여대생의 인유두종 바이러스 예방접종 여부에 영향을 미치는 요인

방경숙(Bang Kyung-Sook),성수미(Sung Sumi),구보연(Koo Boyeon),김민지(Kim Minji),김유나(Kim Yuna),김진숙(Kim Jinsook),류수미(Ryu Sumi) 대한종양간호학회 2011 Asian Oncology Nursing Vol.11 No.3

Purpose: The primary prevention for cervical cancer the human papilloma virus (HPV) vaccination has been available in South Korea and its importance has been emphasized publicly. The purpose of this study was to investigate the knowledge regarding HPV vaccination and identify the factors associated with HPV vaccination in female university students. Methods: A sample of 200 women among university students in Seoul was asked to answer a questionnaire on HPV-related knowledge and attitude and influencing factors on HPV vaccination. Results: Among the respondents 12.0% were HPV vaccinated. Overall HPV-related knowledge was low and knowledge was not different between the vaccinated and unvaccinated groups. The vaccinated group demonstrated a higher score on the knowledge about the place where people could receive HPV vaccination and the cost of the vaccination than that of the unvaccinated group. The major influencing factor on vaccination was the parent's recommendation and the major barrier for vaccination was the cost of the vaccination. Conclusion: A broadened public campaign is recommended to increase the knowledge and positive attitude towards HPV vaccination for university female students as well as their parents.

Research trends in biomimetic medical materials for tissue engineering: 3D bioprinting, surface modification, nano/micro-technology and clinical aspects in tissue engineering of cartilage and bone

Cen Chen,Sumi Bang,Younghak Cho,Sahnghoon Lee,이인섭,ShengMin Zhang,노인섭 한국생체재료학회 2016 생체재료학회지 Vol.20 No.2

This review discusses about biomimetic medical materials for tissue engineering of bone and cartilage, after previous scientific commentary of the invitation-based, Korea-China joint symposium on biomimetic medical materials, which was held in Seoul, Korea, from October 22 to 26, 2015. The contents of this review were evolved from the presentations of that symposium. Four topics of biomimetic medical materials were discussed from different research groups here: 1) 3D bioprinting medical materials, 2) nano/micro-technology, 3) surface modification of biomaterials for their interactions with cells and 4) clinical aspects of biomaterials for cartilage focusing on cells, scaffolds and cytokines.

In Situ Hybrid Biomateiral for 3D Bioprinting and Its Evaluation for Bone and Cartilage Regeneration

Insup Noh,Sumi Bang,Kyu-Eon Kim,Jae-Hoo Lee,Chi-Bum Lee,Sung Soo Kim 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Tissue Regeneration of Human Mesenchymal Stem Cells on Porous Gelatin Micro-Carriers by Long-Term Dynamic In Vitro Culture

Nguyen, LeTuyen,Bang, Sumi,Noh, Insup 한국조직공학과 재생의학회 2019 조직공학과 재생의학 Vol.16 No.1

Synthesis and in vitro characterizations of porous carboxymethyl cellulose-poly(ethylene oxide) hydrogel film

Su Yeon Lee,Sumi Bang,Sumi Kim,Seong Yeon Jo,Bumchul Kim,Yunjae Hwang,노인섭 한국생체재료학회 2015 생체재료학회지 Vol.19 No.2

Background: Cellulose and its derivatives such as carboxymethyl cellulose (CMC) have been employed as a biomaterial for their diverse applications such as tissue engineering, drug delivery and other medical materials. Porosity of the scaffolds has advantages in their applications to tissue engineering such as more cell adhesion and migration leading to better tissue regeneration. After synthesis of CMC-poly(ethylene oxide) (PEO) hydrogel by mixing the solutions of both CMC-acrylate and PEO-hexa-thiols, fabrication and evaluation of a CMC-PEO gel and its film in porous form have been made for its possible applications to tissue regeneration. Physicochemical and biological properties of both CMC-PEO hydrogel and porous films have been evaluated by using physicochemical assays by SEM, FTIR and swelling behaviors as well as in vitro assays of MTT, Neutral red, BrdU, gel covering and tissue ingrowth into the pores of the CMC-PEO gel films. Degradation of CMC-PEO hydrogel was also evaluated by treating with esterase over time. Results: Chemical grafting of acrylate to CMC was verified by analyses of both FTIR and NMR. CMC-PEO hydrogel was obtained by mixing two precursor polymer solutions of CMC-acrylate and PEO-hexa-thiols and by transforming into a porous CMC-PEO gel film by gas forming of ammonium bicarbonate particles. The fabricated hydrogel has swollen in buffer to more than 6 times and degraded by esterase. The results of in vitro assays of live and dead, MTT, BrdU, Neutral red and gel covering on the cells showed excellent cell compatibility of CMC-PEO hydrogel and porous gel films. Furthermore the porous films showed excellent in vitro adhesion and migration of cells into their pore channels as observed by H&E and MT stains. Conclusions: Both CMC-PEO hydrogel and porous gel films showed excellent biocompatibility and were expected to be a good candidate scaffold for tissue engineering.

