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콩 유전자원의 지방함량과 지방산조성 평가 및 유용자원의 선발
송항림(Hang-Lin Song),장은규(Eun Kyu Jang),손은호(Eun Ho Son),이구환(Ku Hwan Lee),황세구(Se Gu Hwang),윤건식(Geon Sig Yun),이정동(Jeong-Dong Lee),김홍식(Hong Sig Kim) 한국육종학회 2015 한국육종학회지 Vol.47 No.3
This study was carried out to evaluate the oil contents and fatty acid compositions of 379 soybean germplasm accessions which is composed of 128 Korean, 214 Chinese and 37 USA accessions, and to select useful resources for the development of high oil content and quality fatty acid varieties in soybean. Korean and Chinese germplasm accessions were obtained from the National Agrobiodiversity Center, National Academy of Agricultural Science, Rural Development Administration, and USA accessions from the Plant Genetics and Breeding Laboratory of Kyungpook National University, Korea. The oil content ranges from 12.7∼26.0% with an average of 19.1% among accessions. The average contents and ranges of palmitic and stearic acid, saturated fatty acids (SFA), were 10.6% with a range of 4.1∼18.1% and 2.9% with a range of 1.9∼12.7% respectively, while those of oleic, linoleic and linolenic acid, unsaturated fatty acids (USFA), were 28.2% with a range of 15.3∼56%, 51.2% with a range of 24.4∼68% and 7.1% with a range of 3.4∼11.1% respectively. The average linoleic(ω-6)/linolenic(ω-3) acid ratio was 7.5 ranging from 3.8∼17, and the average SFA and USFA contents were 13.5% ranging from 6.7∼21.7% and 86.5% ranging 78.3∼93.4% respectively. Accessions with better essential properties were selected as useful resources for the development of high oil content and quality fatty acid varieties. Three accessions, Suinong 14, Dongnong 434 and Dongnong 46 from China contain oil higher than 25.0%, while five accessions including KLG 12073 and KLG 12074 from USA, Jilin 14 from China, Kwangan and Bongeui from Korea contain oleic acid higher than 50%. Eight accessions including KLG12083 and KLG12081 from USA contain linoleic acid higher than 60%. Seven accessions including KLG 12093 and KLG12096 from USA contain linolenic acid lower than 4%. Five accessions, KLG12074 and KLG12073 from USA, Kwangan and Bongeui from Korea, and Dongnong 47 from China were low linoleic acid(ω-6)/linolenic(ω-3) ratio resources with lower than 4.5.
Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson’s Disease
Hung-Li Wang,Chin-Song Lu,Tu-Hsueh Yeh,Yu-Ming Shen,Yi-Hsin Weng,Ying-Zu Huang,Rou-Shayn Chen,Yu-Chuan Liu,Yi-Chuan Cheng,Hsiu-Chen Chang,Ying-Ling Chen,Yu-Jie Chen,Yan-Wei Lin,Chia Chen Hsu,Huang-Li 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.4
Background and Purpose It is essential to develop a reliable predictive serum biomarker for Parkinson’s disease (PD). Te accumulation of alpha-synuclein (αSyn) and up-regulated expression of Rab35 participate in the etiology of PD. Te purpose of this investigation was to determine whether the combined assessment of serum αSyn and Rab35 is a useful predictive biomarker for PD. Methods Serum levels of αSyn or Rab35 were determined in serum samples from 59 sporadic PD patients, 19 progressive supranuclear palsy (PSP) patients, 20 multiple system atrophy (MSA) patients, and 60 normal controls (NC). Receiver operating characteristics (ROC) curves were calculated to determine the diagnostic accuracy of αSyn or/and Rab35 in discriminating PD patients from NC or atypical parkinsonian patients. Results The levels of αSyn and Rab35 were increased in PD patients. The serum level of Rab35 was positively correlated with that of αSyn in PD patients. Compared to analyzing αSyn or Rab35 alone, the combined analysis of αSyn and Rab35 produced a larger area under the ROC curve and performed better in discriminating PD patients from NC, MSA patients, or PSP patients. When age was dichotomized at 55, 60, 65, or 70 years, the combined assessment of αSyn and Rab35 for classifying PD was better in the group below the cutof age than in the group above the cutof age. Conclusions Combined assessment of serum αSyn and Rab35 is a better biomarker for discriminating PD patients from NC or atypical parkinsonian patients, and is a useful predictive biomarker for younger sporadic PD patients.
