sung Jong Lee ),( Jeong Hoon Bae ),( Jin Hwi Kim ),( Sung Ha Lee ),( Sung Eun Namkoong ),( Jong Sup Park ) 대한산부인과학회 2009 Journal of Womens Medicine Vol.2 No.1
Objective: The purpose of the study was to evaluate the sensitivity and specificity of the TruScreen in the diagnosis of cervical intraepithelial neoplasia (CIN) and the benefit of an adjunct test to cervical cytology screening. Methods: Data were collected prospectively on 249 women who had undergone a loop electrosurgical excision procedure (LEEP) or hysterectomy at Kangnam St. Mary`s Hospital of Catholic University between March and December 2008. The TruScreen was performed on 249 patients and the sensitivity and specificity were determined. The accuracy of TruScreen and cervical cytology were also ascertained. Results: A remarkable improvement in the accuracy of the combined test for CIN 1 (sensitivity, 96.8%) and CIN2/3 (sensitivity, 92.4%) was noted. The sensitivity of TruScreen for CIN1 and CIN2/3 was 75.8% and 77.3%, respectively. The specificity of TruScreen for normal tissue was 85.1%. Conclusion: The present study suggests that the TruScreen is an excellent device as an adjunctive test for the detection of CIN. The instantaneous result of TruScreen in women with ASCUS or LSIL can provide rapid and reliable information.
Eun-Kyoung Yim,Jun-Sang Bae,Seung-Bak Lee,Keun-Ho Lee,Chan-Joo Kim,Sung-Eun Namkoong,Soo-Jong Um,Jong-Sup Park 대한암학회 2004 Cancer Research and Treatment Vol.36 No.6
Purpose: It is well known that infection with HPV (human papillomavirus) is the main cause of cervical cancer and certain types of HPV are recognized as carcinogens. At present, there is little information regarding the antineoplastic mechanism of paclitaxel against cervical carcinoma cells. We thus tried to analyze differential protein expression and antineoplastic mechanism-related proteins after paclitaxel treatment on cervical cancer cells by using a proteomic analysis and to investigate the mechanism of action. Materials and Methods: Using proteomics analysis including 2-DE and MALDI-TOF-MS, we detected the antineoplastic mechanism-related proteins. Then, we performed western blot analysis for apoptosis- and transformation- related proteins to confirm expression patterns derived from proteome analysis after paclitaxel treatment. Results: We identified several cellular proteins that are responsive to paclitaxel treatment in HeLa cells using proteomics methods. Paclitaxel treatment elevated main-ly apoptosis, immune response and cell cycle check point- related proteins. On the other hand, paclitaxel treatment diminished growth factor/oncogene-related proteins and transcription regulation-related proteins. Also, in the HPV-associated cervical carcinoma cells, paclitaxel demonstrated anti-proliferative activity through the membrane death receptor-mediated apoptotic pathway and the mitochondrial-mediated pathway. Conclusion: Identification and characterization of functionally modulated proteins involved in anti-cancer regulatory events should lead to a better understanding of the long-term actions of paclitaxel at the molecular level and will contribute to the future development of novel therapeutic drug treatments based upon current therapies.(Cancer Res Treat. 2004;36:395-399)
The Effect of Picibanil on Cell-Immunity in Patients with Gynecological Malignant Tumor
Namkoong, Sung Eun,Lee, Joon Mo,Lee, Hun Young,Jung, Jae Keun,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
Natural killer cell-mediated cytotoxicity(NKMC), total, helper and suppressor T-cells were measured before and 4 weeks after treatment with 0.5-3.0 KE of OK-432 in the patients with trophoblastic disease which were divided into 2 subgroups of low risk (n=10) and high risk (n=11), and compared with those in normal control group (n=9). In the group of low risk trophoblastic disease no change was noted in any of all parameters after treatment. However, in the group of high risk trophoblastic disease, NKMC as well as total and helper T-cells before treatment were significantly lower while suppressor T-cells were higher than those in normal control. And all above data before treatment were definitely reversed after treatment except NKMC that remained unchanged. Considering above results OK-432 may play an important role in host defense mechanism through lymphokine or humoral immune response by increasing the ratio of helper to suppressor T-cells rather than increasing NKMC.
Detection of c-K-ras Point Mutation in Ovarian Cancer
Namkoong, Sung Eun,Lee, Joon Mo,Kim, Jin Woo,Han, Sang Kyun,Kim, Heung Kee,Park, Jong Sup,Kim, Seung Jo CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.1
To detect the point mutation of c-k-ras in ovarian cancer, GGT of codon 12 was replaced by GAT, AGT, TGT and GTT, then we performed polymerase chain reaction and agarose gel electrophoresis and confirmed it using Southern blot hybrization with digoxygenin detection system. The frequency of c-k-ras point mutation was compared with the clinico-pathological characteristics of 37 ovarian cancer patients. The incidences of four-typed point mutations of K-ras oncogene in 37 ovarian cancers were 35.1%(13/37) and distribution were 32.4%(12/37), 2.7%(1/37), 0%(O/37) and 0%(O/37) in GGT to GAT, GGT to AGT, GGT to TGT, and GGT to GTT, respectively. The incidence of K-ras point mutations on codon 12 among 37 patients with ovarian cancer according to histological type was 35.5%(8/22) with serous cystadenocarcinomns, 28.6%(2/7) with mucinous cystadenocarcinomas. Comparing the positive rate of K-ras point mutations on code 12 among 37 patients with ovarian cancer in different clinical stages, point mutation was detected in 14.3%(1/7) with stage Ⅰ, 28.6%(2/7) with stage Ⅱ, and 43.5%(10/23) with stage Ⅲ/Ⅳ and there was statistically significant increasement of point mutations of K-ras oncogene with advance of the clinical stage of ovarian cancer (P<0.05). The incidence of K-ras point mutntions on codon 12 among 33 patients with ovarian cancer who were performed pelvic lymph node dissection was 52.4%(l1/21) of the patients with positive pelvic lymph node metastases and 16.7%(2/12) of the patients without pelvic lymph node metastasis and the difference was statistically significant (P<0.05). The activation of ras oncogene seems to be a major implication of the multistep process of ovarian carcinogenesis and tumor progression. Furthermore, the point mutation of c-K-ras gene could occur more frequently in the patients of ovarian cancer in far advance stage, and the those with pelvic lymph node metastases than in those without pelvic lymph node metastases, suggesting the role in tumor invasion and metastases.