http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Dong-Youb,Won, Kyung-Jong,Lee, Kang Pa,Jung, Seung Hyo,Baek, Suji,Chung, Hyun Woo,Choi, Wahn Soo,Lee, Hwan Myung,Lee, Byeong Han,Jeon, Byeong Hwa,Kim, Bokyung Elsevier 2018 Toxicology and applied pharmacology Vol.347 No.-
<P><B>Abstract</B></P> <P>Angiotensin II (Ang II) is implicated in the development of cardiovascular disorders including hypertension and atherosclerosis. However, the role of Ang II in the interaction between apurinic/apyrimidinic endonuclease/redox factor-1 (APE/Ref-1) and sphingosine-1-phosphate (S1P) signals in relation to vascular disorders remains to be clarified. This study aimed to determine whether APE/Ref-1 plays a role in epigenetic regulation of the S1P receptor (S1PR) in response to Ang II in vascular smooth muscle cell (VSMC) migration and vascular neointima formation. Ang II augmented the expression of S1PR1 in aortic smooth muscle cells of Sprague Dawley rats (RASMCs), which was attenuated by Ang II receptor (AT) 1 inhibitors, antioxidants, and APE/Ref-1 knockdown with small interference RNA. Ang II stimulation produced H<SUB>2</SUB>O<SUB>2</SUB>, and exogenous H<SUB>2</SUB>O<SUB>2</SUB> elevated S1PR1 expression in RASMCs. Moreover, Ang II caused translocation of cytoplasmic APE/Ref-1 into the nucleus in RASMCs. H3 histone acetylation and APE/Ref-1 binding at the S1PR1 promoter were increased in RASMCs treated with Ang II. In addition, Ang II induced migration in RASMCs, which was suppressed by AT1 and S1PR1 inhibitors. The expression of S1PR1, and colocalization of APE/Ref-1 and acetylated histone H3 in vascular neointima, were greater in Ang II-infused rats compared with a control group. These findings demonstrate that Ang II stimulates the epigenetic regulation of S1PR1 expression via H<SUB>2</SUB>O<SUB>2</SUB>-mediated APE/Ref-1 translocation, which may consequently be involved in Ang II-induced VSMC migration and vascular neointima formation. Therefore, APE/Ref-1-mediated overexpression of S1PR1 may be implicated in the vascular dysfunction evoked by Ang II.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Ang II increased S1PR1 expression and H<SUB>2</SUB>O<SUB>2</SUB> generation in VSMCs. </LI> <LI> H<SUB>2</SUB>O<SUB>2</SUB> elevated S1PR1 expression in VSMCs. </LI> <LI> Ang II epigenetically enhanced S1PR1 expression via APE/Ref-1 translocation by H<SUB>2</SUB>O<SUB>2</SUB>. </LI> <LI> These events may be linked to Ang II-increased VSMC migration and vascular neointima. </LI> </UL> </P>
Suji Lee,Heon-Woong Kim,Ryeong Ha Kwon,So-Jeong Lee,Hyemin Na,Ju Hyung Kim,Chi-Do Wee,Seon Mi Yoo,Sang Hoon Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, a total of 93 flavonoid derivatives were identified and quantified from nine fermented soybean leaves (jangajji) with three different fermentation period using UPLC-DAD-QToF/MS on the basis of constructed flavonoid library. In positive ion mode, flavonoids derivatives were classified into fifty-seven flavonols, ten flavones and twenty-six isoflavones are mainly composed of acylated (malonyl and apiosyl) glycosides and mono, di, or tri glycosides based on aglycones including flavonol (quercetin, kaempferol, isorhamnetin), flavone (luteolin, apigenin, chrysoeriol), and isoflavone (daidzein, genistein, tectorigenin, afromosin, formononetin). As the fermentation period goes by, the contents of aglycones increased, however, the contents of mono, di, or triglycosides and acylated glycosides decreased. Overall, the total contents of flavonol, flavone, and isoflavone slightly increased on the fifth day of fermentation, but decreased in the subsequent period. From the results, this study can be a fundamental data for applying various processed soybean leaves, and the fermentation period of jangajji for the consumption of the desired amount of flavonoids can be considered.
한국 교육복지정책의 전개 및 향후 과제에 대한 고찰 : 이돈희의 『교육정의론』을 중심으로
이수지(Lee, Suji),김새론(Kim, Searon),전주현(Jeon, Jyhyun),한지예(Han, Jiyea),황정훈(Hwang, Junghun),엄문영(Eom, Moonyoung) 한국교육행정학회 2021 敎育行政學硏究 Vol.39 No.1
본 연구는 이돈희의 『교육정의론』에 제시된 교육복지와 교육정의의 개념을 이론적으로 고찰하고, 이를 바탕으로 국내 주요 교육복지정책이 정의롭게 운영되고 있는지를 분석하여 향후 교육복지정책에 요구되는 과제를 제시하였다. 『교육정의론』에 따르면 교육복지란 교육정의 실현의 근본적인 출발점으로서 모든 교육대상의 교육적 욕구 충족과 자아실현을 위해 유의미한 학습경험을 제공하는 것이다. 이러한 교육정의의 관점에서 무상교육, 방과 후 학교, 학습부진학생 지원, 교육복지우선지원사업, 교육소외 취약계층 지원, 고등교육 학자금 지원 정책 등 6가지 국내 주요 교육복지정책의 운영을 분석하였다. 그 결과 추후 교육복지정책에 요청되는 과제로 ‘교육소외 취약계층을 위한 교육복지의 양적 확대’, ‘교육기회의 유의미성 보장을 위한 교육복지정책’, ‘특수요소 성장을 지원하는 교육복지정책 예산 확충’, ‘수혜 대상 범위에 대한 공감대 형성’, ‘모든 학생을 대상으로 하는 교육복지정책 지향’을 제시하였다. 본 연구는 이돈희의 『교육정의론』에 관한 이론적 고찰과 정책 분석을 병행함으로써 ‘교육정의’에 대한 관심을 촉구하고, 교육복지정책이 나아갈 정의로운 방향 제시에 기여하고자 하였다. This study theoretically contemplated the concepts of educational welfare and educational justice presented in Lee, Don-hee"s 『Theory of Education Justice』, and analyzed whether major educational welfare policies in Korea are operating equitably, presenting the tasks required for future educational welfare policy making. According to the 『Theory of Education Justice』, educational welfare is a fundamental starting point for the realization of educational justice, providing meaningful learning experiences for the fulfillment of educational needs and self-realization of all educational subjects. From this perspective, six major domestic educational welfare policies were analyzed, including free education, after-school support policies, poor student support, education welfare priority support projects, support for the disadvantaged underprivileged, and higher education funding policies. As a result, the government proposed ‘Quantitative expansion of educational welfare for the underprivileged’, ‘Educational welfare policy to guarantee the significance of educational opportunities’, ‘Expansion of educational welfare policy budget to support growth of special demand’, ‘Forming a consensus for the scope of beneficiaries’, and ‘Oriented educational welfare policy for all students’. This study encouraged interest in ‘education justice’ by combining theoretical consideration of Lee, Don-hee"s 『Theory of Education Justice』 and contributed to the just direction for education welfare policy.
