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Shi Wei Huang,Yuan Yin,Ya Juan Zheng,Ya Ru Dong 대한독성 유전단백체 학회 2015 Molecular & cellular toxicology Vol.11 No.1
Exposure to ischemia/reperfusion leads to the development and progression of retinal degenerative diseases. However, the exact mechanisms are not fully understood. In this article, the role of CIC-3 chloride channel in OGD-R (oxygen-glucose deprivation followed by reperfusion)-induced retinal damage was examined. Mouse photoreceptor-derived 661W cells were treated with the CIC-3 antisense oligonucleotide before exposure to OGD-R. Cell viability, mitochondrial membrane potential, cytochrome-c level, DNA fragmentation, caspase activity and protein expression were detected. Pretreatment of 661W cells with CIC- 3 antisense oligonucleotide significantly decreased OGD-R-mediated toxicity. In addition, apoptosis-related biochemical indicators showed that pre-incubation of CIC-3 antisense oligonucleotide would elevate the mitochondrial membrane potential, decrease the release of cytochrome-c as well as formation of DNA fragmentation, and inhibit activities of caspase-3 and caspase- 9 in exogenous OGD-R-treated 661W cells. Moreover, treatment with CIC-3 antisense oligonucleotide changed the expression of apoptosis-related protein. These results suggest that CIC-3 chloride channel mediates OGD-R-induced apoptosis, at least partially through mitochondrial membrane potential pathway and increasing the levels of proapoptotic molecules in 661W cells. CIC-3 chloride channel blockade may provide a new therapeutic approach for preventing ischemia/reperfusion- induced retinal neural damage.
Hardening steels by the generation of transient phase using additive manufacturing
Huang, E-Wen,Lee, Soo Yeol,Jain, Jayant,Tong, Yang,An, Ke,Tsou, Nien-Ti,Lam, Tu-Ngoc,Yu, Dunji,Chae, Hobyung,Chen, Shi-Wei,Chen, Shih-Min,Chou, Hung-Sheng Elsevier 2019 Intermetallics Vol.109 No.-
<P><B>Abstract</B></P> <P>In the present work, the tensile properties of 15–5 PH steel fabricated by selective laser melting (SLM) were examined with respect to the transient austenite phase. Compared with the 8%-transient-phase sample, the 18%-transient-phase one shows higher ultimate tensile strength and relatively low yield strength, as well as hardening behavior. We conducted <I>in-situ</I> neutron-diffraction study to examine the microstructure evolution for mechanistic understanding. After applying the external load, most non-equilibrium, retained austenite in the 8%-transient-phase sample transforms before the yield strength, whereas in the 18%-transient-phase sample only 50% of the austenite transforms. Accompanying with the phase transformation, a decrease in the dislocation density and the dislocation strain energy-assisted phase transformation of the ferrite phase are found in the 8%-transient-phase sample even before yielding, which, however, is not the case in the 18%-transient-phase sample. The study demonstrates the SLM enables tuning the amount of transient-phase ratio and coherency between phases to realize a mechanical property control for additive manufactured steel.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The tensile behavior was examined for 8%- and 18%-transient-phase additive manufacturing steels using in-situ neutron diffraction. </LI> <LI> The 18%-transient-phase sample exhibited higher ultimate tensile strength and low yield strength. </LI> <LI> The 18%-transient-phase specimen with more non-equilibrium γ-phase revealed a more profound strain hardening effect. </LI> </UL> </P>
Shi, Xueliang,Quintero, Estefaní,a,Lee, Sangsu,Jing, Linzhi,Herng, Tun Seng,Zheng, Bin,Huang, Kuo-Wei,Ló,pez Navarrete, Juan T.,Ding, Jun,Kim, Dongho,Casado, Juan,Chi, Chunyan Royal Society of Chemistry 2016 Chemical Science Vol.7 No.5
<▼1><P>Pro-aromatic <B>Th<I>n</I>-TIPS</B> exhibits distinctly different physical properties from anti-aromatic <B>S<I>n</I>-TIPS</B>.</P></▼1><▼2><P>Open-shell singlet diradicaloids have recently received much attention due to their unique optical, electronic and magnetic properties and promising applications in materials science. Among various diradicaloids, quinoidal π-conjugated molecules have become the prevailing design. However, the need for a fundamental understanding on how the fusion mode and pro-aromaticity/anti-aromaticity affect their diradical character and physical properties remains unaddressed. In this work, a series of pro-aromatic benzo-thia-fused [<I>n</I>]thienoacenequinodimethanes (<B>Th<I>n</I>-TIPS</B> (<I>n</I> = 1–3) and <B>BDTh-TIPS</B>) were synthesized and compared with the previously reported anti-aromatic bisindeno-[<I>n</I>]thienoacenes (<B>S<I>n</I>-TIPS</B>, <I>n</I> = 1–4). The ground-state geometric and electronic structures of these new quinoidal molecules were systematically investigated by X-ray crystallographic analysis, variable temperature NMR, ESR, SQUID, Raman, and electronic absorption spectroscopy, assisted by DFT calculations. It was found that the diradical character index (<I>y</I><SUB>0</SUB>) increased from nearly zero for <B>Th1-TIPS</B> to 2.4% for <B>Th2-TIPS</B>, 18.2% for <B>Th3-TIPS</B>, and 