Parallel Point-multiplication based on the Extended Basic Operations on Conic Curves over Ring Zn

Yongnan Li,Limin Xiao,Siming Chen,Hongyun Tian,Li Ruan,Binbin Yu 한국정보기술융합학회 2011 JoC Vol.2 No.1

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

Wei Li,Haidong Wang,Deyuan Li,Zhongze Hu,Siming Zhao,Zhejun Zheng 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.6

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor- (TNF-), interleukin-1- (IL-1-) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb in-duced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.

Study on the Correction Method for the Dead-time Effects of Neutron Detectors Due to Pulsed Radiation

Siming Guo,Jinjie Wu,Zhongjian Ma,Guanjia Li,Qingbin Wang 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.4

Gas detectors based on a 3He proportional counter play an important role in monitoring the ambient dose equivalent in nuclear reactors and particle accelerators, and the time resolution of such gas detectors is directly related to the accuracy of dose equivalent values when gas detectors are used in pulsed neutron fields. In this article, the dead-time of a proportional 3He counter is measured experimentally, and two methods to correct for the omitted counts resulting from the dead-time effect are adopted. The moderation time of neutrons passing through the moderator of a neutron detector is calculated by means of Monte Carlo simulation software; thus, the equation between the neutron counting rate and the correction coecient in accelerator radiation fields is deduced. In the other method, the parameters of the correction equation are derived experimentally in the pulsed radiation fields around accelerators, and the correction equation is determined. The dead-time effects of neutron detectors due to pulsed radiation can be corrected effectively by using the two methods introduced in this paper.

중국 지능형 택배 서비스의 서비스품질, 고객만족도 및 재이용의도 간의 관계 연구 : 지능형 택배함 이용을 중심으로

이향(Xiang Li),황사명(SiMing Huang),심상렬(Sang-Ryul Shim) 한국통상정보학회 2020 통상정보연구 Vol.22 No.4

전자상거래 활성화에 따라 중국의 택배 서비스 시장규모는 급속히 커지고 있으며, 지능형 택배함과 같은 고객 중심의 새로운 서비스 도입 등 택배 서비스 회사들 간의 경쟁도 치열해지고 있다. 이에 본 논문은 중국의 지능형 택배 서비스품질, 고객만족도 및 재이용의도 간에는 어떤 관계가 있는지를 실증 분석하였다. 먼저 선행연구를 바탕으로 지능형 택배함 서비스품질과 택배회사의 서비스품질을 함께 고려한 연구모형과 연구가설을 설정하였으며, 다중회귀분석을 통해 가설 검증을 하였다. 첫째, 지능형 택배함 서비스품질 중 기능성과 신뢰성은 고객만족도에 유의한 영향을 미치는 것으로 나타났다. 둘째, 택배회사 서비스품질 중 신속성과 정확성은 고객만족도에 유의한 영향을 미치는 것으로 나타났다. 셋째, 지능형 택배 서비스품질에 대한 고객만족도는 재이용의도에 유의한 영향을 미치는 것으로 나타났다. 이러한 분석 결과는 택배 서비스 시장에서의 경쟁력 제고를 위해서는 지능형 택배함의 기능성과 신뢰성을 높이고, 택배회사 서비스의 신속성과 정확성을 높이는 노력이 강화되어야 함을 의미한다. With the vitalization of B2C e-Commerce, China s delivery service market is rapidly growing, and competition among delivery service companies is intensifying, including the introduction of new customer-centered services such as smart express box. Accordingly, the purpose of this study is to empirically analyze the relationship among service quality, customer satisfaction, and reuse intention of intelligent delivery service in China. Based on prior studies, a research model and hypotheses were established by the variables of intelligent delivery service quality, customer satisfaction, and reuse intention. Intelligent delivery service quality is divided into smart express box service quality and delivery company service quality. First, it is shown that functionality and reliability of smart express box service quality have a significant impact on customer satisfaction. Second, it has been shown that the speed and accuracy of delivery company service quality have a significant impact on customer satisfaction. Third, customer satisfaction with the intelligent delivery service quality is shown to have a significant impact on reuse intention of it. The results of this study mean that more efforts to increase the functionality and reliability of smart express box service quality and to increase the speed and accuracy of delivery company service quality should be strengthened to enhance competitiveness in the delivery service market.

