β‐Catenin regulates melanocyte dendricity through the modulation of PKCζ and PKCδ

Kim, Jin‐,Hwa,Sohn, Kyung‐,Cheol,Choi, Tae‐,Young,Kim, Mi Yoon,Ando, Hideya,Choi, Sun Ja,Kim, Sooil,Lee, Young Ho,Lee, Jeung‐,Hoon,Kim, Chang Deok,Yoon, Tae‐,Jin Blackwell Publishing Ltd 2010 Pigment cell & melanoma research Vol.23 No.3

<P><B>Summary</B></P><P>The Wnt/β‐catenin signaling pathway is involved in the melanocyte differentiation and melanoma development. However, the effect of β‐catenin for dendrite formation has not been clearly elucidated yet in normal human epidermal melanocytes (NHEM). To investigate the effect of β‐catenin, we transduced NHEM with recombinant adenovirus expressing β‐catenin. Forced expression of β‐catenin led to the dramatic morphological changes of NHEM, including the reduction of dendrite length and enlargement of cell body. Concomitantly with, the protein levels for dendrite formation‐related molecules, such as Rac1 and Cdc42, were markedly decreased. In addition, phosphorylation of p38 MAPK was significantly reduced by β‐catenin, potentiating its inhibitory role for dendrite formation. Interestingly, overexpression of β‐catenin led to the increase of protein kinase C ζ (PKCζ) level, while protein kinase C δ (PKCδ) was decreased by β‐catenin, suggesting that those PKCs were β‐catenin‐downstream modulators in NHMC. When PKCζ was overexpressed, dendrites were shortened, with the reduced protein levels for Rac1 and Cdc42. In contrast, PKCδ overexpression led to the elongation of dendrites, with the increased levels for Rac1 and Cdc42. These results suggest that β‐catenin play an inhibitory role for dendrite formation through the modulation of PKCζ and PKCδ.</P>

National Conservation Agenda for the Future of Korea

Kim, Sooil 경희대학교 한국조류연구소 1996 연구보고 Vol.5 No.1

본 고는 우리나라 자연환경 보전을 위하여 실천방향을 수립하는데 필요한 전략적 기본 틀을 제시한 것이다. 네 가지 사회적 실천요소를 중시하였는데, 환경인식의 제고, 국가차원의 법과 제도정비, 환경과학기술과 지식의 확대, 그리고 자연보전 활동의 세계공조들로 구성된 전략의 틀이다. 이러한 전략은 지금의 자연환경 보전노력을 보다 생태학적으로 공고하며, 또 효과적인 방향으로 추진될 수 있게 할 것이다. 위의 네가지 요소들을 균형있게 발전시키는 일을, 이미 많이 훼손된 우리나라의 자연환경을 보전, 복원하는데, 그리고 우리 사회의 지금과 미래를 위하여 필수적인 것으로 보았다. 우리 사회는 지금의 환경문제들을 하루 속히 개선해야만 하며, 특히 자연 생태계를 보호하는데 마땅히 구체적 노력들을 추진해나가야만 한다. 그러므로 본고는, 한국의 자연환경 보전이 나갈 방향에 대하여 새로운 목표와 시각, 그리고 새로운 접근방식을 가지고 지금의 환경문제들을 구체적으로 다루어 나간 것을 제안하고 있다. 여기서 소개한 전략의 틀은 한국의 자연보전 운동이 세계 자연보전 전략의 정신에도 합당한 것으로 고안되어 있다. 특별히, 1) 지속가능한 사회의 건설, 2) 생물다양성 보전이라는 두 가지 세계자연환경 보전전략의 주제에 촛점을 맞추고 있다. 아직까지 우리나라에서는, 서로 긴밀히 관현된 이 두 가지 목표가 자연환경 보전활동의 주된 방향으로 설정되거나 적절히 적용되지 못하였다. 이런 원리 적용상의 약점이 우리의 자연환경보전 운동 전반에 자리하고 있었다고도 볼 수가 있다. 여기 소개된 전략의 기본특은 이러한 부족한 점들을 지적하고, 우리 사회의 자연환경 보전의지에 새로운 변화를 통하여 지금의 자연환경 보전문제들을 개선해 나갈 것을 촉구하고 있다. With this study, I propose a national conservation strategy that will serve as a framework on which to build actions specific to the Korean society. The four central components of my strategy are: increasing environmental awareness, establishing national policy, expending knowledge base and environmental technology, and joining international conservation alliances. It is hoped that this strategy will strengthen current conservation efforts by making them more ecologically sound thereby making them more effective. Without commitments to these four areas, there are no immediate alternatives for restoring the damaged condition of the Korean environment now or in the future. Korean society cannot afford to ignore the current problems and will not be able to overcome them with current inadequate conservation measures that fail to protect natural ecosystems. For this reason, this framework of conservation strategy proposes to re-organize Korean conservation, with a new set of goal, scope and approach that addresses the real problems. This strategy aims to bring the current conservation movement in Korea into line with the spirit of recent world conservation strategies. Particularly, it links two recent themes highlighted in the global conservation movement. They are the theme: 1) building a sustainable society, and 2) conserving biological diversity. In Korea, these important themes have not been adequately pursued, nor have the underlying concepts been appropriately embraced. Lack of such principles is the major weakness in the Korean conservation movement, and that is a concern this framework will address. It also identifies specific deficiencies that will be overcome only if there is a significant change in the commitment of Korean society.

