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Im, Seock-Ah,Mazano, Cankelaria Gomez,Fueyo, Juan,Liu, Ta-Jen,Ke, Li-Dao,Jeong Soo Kim,Lee, Ho-Young,Steck, Peter A.,Kyritsis, Athanassios P.,Yung, W.K. Alfred 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Presently, there is no effective treatment for glioblastoma, the most malignant and common brain tumor. Angiogenic factors are potentially optimal targets for therapeutic strategies because they are essential for tumor growth and progression. In this study, we sought a strategy for efficiently delivering and antisinse cDNA molecule of the vascular endothelial growth factor(VEGF) to glioma cells. The recombinant adenoviral vector Ad5CMV-αVEGF carried the coding sequence of wild-type VEGF165 cDNA in an antisense orientation. Infection of U-87 MG malignant glioma cells with the Ad5CMV-αVEGF resulted in reduction of the level of the endogenous VEGF mRNA and drastically decreased the production of the targeted secretory form of the VEGF protein. Treatment of human glioma tumors established in nude mice with intralesional injection of Ad5CMV-αVEGF inhibited tumor growth. Taken together, these findings indicate that the efficient down-regulation of the VEGF produced by tumoral cells using antisense strategies has an antitumor effect in vivo, This is the first time that an adenoviral vector is used to transfer antisense VEGF sequence into glioma cells in an animal model, and our results suggest that this system may have a clinical and therapeutic utility. (Cancer Researcg 59:895-900, 1999)
초등교사의 기초학력부진아 지도실태분석을 통한 학력 신장 지원방안
임영재(Im, Young Jae),김수현(Kim, Soo Hyun),박정아(Park, Jeong Ah) 학습자중심교과교육학회 2021 학습자중심교과교육연구 Vol.21 No.6
본 연구의 목적은 초등교사의 기초학력부진아 지도실태분석을 통한 학력 신장 지원방안을 모색하는 것이다. 이를 위해 2020년 10월부터 11월까지 경기도 소재 초등교사 272명의 설문 내용을 분석하였다. 본 주제 설정의 근본 취지는 코로나19의 확산에 따른 기초학력부진에 대한 우려로 기초학력부진 대응책을 교육부, 교육청, 교육지원청에서 중요 수행과제로 설정하였기 때문이다. 원격수업 사전 준비 부족은 학생들의 자기주도적 학습능력에 따른 학습격차로 이어졌고, 해결방안 강구가 교육혁신의 가장 큰 문제로 부각되었다. 이에 따른 분석결과는 기초학력부진아 지도의 목적 및 운영계획, 추진 방법의 이해 정도가 가장 높게 나타났고, 기초학력부진아 지도, 지원과 관련하여 도움을 받을 수 있는 지역사회 기관을 활용한다는 인식이 가장 낮게 나타났으며, 여교사, 20년 이상 경력 교사, 기초학력부진아 지도 관련 연수경험이 있는 교사의 기초학력부진아 지도실태에 대한 인식 수준이 높은 것으로 나타났다. 그리고 기초학력부진아 학력 신장 지원방안에서는 수업 중 팀티칭을 위한 협력교사 확대가 가장 높게 나타났고, 모니터링 및 컨설팅 지원이 가장 낮게 나타났으며, 경력에 따라 교사의 인식 수준은 차이를 보였다. 따라서 본 연구자는 교사 연수 확대, 지역사회와의 협력강화를 통한 학력부진에 관한 효과적 대응방안, 정책⋅재정 지원 등이 절실히 필요함을 인식하였다. 또한, 기초학력부진아의 지도실태 및 학력 신장을 교육혁신의 방향에서 접근시켜 특색있는 교육프로그램 개발 및 운영이 이루어져야 할 것이다. This study analyzed the responses of 272 teachers from 16 elementary schools in Gyeonggi-do in order to find ways to support slow learners through the analysis of the survey. According to the analysis, female teachers are more aware of the slow learners education than male teachers, general teachers rather than senior teachers, and teachers with more than 20 years of experience in teaching slow learners had a high level of awareness of the actual status for slow learners education. In addition, to support the improvement of education for slow learners is also found to be more recognizable than for female teachers, general teachers, and teachers with experience in teaching slow learners rather than male teachers, senior teachers and teachers without experience in teaching slow learners. The level of perception of teachers differed according to their careers. Therefore, in order to enhance the understanding of slow learners and to provide effective education, an integrated welfare support system shall be established to expand teacher training and strengthen community cooperation. Moreover, it is necessary to expand the deployment of cooperative teachers and to gather opinions from field teachers. Based on the research results, it will be necessary to strengthen connections with families and develop and operate distinctive educational programs that reflect school and regional characteristics in order to increase the educational background.