UPLC-DAD-QToF/MS를 이용한 벚나무 속 과일의 페놀산 특성 비교
이수지 ( Suji Lee ),김헌웅 ( Heon-woong Kim ),이민기 ( Min-ki Lee ),이선혜 ( Seon-hye Lee ),게릴라아사메누 ( Gelila Asamenew ),최용민 ( Yongmin Choi ),박진주 ( Jin Ju Park ),이상훈 ( Sang Hoon Lee ),김정봉 ( Jung-bong Kim ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-
Phenolic acids are widely distributed in plants. Especially, fruits may play a important role in preventing several diseases as phenolics rich source. In this study, phenolic composition and concentration of the Prunus genus were evaluated using ultra performance liquid chromatography with diode array detection and quadrupole time-of-flight mass spectrometric system (UPLC-DAD-QToF/MS). In positive ion mode, a total of 18 hydroxycinnamic acid derivatives (HCAs) and 1 hydroxybenzoic acid derivative were also identified and quantified from Prunus fruits. Among them, 15 phenolic acids were newly identified in the fruits of Prunus genus. One feruloyl acetylsucorse was also newly named from apricot: 3-O-feruloyl (2'-O-acetyl)sucrose (armenose A). Japanese apricot, apricot and cherry showed the highest amounts of HCAs. Overall, 3-O-caffeoylquinic acid was major phenolic acid in Prunus fruits. Various types of feruloyl acetylsucrose and p-coumaroyl acetylsucrose were identified in apricot and Japanese apricot, respectively. With previous studies, the catechin content was increased while flavonol content was reduced during the ripening stage of Japanese apricot, as harvest time late. It was also identified that HCAs content was also reduced from this research. It was considered that phenolic acids and flavonols were used for biosynthesis of catechins in maturing. On the basis of phenolic information, PLS-DA model showed different patterns by cluster in various genus and ripening stages.
Han Suji,Shin Hyemi,Lee Jin-Ku,Liu Zhaoqi,Rabadan Raul,Lee Jeongwu,Shin Jihye,Lee Cheolju,Yang Heekyoung,Kim Donggeon,Kim Sung Heon,Kim Jooyeon,Oh Jeong-Woo,Kong Doo-Sik,Lee Jung-Il,Seol Ho Jun,Choi J 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
이민기 ( Min-ki Lee ),김헌웅 ( Heon-woong Kim ),이선혜 ( Seon-hye Lee ),게릴라아사메누 ( Gelila Asamenew ),이수지 ( Suji Lee ),최용민 ( Yongmin Choi ),박진주 ( Jin Ju Park ),이상훈 ( Sang-hoon Lee ),김정봉 ( Jung-bong Kim ) 한국환경농학회 2019 한국환경농학회 학술대회집 Vol.2019 No.-
Capillary wormwood (Artemisia capillaris Thunberg) and crown daisy (Chrysanthemum coronarium L.) belonging to Family Asteraceae have been regarded as traditional medicinal herbs for preventive effects against chronic diseases including vascular disease, diabetes mellitus, and obesity. These plants are known for major resource of diverse caffeoylquinic acid (CQA) derivatives and flavonoid glycosides. Thus, objective of this study was to observe effects on high thermal and pressure processing to their CQA derivatives from capillary wormwood and crown daisy. A total of twenty-six hydroxycinnamoylquinic acid (HCQA) derivatives including p-coumaroylquinic acids (21), CQAs (3), and feruloylquinic acids (2) were separated and identified using UPLC-DAD-QToF/MS. Among them, a total twelve of HCQA derivatives was newly reported. Capillary wormwood and crown daisy were presented great majority of 5-O-caffeoylquinic acid (chlorogenic acid) and 3,5-di-O-caffeoylquinic acid (isochlorogenic acid A). In addition, 3,5-di-O-caffeoyl-4-O-succinylquinic acid was predominant compound in crown daisy. The total contents of HCQA derivatives were tended to decrease slightly during high thermal and pressure processing. Especially, the CQA derivatives which were esterified at 5- position of quinic acid moiety including chlorogenic acid and isochlorogenic acid A were tended to convert 3- and 4- position of CQA derivatives during processing. Therefore, proper high thermal and pressure processing is possible to enhance active ingredients. Furthermore, it can give valuable information for future research of functional foods and drugs.