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Takashi Takata,Yasusei Kudo,Hiroko Hatano,kuko Ogawa,Samadarani Siriwardena,Shoïro Kitajima,Masae Kitagawa,Mutsumi Miyauchi 대한구강악안면병리학회 2007 대한구강악안면병리학회지 Vol.31 No.2
Oral squamous cel1 carcinoma(OSCC) is the most common malignancy of head neck region. Typically OSCC cells s how persist ent invasion that frequently leads to local recurrence and distant lymphatic metastasls However, molecular mechanisms of invasion of OSCC remain poorly understood. Her e we identifi ed periostin, interferon induced transmembrane protein l (IF1TM1) and wingless-type MMTV integration site family, member 5B(WNT5B) , as invasion promoting molecules in OSCC by comparing gene expression profiles between a parent OSCC cell line(MSCC-l) and its highly invasive clone(MSCC-1nvl). Overexpression of periostin, IFITMl and WNT5B mRNAs were confirmed in MSCC-1nvl by RT-PCR. Transfection of these molecules promoted invasion of OSCC cells Moreover , siRNA t r eatment of these molecules suppressed invasion of cancer cells in vitro I nter estingly, Periostin, 1F1TMl and WNT5B were highly expressed in OSCCs in comparison with nonnal tissues. 1n an orthotopic mouse model of OSCC, periostin-overexpressing cells metas tasized spontaneously to cervical lymph nodes and t o t he lung through their aggressive invasiveness. These findings suggest that peri ostin, IFITMl and WNT5B play important roles for invasion and of OSCC and can be prognostic markers and therapeutic t argets of OSCC.
Minimum variation log-aesthetic surfaces and their applications for smoothing free-form shapes
Sho Suzuki,R.U. Gobithaasan,Péter Salvi,Shin Usuki,Kenjiro T. Miura 한국CDE학회 2018 Journal of computational design and engineering Vol.5 No.2
The log-aesthetic curve, which includes the logarithmic (equiangular) spiral, clothoid, and involute of a circle, achieves a control over curvature distribution by defining its shape as an integral form of its curvature and they are expected to be utilized for the field of design. However, it is very difficult to extend it to surfaces and the existing formulations have some problems that they cannot use arbitrary boundary curves. In this paper, we propose ‘‘minimum variation log-aesthetic surface” as a new formulation for the log-aesthetic surface. Based on variational principle our method can generate surfaces by minimizing the objective function newly proposed in this paper for given arbitrary boundary curves.
Development of Aerial Photographing System with Throwing Device for Disaster Information Gathering
Sho Katayama,Takashi Takimoto 제어로봇시스템학회 2014 제어로봇시스템학회 국제학술대회 논문집 Vol.2014 No.10
Recently, as a disaster information gathering tool, aerial photographing devices which gather photos and videos from the air get much attention. Especially, the aerial photographing method at low altitude below 15 meters is important to the disaster information gathering. As these devices, there are helium gas balloons, radio-controlled helicopters, and pole/crane vehicles. However, these devices have risks that trigger accidental contact and crackup by air stream at low airspace. In order to improve the safety of these devices, in this paper, we have developed a throw type photographing system which consists of an automatically photographing device packaged in a plastic capsule egg and a launching device. The attitude of the photographing device is controlled by the microcomputer with acceleration, gyro and compass sensors. These sensors also used to estimate the time when the device reaches the top of air. Moreover, we have shown the effectiveness of the proposed system by shooting aerial photographs in practice.
Studyon Human body Motion Interface
Sho Yokota,Hiroshi Hashimoto,Yasuhiro Ohyama,Jin-Hua SHE,Daisuke Chugo,Hisato Kobayashi,Pierre Blazevic 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
The joystick is the operation interface of electric wheelchair. The user needs to operate it in accordance with machine’s operational procedure specifications. Therefore the joystick is convenience operation system for the system side rather than the user side We focus on the body motions which humans have, and tryto realize a new type of interface which replaces conventional joystick. There is a body motion which comes from in stinctive adjustment functions to control changes of body shape caused by voluntary actions. We use this kind of motion as an interface and call it HBMI(Human Body Motion Inerface). In this paper, we set a prototype based on the experiment for deriving a suitable measurement to detect human body motion. The evaluation of HBMI by using SD method is also presented.
