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( So Jin Bing ),( Manh Tin Ho ),( Phorl Sophors ),( Sang Gyu Park ),( Young Min Yun ),( Young Heun Jee ),( Moon Jae Cho ) 한국응용생명화학회 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.1
Extracted mushroom water showed an ability to suppress the accumulation of body fat in female mice after feeding 5 weeks with high fat diet. Particularly, in parametrial and mesenteric adipose, it significantly reduced 44 and 47% of weight, respectively. In non-obese mice, maturated NK cell (CD11bhiCD27lo) population were increased (70.9±3.8% ) in mushroom water fed mice compared to control (61.4±4.3%) and NK cell population were augmented in mushroom fed mice compared to control.
Bing, So Jin,Kim, Min Ju,Park, Eunjin,Ahn, Ginnae,Kim, Dae Seung,Ko, Ryeo Kyeong,Lee, Nam Ho,Shin, Taekyun,Park, Jae Woo,Jee, Youngheun Pharmaceutical Society of Japan 2010 Biological & pharmaceutical bulletin Vol.33 No.7
<P>Antioxidant property and hematopoietic repair capacity are important characteristics of radioprotective agents. Some studies have demonstrated that 1,2,3,4,6-penta-<I>O</I>-galloyl-β-<SMALL>D</SMALL>-glucose (PGG), a molecule isolated from the waterlily, has antioxidant, hematopoietic repair, and anti-inflammatory activities. In this study, we try to determine whether PGG extracted from a lily, <I>Nymphaea tetragona</I> var. <I>angusta</I>, has radioprotective effects on splenocytes <I>in vitro</I> against <SUP>60</SUP>Co γ-ray irradiation with absorption doses of 2 Gy and 4 Gy. Results show that PGG treatment dramatically enhances the proliferation of splenocytes compared with irradiated but untreated controls. In addition, PGG treatment before irradiation protects the splenocytes from lethal effects of irradiation and decreases DNA damages as identified by the alkaline comet assay. PGG-treated cells also show less radiation-induced apoptosis. These cells have lower concentrations of the pro-apoptotic protein p53 and more of the anti-apoptotic protein Bcl-2. The results presented in this study suggest that PGG has a cytoprotective effect on immune cells exposed to normally damaging amount of radiation. Thus, PGG could be an effective, non-toxic radioprotective agent.</P>
Youngheun Jee, Hyunyoung Oh, So Jin Bing, Areum Kim, Jinhee Cho 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.4
Our previous research on sulfated polysaccharide purified from Ecklonia cava, a brown alga found in Jeju island, Korea, showed that sulfated polysaccharides modulate the apoptotic threshold of intestinal cells, thereby preventing intestinal damage caused by ionizing radiation. In this study, we investigated the ability of sulfated polysaccharide to augment restoration of small intestinal stem cells from γ-ray-induced damage. In our results, sulfated polysaccharide treatment increased the numbers of Ki-67-positive cells as well as inducible nitric oxide synthase (iNOS)-expressing cells in the small intestine compared with those of irradiated only mice. Meanwhile, exposure to irradiation increased the number of paneth cells, which are frequently associated with intestinal inflammation, whereas sulfated polysaccharide treatment reduced the number of paneth cells in the small intestinal crypt. Conclusively, our data suggest that reduction of iNOS-expressing cells and paneth cells in sulfated polysaccharide-treated mice contributes to the inhibition of radiation-induced intestinal inflammation.
저선량 감마선 조사 마우스의 말초면역 세포에 대한 바나듐 함유, 제주 워터의 면역 활성 효과
하단비 ( Dan Bee Ha ),김민주 ( Min Ju Kim ),주해진 ( Hae Jin Joo ),조진희 ( Jin Hee Cho ),빙소진 ( So Jin Bing ),임윤규 ( Yoon Kyu Lim ),현진원 ( Jin Won Hyun ),지영흔 ( Young Heun Jee ) 한국예방수의학회(구 한국수의공중보건학회) 2011 예방수의학회지 Vol.35 No.1
Vanadium, a dietary micronutrient, has been reported to present interesting biological and pharmacological properties, including superoxide and nitric oxide scavenging effects. Low-dose ionizing radiation (LDR) is known to damage DNA and cause apoptosis of peripheral immunocytes by producing reactive oxygen species (ROS). The aim of this study was to elucidate the capacity of immune activation of Jeju water containing vanadium on immunosuppression caused by LDR. We examined the ROS production, DNA damage, cell apoptosis and proliferation of peripheral immunocytes in irradiated mice drinking different concentrations for 90 days; V0 (vanadium 0㎍/L, control), V1 (vanadium 15~20㎍/ L) and V2 (vanadium 20∼25㎍/L). Compared to V0 control where level of ROS showed tendency to increase, the ROS production was attenuated in peripheral immunocytes of irradiated mice drinking V1 and V2. DNA damage of peripheral immunocytes triggered by LDR significantly increased in mice drinking V0 compared to non-irradiated control, whereas V1 and V2 dramatically induced remission of DNA damage. On the observation of apoptosis of peripheral immunocytes, V1 and V2 showed the potency to reduce the number of apoptotic cells. On the other hand irradiated mice drinking V0 exhibited raised number of apoptotic cells. From the results obtained, we speculated that Jeju water containing vanadium (V1 and V2) has a potential role in decreasing DNA damage and apoptosis of immune cell by inhibiting ROS production. Consistent with this, Jeju water containing vanadium (V1 and V2) exhibits a capacity to enhance cell proliferation of peripheral immunocytes, which is suppressed by LDR as shown in V0 control. Collectively, Jeju water containing vanadium reduced DNA damage and apoptosis and induced the stimulatory potential on immunocytes. Theseresults suggest that Jeju water containing vanadium sustained immune activities under immunosuppression caused by LDR.