http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Jung, Soonjae,Kim, Jung Young,Han, Sang Jin,Seo, Youngbeom,Lee, Kyo Chul,Ryu, Young Hoon,Choi, Jae Yong 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
A bone metastasis is an important factor for prognosis and treatment of breast or prostate cancer patients. [$^{18}F$]Sodium fluoride ([$^{18}F$]NaF) is a PET radiopharmaceutical that can detect bone metastasis. Conventional [$^{18}F$]NaF production process included radioactive metal impurities because the product was prepared by adding saline after beam irradiation to $[^{18}O]H_2O$. In this study, we apply the method of removing radionuclidic impurities. To meet the criteria prescribed by GMP in quality control, we designed the custom-made [$^{18}F$]NaF automatic module. The mean radiochemical yield was $82.1{\pm}4.4%$ (n = 32) productions for 3 years) and the total preparation time was 4 min. The final produced [$^{18}F$]NaF solution meets the USP criteria for quality control. Thus, this fully automated system is validated for clinical use.
Soonjae Jung,Jae Yong Choi,Jung Young Kim,Sang-Jin Han,Youngbeom Seo,Kyo Chul Lee,Young Hoon Ryu 대한방사성의약품학회 2019 Journal of radiopharmaceuticals and molecular prob Vol.5 No.1
A bone metastasis is an important factor for prognosis and treatment of breast or prostate cancer patients. [18F]Sodium fluoride ([18F]NaF) is a PET radiopharmaceutical that can detect bone metastasis. Conventional[18F]NaF production process included radioactive metal impurities because the product was prepared byadding saline after beam irradiation to [18O]H2O. In this study, we apply the method of removing radionuclidicimpurities. To meet the criteria prescribed by GMP in quality control, we designed the custom-made [18F]NaFautomatic module. The mean radiochemical yield was 82.1 ± 4.4% (n = 32) productions for 3 years) and thetotal preparation time was 4 min. The final produced [18F]NaF solution meets the USP criteria for quality control. Thus, this fully automated system is validated for clinical use.
Jung, Pil Young,Ryu, Hoon,Rhee, Ki-Jong,Hwang, Soonjae,Lee, Chang Gun,Gwon, Sun-Yeong,Kim, Jiye,Kim, Juwon,Yoo, Byung-Su,Baik, Soon Koo,Bae, Keum Seok,Eom, Young Woo Elsevier 2019 Cancer letters Vol.440 No.-
<P><B>Abstract</B></P> <P>Although mesenchymal stem cells (MSCs) have been reported to inhibit tumor growth, the mechanism controlling this tumor suppression function is unclear. Here, we report that high-density (40,000 cells/cm<SUP>2</SUP>) cultured adipose tissue-derived MSCs (40K-ASCs) expressed interferon (IFN)-β and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL); we also found that serum deprivation during cell culture induced the expression of IFN-β and TRAIL. In addition, the mRNA expression of <I>IFN-β</I>, but not <I>TRAIL</I>, was increased during the washing step required for the transplantation of normal-density (5000 cells/cm<SUP>2</SUP>) cultured ASCs (5K-ASCs). When the human lung cancer cell line H460 was co-cultured with 40K-ASCs, necrotic cell death was dramatically increased <I>in vitro</I>. When ASCs were injected after four washes, both 5K-ASCs and 40K-ASCs substantially reduced tumor weight in H460-derived cancer animal models. These results suggest that serum deprivation during the culture of 40K-ASCs or during the washing step of 5K-ASCs can induce IFN-β and/or TRAIL expression, ultimately leading to the tumor suppression capability of ASCs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> High-density cultured ASCs expressed IFN-β and TRAIL. </LI> <LI> Serum deprivation induced IFN-β/TRAIL expression in high-density cultured ASCs. </LI> <LI> <I>IFN-β</I> mRNA expression was increased during washing with phosphate-buffered saline. </LI> <LI> H460 necroptosis occurred in culture with high-density cultured ASCs. </LI> <LI> High-density cultured ASCs reduced tumor weight in murine xenograft model. </LI> </UL> </P>
Jung, Hyejeon,Lee, Kangseok,Shim, Sang Eun,Lee, Jung Min,Choe, Soonja 한국공업화학회 2004 응용화학 Vol.8 No.1
A novel crosslinkable macromonomer of vinyl terminated bifunctional polyurethane was synthesized and applied to the dispersion polymerization of MMA in ethanol. The monodisperse crosslinked PMMA microspheres having the size (D_w) of 5.09㎛ and good uniformity of 1.01 were obtained with 20 wt% polyurethane macromonomer. Due to the crosslinked structure of the microspheres, the higher molecular weights and much enhanced thermal stability of the PMMA was obtained compared to the one prepared using the noncrosslinkable conventional stabilizer, PVP. These results indicate that the macromonomer acts as a stabilizer as well as an effective crosslinking agent and that the monodisperse crosslinked microspheres could be prepared using this type of macromonomer without altering the surface smoothness and particle shape.