Combined epitaxial self-assembly of block copolymer lamellae on a hexagonal pre-pattern within microgrooves

Jung, Hyunjung,Woo, Sanghoon,Park, Sungmin,Lee, Sumi,Kang, Minhyuk,Choe, Youngson,Son, Jeong Gon,Ryu, Du Yeol,Huh, June,Bang, Joona The Royal Society of Chemistry 2015 SOFT MATTER Vol.11 No.21

<P>The directed self-assembly (DSA) of block copolymers (BCPs) has emerged as an alternative method to replace or complement conventional photolithography as a result of the approximately 10 nm scale of microdomain ordering, the variety of microstructures that can be obtained and its compatibility with current lithographic processes. In DSA, BCP microdomains are controlled <I>via</I> guide patterns and two main techniques are popular: graphoepitaxy and chemoepitaxy assembly. We have demonstrated a simple and feasible technology for a DSA process by combining graphoepitaxy with “inexpensive” chemoepitaxial assembly to improve the alignment of the lamellar microdomains. For chemoepitaxial assembly, the hexagonal surface patterns from cross-linkable, cylinder-forming BCP were used to guide the graphoepitaxial assembly of the overlying BCP lamellar film. When the guiding patterns were prepared on the hexagonal patterns, it was found that the degree of lamellar alignment was significantly improved compared with the lamellar alignment on the homogeneous neutral layers. Simulation results suggested that the underlying hexagonal pattern can assist the lamellar alignment by reducing the large number of orientation states of the lamellar layers. This strategy is applicable to various nanofabrication processes that require a high degree of fidelity in controlling the nanopatterns over large areas with reduced costs.</P> <P>Graphic Abstract</P><P>We demonstrated a simple and feasible technology for a DSA process by combining graphoepitaxy with “inexpensive” chemoepitaxial assembly to improve the alignment of lamellar microdomains. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5sm00250h'> </P>

우드칩 반탄화와 부생가스의 특성분석

강구 ( Ku Kang ),방나경 ( Nakyoung Bang ),오수미 ( Sumi Oh ),홍성구 ( Seonggu Hong ) 한국농공학회 2014 한국농공학회 학술대회초록집 Vol.2014 No.-

화석연료의 고갈과 함께 이에 대한 대안으로 신재생에너지에 대한 관심이 증대하고 있다. 다양한 신재생에너지 중 하나인 목질계 바이오매스는 탄소중립적 연료이며, 연소시 이산화탄소의 발생량이 화석연료의 10%이하이고, SOx의 발생량도 매우 적다. 최근 정부는 RPS(신재생에너지 발전의무비율 할당제)제도를 2012년부터 도입하여 그 활용성이 높아지고 있다. 목질계 바이오매스로는 주로 우드칩, 목재펠릿을 사용하고 있지만 에너지밀도가 석탄의 50%로 낮아 이에 따른 수송비용이 높아지는 단점이 있다. 또한 목질계 특성상 흡습성이 높아 원료의 장기간 저장시 매우 불리해지는 단점이 있다. 이러한 문제를 해결하기 위해 바이오매스 반탄화(Torrfaction)에 대한 관심이 매우 높아지고 있다. 바이오매스 반탄화란 바이오매스를 고온의 무산소 조건에서 처리하는 것으로 목재의 수분제거와 더불어 목재의 주요구성 성분인 헤미셀룰로오스, 셀룰로오스의 분해로부터 낮은 발열량의 원인인 산소를 일산화탄소, 이산화탄소의 형태로 제거함으로 목재의 흡습성을 소수성으로 변화시키고 발열량을 증가시키는 기술이다. 또한 목재의 분쇄성의 증가로 분쇄시 에너지소모가 적고, 펠릿 성형시 저장과 운반 측면에서 비용이 절감될 수 있다. 본 연구에서는 우드칩을 대상으로 온도와 시간을 달리하여 반탄화 특성을 물리, 화학적 특징을 파악하여 효율적인 연료로서의 가능성을 살펴보았다. 또한 반탄화시 발생되는 부생가스의 물리화학적 특성을 분석하여 재 이용 가능성에 대하여 모색하고자 하였다.