Lan Ting-Yuan,Lin Yen-Chun,Tseng Tai-Chung,Yang Hung-Chih,Kao Jui-Hung,Cheng Chiao-Feng,Lee Tai-Ju,Huang Shang-Chin,Lu Cheng-Hsun,Li Ko-Jen,Hsieh Song-Chou 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Rituximab is known to be associated with high hepatitis B virus (HBV) reactivation rate in patients with resolved HBV infection and hematologic malignancy. However, data regarding HBV reactivation (HBVr) in rheumatic patients receiving rituximab is limited. To assess the HBVr rate in hepatitis B surface antigen (HBsAg)-negative patients receiving rituximab for autoimmune diseases in a large real-world cohort. Methods: From March 2006 to December 2019, 900 patients with negative HBsAg receiving at least one cycle of rituximab for autoimmune diseases in a tertiary medical center in Taiwan were retrospectively reviewed. Clinical outcome and factors associated with HBVr were analyzed. Results: After a median follow-up period of 3.3 years, 21 patients developed HBVr, among whom 17 patients were positive for hepatitis B core antibody (anti-HBc) and four were negative. Thirteen patients had clinical hepatitis flare, while eight patients had HBsAg seroreversion without hepatitis. Old age, anti-HBc positivity, undetectable serum hepatitis B surface antibody level at rituximab initiation and a higher average rituximab dose were associated with a higher HBVr rate. There was no significant difference in the HBVr risk between rheumatoid arthritis and other autoimmune diseases. Among anti-HBc-negative patients, subjects without HBV vaccination at birth had an increased risk of HBVr (4/368, 1.1%) compared with those who received vaccination (0/126, 0%). Conclusions: In HBV endemic areas where occult HBV is prevalent, anti-HBc-negative patients, may still be at risk for HBVr after rituximab exposure. HBVr may still be considered in HBsAgnegative patients developing abnormal liver function after rituximab exposure, even in patients with negative anti-HBc.
Chen, Yu,Wu, Fen,Saito, Eiko,Lin, Yingsong,Song, Minkyo,Luu, Hung N.,Gupta, Prakash C.,Sawada, Norie,Tamakoshi, Akiko,Shu, Xiao-Ou,Koh, Woon-Puay,Xiang, Yong-Bing,Tomata, Yasutake,Sugiyama, Kemmyo,Par Springer-Verlag 2017 Diabetologia Vol.60 No.6
<P>Diabetes was associated with a 26% increased risk of death from any cancer in Asians. The pattern of associations with specific cancers suggests the need for better control (prevention, detection, management) of the growing epidemic of diabetes (as well as obesity), in order to reduce cancer mortality.</P>
Cui Xi-Hua,Hosakatte Niranjana Murthy,Zhang Ji-De,Song Hang-Lin,Jiang Yin-Ji,Qi Wen-Wen,Li Yong Yi,백기엽,박소영 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.3
In this study, we aimed to verify the effect of nutritional factors on the accretion of secondary metabolites in the adventitious root (AR) cultures of Malaysian ginseng (Eurycoma longifolia Jack) grown in small-scale bioreactors. AR were induced from leaf explants and cultured in different types of media including Murashige and Skoog (MS) medium, Driver Kuniyuki Walnut (DKW) medium, Gamborg’s B5 medium, Woody Plant Medium (WPM), and ¾ MS medium. Among these media, the MS and Gamborg’s B5 media induced lateral root development from initial inoculum, which accounted for the increase in AR biomass accretion. By contrast, the DKW and WPM media did not induce lateral root formation from the cultured explants. The ¾ MS medium was optimal for the growth of AR and accretion of secondary metabolites, after 7 weeks of culture, the biomass of AR increased by 8.6-fold in ¾ MS medium, and the total phenolic and flavonoid contents reached 5.23 and 2 mg g−1 of tissue dry weight, respectively. Analysis of mineral elements in the spent medium revealed that ¾ MS medium was most suitable for nutrient supply to developing AR. LC–MS analysis showed the accretion of eurycomanone, a therapeutically useful metabolite, in the AR of Malaysian ginseng.