Proposal of Liquefaction Potential Assessment Procedure using Real Earthquake Loading

Sooil Kim,Keunbo Park 대한토목학회 2008 KSCE JOURNAL OF CIVIL ENGINEERING Vol.12 No.1

In this paper, the application of the energy-based excess pore pressure generation model using damage potential to the assessmentof liquefaction potential is examined through experimental and analytical investigations. For a more realistic description of thedynamic responses of saturated sands, the model parameters of the proposed model were modified based on the relative density.Dynamic undrained triaxial tests were performed for sand with different relative densities. Based on the test results, new equationsfor the model parameters with the relative density were addressed. Further, a liquefaction potential assessment procedure using themodel based on the maximum cumulative excess pore pressure ratio is also proposed. Factors of safety calculated from the stress-based method and the proposed method were compared through examples with different soils and earthquake conditions.

Conditions for Reintroduction of Captive-Bred Endangered Birds: A Review

Kim, Sooil,Park, Heonwoo,Cheong, Seokwan National Institute of Ecology 2022 국립생태원회보(PNIE) Vol.3 No.3

Reintroduction programs have been promoted across the world to recover and rehabilitate endangered birds through ex situ captive breeding and releasing to the nature. The ultimate aims of these reintroduction programs are recovery of sustainable populations in natural habitats. To ensure the success of the reintroduction programs, it is necessary to examine the followings in order to increase the success rate of releasing along with the development of captive breeding techniques: 1) Adequate habitat provision, 2) adaptability of captive-bred individuals, 3) survivability of released individuals, and 4) social interest and will. Before releasing captive-bred individuals, it should be reviewed whether there are habitats in which the limiting factor is removed, and assessed their long-term safety. The quantity and quality of the released individuals must be considered to increase the chances for mate selection, maintain genetic diversity, and acquire the ability to adapt to the wild. The release method must be decided in consideration of characteristics of the target habitats and individuals, and rational means such as careful observation, evaluation, and feedback must be provided throughout the release process. For the long-term success of recovery projects, social awareness, sustainable support, and related experts are needed. Satisfying these criteria can help to increase the success rates of reintroduction programs. For the bird reintroduction program in the future, the feasibility of the methods and procedures must be closely reviewed before starting.

Pulsed laser induced mechanical behavior of Zircaloy-4

Kim, Sooil,Lee, Woo-Ju,Han, Quhon,Kim, Dongchoul Cambridge University Press (Materials Research Soc 2015 Journal of materials research Vol.30 No.4

<▼1><B>Abstract</B><P/></▼1><▼2><P>The mechanical behavior of a Zircaloy-4 sheet as induced by a pulsed laser was studied with an accurately developed computational process that was validated with experiments. A modified Gaussian model of the heat source and the use of experimentally obtained thermal and mechanical properties of Zircaloy-4 in the computational process provided reliable simulation results of the phase transition and mechanical deformation of Zircaloy-4. A parametric study of the pulsed laser welding conditions of Zircaloy-4 was undertaken using the developed computational process. The analyzed parameters were the laser power, pulse duration, and pulse frequency. The simulation results revealed that the deformation was significantly dependent on the geometry of the molten zone and the heat-affected zone, which can be designed by the analyzed laser parameters.</P></▼2>

Gaussian 곡률 오차 추정을 이용한 Mesh 간략화

임수일(Sooil Lim),김선정(Sun-Jeong Kim),김창헌(Chang-Hun Kim) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.2Ⅱ

본 논문은 mesh 간략화를 위한 새로운 Gaussian 곡률 오차 추정 방법을 제안한다. Gaussian 곡률은 임의의 형상을 갖는 삼각화 된 다면체 표면에 대하여 위상과 기하학적 정보를 angle과 face의 관계를 정형화하여, vertex에 관한 곡률로 근사하여 표현한다. 간략화 방법은 지역적 형상으로부터 전체적인 형상을 추정한 후, 적절한 curvature criteria로 간략화가 될 vertex를 선택하고 제거한다. 제거된 vertex에 의해 생성된 hole은 곡률에 기반하여 삼각화 하고 곡률이 변화되는 vertex들이 Gaussian 곡률 오차를 계산한다. 각 간략화 level마다 최대 Gaussian 곡률 오차를 계산하므로, 사용자는 Gaussian 곡률 오차 추정으로 원하는 간략화 level을 지정할 수 있다. 또한 주어진 오차 안에서 vertex 뿐만 아니라 edge나 face의 제거로, 간략화 되는 영역을 확산시켜 필요한 위상과 기하학적 정보를 유지하는 간략화를 할 수 있다.

수중에서의 전술항해 기법에 대한 연구

김형관(Kim Hyungkwan),권수일(Kwon Sooil),김규백(Kim Kyubaek) 제어로봇시스템학회 2011 제어로봇시스템학회 합동학술대회 논문집 Vol.1 No.2

수중에서는 은밀하게 수상 및 수중의 표적을 탐지하고 추적할 수 있는 뛰어난 전술적 장점을 가지나 수중에서의 기동성은 수상세력에 비해 크게 제한되는 조건으로 인하여 위협세력으로부터 피탐이 된다면 생존성 보장이 매우 어렵다. 본 논문에서는 수중에 발생될 수 있는 전술상황을 고려한 전술항해 기법으로 표적으로 가장 가깝게 접근할 수 있거나 가장 신속하게 멀어질 수 있는 기능과 위협표적을 회피한 후 원래의 항로로 복귀할 수 있는 기능을 제안한다.

LH 스마트시티 추진현황

김수일 ( Sooil Kim ) 한국품질경영학회 2018 한국품질경영학회 학술대회 Vol.2018 No.-

리튬 이차전지의 양극 내부 이온 확산 및 상변화 특성 연구

김수일(Sooil Kim),김동철(Dongchoul Kim) 대한기계학회 2013 大韓機械學會論文集B Vol.37 No.7

리튬 이차전지의 양극재에 따른 이온 확산 및 상전이 연구

김수일(Sooil Kim),김동철(Dongchoul Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5