Jung, Kyung-Won,Lee, Soonjae,Lee, Young Jae Elsevier 2017 Bioresource technology Vol.245 No.1
<P><B>Abstract</B></P> <P>In this work, magnesium ferrite (MgFe<SUB>2</SUB>O<SUB>4</SUB>)/biochar magnetic composites (MFB-MCs) were prepared and utilized to remove phosphate from aqueous solutions. MFB-MCs were synthesized via co-precipitation of Fe and Mg ions onto a precursor, followed by pyrolysis. Characterization results confirmed that MgFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles with a cubic spinel structure were successfully embedded in the biochar matrix, and this offered magnetic separability with superparamagnetic behavior and enabled higher phosphate adsorption performance than that of pristine biochar and sole MgFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles. Batch experiments indicated that phosphate adsorption on the MFB-MCs is highly dependent on the pH, initial phosphate concentration, and temperature, while it was less affected by ionic strength. Analysis of activation and thermodynamic parameters as well as the isosteric heat of adsorption demonstrated that the phosphate adsorption is an endothermic and physisorption process. Lastly, highly efficient recyclability of the MFB-MCs suggested that they are a promising adsorbent for phosphate removal from wastewater.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Magnesium ferrite/biochar magnetic composites (MFB-MCs) have been synthesized. </LI> <LI> MFB-MCs exhibited superior removal performance than either biochar or MgFe<SUB>2</SUB>O<SUB>4</SUB> alone. </LI> <LI> The phosphate adsorption follows an inner-sphere coordination mechanism. </LI> <LI> Kinetic and isotherm results indicate the physisorption and endothermic in nature. </LI> <LI> MFB-MCs could be separated magnetically and regenerated effectively. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Soonjae Hwang,Min Ho Lee,Sun-Yeong Gwon,Seunghyung Lee,Dongju Jung,Ki-Jong Rhee 대한의생명과학회 2013 Biomedical Science Letters Vol.19 No.2
Enterotoxigenic Bacteroides fragilis (ETBF) causes inflammatory diarrhea in humans and animals and is also implicated in colorectal cancer. ETBF-infected mice exhibit a prominent large intestinal inflammation characterized by neutrophil infiltration and induction of the Th17 response. In this study, we examined differences in the secreted cytokine profile of the cecum and proximal colon of ETBF-infected mice using an antibody array. Of the cytokines examined, we found that the cecal tissues from ETBF-infected mice secreted elevated levels of G-CSF, IL-6, IL-17 and LIX compared to non-toxigenic Bacteroides fragilis (NTBF) and Mock infected mice. The proximal colon tissues from ETBF-infected mice secreted higher levels of G-CSF, IL-6, KC, LIX, MIP-1g and MCP-1. This study demonstrates that the cecum and colon should be considered separately when assays are used to determine immune responsiveness to enteric infections.
Jung, Hyejun,Kim, So Yeoun,Lee, Kangseok,Lee, Byung H.,Shim, Sang Eun,Choe, Soonja Wiley Subscription Services, Inc., A Wiley Company 2005 Journal of polymer science Part A, Polymer chemist Vol.43 No.16
<P>A novel bifunctional vinyl-terminated polyurethane macromonomer was applied to the dispersion polymerization of styrene in ethanol. Monodisperse polystyrene (PS) microspheres were successfully obtained above 15 wt % of macromonomer relative to styrene. The steep slope from the reduction of the average particle size reveals that the macromonomer can efficiently stabilize higher surface area of the particles when compared with a conventional stabilizer, poly(N-vinylpyrrolidone). The stable and monodisperse PS microspheres having the weight-average diameter of 1.2 μm and a good uniformity of 1.01 were obtained with 20 wt % polyurethane macromonomer. The grafting ratio of the PS calculated from <SUP>1</SUP>H NMR spectra linearly increased up to 0.048 with 20 wt % of the macromonomer. In addition, the high molecular weights (501,300 g/mol) of PS with increased glass transition and enhanced thermal degradation temperature were obtained. Thus, these results suggest that the bifunctional vinyl-terminated polyurethane macromonomer acts as a reactive stabilizer, which gives polyurethane-grafted PS with a high molecular weight. © 2005 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 43: 3566–3573, 2005</P> <B>Graphic Abstract</B> <P>A novel macromonomer of vinyl-terminated bifunctional polyurethane was synthesized and applied to the dispersion polymerization of styrene as the reactive stabilizer and grafting agent. The monodisperse polystyrene microspheres having the average diameter 1.2 μm and the high molecular weight of 501,300 g/mol were obtained with 20 wt% macromonomer via dispersion polymerization. <img src='wiley_img/0887624X-2005-43-16-POLA20827-gra001.gif' alt='wiley_img/0887624X-2005-43-16-POLA20827-gra001'> </P>