Sho Dohzono,Hiromitsu Toyoda,Akira Matsumura,Hidetomi Terai,Akinobu Suzuki,Hiroaki Nakamura 대한척추외과학회 2017 Asian Spine Journal Vol.11 No.2
Study Design: A retrospective study. Purpose: To assess postoperative bone regrowth at surgical sites after lumbar decompression with >5 years of follow-up. Postoperative preservation of facet joints and segmental spinal instability following surgery were also evaluated. Overview of Literature: Previous reports have documented bone regrowth after conventional laminectomy or laminotomy and several factors associated with new bone formation. Methods: Forty-nine patients who underwent microscopic bilateral decompression via a unilateral approach at L4–5 were reviewed. Primary outcomes included correlations among postoperative bone regrowth, preservation of facet joints, radiographic parameters, and clinical outcomes. Secondary outcomes included comparative analyses of radiographic parameters and clinical outcomes among preoperative diagnoses (lumbar spinal stenosis, degenerative spondylolisthesis, and degenerative lumbar scoliosis). Results: The average value of bone regrowth at the latest follow-up was significantly higher on the dorsal side of the facet joint (3.4 mm) than on the ventral side (1.3 mm). Percent facet joint preservation was significantly smaller on the approach side (79.2%) than on the contralateral side (95.2%). Bone regrowth showed a significant inverse correlation with age, but no significant correlation was observed with facet joint preservation, gender, postoperative segmental spinal motion, or clinical outcomes. Subanalysis of these data revealed that bone regrowth at the latest follow-up was significantly greater in patients with degenerative lumbar scoliosis than in those with lumbar spinal stenosis. Postoperative segmental spinal motion at L4–L5 did not progress significantly in patients with degenerative spondylolisthesis or degenerative lumbar scoliosis compared with those with lumbar spinal stenosis. Conclusions: Microscopic bilateral decompression via a unilateral approach prevents postoperative spinal instability because of satisfactory preservation of facet joints, which may be the primary reason for inadequate bone regrowth. Postoperative bone regrowth was not related to clinical outcomes and postoperative segmental spinal instability.
Sho Suzuki,Takuji Gotoda,Chika Kusano,Hisatomo Ikehara,Yo Miyakoshi,Kenji Fujii 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.1
Bowel habits affect the quality of life (QOL) of patients with functional gastrointestinal disorders. This study evaluated the effects of reduced form coenzyme Q 10 (ubiquinol) intake on defecation frequency and stool form in patients with daily abdominal symptoms. This was a single-center, prospective, double-blind, randomized control study. Forty-one patients who had the daily symptom of constipation or diarrhea were randomly assigned at a 1:1 ratio to receive either ubiquinol (150 mg/day) or placebo for 12 weeks. Patients completed a daily diary to collect information regarding their numbers of defecations and stool forms according to the Bristol Stool Form (BSF) Scale for 7 days at baseline and 12 weeks. QOL was assessed using the 36-item short-form (SF-36) at baseline and 12 weeks. Twenty-one patients were assigned to the ubiquinol group, and 20 were assigned to the placebo group. At 12 weeks, the mean defecation frequency, compared to baseline, significantly decreased in the ubiquinol group (−0.1 times/day, P = .034) and increased in the placebo group (+0.3 times/day, P = .004). There was no significant change in the 12-week BSF Scale score of the ubiquinol group (+0.2, P = .123), whereas that of the placebo group was increased (+0.5, P < .001). The 12-week general health perception SF-36 score was significantly increased in the ubiquinol group (+3.5, P = .045), whereas there was no significant difference in that score in the placebo group (+1.2, P = .178). In conclusion, taking ubiquinol for 12 weeks decreased defecation frequencies and increased the QOL score, suggesting that ubiquinol may change the bowel habits and improve QOL in patients with abdominal distress.
Sho Hasegawa,Shinsuke Koshita,Yoshihide Kanno,Takahisa Ogawa,Toshitaka Sakai,Hiroaki Kusunose,Kensuke Kubota,Atsushi Nakajima,Yutaka Noda,Kei Ito 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.6
Background/Aims: The use of endoscopic intervention (EI) for acute biliary pancreatitis (ABP) remains controversial because theseverity of biliary obstruction/cholangitis/pancreatitis is not reflected in the indications for early EI (EEI). Methods: A total of 148 patients with ABP were included to investigate 1) the differences in the rate of worsening cholangitis/pancreatitis between the EEI group and the early conservative management (ECM) group, especially for each severity of cholangitis/pancreatitis, and 2) the diagnostic ability of imaging studies, including endoscopic ultrasound (EUS), to detect common bile ductstones (CBDSs) in the ECM group. Results: No differences were observed in the rate of worsening cholangitis between the EEI and ECM groups, regardless of theseverity of cholangitis and/or the existence of impacted CBDSs. Among patients without impacted CBDSs and moderate/severecholangitis, worsening pancreatitis was significantly more frequent in the EEI group (18% vs. 4%, p=0.048). In patients in the ECMgroup, the sensitivity and specificity for detecting CBDSs were 73% and 98%, respectively, for EUS, whereas the values were 13% and92%, respectively, for magnetic resonance cholangiopancreatography. Conclusions: EEI should be avoided in the absence of moderate/severe cholangitis and/or impacted CBDSs because of the high rateof worsening pancreatitis. EUS can contribute to the accurate detection of residual CBDSs, for the determination of the need forelective EI.