38.2% for <B>BDTh-TIPS</B>, due to the enhanced aromatic stabilization. Consequently, with the extension of molecular size, the one-photon absorption spectra are gradually red-shifted, the two-photon absorption (TPA) cross section values increase, and the singlet excited state lifetimes decrease. By comparison with the corresponding anti-aromatic analogues <B>S<I>n</I>-TIPS</B> (<I>n</I> = 1–3), the pro-aromatic <B>Th<I>n</I>-TIPS</B> (<I>n</I> = 1–3) exhibit larger diradical character, longer singlet excited state lifetime and larger TPA cross section value. At the same time, they display distinctively different electronic absorption spectra and improved electrochemical amphotericity. Spectroelectrochemical studies revealed a good linear relationship between the optical energy gaps and the molecular length in the neutral, radical cationic and dicationic forms. Our research work discloses a significant difference between the pro-aromatic and anti-aromatic quinoidal compounds and provides guidance for the design of new diradicaloids with desirable properties.</P></▼2>
Shi, Xueliang,Lee, Sangsu,Son, Minjung,Zheng, Bin,Chang, Jingjing,Jing, Linzhi,Huang, Kuo-Wei,Kim, Dongho,Chi, Chunyan The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.67
<P>A pro-aromatic bisphenaleno-thieno[3,2-b]thiophene (BPT-TIPS) was synthesized and compared with an anti-aromatic bisindeno-thieno[3,2-b]thiophene (S2-TIPS). BPT-TIPS showed larger diradical character, stronger absorption, longer excited state lifetime and better redox amphotericity than S2-TIPS.</P>
Influence of track irregularities in high-speed Maglev transportation systems
Huang, Jing Yu,Wu, Zhe Wei,Shi, Jin,Gao, Yang,Wang, Dong-Zhou Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.21 No.5
Track irregularities of high-speed Maglev lines have significant influence on ride comfort. Their adjustment is of key importance in the daily maintenance of these lines. In this study, an adjustment method is proposed and track irregularities analysis is performed. This study considers two modules: an inspection module and a vehicle-guideway coupling vibration analysis module. In the inspection module, an inertial reference method is employed for field-measurements of the Shanghai high-speed Maglev demonstration line. Then, a partial filtering, integration method, resampling method, and designed elliptic filter are employed to analyze the detection data, which reveals the required track irregularities. In the analysis module, a vehicle-guideway interaction model and an electromagnetic interaction model were developed. The influence of the measured line irregularities is considered for the calculations of the electromagnetic force. Numerical integration method was employed for the calculations. Based on the actual field detection results and analysis using the numerical model, a threshold analysis method is developed. Several irregularities modalities with different girder end's deviations were considered in the simulations. The inspection results indicated that long-wavelength irregularities with larger girder end's deviations were the dominant irregularities. In addition, the threshold analysis of the girder end's deviation shows that irregularities that have a deviation amplitude larger than 6 mm and certain modalities (e.g., M- and N-shape) are unfavorable. These types of irregularities should be adjusted during the daily maintenance.
Fengxia Shi,Quanbo Yu,Wei Huang,Chaochao Tan 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.5
Recently, some global cases of 2019 novel coronavirus (COVID-19) pneumonia have been caused by second- or third-generation transmission of the viral infection, resulting in no traceable epidemiological history. Owing to the complications of COVID-19 pneumonia, the first symptom and imaging features of patients can be very atypical and early diagnosis of COVID-19 infections remains a challenge. It would aid radiologists and clinicians to be aware of the early atypical symptom and imaging features of the disease and contribute to the prevention of infected patients being missed.
Cai, Wei,Huang, Yanyan,Fangyuan, Zhou,Qiu, Wenjun,Wang, Caixiao,Wu, Qiang,Erlei, Shi,Wen, Tao The Korean Institute of Electrical Engineers 2013 The Journal of International Council on Electrical Vol.3 No.1
For extending the power and improving the performance of SVG, a topology with several parallel plugging convertor modules is obtained, which has no common DC bus. In respect that the parameter difference among converters, reactive power of total output sharing has to be resolved. In this article, mathematics model with DQ analytic transformation is analyzed. Based on double close-loop decoupling control, and direct current control, a reactive power balance current sharing method is proposed. By using CPS-SPWM, the current harmonic of SVG is reduced, which is indicated by simulation result. Further, in order to apply the method to project application, a 2Mvar platform with a double FPGA-DSP controller broad is carried out. The simulation and practical performance of SVG are given. The validity and feasibility of the method is demonstrated by the results.