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Kim, Sujin,Cho, Yoon Hee,Won, Sungho,Ku, Ja-Lok,Moon, Hyo-Bang,Park, Jeongim,Choi, Gyuyeon,Kim, Sungkyoon,Choi, Kyungho Elsevier 2019 Environment international Vol.130 No.-
<P><B>Abstract</B></P> <P>Exposure to persistent organic pollutants (POPs) during pregnancy is associated with a disruption in thyroid hormone balance. The placenta serves as an important environment for fetal development and also regulates thyroid hormone supply to the fetus. However, epigenetic changes of thyroid regulating genes in placenta have rarely been studied. This study was conducted to evaluate the association between several POP concentrations in maternal serum and DNA methylation of thyroid hormone-related genes in the placenta. The placenta samples were collected from 106 Korean mother at delivery, and the promoter methylation of the placental genes was measured by a bisulfite pyrosequencing. The <I>deiodinase type 3</I> (<I>DIO3</I>), <I>monocarboxylate transporter 8</I> (<I>MCT8</I>), and <I>transthyretin</I> (<I>TTR</I>) genes were selected as the target genes as they play an important role in the regulation of fetal thyroid balance. Because people are exposed to multiple chemicals at the same time, a multiple-POP model using principal component analysis (PCA) was applied to evaluate the association between the multiple POPs exposure and the epigenetic change in placenta. In addition, a single-POP model which includes one chemical each in the statistical model for association was conducted.</P> <P>Based on the single-POP models, serum concentrations of <I>p,p</I>′-dichlorodiphenyldichloroethylene (<I>p,p</I>′-DDE) and brominated diphenyl ether-47 (BDE-47) were significantly associated with an increase in placental <I>DIO3</I> methylation, but only among female infants. Among male infants, a positive association between serum <I>p,p</I>′-DDT and <I>MCT8</I> methylation level was found. According to the multiple-POP models, serum DDTs were positively associated with <I>DIO3</I> methylation in the placenta of female infants, while a positive association with <I>MCT8</I> methylation was observed in those of the male infants. Our observation showed that in utero exposure to DDTs may influence the DNA methylation of <I>DIO3</I> and <I>MCT8</I> genes in the placenta, in a sexually dimorphic manner. These alterations in placental epigenetic regulation may in part explain the thyroid hormone disruption observed among the newborns or infants followed by in utero exposure to POPs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Promoter DNA methylation of placental genes related to thyroid hormone was measured. </LI> <LI> Some maternal serum POPs were associated with methylation of these placental genes. </LI> <LI> DNA methylation of <I>DIO3</I> and <I>MCT8</I> genes by maternal POP was differed by infant sex. </LI> </UL> </P>
Kim, Sujin,Cho, Yoon Hee,Lee, Inae,Kim, Wonji,Won, Sungho,Ku, Ja-Lok,Moon, Hyo-Bang,Park, Jeongim,Kim, Sungkyoon,Choi, Gyuyeon,Choi, Kyungho Elsevier 2018 Environment international Vol.119 No.-
<P><B>Abstract</B></P> <P>Prenatal exposure to persistent organic pollutants (POPs) has been linked to numerous adverse birth outcomes among newborn infants in many epidemiological studies. Although epigenetic modifications have been suggested as possible explanations for those associations, studies have rarely reported a relationship between POP exposure during pregnancy and DNA methylation in the placenta.</P> <P>In the present study, we investigated the association between prenatal exposure to several POPs, including organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), and methylation levels of long interspersed element 1 (LINE-1), as well as imprinted genes in placental DNAs among Korean mother-child pairs (N = 109). We assessed the association of DNA methylation not only with each target POP (single-POP models) but also with multiple POPs applying principal component analysis (multiple-POP models). Potential associations between placental DNA methylation and birth outcomes of newborn infants were also estimated.</P> <P>In single-POP models, significant associations were detected between OCP measurements and placental DNA methylation. Elevated concentrations of β-hexachlorhexane (β-HCH) in maternal serum collected during delivery were significantly associated with a decrease in methylation of LINE-1 in the placenta. Higher levels of <I>p</I>,<I>p</I>′-dichlorodiphenyltrichloroethane (<I>p</I>,<I>p</I>′-DDT) in maternal serum were associated with hypermethylation of <I>insulin-like growth factor 2</I> (<I>IGF2</I>). In multiple-POP models, a significant and positive association between DDTs and <I>IGF2</I> methylation was also observed. Placental LINE-1 methylation was inversely associated with birth length. Our observations indicate that prenatal exposure to several POPs including DDTs is associated with the changes in methylation of genes, including major imprinted genes in the placenta. The consequences of these epigenetic alterations in placenta during development deserve further investigation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Associations between POP exposure and placental DNA methylation were evaluated. </LI> <LI> A multi-pollutant exposure was added in the models with principal component analysis. </LI> <LI> Exposure to DDTs, including <I>p</I>,<I>p</I>′-DDT, was related to methylation of <I>IGF2</I> in the placenta. </LI> <LI> Several POPs might affect epigenetic regulation of key placental DNAs. </LI> </UL> </P>
국내 임상에서 실시된 아동간호중재 연구논문(2000-2011년) 동향 분석
방경숙(Bang, Kyung-Sook),강현주(Kang, Hyunju),김미영(Kim, Miyoung),민수정(Min, Sujung),이수진(Lee, Sujin),이해인(Lee, Haein),임지희(Lim, Jihee) 한국간호교육학회 2013 한국간호교육학회지 Vol.19 No.1
Purpose: The purpose of this study was to analysis the research trends of pediatric nursing intervention studies in Korea form 2000 to 2011. Methods: A literature search was conducted from the databases. RISS and ‘Infant’, ‘Toddler’, ‘Preschooler’, ‘Schooler’, ‘Adolescent’, ‘Child’, ‘Effect’, ‘Program’, ‘Intervention’ and ‘Nursing’ were used for keyword searches to find relevant studies. A total of 37 published articles and dissertations in Korea from 2000 to 2011 were reviewed using a structured analytical frame. Results: A quasi-experimental design was more common at 91.9% with a true experimental design at 2.7%. The portion of studies in which theoretical framework was suggested was 27.0%. Only 8.1% mentioned International Review Board (IRB) approval and 78.4% received only the participant’s agreement. The participants’ developmental stage was mostly preschool stage, and 37.0% of the child’s health problem was a chronic disease. Sensory interventions made up 45.9% of the types of intervention and most of the sensory interventions were distraction interventions. The contents of intervention outcomes were physiological (54.0%) and psychological (28.0%) categories mostly. Conclusion: This study will help in identifying current research trends of pediatric nursing intervention studies in Korea and provide basic data for the direction of developing pediatric nursing interventions.
