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Suin Shin,Yong Ho Cho,박진혁,안동준 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.116 No.-
In this study, we successfully performed protein-cell recognition by combining an organic light-emittingdiode (OLED) material and an aptamer with a three-dimensional DNA structure. Tris (8-hydroxyquinoline) aluminum (Alq3), one of the most widely used green OLED components used in displays,was chosen as an emitter. Epithelial cell adhesion molecule (EpCAM) was selected as a targetbecause it is well-established in cancer studies. The generated micrometer-sized particles exhibitedincreased luminous intensity based on the specific recognition to proteins and cells on hybrid interfaces,proving that the aptamer maintained its three-dimensional structure while binding to its target. Interestingly, only human cells expressing EpCAMs were distinguishable, whereas mouse carcinoma cellswere not. Furthermore, use of graphene oxide as a quencher made these aptamer-Alq3 microrods 2-foldmore effective at enhancing the fluorescence signal upon interaction with human oral squamous carcinomacells. This new approach, which imparts biometric functionality to organic semiconductor materials,will provide a new platform for the evolution of OLED hybrid materials.
치매 치료를 위한 한약 자원 탐색에서 네트워크 약리학 분석법의 유용성
조수인,Suin Cho 턱관절균형의학회 2022 턱관절균형의학회지 Vol.12 No.1
Objectives: Dementia is a disease in which a person maintains a normal intellectual level during the growth period, but has acquired cognitive impairment and personality change. In this study, we tried to check whether the network pharmacology analysis method is useful in the search for herbal medicine resources for the treatment of dementia. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) database is a database frequently used in Chinese medicine research. We used the TCMSP to identify herbal medicines and their molecular targets that can be used for dementia by using network pharmacology research methods. Results: It was possible to select 28 types of components that are expected to be active by applying them to the living body, and 75 types of targets that these components act on were secured. In addition, 16 kinds of drugs were identified by checking the drugs containing 28 kinds of ingredients, and it was found that Radix Salviae contained 2 kinds of the selected 28 kinds of ingredients. Conclusions: Through this study, we were able to identify ingredients, drugs, and targets that can be used for basic and clinical research on dementia.
네트워크 약리학 분석을 통한 뚜렛 증후군에 유용할 것으로 예측되는 한약 자원 탐색
이병호(Byoungho Lee),조수인(Suin Cho) 턱관절균형의학회 2020 턱관절균형의학회지 Vol.10 No.1
Objectives: Tourette syndrome (TS) is a disease that occurs evenly in many social classes. Despite the long experience of drug treatment, the preference is low due to various side effects. The aim of this study was to discover herbal medicine resources through network pharmacology analysis predicted to be useful for Tourette syndrome. Methods: We used Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) to identify herbal medicines that can be used for TS by using network pharmacology research methods and to predict the mechanism of action. After evaluating compounds of each identified herb, molecular target proteins and mechanisms of action were analyzed, focusing on compounds that are likely to exhibit clinical activity in consideration of the pharmacokinetic parameters of these individual compounds. Results: Fifty nine ingredients such as atropine, veraguensin, and nuciferin among the compounds contained in 48 types of medicinal herbs such as Daturae Flos (洋金花), Salviae Radix (丹参), and Nelumbinis Plumula (蓮子心) act on the D(2) dopamine receptor, which is a protein involved in the development of TS. It has been found that atropine, veraguensin, and nuciferin are highly likely to exhibit activity by acting on the G protein-coupled receptor signaling pathway. Conclusions: It can be used in conjunction with non-invasive treatment means such as FCST Yinyang Balancing Appliance with herbal therapy to bring about a significant therapeutic effect, and it will be possible to develop a treatment that can replace drug therapy used in Western medicine.