천식 환아와 보호자의 삶의 질에 영향을 주는 요인 조사를 위한 다 기관 공동 연구
조아름 ( Ah Rum Cho ),이소연 ( So Yeon Lee ),김영호 ( Young Ho Kim ),유영 ( Young Yoo ),양현종 ( Hyeon Jong Yang ),이주석 ( Ju Seok Lee ),송태원 ( Tae Won Song ),김우경 ( Woo Kyung Kim ),홍수종 ( Soo Jong Hong ),강임주 ( Im Ju Ka 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.1
Purpose: Pediatric asthma is the most common chronic disease in children. It negatively affects the health-related quality of life (QoL) in children with this disease and of their caregivers. This study evaluated the relationship between clinical disease severity and the QoL of patients with asthma and their caregivers. Methods: The study included 247 patients with asthma and their caregivers. The patients and caregivers completed the Korean Pediatric Asthma Quality of Life Questionnaire and the Korean Pediatric Asthma Caregivers Quality of Life Questionnaire, respectively, during clinic visits. The results were expressed as the mean score for each domain. All items were rated from 1 to 5:1, low QoL; and 5, satisfactory QoL. Results: The emotion and activity QoL scores of boys were significantly higher than those of girls (P=0.001). The QoL of both patients and their caregivers was correlated more with the patients` subjective symptom scores than with the clinical severity of asthma or with lung function. Conclusion: The QoL of patients with asthma and their caregivers decreased as asthmatic symptoms became worse. Controlling asthma symptoms is important for improving the QoL of both patients and their caregivers. Patients and their caregivers need to be evaluated and counseled during asthma treatment to improve their QoL.
Kim, Jeong-Soo,Jeon, Hae-Myung,Im, Seock-Ah,Kim, Jae-Sung 가톨릭대학교 2000 Bulletin of The Catholic Research Institutes of Me Vol.28 No.-
Adenoviruses are currently widely used as vectors in gene therapy. The steps involved in adenoviral infection have been investigated, but the factors regulating viral entry to the cell have not been clearly identified. We ovserved a high adenoviral infection rate in HER-2/neu-overexpressing breast cancer cells in vitro (435.eb1 and MCF-7/H18) and in vivo (435.eb1). We used emodin, a tyrosine kinase inhibitor that suppresses autophosphorylation and transphosphorylation activities of the HER-2/neu tyrosine kinase, to test the role of HER-2/neu in adenoviral transductin. Emodin treatment resulted in a marked decrease in the transduction efficiency oif HER-2/neu - overexpressing cells but not in the parental cells. Because previous studies have shown that epidermal growth factor and tumor growth factor-α increase the expression level of integrin. Because integrin αv is known as a promotor of viral internalization, penetration, or both, we investigated whether the observed increased transduction rate in HER-2/neu transfectants was mediated through the increased expression of integrin αv. To test this hypothesis, we examined the level of integrin αv of in HER-2/neu overexpressing cells. We found that the level of integrin αv expression detected in HER-2/neu overexpressing cells by immunoblot analysis was similar to the level of integrin αv found in its parental cells. These results suggest that HER-2/neu expression may have a significant role in the viral transduction efficiency through an integrin αv independent pathway. (Oncology Reports 6:1237-1242, 1999)
Choi, Yeon Ah,Yoon, You Hyun,Choi, Kwangik,Kwon, Mihwa,Goo, Soo Hyeon,Cha, Jin-Sun,Choi, Min-Koo,Lee, Hye Suk,Song, Im-Sook Pharmaceutical Society of Japan 2015 Biological & pharmaceutical bulletin Vol.38 No.2
<P>To overcome the low oral bioavailability of morin, a mixed micelle formulation with pharmaceutical excipients that facilitate solubilization and modulate P-glycoprotein (P-gp) was developed and evaluated in vitro and in vivo rats. Morin-loaded mixed micelle formulation with a morin-PluronicF127-Tween80 ratio of 1 : 10 : 0.02 (w/w/w) was prepared by a thin-film hydration method. The solubility, size distribution, drug encapsulation efficiency, and percent drug loading of the formulation were characterized. Subsequently, in vivo pharmacokinetic parameters of morin loaded in a PluronicF127 and Tween80 mixed-micelle formulation were investigated in rats. Absolute bioavailability of morin was dramatically increased by the oral administration of morin-loaded PluronicF127 and Tween80 mixed micelle from 0.4% to 11.2% without changing the systemic clearance and half-life. In Caco-2 cells, absorption permeability of morin from the novel formulation was increased 3.6-fold compared with that of morin alone. P-gp inhibition by cyclosporine A (CsA) increased absorptive permeability of morin 2.4-fold but decreased the efflux of morin by 52%, which was consistent with increased plasma concentration of morin in the pretreatment of CsA in rats. The morin formulation inhibited P-gp transport activity by 83.1% at 100 ?M as morin concentration. Moreover, morin formulation increased paracellular permeability of Lucifer yellow by 1.6-1.8 fold. In conclusion, enhanced oral bioavailability of morin from morin-loaded PluronicF127 and Tween80 mixed micelle formulation can be attributed to increased intestinal permeation of morin, which was mediated at least by P-gp inhibition and enhanced paracellular route.</P>
임석아(Seock Ah Im),이순남(Soon Nam Lee),경난호(Nan Ho Kyung),박응범(Eung Bum Park),서정수(Jung Soo Seo),한운섭(Woon Sup Han) 대한내과학회 1996 대한내과학회지 Vol.50 No.3
Islet cell hyperlasia is a common cause of persistent hyperinsulinemic hypoglycemia in pediatric population, but is very rare in adults. We experienced 64-year-old woman with history of symptomatic hypoglycemia such as ligh-headedness and loss of consciousness. Her blood glucose level measured in the emergency room after this incident, was 33mg/dl and documented elevation of her fasting plasma insulin to glucose ratio(0.76). She responded to intravenous glucose administration. She was performed preoperative percutaneous transhepatic portal venous insulin sampling at 2cm intervals along the portal and splenic veins. Insulin levels at these sites were measured and localization of oversecretion of insulin preoperatively and the patient underwent a distal pancreatectomy, which revealed islet cell hyperplasia only without definite mass. She remains asymptomatic 4 years after surgery with normal blood glucose and insulin level.