허건 ( Gun Hur ),장성진 ( Seong Jin Jang ),이윤호 ( Yun Ho Lee ),송항림 ( Hang Lin Song ),김성진 ( Seong Jin Kim ),정헌상 ( Heon Sang Jeong ),조용구 ( Yong Gu Cho ),김홍식 ( Hong Sig Kim ) 한국콩연구회 2008 韓國콩硏究會誌 Vol.25 No.1
한국야생콩 200종, 한국재래콩 300종 및 도입유전자원 398종을 포함한 총 898종에 대하여 SDS-PAGE에 의한 종실 단백질의 변이를 구명하고 변이자원을 발굴하여 고품질 콩 품종개발의 기초자료로 이용코자 수행하였다. 1. 7S함량은 평균 45.85%로서 7.16-66.24%의 범위였고, 변이자원은 α` subunit 결실 6종, α subunit 결실 1종, α` 및 α subunit 동시 결실 2종, β subunit 결실 6종, α 및 β subunit 동시저하 1종의 총 16종이 발굴되었다. 2. 11S함량은 평균 54.16%로서 33.76-89.67%의 범위였고, 변이자원은 A3 subunit 결실 6종, Acidic 저하 3종, Basic 저하 5종, Acidic 및 Basic 동시저하 1종의 총 15종이 발굴되었다. 3. 11S/7S 비율은 평균 1.18로서 0.5-8.68의 범위였으며, 도입유전자원의 변이가 가장 컸고, 다음으로 한국 야생콩이 컸으며 한국 재래콩이 작았다. 11S/7S 비율이 높은 자원으로는 CS1733, CS79, CS1228, CS1230 및 CS667의 5종이 발굴되었다. 4. Lipoxygenase 결실 변이자원은 11종, Kunitz trypsin inhibitor 결실 변이자원은 12종이 발굴되었다. To identify soybean genetic resources with specific seed proteins, a total of 898 soybean resources including 200 Korean wild soybeans, 300 korean local soybeans and 398 introduced soybeans were screened to evaluate variations of seed storage protein by SDS-PAGE. 7S concentrations of seed storage protein ranged from 7.16% to 66.24% with a mean of 45.85%. Sixteen variants including six lacking of α` subunit, one lacking of α subunit, two lacking of both α` and α subunits, six lacking of β subunit and one low level of both α and β subunits were detected for 7S seed storage protein. 11S concentrations of seed storage protein ranged from 33.76% to 89.67% with a mean of 54.16%. Fifteen variants including six lacking of A3 subunit, three low level of acidic group, five low level of basic group were detected for 11S seed storage protein. 11S/7S ratio of seed storage protein ranged from 0.5 to 8.68 with a mean of 1.18. Variation of 11S/7S ratio was largest in introduced soybeans, medium in Korean wild soybeans, and smallest in Korean local soybeans among three soybean groups. Of 898 soybean germplasms, CS1733, CS79, CS1228, CS1230 and CS667 were extremely high in 11S/7S ratio of seed storage protein. Eleven and twelve variants were detected for lacking lipoxygenase and for lacking kunitz trypsin inhibitor, respectively.
