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옥수수 유래 아라비노자일란 함유 다당체가 자연면역 활성에 미치는 영향
신수용(Sooyong Shin),김서현(Seo Hyun Kim),이호성(Ho Sung Lee),권동주(Dong Ju Kwon),전성호(Sung Ho Jeon) 한국식품영양과학회 2020 한국식품영양과학회지 Vol.49 No.2
본 연구에서는 찰옥수수 가공 부산물인 옥수수침지액(CSL)에서 추출한 수용성 다당체(CBP-1S)가 대식세포 및 수지상세포에서 면역 활성을 유도함을 밝혔다. CBP-1S를 처리한 대식세포에서는 NO 생성이 유도되었으며, NO 합성효소인 iNOS와 자연면역 활성에 중요한 COX-2와 다양한 면역활성 사이토카인의 발현이 유도되었다. 또한 CBP-1S를 경구 투여한 마우스의 비장에서는 IL-12를 발현하는 수지상세포의 비율이 증가하였으며, 이는 종양의 증식과 전이를 억제하는 NK 및 T 세포 활성에서 중요한 역할을 수행할 것이라 기대된다. CBP-1S의 주성분인 아라비노자일란은 TLR4 수용체를 통한 신호전달을 매개하는 것으로 생각되며, 이 물질이 MAPK의 인산화를 유도하고 NF-κB를 통한 전사활성에 촉진하는 것을 확인하였다. 이러한 결과들은 아라비노자일란을 포함하는 옥수수유래 다당체를 면역기능 향상을 위한 기능성 식품 원료 등으로 활용할 가능성을 제시한다. A water-soluble polysaccharide fraction derived from corn steep liquor, called corn byproduct polysaccharide-1-supernatant (CBP-1S), was analyzed for its immune activity in innate immune cells. Murine peritoneal macrophages, Raw264.7 cells, were treated with CBP-1S, which induced nitric oxide production in a dose dependent manner. The CBP-1S treatment also increased the inducible isoform of nitric oxide synthase and cyclooxygenase-2 as well as cytokine gene expression involved in the innate immune response. In addition, the proportion of dendritic cells expressing interleukin-12 was higher in the splenocytes of mice administered CBP-1S orally, which is expected to play an important role in the natural killer and T cell activity that inhibits tumor proliferation and metastasis. Arabinoxylan, a major component of CBP-1S, induced the phosphorylation of mitogen-activated protein kinase and promoted transcriptional activity through nuclear factor-kB. Therefore, this compound is believed to mediate signal transduction through the toll-like receptor 4 receptor. These results suggest the possibility of using corn-derived polysaccharides containing arabinoxylan as a functional food ingredient for improving the immune function.
Power Plant Pump Process Model Error Minimization Technique for Improving Simulator Fidelity
SooYong Yun,Kwan-Woong Gwak,Seung-Hyun Byun,Deockho Kim,Jaeyong Cho,Man-su Shin,ChangHyun Kim 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
The power plant simulator is used to simulate the actual operation of a power plant, and for training and control verification. The simulator is built with the design data during the plant construction. The fidelity is low in the initial stage of operation because power plant modifications, deterioration, and logic corrections are not sufficiently reflected in a timely manner. To solve this problem, we propose a model error minimization technique for a pump process, one of the fundamental elements of the plant process, to improve fidelity. Model accuracy is improved by adjusting the parameters of the pump rated speed and characteristic curve based on the actual operating data. Performance is verified using actual operation data of the boiler feedwater pump in the circulating fluidized bed power plant.
Nam, Sungho,Shin, Minjung,Park, Soohyeong,Lee, Sooyong,Kim, Hwajeong,Kim, Youngkyoo The Royal Society of Chemistry 2012 Physical chemistry chemical physics Vol.14 No.43
<P>We report the improved performance of all-polymer solar cells with bulk heterojunction nanolayers of an electron-donating polymer (poly(3-hexylthiophene) (P3HT)) and an electron-accepting polymer (poly(9,9-dioctylfluorene-co-benzothiadiazole) (F8BT)), which were both doped with 4-ethylbenzenesulfonic acid (EBSA). To choose the doping ratio of P3HT for all-polymer solar cells, various EBSA doping ratios (0, 1, 3, 5, 10, 20 wt%) were tested by employing optical absorption spectroscopy, photoluminescence spectroscopy, photoelectron yield spectroscopy, and space-charge-limited current (SCLC) mobility measurement. The doping reaction of P3HT with EBSA was followed by observing the colour change in solutions. The final doping ratio for P3HT was chosen as 1 wt% from the best hole mobility measured in the thickness direction, while that for F8BT was fixed as 10 wt% (F8BT-EBSA). The polymer:polymer solar cells with bulk heterojunction nanolayers of P3HT-EBSA (EBSA-doped P3HT) and F8BT-EBSA (EBSA-doped F8BT) showed greatly improved short circuit current density (<I>J</I><SUB>SC</SUB>) and open circuit voltage (<I>V</I><SUB>OC</SUB>), compared to the undoped solar cells. As a result, the power conversion efficiency (PCE) was enhanced by <I>ca.</I> 300% for the 6 : 4 (P3HT-EBSA : F8BT-EBSA) composition and <I>ca.</I> 400% for the 8 : 2 composition. The synchrotron-radiation grazing incidence angle X-ray diffraction (GIXD) measurement revealed that the crystallinity of the doped nanolayers significantly increased by EBSA doping owing to the formation of advanced phase segregation morphology, as supported by the surface morphology change measured by atomic force microscopy. Thus the improved PCE can be attributed to the enhanced charge transport by the formation of permanent charges and better charge percolation paths by EBSA doping.</P> <P>Graphic Abstract</P><P>The performance of all-polymer solar cells was remarkably improved by chemical doping of both electron-donating polymer and electron-accepting polymer due to the enhanced charge transport in the double doped bulk heterojunction nanolayers. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp43002a'> </P>