Chitosan/PLGA/Polysorbate80 생분해성 나노섬유의 제조 및 조직유착방지제로의 응용

김대연,방수미,김철주,김원일,권오형,Kim, Daeyeon,Bang, Sumi,Kim, Cheol Joo,Kim, Won Il,Kwon, Oh Hyeong 한국섬유공학회 2015 한국섬유공학회지 Vol.52 No.2

In the field of surgery, several instances of adhesions in the abdomen, bowel, uterus, and pelvis are observed. Severe post-operative adhesions cause pain in the pelvis and bowel, infertility, and intestinal obstruction. Despite much interest in preventing postoperative adhesion, these symptoms appear persistently. In this study, various composition of chitosan and PLGA blend nanofibrous sheets containing a small quantity of nonionic surfactant, polysorbate80 were fabricated by electrospining technique for application to anti-adhesion barrier. The average diameter of fabricated nanofibers as determined by SEM ranged between 100 to 130 nm. Surface hydrophilicity and biodegradability of nanofibrous mats increased with increasing chitosan content. However, cell attachment and proliferation on nanofibrous surfaces were decreased with increasing chitosan content, probably due to enhanced hydrophilicity. In vivo animal test confirmed that the Chitosan/PLGA(5:5)/Polysorbate80 nanofibrous sheet was sufficiently effective, than the PLGA nanofibrous sheet, in preventing undesired tissue adhesion.

Efficient Surface Neutralization and Enhanced Substrate Adhesion through Ketene Mediated Crosslinking and Functionalization

Jung, Hyunjung,Leibfarth, Frank A.,Woo, Sanghoon,Lee, Sumi,Kang, Minhyuk,Moon, Bongjin,Hawker, Craig J.,Bang, Joona WILEY‐VCH Verlag 2013 Advanced functional materials Vol.23 No.12

<P><B>Abstract</B></P><P>Balancing the interfacial interactions between a polymer and substrate is one of the most commonly employed methods to ensure the vertical orientation of nanodomains in block copolymer lithography. Although a number of technologies have been developed to meet this challenge, there remains a need for a universal solution for surface neutralization that combines simple synthesis, fast processing times, generality toward substrate, low density of film defects, and good surface adhesion. The chemistry of ketenes, which combines highly efficient polymer crosslinking through dimerization and surface adhesion through reaction with the substrate, is shown to be well suited to the challenge. The versatile chemistry of ketenes are accessed through the post‐polymerization of Meldrum's acid, which can be easily incorporated into copolymers through controlled radical polymerization processes. Further, the Meldrum's acid monomer is synthesized on a large scale in one step without the need for chromatography. Processing times of seconds, low defect density, simple synthetic procedures, and good substrate adhesion make these materials attractive as robust block copolymer neutralization layers.</P>

Directed Assembly of High Molecular Weight Block Copolymers: Highly Ordered Line Patterns of Perpendicularly Oriented Lamellae with Large Periods

Kim, Eunhye,Ahn, Hyungju,Park, Sungmin,Lee, Hoyeon,Lee, Moongyu,Lee, Sumi,Kim, Taewoo,Kwak, Eun-Ae,Lee, Jun Han,Lei, Xie,Huh, June,Bang, Joona,Lee, Byeongdu,Ryu, Du Yeol American Chemical Society 2013 ACS NANO Vol.7 No.3

<P>The directed assembly of block copolymer nanostructures with large periods exceeding 100 nm remains challenging because the translational ordering of long-chained block copolymer is hindered by its very low chain mobility. Using a solvent-vapor annealing process with a neutral solvent, which was sequentially combined with a thermal annealing process, we demonstrate the rapid evolution of a perpendicularly oriented lamellar morphology in high molecular weight block copolymer films on neutral substrate. The synergy with the topographically patterned substrate facilitated unidirectionally structural development of ultrahigh molecular weight block copolymer thin filmseven for the structures with a large period of 200 nmleading to perfectly guided, parallel, and highly ordered line-arrays of perpendicularly oriented lamellae in the trenched confinement. This breakthrough strategy, which is applicable to nanolithographic pattern transfer to target substrates, can be a simple and efficient route to satisfy the demand for block copolymer assemblies with larger feature sizes on hundreds of nanometers scale.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-3/nn3051264/production/images/medium/nn-2012-051264_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn3051264'>ACS Electronic Supporting Info</A></P>