Protective Effects of Green Tea Polyphenol Against Renal Injury Through ROS-Mediated JNK-MAPK Pathway in Lead Exposed Rats

Wang, Haidong,Li, Deyuan,Hu, Zhongze,Zhao, Siming,Zheng, Zhejun,Li, Wei Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.6

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum blood urea nitrogen (BUN) and creatinine. Histological evaluations were then performed. In vitro studies were performed using primary kidney mesangial cells to reveal detailed mechanisms. Cell counting kit-8 (CCK-8) was used to evaluate cell viability. Pb induced cell apoptosis was measured by flow cytometry. Reactive oxygen species (ROS) generation and scavenging were tested by DCFH-DA. Expression level of tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$), interleukin-1-${\beta}$ (IL-1-${\beta}$) and IL-6 were assayed by ELISA. Western blot and qPCR were used to measure the expression of ERK1/2, JNK1/2 and p38. Polyphenols have obvious protective effects on Pb induced renal dysfunction and intoxication both in vivo and in vitro. Polyphenols reduced Pb concentration and accumulation in kidney. Polyphenols also protected kidney mesangial cells from Pb induced apoptosis. Polyphenols scavenged Pb induced ROS generation and suppressed ROS-mediated ERK/JNK/p38 pathway. Downstream pro-inflammatory cytokines were inhibited in consistency. Polyphenol is protective in Pb induced renal intoxication and inflammatory responses. The underlying mechanisms lie on the antioxidant activity and ROS scavenging activity of polyphenols.

Determination of the air-kerma in mammography x-rays at NIM

Ji Wang,Siming Guo,Pingzhou Lu,Jinjie Wu,Ying Liu,Ruonan Li,Yulong Wang 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.4

Breast cancer has become the top killer of women’s health in the world, and mammography X-ray has become the gold standard in various diagnostic methods, due to its low energy, low dose and high resolution. To meet the quality control requirements of mammography X-rays dose in clinical, the National Institute of Metrology (NIM,China) has established a mammography X-ray reference radiation facility. The radiation quality half-value layer (HVL) range from 0.274 to 0.364 mm (aluminum) meets the requirements of IEC61267, and a new parallel-plate free-air ionization is designed. At NIM, various correction factors were measured and simulated, and fnally, the absolute measurement of the X-ray air kerma rate of the mammography was realized. By analysis, the combined standard uncertainty of the air kerma is 0.44%. Provide traceability services for the use and quality control of mammography in China.

SNPs in the 5’ terminal-region of IGFBP6 gene and its linkage with pig body size

Xibi Fang,Songcai Liu,Yunyun Cheng,Siming Li,Qingyan Wu,Dan Su,Chao Lu,Hao Yu,Linlin Hao 한국통합생물학회 2015 Animal cells and systems Vol.19 No.6

Insulin-like growth factor binding protein 6 (IGFBP6) is a key factor in regulating the effects of insulin-like growth factor 2 (IGF2) on the animal growth and development, but the mechanism is far from known. In this study, the 5’-terminal sequence of the IGFBP6 gene (from −920 to −1 bp) which may regulate gene expression was sequenced in the Bama mini-pigs, the Tibetan mini-pigs, the Landrace pigs, the Large White pigs and the Northeast wild boars to screen for the single nucleotide polymorphisms (SNPs) and analyze the relations with the body size traits of swine through a chi-square test analysis. The genotype frequencies of the SNPs in the 5’-terminal sequence have shown that c.-726C > T, c.-722T > C, c.-535C > A, c.- 488T > C, c.-403A > G, and c.-378T > C may be related to the dwarf traits of the Bama mini-pig and the Tibetan minipigs (P < .05). A haplotype analysis of the 5’-terminal sequence of the IGFBP6 gene in the Landrace pigs, the Large White pigs and the Northeast wild boars found the two SNPs at −403 nt and −378 nt were in linkage and formed three kinds of haplotypes; AT was the dominant haplotype and the haplotype block was not formed in the Bama mini-pigs and Tibetan mini-pigs. Above all, the SNPs and haplotypes of the 5’-terminal sequence of the IGFBP6 gene may be involved in the regulation of swine body size.

Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies

Dong Jiale,Wang Wenzhi,Zhou Wei,Zhang Siming,Li Meng,Li Ning,Pan Guoqing,Zhang Xianzuo,Bai Jiaxiang,Zhu Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Implant-associated infection (IAI) is increasingly emerging as a serious threat with the massive application of biomaterials. Bacteria attached to the surface of implants are often difficult to remove and exhibit high resistance to bactericides. In the quest for novel antimicrobial strategies, conventional antimicrobial materials often fail to exert their function because they tend to focus on direct bactericidal activity while neglecting the modulation of immune systems. The inflammatory response induced by host immune cells was thought to be a detrimental force impeding wound healing. However, the immune system has recently received increasing attention as a vital player in the host’s defense against infection. Anti-infective strategies based on the modulation of host immune defenses are emerging as a field of interest. This review explains the importance of the immune system in combating infections and describes current advanced immune-enhanced anti-infection strategies. First, the characteristics of traditional/conventional implant biomaterials and the reasons for the difficulty of bacterial clearance in IAI were reviewed. Second, the importance of immune cells in the battle against bacteria is elucidated. Then, we discuss how to design biomaterials that activate the defense function of immune cells to enhance the antimicrobial potential. Based on the key premise of restoring proper host-protective immunity, varying advanced immune-enhanced antimicrobial strategies were discussed. Finally, current issues and perspectives in this field were offered. This review will provide scientific guidance to enhance the development of advanced anti-infective biomaterials.

Reduction of Graphene Oxide and its Effect on Square Resistance of Reduced Graphene Oxide Films

Zhaoxia Hou,Yin Zhou,Guangbin Li,Shaohong Wang,Meihan Wang,Xiaodan Hu,Siming Li 대한화학회 2015 Bulletin of the Korean Chemical Society Vol.36 No.6

Graphite oxide was prepared via the modified Hummers’ method and graphene via chemical reduction. Deoxygenation efficiency of graphene oxide was compared among single reductants including sodium borohydride, hydrohalic acids, hydrazine hydrate, and vitamin C. Two-step reduction of graphene oxide was primarily studied. The reduced graphene oxide was characterized by XRD, TG, SEM, XPS, and Raman spectroscopy. Square resistance was measured as well. Results showed that films with single-step N2H4 reduction have the best transmittance and electrical conductivity with square resistance of ~5746 Ω/sq at 70% transmittance. This provided an experimental basis of using graphene for electronic device applications.

Peripheral nerve defects repaired with autogenous vein grafts flled with platelet-rich plasma and active nerve microtissues and evaluated by novel multimodal ultrasound techniques

Yaqiong Zhu,Nan Peng,Jing Wang,Zhuang Jin,Lianhua Zhu,Yu Wang,Siming Chen,Yongqiang Hu,Tieyuan Zhang,Qing Song,Fang Xie,Lin Yan,Yingying Li,Jing Xiao,Xinyang Li,Bo Jiang,Jiang Peng,Yuexiang Wang,Yukun 한국생체재료학회 2022 생체재료학회지 Vol.26 No.3

Background: Developing biocompatible nerve conduits that accelerate peripheral nerve regeneration, lengthening and functional recovery remains a challenge. The combined application of nerve microtissues and platelet-rich plasma (PRP) provides abundant Schwann cells (SCs) and various natural growth factors and can compensate for the deficiency of SCs in the nerve bridge, as well as the limitations of applying a single type of growth factor. Multimodal ultrasound evaluation can provide additional information on the stiffness and microvascular flow perfusion of the tissue. This study was designed to investigate the effectiveness of a novel tissue-engineered nerve graft composed of an autogenous vein, nerve microtissues and PRP in reconstructing a 12-mm tibial nerve defect and to explore the value of multimodal ultrasound techniques in evaluating the prognosis of nerve repair. Methods: In vitro, nerve microtissue activity was first investigated, and the effects on SC proliferation, migration, factor secretion, and axonal regeneration of dorsal root ganglia (DRG) were evaluated by coculture with nerve microtissues and PRP. In vivo, seventy-five rabbits were equally and randomly divided into Hollow, PRP, Micro-T (Microtissues), Micro-T + PRP and Autograft groups. By analysing the neurological function, electrophysiological recovery, and the comparative results of multimodal ultrasound and histological evaluation, we investigated the effect of these new nerve grafts in repairing tibial nerve defects. Results: Our results showed that the combined application of nerve microtissues and PRP could significantly promote the proliferation, secretion and migration of SCs and the regeneration of axons in the early stage. The Micro-T + PRP group and Autograft groups exhibited the best nerve repair 12 weeks postoperatively. In addition, the changes in target tissue stiffness and microvascular perfusion on multimodal ultrasound (shear wave elastography; contrast-enhanced ultrasonography; Angio PlaneWave UltrasenSitive, AngioPLUS) were significantly correlated with the histological results, such as collagen area percentage and VEGF expression, respectively. Conclusion: Our novel tissue-engineered nerve graft shows excellent efficacy in repairing 12-mm defects of the tibial nerve in rabbits. Moreover, multimodal ultrasound may provide a clinical reference for prognosis by quantitatively evaluating the stiffness and microvescular flow of nerve grafts and targeted muscles