Pak Yujin,Baek Sujin,Bang Minhae,Kim Hoseop,Jo Yumin,Oh Chahyun,Hong Boohwi 조선대학교 의학연구원 2023 Medical Bilogical Science and Engineering Vol.6 No.1
Regional anesthesia has become an alternative to general anesthesia in patients with risk factors that may cause perioperative complications. The transversalis fascial plane block (TFPB) is a useful regional technique for blocking the ilioinguinal and iliohypogastric nerves. An 87-yearold female patient with symptomatic severe aortic stenosis was scheduled to undergo open reduction and fixation with an autogenous iliac crest bone graft (ICBG) for the nonunion of the proximal shaft of an ulnar fracture. General anesthesia was avoided due to cardiac comorbidities; therefore, regional anesthesia was considered. ICBG can be performed under spinal anesthesia. However, we performed TFPB since severe aortic stenosis is a contraindication for spinal anesthesia. A brachial plexus block was performed for the primary forearm surgical site. The surgery proceeded safely without any hemodynamic compromise or special events. TFPB for ICBG can be a useful alternative in patients with severe cardiac comorbidities to avoid perioperative risks.
Lee Ha Eun,Bang Won Yeong,Kim Yeojin,Bae Sujin,Hahn Dongyup,Jung Young Hoon 한국곤충학회 2020 Entomological Research Vol.50 No.11
In order to broaden the usability of the two‐spotted cricket (Gryllus bimaculatus De Geer) as a food ingredient, we investigated the effects of freeze‐drying and hot air‐ drying, as well as the effects of storage at various temperatures (4–40°C), on the quality of cricket powder during short‐term storage. We found that the water absorption index values of freeze‐dried and hot air‐dried powder were 3.6 and 3.0 g/g, respectively, while the pH and color values of the powders were similar for the two drying methods. During storage at various temperatures over 14 days, water absorption and pH remained similar regardless of the drying method and storage temperature. However, freeze‐dried powder showed more color change compared to air‐dried powder according to their chroma values. In total bacteria and Escherichia coli detection tests, Escherichia coli was not detected under all storage conditions, whereas total bacteria were observed (~4 Log CFU/g) only in freeze‐dried powder stored for 14 days at 40°C. Therefore, our results suggest that the quality characteristics of two‐spotted cricket powder can be affected by the drying method applied, but these powders can be maintained for 14 days, largely without changes, at storage temperatures up to 40°C.
Lee, Jungeun,Kim, Sujin,Park, Young Joo,Moon, Hyo-Bang,Choi, Kyungho American Chemical Society 2018 Environmental science & technology Vol.52 No.15
<P>Benzophenones (BPs) have been widely used in personal care products (PCPs) such as UV protectants. Sex endocrine-disrupting effects have been documented for some BPs, but, significant knowledge gaps are present for their thyroid-disrupting effects. To investigate the thyroid-disrupting potential of BPs, a rat pituitary (GH3) and thyroid follicle (FRTL-5) cell line were employed on six BPs, i.e., benzophenone (BP), benzophenone-1 (BP-1), benzophenone-2 (BP-2), benzophenone-3 (BP-3), benzophenone-4 (BP-4), and benzophenone-8 (BP-8). Subsequently, zebrafish (<I>Danio rerio</I>) embryo exposure was conducted for three potent BPs that were identified based on the transcriptional changes observed in the cells. In GH3 cells, all BPs except BP-4 down-regulated the <I>Tshβ</I>, <I>Trhr</I>, and <I>Trβ</I> genes. In addition, some BPs significantly up-regulated the <I>Nis</I> and <I>Tg</I> genes while down-regulating the <I>Tpo</I> gene in FRTL-5 cells. In zebrafish embryo assay conducted for BP-1, BP-3, and BP-8, significant decreases in whole-body T4 and T3 level were observed at 6 day postfertilization (dpf). The up-regulation of the <I>dio1</I> and <I>ugt1ab</I> genes in the fish suggests that decreased thyroid hormones are caused by changing metabolism of the hormones. Our results show that these frequently used BPs can alter thyroid hormone balances by influencing the central regulation and metabolism of the hormones.</P> [FIG OMISSION]</BR>