Xiang-Min Piao,Yun-Ho Lee,Seong Jin Kim,Hang-Lin Song,Sang-Young Nam,In-Jae Kim,Hong-Sig Kim 한국작물학회 2010 한국작물학회 학술발표대회 논문집 Vol.2010 No.04
This study was conducted to examine the variations of seed hull color characteristics, the oil contents and fatty acid composition in 275 sunflower germplasms. The seed hull of sunflower germplasms were classified into 4 colors of white, black, grey, and brown. The grey color of seed hull was the highest percentage of 33.8%, whereas the white color of seed hull was the lowest percentage of 5%. Average oil content was 22.5% with a range from 11.7% to 45.5%. Average saturated fatty acid contents were 6.9%, while average content of unsaturated fatty acid was 93%. The average contents of fatty acids such as palmitic acid, stearic acid, oleic acid, and linoleic acid were 4.7%, 2.2%, 55.2%, and 38%, respectively. Comparing the oil contents and fatty acids among different seed hull colors, the highest content of oil was with grey seed hull color and the lowest with white seed hull color. Saturated fatty acid were higher in brown seed hull color. Unsaturated fatty acids were higher in grey and black seed hull colors. It could be observed that there was significant negative correlation(r=-0.998**) between linoleic and oleic acid content, and also L-value(Lightness of seed hull color) showed significant negative correlations with oil content, oleic acid content and linoleic acid content.
국산 장려콩으로 만든 두유의 Mineral, Oxalate 및 Phytate 함량과 품질특성
김기찬(Ki Chan Kim),황인국(In Guk Hwang),김현영(Hyun Young Kim),송항림(Hang Lin Song),김홍식(Hong Sig Kim),장금일(Keum Il Jang),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.8
국산 콩으로 제조한 두유의 품질특성과 무기성분, oxalate 및 phytate 함량을 분석한 결과는 다음과 같다. 두유의 수율 및 고형분 함량은 각각 8.43(보광콩)~9.15 mL/g(봉의콩과 한남콩) 및 4.37°Brix(안평콩)~7.17°Brix(봉의콩) 범위로 나타났으며, pH와 총산도는 각각 6.43~6.86 및 1.48~1.65% 범위를 나타내었다. 점도는 15.73(다원콩)~20.80 cP(한남콩) 범위를 나타내었다. 색도는 검은색 외피를 갖고 있는 청자콩, 다원콩, 선흑콩 및 검정콩4호로 만든 두유의 L값이 작았고 a값은 크게 나타났다. Calcium 함량은 0.714(금강콩)~1.589 ㎎/g(선흑콩) 범위였으며, oxalate 함량은 0.24(안평콩)~2.14 ㎎/g(한남콩), phytate 함량은 0.63(호장콩)~ 2.18 ㎎/g(안평콩) 범위였다. Calcium/oxalate 함량 분포에서 oxalate 함량이 calcium보다 넓은 분포를 나타내었으며, phytate/ oxalate 간에는 phytate가 넓은 분포를 나타내었다. 콩에서 두유로의 oxalate 전이율은 13.6(안평콩)~77.6%(진품콩2호) 범위였으며, phytate는 13.9~87.5%로 동북태가 가장 높았고 호장콩이 가장 낮았다. 이상의 결과를 종합해보면 국산 장려 콩을 이용하여 두유를 제조할 경우 phytate의 전이율이 높고 oxalate의 전이율이 낮은 봉의, 안평콩 및 보광콩이 좋을 것으로 판단되었다. This study was conducted to investigate the changes of quality characteristics, and mineral, oxalate and phytate content during soymilk process. The yields of soymilk ranged from 8.43 mL/g in Bokwangkong to 9.15 mL/g in Bongeuikong and Hannamkong, and total soluble solid contents were ranged from 4.37°Brix in Anpyeongkong to 7.17°Brix in Bongeuikong, respectively. The pH and total acidity of soymilk ranged from 6.43 to 6.86 and from 1.48% to 1.65%, respectively. The viscosity of soymilk was the highest value of 20.80 cP in Hannamkong and the lowest value of 15.73 cP in Dawonkong. The highest value of calcium content of soymilk was 1.589 ㎎/g in Seonheukkong, and oxalate and phytate in soymilk were high at 2.14 ㎎/g in Hannamkong and 2.18 ㎎/g in Anpyeongkong, respectively. The transfer ratio of oxalate from soybean to soymilk was the highest value of 77.6% in Jinpumkong 2, and one of the phytate was the highest value of 87.5% in Dongpuktae and the lowest value of 13.9% in Hojangkong.